Angiotensin converting enzyme inhibition from birth reduces body weight and body fat in Sprague-Dawley rats

In vitro studies have demonstrated that angiotensin II (ANG II) induces adipocyte hyperplasia and hypertrophy. The aim of the present study was to determine the effect of angiotensin-converting enzyme inhibition on body weight, adiposity and blood pressure in Sprague–Dawley rats. From birth half of the animals (n = 15) were given water to drink, while the remainder were administered perindopril in their drinking water (2 mg/kg/day). Food intake, water intake and body weight were measured weekly. Blood pressure was measured by tail cuff plethysmography at 11-weeks. Body fat content and distribution were assessed using dual energy X-ray absorptiometry and Magnetic Resonance Imaging at 12 weeks. Animals administered with perindopril had a body fat proportion that was half that of controls. This was consistent with, but disproportionately greater than the observed differences in food intake and body weight. Perindopril treatment completely removed hypertension. We conclude that the chronic inhibition of ANG II synthesis from birth specifically reduces the development of adiposity in the rat.

Playing the Agnes : Hester Thrale-Piozzi and Frances Burney

Guided by the feminist intention of reasserting the importance of neglected female writers, I have used this work to re-examine the lives and texts of eighteenth-century diarists Hester Thrale-Piozzi and Frances Burney. Adopting an interdisciplinary methodology, I draw on both literary and non-literary material to examine the effect of familial and social patriarchy in eighteenth-century England. Using the diaries, journals and letters of Hester and Frances, I ask why female conformity to masculine domination was expected, and how violence was used to extract subserviant behaviour from women. Beginning with gossip, and encompassing social, editorial and physical abuse, I use the medical profession's manipulation of female vulnerability to exemplify the way society legitimates violence to ensure female ductility. Moving beyond this physical aspect, I then examine the psychical, and question the existence of a ‘self’ which is vulnerable to external manipulation. By diverging from the influence of Freudian psychology, and developing a form of Jungian feminism, I propose the existence of an essential female Self which transcends the constraints of societal expectations and physical violence. In this work, both Hester and Frances emerge as physically and psychically strong entities who were forced to adopt socially conformist personae to survive.

Integrating agriculture and food policy to achieve sustainable peri-urban fruit and vegetable production in Victoria, Australia

Efforts to increase fruit and vegetable consump­tion are a significant aspect of national approaches to preventive health. However, policy frameworks for increasing fruit and vegetable consumption rarely take an integrated food-systems approach that includes a focus on production. In this policy analysis and commentary we examine fruit and vegetable production in peri-urban areas of Melbourne in Victoria, Australia, and highlight the significance of emerging environmental and eco­nomic pressures on fruit and vegetable production. This examination will be of interest to other locations around the world also experiencing pressure on their peri-urban agriculture. These pressures suggest that the availability and afforda­bility of fruit and vegetable supplies cannot be taken for granted, and that future initiatives to increase fruit and vegetable consumption should include a focus on sustainable production. Threats to production that include environmental pressures, together with the loss and cost of peri-urban agri­cultural land and a cost-price squeeze due to rising input costs and low farm-gate prices, act in combi­nation to threaten the viability of the Victorian fruit and vegetable industries. We pro­pose that policy initiatives to increase fruit and vegetable consumption should include measures to address the pressures facing production, and that the most effective policy responses are likely to be integrated approaches that aim to increase fruit and vegetable availability and affordability through innovative solutions to problems of production and distribu­tion. Some brief examples of potential integrated policy solutions are identified to illu­strate the possibilities and stimulate discussion.