Porous titanium with porosity gradients for biomedical applications

Highly porous titanium and titanium alloys with an open cell structure are promising implant materials due to their low elastic modulus, excellent bioactivity, biocompatibility and the ability for bone regeneration. However, the mechanical strength of the porous titanium decreases dramatically with increasing porosity, which is a prerequisite for the ingrowth of new bone tissues and vascularization. In the present study, porous titanium with porosity gradients, i.e. solid core with highly porous outer shell was successfully fabricated using a powder metallurgy approach. Satisfactory mechanical properties derived from the solid core and osseointegration capacity derived from the outer shell can be achieved simultaneously through the design of the porosity gradients of the porous titanium. The outer shell of porous titanium exhibited a porous architecture very close to
that of natural bone, i.e. a porosity of 70% and pore size distribution in the range of 200 - 500 μm. The peak stress and the elastic modulus of the porous titanium with a porosity gradient (an overall porosity 63%) under compression were approximately 152 MPa and 4 GPa, respectively. These
properties are very close to those of natural bone. For comparison, porous titanium with a uniform porosity of 63% was also prepared and haracterised in the present study. The peak stress and the elastic modulus were 109 MPa and 4 GPa, respectively. The topography of the porous titanium
affected the mechanical properties significantly.

Multiple lines of evidence for the beneficial effects of environmental flows in two lowland rivers in Victoria, Australia

The aim of this study was to identify whether environmental flows released into two lowland rivers (the Glenelg and Wimmera Rivers, western Victoria, Australia) during the spring to autumn period had successfully ameliorated the negative effects of multiple human impacts. Macroinvertebrates and a range of physico-chemical variables were sampled from three reaches in each river. Both rivers were sampled during three environmental release seasons with average-sized releases (1997-1998, 1998-1999 and 2001-2002) and two drought seasons with limited releases (1999-2000 and 2000-2001). The effects of releasing average-sized environmental flows on macroinvertebrates and physico-chemical variables were assessed by comparison with data from the two drought seasons. For the Glenelg River, data from a reference season prior to the release of environmental flows (1995-1996) was also compared to data from the five environmental flow seasons. Multivariate analyses revealed four pieces of evidence indicating that the release of environmental flows effectively slowed the process of environmental degradation in the Glenelg River but not in the Wimmera River: (1) the magnitude of the river discharge was dependent on the size of environmental flow releases; (2) in the Wimmera River, water quality deteriorated markedly during the two drought seasons and correlated strongly with macroinvertebrate assemblage structure, but this was not observed in the Glenelg River; (3) the taxonomic composition of the macroinvertebrate assemblages among contrasting flow release seasons reflected the severe deterioration in water quality of the Wimmera River; (4) despite two drought seasons with minimal environmental flow releases, the macroinvertebrate assemblage in the Glenelg River did not differ from the average-release seasons, nor did it return to a pre-environmental flows condition. Therefore, it appears that environmental flow releases did sustain the macroinvertebrate assemblage and maintain reasonable water quality in the Glenelg River. However, in the Wimmera River, release volumes were too small to maintain low salinities and were associated with marked changes in the macroinvertebrate assemblage. Therefore, there are multiple lines of evidence that environmental flow releases of sufficient magnitude may slow the process of degradation in a regulated lowland river.

Do socioeconomic gradients in women's health widen over time and with age?

A population-based study was conducted to investigate changes over time in women's well-being and health service use by socio-economic status and whether these varied by age. Data from 12,328 mid-age women (aged 45–50 years in 1996) and 10,430 older women (aged 70–75 years) from the Australian Longitudinal Study on Women's Health were analysed. The main outcome measures were changes in the eight dimensions of the Short Form General Health Survey (SF-36) adjusted for baseline scores, lifestyle and behavioural factors; health care utilisation at Survey 2; and rate of deaths (older cohort only). Cross-sectional analyses showed clear socioeconomic differentials in well-being for both cohorts. Differential changes in health across tertiles of socioeconomic status (SES) were more evident in the mid-age cohort than in the older cohort. For the mid-aged women in the low SES tertile, declines in physical functioning (adjusted mean change of –2.4, standard error (SE) 1.1) and general health perceptions (−1.5, SE 1.1) were larger than the high SES group (physical functioning –0.8 SE 1.1, general health perceptions –0.8 SE 1.2). In the older cohort, changes in SF-36 scores over time were similar for all SES groups but women in the high SES group had lower death rates than women in the low SES group (relative risk: 0.79, 95% confidence interval 0.64–0.98). Findings suggest that SES differentials in physical health seem to widen during women's mid-adult years but narrow in older age. Nevertheless, SES remains an important predictor of health, health service use and mortality in older Australian women.

What determines migration flows from low-income to high-income countries? An empirical investigation of Fiji-U.S. migration 1972-2001

This article examines the long-run and short-run determinants of migration from Fiji to the United States between 1972 and 2001 using a human capital framework, which is extended to take account of political instability in Fiji. In the long-run the authors find that differences in income levels, disparities in police strength, disparities in the number of doctors, costs of moving, and political instability in Fiji are all statistically significant with the expected sign. In the short run the cost of moving, lagged migration, political instability, and differences in both police strength and medical care are the main determinants of Fiji-United States immigration.

Effect of environmental flows on deep, anoxic pools

A series of field surveys were carried out on two permanent pools of the upper Glenelg River in SW Victoria, Australia. One was representative of the wider and deeper pools while the other was representative of the more-narrow and shallower pools. Both pools showed a typical seasonal cycle of warm, brackish, oxygen-poor, summer conditions and cool, oxygen-rich, low-salinity, winter conditions. The summer salinity increases were larger than expected, suggesting possible saline groundwater inflow from unidentified springs. Both pools contained anoxic water in their deeper sections but this was permanent only in the deeper pool. A simple model of the flushing rate of such anoxic pools subject to flows, such as environmental flow releases, was developed, based on an energy balance between the potential energy required to lift the anoxic layer and the kinetic energy derived from the river flow. The results were tested against and in agreement with the field measurements. The model also suggests that the anoxic layers are resilient to all but the largest environmental flows.