Suppressors of cytokine signaling : functions in normal biology and roles in disease

Suppressor of cytokine signaling (SaCS) proteins have been identified as key negative regulators of cytokine and growth factor signaling. Therefore, given the diverse roles played by cytokines and growth factors in development and disease, it is not surprising that the sacs proteins themselves possess equally diverse and important functions, such as the control of hematopoiesis, immune function, growth and placental development. Significantly, more recent studies are increaSingly highlighting the crucial roles played by SOCS proteins in disease, particularly their tumor suppressor and anti-infammatory functions. Collectively, this research has served to confirm the importance of this class of proteins and suggests that therapeutic strategies for modulating SOCS proteins might be relevant for a range of diseases.

The fishery, biology and management of three inland water-bodies, Vietnam

This study was carried out from 1997 to 2004 and its findings have significantly enhanced our understanding on fishery, biology, and management of three inland water bodies in Vietnam. The study also provides insights into development of management guidelines and recommendations for future fisheries development in the research area.

Biology and control of white blister rust of Brassicaceae vegetables

This research project was a response to the outbreak of white blister rust disease and its spread to Brassica oleracea crops in Australia. Disease management strategies based on the understanding of the Albugo - Brassica pathosystem, epidemiology, and the use of chemical control measures were developed for the Australian Brassica industry.

Biology and management of Murray cod reproduction within controlled environments

The emerging Murray cod aquaculture industry is currently restricted by a lack of consistent and year-round production of fingerlings. Biological information and reproductive technologies developed during this research have facilitated the development of indoor, environmentally-controlled breeding practices for this species, thereby enabling Murray cod juveniles to be produced on-demand.

Thai river sprat : biology and management in Sirinthorn Reservoir, Thailand

The Thai river sprat (Clupeichthys aesarnensis) is a short-lived clupeid, which supports an artisanal fishery in a number of reservoirs in the Lower Mekong Basin. This study presents the C. aesarnensis biology, population dynamics and its fishery in Sirinthorn Reservoir, NE Thailand. C. aesarnensis fishery management schemes are also proposed.

Multicellular spheroids in ovarian cancer metastases: Biology and pathology

Epithelial ovarian cancer (EOC) has a relatively high mortality rate (~55%). One of the presiding causes is that the current chemotherapeutic regimes are unable to achieve sustained remission, despite frequently producing a positive response at first treatment. One of the reasons that EOC is difficult to treat is that the mechanism of dissemination is unusual. EOC dissemination characteristically involves local invasion of pelvic and abdominal organs. Unlike many epithelial cancers, initial dissemination rarely requires the vasculature, although the vasculature is often implicated in the advanced stages of disease. Recently, it has become apparent that aggregates of malignant cells (spheroids) contained within malignant ascites represent a significant impediment to efficacious treatment of late stage EOC. In vivo, spheroids are present in the malignant ascites of EOC patients, while in vitro cultured spheroids are capable of tumorgenesis in vivo and display a reduced response to chemotherapeutic drugs when compared to monolayers. A major problem associated with the current generation of chemotherapy agents is that they do not address the anchorage and vascular-independent growth conditions associated with a 3-dimensional structure that has formed and/or grown in suspension. Thus, spheroid formation may represent a key component of platinum/taxanesensitive recurrence. If this is correct, a better understanding of spheroid biology may contribute to the identification of new treatment opportunities for the sustained treatment of metastatic EOC. This review article outlines the key biological features of spheroids, specifically discussing their role in EOC dissemination and chemo-response as well as providing insights into spheroid functionality.

The biology and ecology of the ocean sunfish Mola mola : a review of current knowledge and future research perspectives

Relatively little is known about the biology and ecology of the world’s largest (heaviest) bony fish, the ocean sunfish Mola mola, despite its worldwide occurrence in temperate and tropical seas. Studies are now emerging that require many common perceptions about sunfish behaviour and ecology to be re-examined. Indeed, the long-held view that ocean sunfish are an inactive, passively drifting species seems to be entirely misplaced. Technological advances in marine telemetry are revealing distinct behavioural patterns and protracted seasonal movements. Extensive forays by ocean sunfish into the deep ocean have been documented and broad-scale surveys, together with molecular and laboratory based techniques, are addressing the connectivity and trophic role of these animals. These emerging molecular and movement studies suggest that local distinct populations may be prone to depletion through bycatch in commercial fisheries. Rising interest in ocean sunfish, highlighted by the increase in recent publications, warrants a thorough review of the biology and ecology of this species. Here we review the taxonomy, morphology, geography, diet, locomotion, vision, movements, foraging ecology, reproduction and species interactions of M. mola. We present a summary of current conservation issues and suggest methods for addressing fundamental gaps in our knowledge.

