Project management practice in transition of old residential region

With the rapid urbanisation worldwide, the transitions of old residential regions inside or close to the urban districts have been challenging both governments and professionals. The sustainable maintenance, innovation and construction of these regions incorporate the history, culture, environment and policy factors into the economic objectives. Over the long and complex process of a transition project, the dedicated project management crew are frequently confronted with diversified novel issues and obliged to contribute appropriate solutions urgently. In this paper, the authors first analyse the state of the art of transition projects of old residential regions based on their practices in real projects. Furthermore, the authors explore the sustainable alternatives of transition projects from the reservation and development perspectives of culture, environment, society and infrastructure. Finally, the authors develop a multi-dimensional implementary framework for guiding the practices of management of transition projects.

Some osmoregulatory parameters in selected fishes of the Australasian region

Fish must maintain their internal ionic concentration. This occurs through co-ordination of cellular ion channels and transporters, and hormones acting on and within the cells of the gill, kidney, intestine, and, in some species, unique organs. This study measured some of these transporters and hormones in unusual species of the Australasian region.

Above and beyond: exploring outcomes and practices of Scope Southern Region Early Childhood Intervention Service for children with disability

This research project is an exploration of the early childhood intervention service (ECIS) provided by Scope Southern Region. The research seeks to examine the benefits and outcomes for families and children. In doing so, the project’s emphasis is on key practices such as family centred practice and transdisciplinary practice, while examining the enablers and barriers to providing positive benefits to families and children. The central question is whether the interventions are of assistance to families and children.

The effect of mechanical loading on the size and shape of bone in pre-, peri-, and postpubertal girls: a study in tennis players

Exercise during growth results in biologically important increases in bone mineral content (BMC). The aim of this study was to determine whether the effects of loading were site specific and depended on the maturational stage of the region. BMC and humeral dimensions were determined using DXA and magnetic resonance imaging (MRI) of the loaded and nonloaded arms in 47 competitive female tennis players aged 8-17 years. Periosteal (external) cross-sectional area (CSA), cortical area, medullary area, and the polar second moments of area (I_p, mm⁴) were calculated at the mid and distal sites in the loaded and nonloaded arms. BMC and I _p of the humerus were 11-14% greater in the loaded arm than in the nonloaded arm in prepubertal players and did not increase further in peri- or postpubertal players despite longer duration of loading (both, _p < 0.01). The higher BMC was the result of a 7-11% greater cortical area in the prepubertal players due to greater periosteal than medullary expansion at the midhumerus and a greater periosteal expansion alone at the distal humerus. Loading late in puberty resulted in medullary contraction. Growth and the effects of loading are region and surface specific, with periosteal apposition before puberty accounting for the increase in the bone's resistance to torsion and endocortical contraction contributing late in puberty conferring little increase in resistance to torsion. Increasing the bone's rt.osistance to torsion is achieved hy modifying bone shape and mass, not necessarily bone density.

The taxonomy and phylogeny of the Cherax destructor complex (Decapoda : Parastacidae) examined using mitochondrial 16S sequences

This study uses nucleotide sequences from the 16S rRNA mitochondrial gene to investigate the taxonomy and phylogeny of freshwater crayfish belonging to the 'Cherax destructor' complex. The sequencing of an approximately 440-bp fragment of this gene region from freshwater crayfish sampled from 14 locations identified significant haplotype diversity. Phylogenetic analysis found three distinct clades that correspond to the species C. rotundus, C. setosus and C. destructor. C. rotundus is largely confined to Victoria, and C. setosus is restricted to coastal areas north of Newcastle in New South Wales. C. destructor is widely distributed in eastern Australia and shows significant phylogeographic structure, with three well supported clades. None of these clades, however, correspond to species previously recognised as C. esculus, C. davisi or C. albidus. The failure to genetically distinguish these morphologically defined species is consistent with reproductive information and morphological plasticity relating to habitat similar to that documented for other Cherax species.

