Manufacturing techniques and surface engineering of polymer based nanoparticles for targeted drug delivery to cancer

The evolution of polymer based nanoparticles as a drug delivery carrier via pharmaceutical nano/microencapsulation has greatly promoted the development of nano- and micro-medicine in the past few decades. Poly(lactide-co-glycolide) (PLGA) and chitosan, which are biodegradable and biocompatible polymers, have been approved by both the Food & Drug Administration (FDA) and European Medicine Agency (EMA), making them ideal biomaterials that can be advanced from laboratory development to clinical oral and parental administrations. PLGA and chitosan encapsulated nanoparticles (NPs) have successfully been developed as new oral drug delivery systems with demonstrated high efficacy. This review aims to provide a comprehensive overview of the fabrication of PLGA and chitosan particulate systems using nano/microencapsulation methods, the current progress and the future outlooks of the nanoparticulate drug delivery systems. Especially, we focus on the formulations and nano/micro-encapsulation techniques using top-down techniques. It also addresses how the different phases including the organic and aqueous ones in the emulsion system interact with each other and subsequently influence the properties of the drug delivery system. Besides, surface modification strategies which can effectively engineer intrinsic physicochemical properties are summarised. Finally, future perspectives and potential directions of PLGA and chitosan nano/microencapsulated drug systems are outlined.

Industrial and economic development : a holistic study of Brunei Darussalam

The primary objective of this research is to provide a framework for industrial and economic development with respect to Brunei Darussalam. The study is both novel and unique as it is potentially the most comprehensive holistic study performed to date with respect to industrial and economic development in Brunei.

Globalisation and manufacturing strategy in the TCF industry

Purpose – The textiles, clothing, and footwear (TCF) industry has struggled in Australia since the government commenced dismantling tariffs. By sourcing from Asia, middlemen undercut established suppliers, and retail chains set benchmark low prices with their imported “house” labels. The policy-makers predicted that local producers would become more efficient, and export to make up for lost sales, but the media paints a picture of rising imports, retrenchments, and factory closures. The research objective was to discover what strategies the survivors (actually) employ in adapting to the pressures of globalisation.

Design/methodology/approach – More than 30 companies were involved in the study, ranging from small family businesses to subsidiaries of big multinationals. Each case study was based on an interview with a senior executive, normally followed by a plant tour. This methodology suits a fresh topic, as it avoids preconceptions and imposes no bounds.

Findings – Results show that the policy change was based on “pie in the sky” forecasts. Increasingly, TCF production is transferred to cheap offshore locations, generally via subcontracting plus the “badging” of foreign designs. To survive, local factories should focus on quality and customer service, preferably in niche markets (like uniforms), or for specific customer groups, and develop technologically advanced products. A move down the supply chain into retailing can also assist. Large multinational corporations that engage in foreign direct investment dominate the management literature.

Originality/value – This paper presents a different perspective, neglected in international operations management, whereby domestically oriented businesses attempt to defend themselves against the adverse consequences of globalisation.

Computational simulation of chassis design and manufacturing

Australian Universities including Deakin University are entering the Formula One SAE car competition this year which was initialised in USA many years ago and has attracted many universities to participate all over the world. There are many categories to be competed for novelty of the design. To achieve optimised design of the car, computational techniques have widely been used in all aspects of the design and manufacturing of the car for the team at Deakin University. In this work, the design and manufacturing of the chassis was computationally simulated to optimise the structure for stress and natural frequencies. The chassis is designed using solid modelling code IDEAS with the geometry exported to ABAQUS, a FEM software, for optimisation.

Meteorological influences on coastal sea levels west of Port Phillip and their engineering significance

This report presents the results of an analysis of three years of tide and meteorological data aimed at delineating the influences of atmospheric pressure, waves, onshore winds and longshore winds on coastal sea levels West of Port Phillip Bay, Victoria« The data was used to develop predictive and hindcasting techniques for meteorological tides on the Otway Coast, using statistical methods, an empirical method and a mathematical model. The nature and magnitude of contributions of the various components of the meteorological tide, and the general variability of monthly and seasonal variations were also studied. It was found that meteorological tides on the Otway Coast can account for significant sea level changes, with the main factors being wind and atmospheric pressure. The wind component of the meteorological tide was found to be approximately twice the pressure component, and longshore winds were found to be more significant than onshore winds for wind setup on the Otway Coast. The meteorological tide models developed enable estimates of wind setup and atmospheric pressure setup on the Otway Coast to be readily computed using data from synoptic charts. The wave setup component could not be separated from the meteorological tide and is included in the wind setup component. The results of the investigation are relevant to the design and maintenance of coastal engineering works, and point to the need for the establishment and operation of coastal management schemes on the Otway Coast.

Analysis of twelve electrical and electronics engineering programs

This paper investigates undergraduate programs in electrical and electronics engineering offered by twelve universities in Australia, Asia, Europe, and America. The investigation focuses on the structure and content of the programs, and the contact hour and assessment of the subjects involved in the programs. The investigation is carried out in four stages: selection of universities, collection of data, analysis of data, and formulation of outcomes. A list of subjects is created based on the content of the programs. The average percentage coverage of each subject in the twelve programs is calculated. The subjects are then grouped into nine program components. The average percentage coverage of each component per university is calculated. For each component, the total number of contact hours for lecture, tutorial, and practical is calculated. Also, the average percentage of four assessment methods for each component is found. Discussions on the outcome of the investigation are presented.

Network and traffic engineering in emerging distributed computing applications

This book focuses on network management and traffic engineering for Internet and distributed computing technologies, as well as present emerging technology trends and advanced platform