A clustering based hybrid system for mass spectrometry data analysis

Recently, much attention has been given to the mass spectrometry (MS) technology based disease classification, diagnosis, and protein-based biomarker identification. Similar to microarray based investigation, proteomic data generated by such kind of high-throughput experiments are often with high feature-to-sample ratio. Moreover, biological information and pattern are compounded with data noise, redundancy and outliers. Thus, the development of algorithms and procedures for the analysis and interpretation of such kind of data is of paramount importance. In this paper, we propose a hybrid system for analyzing such high dimensional data. The proposed method uses the k-mean clustering algorithm based feature extraction and selection procedure to bridge the filter selection and wrapper selection methods. The potential informative mass/charge (m/z) markers selected by filters are subject to the k-mean clustering algorithm for correlation and redundancy reduction, and a multi-objective Genetic Algorithm selector is then employed to identify discriminative m/z markers generated by k-mean clustering algorithm. Experimental results obtained by using the proposed method indicate that it is suitable for m/z biomarker selection and MS based sample classification.

A new physarum-based hybrid optimization algorithm for solving 0/1 knapsack problem

As a typical NP-complete problem, 0/1 Knapsack Problem (KP), has been widely applied in many domains for solving practical problems. Although ant colony optimization (ACO) algorithms can obtain approximate solutions to 0/1 KP, there exist some shortcomings such as the low convergence rate, premature convergence and weak robustness. In order to get rid of the above-mentioned shortcomings, this paper proposes a new kind of Physarum-based hybrid optimization algorithm, denoted as PM-ACO, based on the critical paths reserved by Physarum-inspired mathematical (PM) model. By releasing additional pheromone to items that are on the important pipelines of PM model, PM-ACO algorithms can enhance item pheromone matrix and realize a positive feedback process of updating item pheromone. The experimental results in two different datasets show that PM-ACO algorithms have a stronger robustness and a higher convergence rate compared with traditional ACO algorithms.

Integration of supervised ART-based neural networks with a hybrid genetic algorithm

In this paper, two evolutionary artificial neural network (EANN) models that are based on integration of two supervised adaptive resonance theory (ART)-based artificial neural networks with a hybrid genetic algorithm (HGA) are proposed. The search process of the proposed EANN models is guided by a knowledge base established by ART with respect to the training data samples. The EANN models explore the search space for “coarse” solutions, and such solutions are then refined using the local search process of the HGA. The performances of the proposed EANN models are evaluated and compared with those from other classifiers using more than ten benchmark data sets. The applicability of the EANN models to a real medical classification task is also demonstrated. The results from the experimental studies demonstrate the effectiveness and usefulness of the proposed EANN models in undertaking pattern classification problems.

A multi-objective evolutionary algorithm-based decision support system: a case study on job-shop scheduling in manufacturing

In this paper, an evolutionary algorithm is used for developing a decision support tool to undertake multi-objective job-shop scheduling problems. A modified micro genetic algorithm (MmGA) is adopted to provide optimal solutions according to the Pareto optimality principle in solving multi-objective optimisation problems. MmGA operates with a very small population size to explore a wide search space of function evaluations and to improve the convergence score towards the true Pareto optimal front. To evaluate the effectiveness of the MmGA-based decision support tool, a multi-objective job-shop scheduling problem with actual information from a manufacturing company is deployed. The statistical bootstrap method is used to evaluate the experimental results, and compared with those from the enumeration method. The outcome indicates that the decision support tool is able to achieve those optimal solutions as generated by the enumeration method. In addition, the proposed decision support tool has advantage of achieving the results within a fraction of the time.

A particle swarm based hybrid system for imbalances medical data sampling

Background
Medical and biological data are commonly with small sample size, missing values, and most importantly, imbalanced class distribution. In this study we propose a particle swarm based hybrid system for remedying the class imbalance problem in medical and biological data mining. This hybrid system combines the particle swarm optimization (PSO) algorithm with multiple classifiers and evaluation metrics for evaluation fusion. Samples from the majority class are ranked using multiple objectives according to their merit in compensating the class imbalance, and then combined with the minority class to form a balanced dataset.

Results
One important finding of this study is that different classifiers and metrics often provide different evaluation results. Nevertheless, the proposed hybrid system demonstrates consistent improvements over several alternative methods with three different metrics. The sampling results also demonstrate good generalization on different types of classification algorithms, indicating the advantage of information fusion applied in the hybrid system.

Conclusion
The experimental results demonstrate that unlike many currently available methods which often perform unevenly with different datasets the proposed hybrid system has a better generalization property which alleviates the method-data dependency problem. From the biological perspective, the system provides indication for further investigation of the highly ranked samples, which may result in the discovery of new conditions or disease subtypes.

