Interview with Sim Sar

Sim Sar is a Papua New Guinean who studied at the University of Queensland in 2008-2011. He studied on a John Allwright Fellowship and completed a PhD in Agriculture. The interview was conducted in English on 9 September 2014 by Dr. Jonathan Ritchie of Deakin University and Dr. Musawe Sinebare of the Pacific Adventist University. This set comprises: an interview recording, a timed summary, and a photograph.

Arts governance - marching Western models to Asia

Corporate failures and fraud have turned attention to company governance. While much of the literature is on for-profit governance, there is a steadily increasing non-profit literature arguing for industry specific governance studies, such as this one. Researching arts organisation governance in Asia, where profitability or sustainability are not the only measures for performance, provides a better understanding of theses cultures and economies. Here, a comparative review of arts governance is undertaken in order to inform debate in a discipline and in countries less frequently included in analysis. The Hong Kong Special Administrative Region (SAR) and Singapore are included in this brief review of Asian governance. What constitutes good governance and the unique cultural variables in each region are considered.

New educational service products : tertiary EC/EB education - the Asia-Pacific region

Electronic Commerce (EC) / Electronic Business (EB) has been (and is expected to continue to be) a dynamic, rapidly evolving area of technology, requiring skilled people with up-to-date knowledge and skills. The global community has required (and still requires) tertiary academic programs to prepare and train these people quickly. In the late nineties, following a tidal wave of tertiary EC program development in the United States, new tertiary programs began to appear in the Asia-Pacific (AP) region to satisfy this need, over a very short period of time. This research project aims to examine whether the development and effectiveness of tertiary EC/EB educational programs can be enhanced through employing a particular marketing paradigm. Four regions - Australia, New Zealand, Hong Kong SAR and the Republic of Singapore — were selected from the AP region, for this study. Based on a review of marketing literature, an inductive approach is adopted to build a model for new educational service product offerings. I also provide a description and comprehensive analysis of EC/EB education, and explore the model empirically, examining how it applies to the way EC education programs have been developed, to date. Essentially, this project consists of two major activities: theory building and theory testing – and is divided into three parts. Part 1: Preliminary study – literature review for theory building. This section of the thesis provides a literature review of the domains of curriculum development, EC/EB program development and management, EC/EB component models and new service product development. Part 2 : Understanding the marketplace – quantitative analysis. This section comprises five major surveys which provide an understanding of EC/EB education. Part 3 : In-depth analysis – qualitative research for theory testing. This section discusses the results of the multiple case studies of EC/EB degree programs undertaken over a five year period. The results of this project highlight both theoretical and practical aspects of the topic. In terms of the theoretical aspect, I provide a contribution to existing theory concerning the planning and development of new tertiary education programs. Research into academic course development in the past has tended to assume that all program development is pedagogically based and influenced. There is an assumption that people only develop academic programs and academic courses for pedagogic reasons. What this research project has done is to suggest that there are, in fact, many possible reasons for developing new programs and that, although these reasons might be pedagogic in nature, they can also be industry-focased, and market-oriented in the following ways: -the university is shaping the way it is perceived by the public – that is, the market; -the university is highlighting where its expertise lies. This led me to a form of new service product development consistent with the new image of the university. There is a clear need for diverse models for program development which accommodate the dynamic roles of modern universities. My research project develops such a model based on conditions in the Asia-Pacific region, and discusses findings arising from the overall project, which can be used to improve new educational program offerings in future, in both the Asia-Pacific and, I suggest, in other regions. This potential use of my findings highlights the practical contribution made by the research Project.

Structural and functional properties of human multidrug resistance protein 1 (MRP1/ABCC1)