Report on the biology and ecology of Limonium hyblaeum Brullo at Port Fairy, Victoria, with respect to its invasive potential

Limonium hyblaeum Brullo, a perennial, salt tolerant plant native to Sicily forms a large invasion at Griffiths Island and along the strand of nearby Ocean Road, in Port Fairy, Victoria. This is causing concern as it has every appearance of having a high invasive potential but there is little known of its biology and ecology. This study therefore aimed to investigate aspects of its biology and ecology at Griffiths Island and nearby Ocean Road to identify any characteristics that would indicate its invasive nature, quantitatively determine its impact and determine how invasive it was. It was identified as having some key 'weed' attributes, i.e. being apomictic, allelopathic, fast growing in terms of both cover (40% increase in cover between spring and summer or 0.6 m along a transect line) and dry weight, being able to grow in saline and non-saline conditions and of being a transformer. A weed risk assessment demonstrated it was highly invasive and swift management of the species is recommended.

Conservation biology : a crisis discipline

Conserving biodiversity is of utmost importance on a global scale. Species conservation, however, is a challenging task, which is often compounded by a lack of knowledge of target species. New advances in information technology and molecular techniques, however, are enabling conservation biologists to obtain large amounts of data quickly, which will certainly aid in assigning conservation priorities. This article reviews the use of genetics in conservation biology and highlights, using the Powerful Owl Ninox strenua as an example, how DNA can be a valuable source of data.

Genetics and public health - evolution, or revolution?

During the 19th and early 20th century, public health and genetics shared common ground through similar approaches to health promotion in the population. By the mid-20th century there was a division between public health and genetics, with eugenicists estranged and clinical genetics focused on single gene disorders, usually only relevant to small numbers of people. Now through a common interest in the aetiology of complex diseases such as heart disease and cancer, there is a need for people working in public health and genetics to collaborate. This is not a comfortable convergence for many, particularly those in public health. Nine main concerns are reviewed: fear of eugenics; genetic reductionism; predictive power of genes; non-modifiable risk factors; rights of individuals compared with populations; resource allocation; commercial imperative; discrimination; and understanding and education. This paper aims to contribute to the thinking and discussion about an evolutionary, multidisciplinary approach to understanding, preventing, and treating complex diseases.

Race, genetic determinism and the media: an exploratory study of media coverage of genetics and Indigenous Australians

Social scientists and Indigenous people have voiced concerns that media messages about genetics and race may increase the public's belief in genetic determinism and even increase levels of racism. The degree of genetic determinism in media messages has been examined as a determining factor. This study is the first to consider the implications of this area of scholarship for the indigenous minority in Australia. A search of the last two decades of major Australian newspapers was undertaken for articles that discussed Indigenous Australians and genetics. The review found 212 articles, of which 58 concerned traits or conditions that were presented in a genetically deterministic or antideterministic fashion. These 58 articles were analysed by topic, slant, and time period. Overall, 23 articles were anti-deterministic, 18 were deterministic, 14 presented both sides and three were ambiguous. There was a spike in anti-deterministic articles in the years after the Human Genome Diversity Project, and a parallel increase in deterministic articles since the completion of the Human Genome Project in 2000. Potential implications of the nature of media coverage of genetics for Indigenous Australians is discussed. Further research is required to test directly the impact of these messages on Australians.

Colour polymorphism is likely to be disadvantageous to some populations and species due to genetic architecture and morph interactions

Polymorphism describes two or more distinct, genetically determined, phenotypes that co-occur in the same population, where the rarest morph is maintained at a frequency above the mutation rate (Ford 1945; Huxley 1955). In a recent opinion piece, we explored a new idea regarding the role of genetic architectures and morph interactions in colour polymorphisms and how this can negatively affect population performance (Bolton et al. 2015). In this issue of Molecular Ecology, Forsman (2016) thoroughly discusses the current evidence for polymorphisms enhancing population performance and critiques the validity of the definitions of polymorphism we use in our original paper. We respond by clarifying that the negative consequences of polymorphisms that we discussed are likely to be most pertinent in species that have a particular set of characteristics, such as strong sexual or social interactions between morphs and discrete genetic architectures. Although it was not our intention to redefine polymorphism, we do believe that there should be further discussion about refining or characterizing balanced polymorphisms with respect to the degree of morph sympatry, discreteness of traits and their underlying genetic architecture, and the types of selection that drive and maintain the variation. The latter describes whether polymorphism is primarily maintained by external factors such as predation pressure or internal factors such as interactions with members of the same species. The contribution of Forsman (2016) is useful to this discussion, and we hope that our exchange of opinions will inspire new empirical and theoretical ideas on the origin and maintenance of colour polymorphisms.