Evidence for Megalake Chad, north-central Africa, during the late quaternary from satellite data

The existence of a very large Lake Chad during the late Quaternary, Megalake Chad, has long been questioned. A Megalake Chad would present strong evidence for climatic fluctuations of great magnitude during the Holocene in tropical Africa. In this paper we used satellite data from Landsat and Modis sensors to collect and analyse new information on landforms in a 2 000 000 km2 region of the Lake Chad Basin. We detected 2300 km of remains marking the ancient shoreline of Megalake Chad. The satellite data also indicated many Saharan rivers and relict deltas leading to the long paleoshoreline. Large dunefield flattenings were observed and interpreted as the result of wave-cut erosion by the paleolake. Similarities were noticed between the landforms observed along the paleoshoreline of Megalake Chad and that of the former Aral Sea. This finding has significant consequences for reconstructing paleohydrology and paleoenvironments through the Lake Chad basin, and continental climate change.

Onset of word form recognition in English, Welsh, and English-Welsh bilingual infants

Children raised in the home as English or Welsh monolinguals or English–Welsh bilinguals were tested on untrained word form recognition using both behavioral and neurophysiological procedures. Behavioral measures confirmed the onset of a familiarity effect at 11 months in English but failed to identify it in monolingual Welsh infants between 9 and 12 months. In the neurophysiological procedure the familiarity effect was detected as early as 10 months in English but did not reach significance in monolingual Welsh. Bilingual children showed word form familiarity effects by 11 months in both languages and also revealed an online time course for word recognition that combined effects found for monolingual English and Welsh. To account for the findings, accentual, grammatical, and sociolinguistic differences between English and Welsh are considered.

Reconstruction of megalake Chad using shuttle radar topographic mission data

In the 2,500,000 km² Lake Chad Basin in central Africa, the 2000 Shuttle Radar Topographic Mission (SRTM) data have been used to supplement the existing topographic data. SRTM data produce much sharper images of the region's topography and provide new insights into debates about the nature and extent of late Quaternary Lake Chad. This paper shows that the accuracy of SRTM30, the recently released 30 arc seconds topographic data from SRTM, largely surpasses that of previous global Digital Elevation Models (DEMs) available in the region. Using a GIS we identified from SRTM30 elevation data key features in the landscape topography providing further evidence for the existence of a Megalake Chad. The SRTM30 data corroborate the presence of two ancient shorelines associated with stillstands of the paleolake at the elevation of the Mayo Kebbi and Bahr el Ghazal spillovers. We found a general flattening of the topography in the region covered by Megalake Chad which is most likely the result of wave-cut action. The SRTM30 data show that the remains of the highest paleoshoreline have a constant elevation of 325 ± 5 m amsl. At its maximum extent, Megalake Chad had an area of about 340 000 km² (only 8% less than the present-day world's largest lake, the Caspian Sea). The SRTM30 data also revealed ancient drainage networks in the Sahara that lead to Megalake Chad. We compiled available 14C dates to constrain Holocene Megalake Chad events. The results presented in this paper have significant consequences for improving our knowledge of regional paleohydrology and continental climate change. This study is also the first step for a GIS-based reconstruction of late Quaternary paleohydrology in tropical Africa.

Tale of Gresham's law

Gresham’s law, which says that bad money tends to drive good money out of circulation, may account for many nations’ episodes of money troubles, as far back as ancient Athens. This Commentary discusses the two main explanations for Gresham’s law and suggests some circumstances in which the law does not apply.

8-modified-2'-deoxyadenosine analogues induce delayed polymerization arrest during HIV-1 reverse transcription

The occurrence of resistant viruses to any of the anti-HIV-1 compounds used in the current therapies against AIDS underlies the urge for the development of new drug targets and/or new drugs acting through novel mechanisms. While all anti-HIV-1 nucleoside analogues in clinical use and in clinical trials rely on ribose modifications for activity, we designed nucleosides with a natural deoxyribose moiety and modifications of position 8 of the adenine base. Such modifications might induce a steric clash with helix αH in the thumb domain of the p66 subunit of HIV-1 RT at a distance from the catalytic site, causing delayed chain termination. Eleven new 2′-deoxyadenosine analogues modified on position 8 of the purine base were synthesized and tested in vitro and in cell-based assays. In this paper we demonstrate for the first time that chemical modifications on position 8 of 2′-deoxyadenosine induce delayed chain termination in vitro, and also inhibit DNA synthesis when incorporated in a DNA template strand. Furthermore, one of them had moderate anti-HIV-1 activity in cell-culture. Our results constitute a proof of concept indicating that modification on the base moiety of nucleosides can induce delayed polymerization arrest and inhibit HIV-1 replication.

Field emission properties from boron nitride nanotube field emitters

Boron nitride nanotubes (BNNTs) have been studied as a field emission material due to their unique and excellent properties such as high oxidation resistance and negative electron affinity. However, field emission properties of BNNT field emitters were rarely reported until now because it is difficult to synthesize high purity BNNTs and fabricate stable BNNT field emitters. Here, we report high field emission properties from BNNT field emitters fabricated on a tungsten rod.