Multidrug ABC transporters such as P-glycoprotein (P-gp/MDR1/ABCB1) and multidrug resistance protein 1 (MRP1/ABCC1) play an important role in the extrusion of drugs from the cell and their overexpression can be a cause of failure of anticancer and antimicrobial chemotherapy. Recently, the mouse P-gp/Abcb1a structure has been determined and this has significantly enhanced our understanding of the structure-activity relationship (SAR) of mammalian ABC transporters. This paper highlights our current knowledge on the structural and functional properties and the SAR of human MRP1/ABCC1. Although the crystal structure of MRP1/ABCC1 has yet to be resolved, the current topological model of MRP1/ABCC1 contains two transmembrane domains (TMD1 and TMD2) each followed by a nucleotide binding domain (NBD) plus a third NH2-terminal TMD0. MRP1/ABCC1 is expressed in the liver, kidney, intestine, brain and other tissues. MRP1/ABCC1 transports a structurally diverse array of important endogenous substances (e.g. leukotrienes and estrogen conjugates) and xenobiotics and their metabolites, including various conjugates, anticancer drugs, heavy metals, organic anions and lipids. Cells that highly express MRP1/ABCC1 confer resistance to a variety of natural product anticancer drugs such as vinca alkaloids (e.g. vincristine), anthracyclines (e.g. etoposide) and epipodophyllotoxins (e.g. doxorubicin and mitoxantrone). MRP1/ABCC1 is associated with tumor resistance which is often caused by an increased efflux and decreased intracellular accumulation of natural product anticancer drugs and other anticancer agents. However, most compounds that efficiently reverse P-gp/ABCB1-mediated multidrug resistance have only low affinity for MRP1/ABCC1 and there are only a few effective and relatively specific MRP1/ABCC1 inhibitors available. A number of site-directed mutagenesis studies, biophysical and photolabeling studies, SAR and QSAR, molecular docking and homology modeling studies have documented the role of multiple residues in determining the substrate specificity and inhibitor selectivity of MRP1/ABCC1. Most of these residues are located in the TMs of TMD1 and TMD2, in particular TMs 4, 6, 7, 8, 10, 11, 14, 16, and 17, or in close proximity to the membrane/cytosol interface of MRP1/ABCC1. The exact transporting mechanism of MRP1/ABCC1 is unclear. MRP1/ABCC1 and other multidrug transporters are front-line mediators of drug resistance in cancers and represent important therapeutic targets in future chemotherapy. The crystal structure of human MRP1/ABCC1 is expected to be resolved in the near future and this will provide an insight into the SAR of MRP1/ABCC1 and allow for rational design of anticancer drugs and potent and selective MRP1/ABCC1 inhibitors.

Performance evaluation of multi-frame super-resolution algorithms

Multi-frame super-resolution algorithms aim to increase spatial resolution by fusing information from several low-resolution perspectives of a scene. While a wide array of super-resolution algorithms now exist, the comparative capability of these techniques in practical scenarios has not been adequately explored. In addition, a standard quantitative method for assessing the relative merit of super-resolution algorithms is required. This paper presents a comprehensive practical comparison of existing super-resolution techniques using a shared platform and 4 common greyscale reference images. In total, 13 different super-resolution algorithms are evaluated, and as accurate alignment is critical to the super-resolution process, 6 registration algorithms are also included in the analysis. Pixel-based visual information fidelity (VIFP) is selected from the 12 image quality metrics reviewed as the measure most suited to the appraisal of super-resolved images. Experimental results show that Bayesian super-resolution methods utilizing the simultaneous autoregressive (SAR) prior produce the highest quality images when combined with generalized stochastic Lucas-Kanade optical flow registration.

Multi-layer implantable antenna for closed loop deep brain stimulation system

A multi-layer circular planar inverted-F antenna is designed and simulated at the industrial, scientific, and medical (ISM) band of 915 MHz for closed loop deep brain stimulation implant. The ISM band is considered due to the capabilities of small antenna size, high data rate, and long transmission range. In the proposed four-layer antenna, the top three radiating layers are meandered, and a high permittivity substrate and superstrate materials are used to limit the radius and the height of the antenna to 3.5 mm and 2.2 mm, respectively. The bottom layer works as a ground plate. The Roger RO3210 of εr = 10.2 and δ = 0.003 is used as a dielectric substrate and superstrate. The resonance frequency of the proposed antenna is 915 MHz with a bandwidth of 12 MHz at the return loss of -10 dB in free space. The stacked layered structure reduces the antenna size, and the circular shape makes it easily implantable into the human head. The antenna parameters (e.g. 3D gain pattern), SAR value, and electric field distribution within a six layers spherical head model are evaluated by using the finite element method (FEM). The feasibility of the wireless transmission of power, control and command signal to the implant in the human head is also examined. © 2012 IEEE.

