Molecular recognition of DNA by rigid [n]-polynorbornane-derived bifunctional intercalators: synthesis and evaluation of their binding properties

We have exploited the concept of multivalency in the context of DNA recognition, using novel chemistry to synthesize a new type of bis-intercalator with unusual sequence-selectivity. Bis-intercalation has been observed previously, but design principles for de novo construction of such molecules are not known. Our compounds feature two aromatic moieties projecting from a rigid, polynorbornane-based scaffold. The length and character of the backbone as well as the identity of the intercalators were varied, resulting in mono- or divalent recognition of the double helix with varying affinity. Our lead compound proved to be a moderately sequence-selective bis-intercalator with an unwinding angle of 27 and a binding constant of about 8 M. 9-Aminoacridine rings were preferred over acridine carboxamides or naphthalimides, and a rigid [3]-polynorbornane scaffold was superior to a [5]-polynorbornane. The flexibility of the linker connecting the rings to the scaffold, although less influential, could affect the strength and character of the DNA binding.

syn-Facial hetero-bridged [n]polynorbornanes : a new class of polarofacial framework molecules composed of fused 7-oxa- and 7-azanorbornanes

New oxygen-bridged norbornane-fused cyclobutene epoxides and bis-(cyclobutene epoxides) are described and shown to react stereoselectively with 7-azanorbornenes to produce syn-facial N,O-bridged polynorbornanes and stereorandomly with 7-oxanorbornenes to produce O,O-bridged polynorbornanes as mixtures of syn-facial and anti-facial products.[1] Polarofacial systems containing up to six syn-facial norbornane bridges are described, while systems with seven co-facial oxygen atoms have been prepared by incorporating terminal epoxide rings to O5-[5]polynorbornanes. Ester-substituted 1,3,4-oxadiazoles are shown to be useful reagents for coupling 7-oxanorbornanes and produce predominantly syn-facial O-bridged polarofacial systems together with their anti-facial isomers.

Implementing training packages in a TAFE institute: perceptions and concerns of staff

The advent of training packages is a further change to the vocational education and training sector and is currently being implemented by teaching professionals. This paper outlines the findings of a project involving teachers in a TAFE institution as they begin the process of implementing the cross-industry Laboratory Operations Training Package into their teaching centre. The impetus for the research was the recognition that the change brought about by the new initiative would present a challenge for the teachers and a further change to their role in vocational education and training (VET). The research was qualitative in the form of a case study. Findings demonstrated that the implementation required a significant change in the philosophy of educational practice within the centre and that the implementation process was causing the teachers anxiety and confusion.

Best books of the year

This article identifies favourite publications from 2003 selected by the following writers: Tony Birch, Neal Blewett, Ian Britain, Alison Broinowski, Paul Brunton, Inga Clendinnen, Martin Duwell, Morag Fraser, Andrea Goldsmith, Kerryn Goldsworthy, Peter Goldsworthy, Bridget Griffen-Foley, Clive James, Gail Jones, Nicholas Jose, Brian McFarlane, Brenda Niall, Ros Pesman, Peter Porter, Peter Steele, Chris Wallace-Crabbe, and Robyn Williams.

The institutional foundation of materialism in western societies

Studies of materialism have increased in recent years, and most of these studies examine various aspects of materialism including its individual or social consequences. However, understanding, and possibly shaping, a society’s materialistic tendencies requires a more complete study of the relationship between a society’s institutional patterns and the acceptance of materialism by its members. Consequently, the current study examines five of the institutional antecedents of materialism to understand better how and why it develops as a mode of consumption within a society. More specifically, a model relating materialism and a set of institutionalized patterns of social behavior referred to as the dominant social paradigm was developed and tested in a study of seven industrial, market-based countries. The results suggest that the economic, technological, political, anthropocentric, and competition institutions making up the dominant social paradigm are all positively related to materialism. The implications of the relationship are then discussed.

Indigenous entrepreneurs in Australia and New Zealand : a test of social marginality theory

Focusing on the original inhabits of Australia and New Zealand, we examine the basic precept of social marginality theory, namely whether socially marginalised and disadvantaged entrepreneurs might actually be more likely to start a new venture. Using survey data and in-depth interviews, we find mixed results. For Mäori, their position of disadvantage coupled with a history and cultural attitudes favouring enterprise has led to one of the world’s highest rates of entrepreneurial activity. However, for Indigenous Australians, their disadvantage and marginal status within Australian society, compounded by a continued legacy of inequity and by internal factors, has not encouraged an enterprising culture.

Water, weeds and autumn leaves : learning to be drier in the alpine region

Our paper explores how and what adults living and working in the Alpine region of Victoria understand and are learning about the changes to water availability, in a time when the response to water availability is subject to extensive debate and policy attention. Interviews for this study were conducted in the towns of Bright and Mount Beauty, with participants drawn from across the Alpine region. The interviews focused on what local stakeholders from the Alpine region understood about water availability in the region and how and what they had learned about living and working with climatic changes in their local area.

The findings of our study see that there was evidence of a strong understanding of the direct and indirect impact of climate change on participants' local community area. The study also sees evidence of learning through a community 'frames of reference' as outlined by Berkhout, Hertin and Dann et al.

Climate change in the Victorian Alps : can VET be a change agent?

Of all the factors contributing to turbulent times in Australia, climate change is one that offers both challenges and opportunities for VET. In a time when the response to water availability is subject to ‘extensive debate and policy attention’, our presentation explores what adults living and working in the Alpine region of Victoria understand about the changes to water availability, and what they have learned about adapting to significant climatic changes in their local area. Interviews were conducted in the towns of Bright, Mount Beauty and Albury, with participants from across the Alpine region. Our study found evidence of a strong understanding of the direct impact of climate change on participants’ local community area, and a keen desire to learn about adaptation to change. In addition to an identified need for more information around climate change issues and projected impacts in general, participants saw practical hands-on water education strategies as an important way to educate people to help themselves. Conversations about where or how people learned to adapt to change were broad ranging, and clearly connected to the participants’ backgrounds, livelihoods or where they were situated. This raised the question of what responses VET might develop to address these identified learning needs. Major local industries
of tourism, agriculture, water harvesting and land care are all covered by national Training Packages that include industry- specific units of competence to support learning to live and work in an environmentally sustainable way. In addition, the national Employability Skills framework offers opportunities to build climate change awareness and adaptation into units of competency where they may not be explicitly incorporated. Our presentation will outline the opportunities for VET to act as a change agent in this and other Australian communities impacted by climate change.

Attachment of magnetic molecules on a nanoSQUID

A novel procedure combining monolayer self-assembly with electron beam lithography has been developed for attaching ferritin nanoparticles to a submicron thin-film SQUID (superconducting quantum interference device). After opening a window in the PMMA (polymethylmethacrylate) resist, organic linker molecules are used to attach ferritin to the exposed parts of the gold overlayer of a Nb nanoSQUID. This allows the magnetic nanoparticles to be located optimally as far as magnetic coupling to the nanoSQUID is concerned.