Genome - wide association study identifies novel breast cancer susceptibility loci

Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate risks. To identify further susceptibility alleles, we conducted a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls, followed by a third stage in which 30 single nucleotide polymorphisms (SNPs) were tested for confirmation in 21,860 cases and 22,578 controls from 22 studies. We used 227,876 SNPs that were estimated to correlate with 77% of known common SNPs in Europeans at r² > 0.5. SNPs in five novel independent loci exhibited strong and consistent evidence of association with breast cancer (P < 10^-7). Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 and LSP1). At the second stage, 1,792 SNPs were significant at the P < 0.05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach.

Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): a randomised control trial

Objectives To determine the benefits and risks of a non-steroidal anti-inflammatory drug (NSAID) as prophylaxis for ectopic bone formation in patients undergoing total hip replacement (or revision) surgery.
Design Double blind randomised placebo controlled clinical trial, stratified by treatment site and surgery (primary or revision).
Setting 20 orthopaedic surgery centres in Australia and New Zealand.
Participants 902 patients undergoing elective primary or revision total hip replacement surgery.
Intervention 14 days' treatment with ibuprofen (1200 mg daily) or matching placebo started within 24 hours of surgery.
Main outcome measures Changes in self reported hip pain and physical function 6 to 12 months after surgery (Western Ontario and McMaster University Arthritis index).
Results There were no significant differences between the groups for improvements in hip pain (mean difference -0.1, 95% confidence interval -0.4 to 0.2, P = 0.6) or physical function (-0.1, -0.4 to 0.2, P = 0.5), despite a decreased risk of ectopic bone formation (relative risk 0.69, 0.56 to 0.83) associated with ibuprofen. There was a significantly increased risk of major bleeding complications in the ibuprofen group during the admission period (2.09, 1.00 to 4.39).
Conclusions These data do not support the use of routine prophylaxis with NSAIDs in patients undergoing total hip replacement surgery.
Trial registration NCT00145730.

Australasia

Australia and New Zealand are home to some of the hungriest media consumers in the world. On a per capita basis newspaper and magazine readership in Australia is one of the highest in the world. Australian homes have an average of two television sets and five radios.
Internet penetration is high, with almost universal adoption in offices and almost 11 million people using the Internet from home, as of June 2007, in a population of 21 million. The Australian information and communications technology market was worth about US$38 billion in 2007, the third largest in the Asia Pacific region after Japan and China. New Zealand's information technology (IT) goods and services sector was estimated at almost US$9 billion. New Zealanders are also major media consumers. This chapter looks first at Australian media and journalism, and then New Zealand before looking briefly at the Pacific.

Stephen Procter: reflections of a glass artist

Stephen Procter: Reflections of a Glass Artist, records the thoughts and philosophies of the artist and glassmaker who for a number of years headed the Glass Department of the Australian National University School of Art. It traces his career in glass working from his first interest developed through a pointillist technique while living on Dartmoor; through his British Council-funded grant that enabled him to learn glass blowing and cutting techniques in Austria; to the mature landscape paintings and glass sculptures created during his years living in Australia.