Salicylic acid suppression of clubroot in broccoli (Brassicae oleracea var. italica) caused by the obligate biotroph Plasmodiophora brassicae

The obligate soil-borne biotroph Plasmodiophora brassicae has a significant economic impact on Brassicaceae crops. The pathogen severely disrupts the roots by inducing the production of galls which leads to malformation and reduced growth of the roots and a reduced ability to take up water and nutrients. Control of P. brassicae is difficult because it has a number of survival and dissemination strategies that involve both motile and resting stages that need to be targeted by any control agent. We investigated, under controlled conditions and in glasshouse and field experiments, the potential of salicylic acid (SA), a key phytohormone, that is required for defence against certain biotic and abiotic stresses, to reduce infection by P. brassicae in broccoli (Brassicae oleracea var. italica). Under controlled conditions in a growth cabinet exogenous application of SA to roots resulted in its transport systemically to the leaves where it promoted the up-regulation of the pathogenesis related genes PR-1 and PR-2 in an SAR-like response as early as 24 h post-treatment. Concentrations of SA >20 mM reduced significantly both shoot and root weights when applied exogenously but lower concentrations had little measureable effect on plant growth. When SA was applied to plants above 5 mM there was a significant reduction (25-65 %) in gall formation 6 weeks post-inoculation with P. brassicae, indicating that the pathogen was being controlled by the addition of SA. A combination of SA and JA was also shown to reduce severity (25-35 %) of disease associated with P. brassicae. These findings indicate that there may be SA inducible mechanisms in B. oleracea that if fine-tuned could provide enhanced resistance to clubroot disease.

Adult attachment insecurities are associated with obsessive compulsive disorder

Objectives.  Obsessive compulsive disorder (OCD) is one of the most disabling and highly prevalent anxiety disorders (ADs). Current cognitive models of OCD implicate views about the self and world in the maintenance of the disorder. However, little research has focused on issues that may lead to vulnerability to such views. In particular, a person's attachment insecurities (attachment anxiety, avoidance) may be important risk factors increasing the likelihood of such non-adaptive perceptions (Doron & Kyrios, 2005).

Design.  Participants meeting criteria for OCD were compared with cohorts meeting criteria for other ADs and healthy controls on a range of measures including adult attachment, OC symptoms, cognitions, and mood.

Methods.  Diagnosis of the clinical groups was established using the Anxiety Disorders Interview Schedule for DSM-IV (Brown, Di Nardo, & Barlow, 1994). The clinical relevance of attachment insecurities was ascertained by comparing their prevalence in an OCD sample (N= 30), an ADs sample (N= 20), and a community sample (N= 32). Results.  Attachment anxiety was significantly higher in individuals with OCD, even when controlling for depression.

Conclusions.  Addressing attachment anxiety in individuals presenting with OCD may be important for enhancing therapeutic outcomes. However, findings are based on cross-sectional data that preclude conclusions relating to causal influence.

Design and analysis of an antenna for wireless energy harvesting in head-mountable DBS device

This paper presents design and simulation of a circular meander dipole antenna at the industrial, scientific, and medical band of 915 MHz for energy scavenging in a passive head-mountable deep brain stimulation device. The interaction of the proposed antenna with a rat body is modeled and discussed. In the antenna, the radiating layer is meandered, and a FR-4 substrate is used to limit the radius and height of the antenna to 14 mm and 1.60 mm, respectively. The resonance frequency of the designed antenna is 915 MHz and the bandwidth of 15 MHz at a return loss of -10 dB in free space. To model the interaction of the antenna with a rat body, two aspects including functional and biological are considered. The functional aspect includes input impedance, resonance frequency, gain pattern, radiation efficiency of the antenna, and the biological aspect involves electric field distribution, and SAR value. A complete rat model is used in the finite difference time domain based EM simulation software XFdtd. The simulated results demonstrate that the specific absorption rate distributions occur within the skull in the rat model, and their values are higher than the standard regulated values for the antenna receiving power of 1W.