Observations of loxocythere (loxocythere) ouyenensis (chapman, 1914) (ostracoda) from the cenozoic of S.E. Australia with comments on species attributed to microcytherura müller, 1894 and hemiparvocythere hartmann, 1982 from Australian and New Zealand ma

The type material of Loxocythere (Loxocythere) ouyenensis (Chapman, 1914) from mid Cenozoic strata of the Mallee Bore No. 11 in the Murray Basin, S.E. Australia is partially redescribed and refigured. This species belongs to a discrete group of large elongate Cenozoic fossil and living Loxocythere species, the carapaces of which possess sub-rectangular inner margin outlines, and broadly rounded posterior extremities. Some much smaller but otherwise very similarly shaped species, that have previously been placed under the genus Microcytherura (i.e. Microcytherura? peterroyi Yassini and Jones, 1995) or the genus Hemiparvocythere Hartmann, 1982 (i.e. Hemiparvocythere Iagunicola Hartmann, 1982), are also known from marine Cenozoic strata and modern seas of the Australasian region. There is a marked difference in the shape of the inner margin between this group of small Australasian forms and European species of Microcytherura s.s .. The former have broadly rounded posterior inner margins, whilst the latter have acutely rounded posterior inner margins. The latter also usually present posterior extremities located well below mid carapace height. It is here argued that this difference in inner margin shape between smaller Australasian species such as Microcytherura? peterroyi, and European species of Microcytherura s.s ., suggests that there is not a direct phylogenetic relationship between these two species groups.

Southeast Asia: a community of diversity

The region known as the Southeast provides the basis for a broad political community characterized by cultural and ethnic diversity, disparities in economic performance, and differences in regime and constitutional foundations. In recent years, the Association of Southeast Asian Nations (ASEAN) group of nations has made strides toward building a community based on respect for these differences. Despite a growing acceptance for democratic processes and human rights, the influence of these values over existing institutions and state behavior remains incomplete. The future development of the ASEAN region, and the nations that comprise it, is likely to be based on the strength and character of the relationships these states forge with one another and with more powerful external actors.

The resource-based view of strategy: application to the agricultural industry

IP a The paper examines the application of the Resource-Based View of strategy (RBV) to the Australian floral industry. Despite the RBV's successful application to research in a number of discipline areas and the formalisation of its relationship with Competitive Advantage (CA) 15 years ago, the empirical support for the benefit of the RBV and development of research constructs has been inadequate. This has been partly due to the difficulty of identifying and separating the contribution of resources. The RBV literature is now consistent in the criteria required of a resource for CA and identifies a range of empirical research objectives (e.g. the need for contextual constructs), data evaluation focuses (e.g. measuring the impact of management, process, regional and scale affects) and results objectives (such as identifying the causal structure of resources). Research was conducted in the Australian floral industry to produce supporting generalisable data and constructs for the RBV. This industry is well bounded with several strongly differentiating resources and operates in a global market environment, which is necessary for these research objectives. Six hypotheses were examined; (1) the use of resources as the input of the CA, (2) the impact of the development process on resources, (3) the impact of management control on the development of resources (4) the impact on capability of management, process, region and scale, (5) the impact of resource development maturity on the approach to resource development and (6) the possibility of evaluating individual resources according to various criteria. The data was collected using selected participant interviews, with validation of conclusions by industry experts. It was analysed using content analysis, comparative analysis and cognitive mapping. The research determined that organisations in the Australian floral industry possessed important resources including geography, skills, technology, R&D, supply chains and production costs. These contributed to four CA creating production outputs; quality, capacity, reliability and customer convenience. The research findings supported hypotheses 1, 3, 4, 5 and 6. The lack of support for the two remaining hypotheses, relating to the process of resource development, may be explained by the low resource development maturity of the industry which masks the impact of the resource development process. The results also determined that one resource could contribute to a number of CAs and that resources not meeting all of the normal RBV CA criteria could still provide a CA in an industry where few resources met all criteria. It was postulated that these resources’ contribution to competitive was not durable.

