The associations between attachment style and leadership behaviours

Research has suggested that effective leadership, specifically the use of transformational and transactional leadership behaviours is heavily embedded in a leader’s interpersonal abilities. However, few studies have investigated the interpersonal factors that drive the appropriate use of transformational and transactional leadership behaviour in leader-follower settings. Attachment theory provides an appropriate framework in which to understand the epigenesis of leadership behaviours and the impact of these behaviours on followers. In this preliminary study, 31 manager-non manager dyads recruited from a Victorian education institution and a national telecommunications company (managers – Mean age = 48.32 years, SD = 7.59; non-managers –Mean age = 44.44 years, SD = 9.56) took part in an online questionnaire. As part of the online questionnaire, participants completed self-report measures of attachment, leadership behaviour and employee outcomes. Analyses revealed that managers’ attachment style made a significant contribution to their use of transformational and transactional leadership, which in turn, was associated with follower’s satisfaction and effectiveness ratings of their managers. Correlations between leader and follower ratings revealed that managers and non-managers held distinct perceptions of leadership performance. These findings are discussed within the context of attachment theory and the personal relationships literature.

Prospects for epigenetic epidemiology

Epigenetic modification can mediate environmental influences on gene expression and can modulate the disease risk associated with genetic variation. Epigenetic analysis therefore holds substantial promise for identifying mechanisms through which genetic and environmental factors jointly contribute to disease risk. The spatial and temporal variance in epigenetic profile is of particular relevance for developmental epidemiology and the study of aging, including the variable age at onset for many common diseases. This review serves as a general introduction to the topic by describing epigenetic mechanisms, with a focus on DNA methylation; genetic and environmental factors that influence DNA methylation; epigenetic influences on development, aging, and disease; and current methodology for measuring epigenetic profile. Methodological considerations for epidemiologic studies that seek to include epigenetic analysis are also discussed.

Epigenetic deregulation in pediatric acute lymphoblastic leukemia

Similar to most cancers, genome-wide DNA methylation profiles are commonly altered in pediatric acute lymphoblastic leukemia (ALL); however, recent observations highlight that a large portion of malignancy-associated DNA methylation alterations are not accompanied by related gene expression changes. By analyzing and integrating the methylome and transcriptome profiles of pediatric B-cell ALL cases and primary tissue controls, we report 325 genes hypermethylated and downregulated and 45 genes hypomethylated and upregulated in pediatric B-cell ALL, irrespective of subtype. Repressed cation channel subunits and cAMP signaling activators and transducers are overrepresented, potentially indicating a reduced cellular potential to receive and propagate apoptotic signals. Furthermore, we report specific DNA methylation alterations with concurrent gene expression changes within individual ALL subtypes. The ETV6-RUNX1 translocation was associated with downregulation of ASNS and upregulation of the EPO-receptor, while Hyperdiploid patients (> 50 chr) displayed upregulation of B-cell lymphoma (BCL) members and repression of PTPRG and FHIT. In combination, these data indicate genetically distinct B-cell ALL subtypes contain cooperative epimutations and genome-wide epigenetic deregulation is common across all B-cell ALL subtypes.