Agent-Based Hybrid Intelligent Systems: An Agent-Based Framework for Complex Problem Solving

Pt. I. Fundamentals of hybrid intelligent systems and agents -- 1. Introduction -- 2. Basics of hybrid intelligent systems -- 3. Basics of agents and multi-agent systems -- Pt. II. Methodology and framework -- 4. Agent-oriented methodologies -- 5. Agent-based framework for hybrid intelligent systems --6. Matchmaking in middle agents -- Pt. III. Application systems -- 7. Agent-based hybrid intelligent system for financial investment
planning -- 8. Agent-based hybrid intelligent system for data mining -- Pt. IV. Concluding remarks -- 9. The less the more -- App. Sample source codes of the agent-based financial planning system

An agent-based hybrid framework for database mining

While knowledge discovery in databases (KDD) is defined as an iterative sequence of the following steps: data pre-processing, data mining, and post data mining, a significant amount of research in data mining has been done, resulting in a variety of algorithms and techniques for each step. However, a single data-mining technique has not been proven appropriate for every domain and data set. Instead, several techniques may need to be integrated into hybrid systems and used cooperatively during a particular data-mining operation. That is, hybrid solutions are crucial for the success of data mining. This paper presents a hybrid framework for identifying patterns from databases or multi-databases. The framework integrates these techniques for mining tasks from an agent point of view. Based on the experiments conducted, putting different KDD techniques together into the agent-based architecture enables them to be used cooperatively when needed. The proposed framework provides a highly flexible and robust data-mining platform and the resulting systems demonstrate emergent behaviors although it does not improve the performance of individual KDD techniques.

An agent-based hybrid intelligent system for financial investment planning

Many complex problems including financial investment planning require hybrid intelligent systems that integrate many intelligent techniques including expert systems, fuzzy logic, neural networks, and genetic algorithms. However, hybrid intelligent systems are difficult to develop due to complicated interactions and technique incompatibilities. This paper describes a hybrid intelligent system for financial investment planning that was built from agent points of view. This system currently consists of 13 different agents. The experimental results show that all agents in the system can work cooperatively to provide reasonable investment advice. The system is very flexible and robust. The success of the system indicates that agent technologies can significantly facilitate the construction of hybrid intelligent systems.

An agent-based hybrid intelligent system for foreign exchange trading

The foreign exchange (FX) market has many features including (1) Each trader’s payoff depends not only on his own behavior, but also on other traders’ decisions; (2) The number of traders is too large to make them all know the other dealers’ methods of decision making; and (3) The FX market has many levels. The FX market is complex because of these features. A diversity of techniques are required to deal with such complex problems. That is hybrid solutions are crucial for the FX market. On the other hand, research into the FX market has revealed that it demonstrates some characteristics of multi-agent systems such as autonomy, interaction, and emergence. To this end, an agent-based hybrid intelligent system was developed for FX trading, which is based on our proposed agent-based hybrid framework. This paper is to discuss the analysis, design, and implementation such a system. Some experimental results and comparisons with related works are also provided. The interest of this paper does not reside in improving the predictive capabilities of different FX models, but rather in how to integrate different models into one system under the unifying agent framework. The success of this system indicates that agent perspectives are very appropriate to model complex problems such as the FX trading.

Building agent-based hybrid intelligent systems

Many complex problems including financial investment planning, foreign exchange trading, knowledge discovery from large/multiple databases require hybrid intelligent systems that integrate many intelligent techniques including expert systems, fuzzy logic, neural networks, and genetic algorithms. However, hybrid intelligent systems are difficult to develop because they have a large number of parts or components that have many interactions. On the other hand, agents offer a new and often more appropriate route to the development of complex systems, especially in open and dynamic environments. In this paper, it is argued that agent technology is well snited for constructing hybrid intelligent systems (especially loosely coupled hybrid intelligent systems) through a successful case study. A great number of heterogeneous computing techniques/packages are easily integlated into the experimental system under a unifying agent framework, which implies that agent technology can greatly facilitate the construction of hybrid intelligent systems.

Building agent-based hybrid intelligent systems : a case study

Many complex problems (e.g., financial investment planning, foreign exchange trading, data mining from large/multiple databases) require hybrid intelligent systems that integrate many intelligent techniques (e.g., fuzzy logic, neural networks, and genetic algorithms). However, hybrid intelligent systems are difficult to develop because they have a large number of parts or components that have many interactions. On the other hand, agents offer a new and often more appropriate route to the development of complex systems, especially in open and dynamic environments. Thus, this paper discusses the development of an agent-based hybrid intelligent system for financial investment planning, in which a great number of heterogeneous computing techniques/packages are easily integrated into a unifying agent framework. This shows that agent technology can indeed facilitate the development of hybrid intelligent systems.