The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling

PRK1 is a lipid- and Rho GTPase-activated serine/threonine protein kinase implicated in the regulation of receptor trafficking, cytoskeletal dynamics and tumorigenesis. Although Rho binding has been mapped to the HR1 region in the regulatory domain of PRK1, the mechanism involved in the control of PRK1 activation following Rho binding is poorly understood. We now provide the first evidence that the very C-terminus beyond the hydrophobic motif in PRK1 is essential for the activation of this kinase by RhoA. Deletion of the HR1 region did not completely abolish the binding of PRK1-ΔHR1 to GTPγS-RhoA nor the activation of this mutant by GTPγS-RhoA in vitro. In contrast, removing of the last six amino acid residues from the C-terminus of PRK1 or truncating of a single C-terminal residue from PRK1-ΔHR1 completely abrogated the activation of these mutants by RhoA both in vitro and in vivo. The critical dependence of the very C-terminus of PRK1 on the signaling downstream of RhoA was further demonstrated by the failure of the PRK1 mutant lacking its six C-terminal residues to augment lisophosphatidic acid-elicited neurite retraction in neuronal cells. Thus, we show that the HR1 region is necessary but not sufficient in eliciting a full activation of PRK1 upon binding of RhoA. Instead, such activation is controlled by the very C-terminus of PRK1. Our results also suggest that the very C-terminus of PRK1, which is the least conserved among members of the protein kinase C superfamily, is a potential drug target for pharmacological intervention of RhoA-mediated signaling pathways

G21 healthy region project part 1 : business plan

Executive Summary
Background
G21 Geelong Region Alliance (G21), through the partnership activities of the
G21 Health & Wellbeing Pillar, seeks to position health and wellbeing as a
central element to all regional planning processes and outcomes. As a result, G21 wanted to explore the potential application of the World Health
Organisation’s (WHO) ‘Healthy Cities’ approach across the region to provide a comprehensive framework and set of principles to inform future planning and decision-making.
With this aim, G21 commissioned Deakin University to undertake a 6-month
independent research project. The research project involved two stages:
Part 1: A Healthy Region Research Report involved scoping and determining:
- The suitability of the World Health Organisations (WHO) ‘Healthy Cities’
approach to the G21 region; and
- The capacity of G21 Geelong Region Alliance to be the organisation to
facilitate this approach across the region.

Colonising Poso : the diary of Controleur Emile Gobee, June 1909 - May 1910

"While the colonisation of Central Sulawesi was a process that was unique to the particular demographic, social, political and economic characteristics of the region, in broad terms it replicated Dutch colonial policy and practice in the rest of the archipelago at the beginning of the 20th century. The diary of Aspirant Controleur Emile Gobee, records the process which imposed the relocation and resettlement of the Pamona people of the Poso region of Central Sulawesi into villages and therefore began a dramatic process of change. The document provides a rare example of the process of colonialism and goes to the heart of understanding the nature of the colonial project in the Dutch East Indies."--Publisher's website.
"The 1909-10 diary of Aspirant Controleur Emile Goběe, of Poso, Sulawesi in the Dutch East Indies, with a scholarly introduction that explains the significance of Dutch colonial and missionary intervention, which intentionally destroyed traditional cultures and lifestyles. During the time covered by this diary, the administration moved entire villages to places where they could be observed, changed their farming practices, and introduced trade and Christianity." -- Publisher.