Electromagnetic energy harvesting in a head-mountable DBS device using a circular PIFA

A circular planar inverted-F antenna (PIFA) is designed and simulated at the industrial, scientific, and medical (ISM) band of 915 MHz for energy harvesting in a head-mountable deep brain stimulation device. Moreover, a rectifier is designed, and also the interaction of the PIFA with a rat head model is investigated. In the proposed PIFA, the top radiating layer is meandered, and a substrate of FR-4 is used. The radius and the height of the antenna are 10 mm and 1.8 mm, respectively. The bottom conductive layer works as a ground plate, and a superstrate of polyethylene reduces the electromagnetic penetration into the rat head. The resonance frequency of the designed antenna is 915 MHz with a bandwidth of 18 MHz at the return loss of -10 dB in free space. The antenna parameters (e.g. reflection coefficient, gain, radiation efficiency), electric field distribution, and SAR value are evaluated within a seven-layer rat head model by using the finite difference time domain EM simulation software XFdtd. The interactions of the antenna and the rat head model are studied in both functional and biological aspects.

An early Permian brachiopod–gastropod fauna from the Calytrix Formation, Barbwire Terrace, Canning Basin, Western Australia

A small brachiopod–gastropod fauna from a core close to the base of the Calytrix Formation within the Grant Group includes the brachiopods Altiplecus decipiens (Hosking), Myodelthyrium dickinsi (Thomas), Brachythyrinella narsarhensis (Reed), Neochonetes (Sommeriella) obrieni Archbold, Tivertonia barbwirensis sp. nov. and the gastropod Peruvispira canningensis sp. nov. The fauna has affinities with that of the late Sakmarian‒early Artinskian Nura Nura Member directly overlying the Grant Group in other parts of the basin but, as with all lower Cisuralian (and Pennsylvanian) glacial strata in Western Australia, its precise age remains poorly constrained, especially in terms of correlation to international stages. Although the Calytrix fauna lies within the Pseudoreticulatispora confluens Palynozone, the only real constraint on its age (and that of the associated glacially influenced strata) is from Sakmarian (Sterlitamakian) and stratigraphically younger faunas. A brief review of radiometric ages from correlative strata elsewhere in Gondwana shows that those ages need to be updated. The presence of Asselian strata and the position of the Carboniferous‒Permian boundary remain unclear in Western Australia.Arturo César Taboada [ataboada@unpata.edu.ar], CONICET-Laboratorio de Investigaciones en Evolución y Biodiversidad (LIEB), Facultad de Ciencias Naturales, Sede Esquel, Universidad Nacional de la Patagonia ‘San Juan Bosco’, Edificio de Aulas, Ruta Nacional 259, km. 16,5, Esquel U9200, Chubut, Argentina; Arthur Mory [arthur.mory@dmp.wa.gov.au], Geological Survey of Western Australia, 100 Plain Street, East Perth, WA 6004, School of Earth and Environment, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia; Guang R. Shi [grshi@deakin.edu.au], School of Life and Environmental Sciences, Deakin University, Melbourne Burwood Campus, 221 Burwood Highway, Burwood, Victoria 3125, Australia; David W. Haig [david.haig@uwa.edu.au], School of Earth and Environment (M004), The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia; María Karina Pinilla [mkpinilla@fcnym.unlp.edu.ar], División Paleozoología Invertebrados, Museo de Ciencias Naturales de La Plata, Paseo del Bosque s/n, 1900 La Plata, Buenos Aires, Argentina.

The South African Doctrine of Notice: a comparative law perspective

The doctrine of notice was received into South African law in Cohen v Shires, Mchattie and King (1881-1884) 1 SAR TS 41 by reference to a 17th century Dutch decision and English equity.The reception of the polar star of equity has led to doctrinal problems and differing views as to requirements for the operation of the doctrine ever since. This is illustrated in the decision of the Supreme Court of Appeal in Meridian Bay Restaurant (Pty) Ltd v Mitchell 2011 (4) SA 1 (SCA). The Court mentioned fraud and equity as the doctrinal basis but also accepted the view that the doctrine is an anomaly which does not fit into the principles of either the law of delict or property law.The Court required actual notice (or dolus eventualis) and wrongfulness for the operation of the doctrine of notice. In the following discussion of the decision it is argued that for the operation of the doctrine it should be required that: (a) a prior personal right aimed at the acquisition of a real right existed; (b) a holder of a subsequent personal right was actually aware or foresaw the possibility of the existence of the prior personal right; and (c) the holder of the real right nonetheless infringed upon the prior personal right by concluding a subsequent contract and obtaining registration of the real right in the deeds office.