History of the Geelong Regional Commission

This thesis is the first systematic history of the Geelong Regional Commission (GRC), and only the second history of a regional development organisation formed as a result of the growth centres policy of the Commonwealth Labor Government in the first half of the 1970s. In particular, the thesis examines the historical performance of the GRC from the time of its establishment in August 1977 to its abolition in May 1993. The GRC Commissioners were subject to ongoing criticism by some elements of the region's political, business, rural and local government sectors. This criticism focused on the Commissioners' policies on land-use planning, their interventionist stance on industrial land development, major projects and industry protection and their activities in revitalising the Geelong central business district. This thesis examines these criticisms in the light of the Commission's overall performance. This thesis found that, as a statutory authority of the Victorian Government, the GRC was successful over its lifetime, when measured against the requirements of the Geelong Regional Commission Act, the Commission's corporate planning objectives and performance indicators, the corporate performance standards of private enterprise in the late 1990s, and the performance indicator standards of today's regional economic development organisations in the United States of America, parts of the United Kingdom and Australia. With the change of Government in Victoria in October 1992 came a new approach to regional development. The new Government enacted legislation to amalgamate six of the nine local government councils of the Geelong region and returned regional planning responsibilities to the newly formed City of Greater Geelong Council. The new Government also made economic development a major objective of local government. As a result, the raison d'etre for the GRC came to an end and the organisation was abolished.

Modeling of enzyme–substrate complexes for the metalloproteases MMP-3, ADAM-9 and ADAM-10

The matrix metalloproteases (MMPs) and the ADAMs (A Disintegrin And Metalloprotease domain) are proteolytic enzyme families containing a catalytic zinc ion, that are implicated in a variety of normal and pathological processes involving tissue remodeling and cancer. Synthetic MMP inhibitors have been designed for applications in pathological situations. However, a greater understanding of substrate binding and the catalytic mechanism is required so that more effective and selective inhibitors may be developed for both experimental and clinical purposes. By modeling a natural substrate spanning P4-P4‘ in complex with the catalytic domains, we aim to compare substrate-specificities between Stromelysin-1 (MMP-3), ADAM-9 and ADAM–10, with the aid of molecular dynamics simulations. Our results show that the substrate retains a favourable antiparallel beta-sheet conformation on the P-side in addition to the well-known orientation of the P'-region of the scissile bond, and that the primary substrate selectivity is dominated by the sidechains in the S1' pocket and the S2/S3 region. ADAM-9 has a hydrophobic residue as the central determinant in the S1' pocket, while ADAM-10 has an amphiphilic residue, which suggests a different primary specificity. The S2/S3 pocket is largely hydrophobic in all three enzymes. Inspired by our molecular dynamics calculations and supported by a large body of literature, we propose a novel, hypothetical, catalytic mechanism where the Zn-ion polarizes the oxygens from the catalytic glutamate to form a nucleophile, leading to a tetrahedral oxyanion anhydride transition state.

Development in Papua New Guinea : various meanings in the context of logging in West New Britain

Development in Papua New Guinea ... is research into village level issues of logging. In New Britain, nationals are offered royalties for cutting their rainforest. Information about ecology and biodiversity is usually late in coming, and such information to them does not appear to advance their development. This thesis offers the most specific method for dealing with small communities in Papua New Guinea, and confronts the issue of self development. It is posited that all other development must encourage self development in Papua New Guinea. Evidence brought here shows the need to make the Melanesian community central to development strategies.

To accomplish such a strategy, there is a need to consider Melanesian cultures. An explanation of world views ensues. The world views of people of the Pasismanua region, of New Britain's south coast, was compared broadly with Melanesian cultures and Melanesian development in a variety of circumstances. Consequently, the suggestions made are broadly applicable to situations where resources must be well monitored. There are many such situations in Pacific nations, which suggests that the thesis will be of usc to a wide research community.

Since research is grounded in ethnographic as well as other research, this kind of study generates many other research questions, and the research is designed to lead to other studies. Certain aspects of the design become disclosed when the research has progressed. As well, the background of an expatriate researcher is intrusive, and must be mitigated by some form of participation in the host culture. This is a central tenet of the thesis. This participation increases sensitivity to culture and yields a circumspect consideration of the colonial issue. Occupied for many years by colonial powers especially Australia, all New Guinea including West New Britain shows the effects of colonisation. It also shows evidence of the new colonialism of cash-cropping, and of the destruction of biodiversity. This becomes a central theme, as does the position of this researcher as a participant in a global economic culture encroaching on and invited by Papua New Guinea.