Integrating insurance services, trust and risk mechanisms into multi-agent systems

In multi-agent systems, there is often the need for an agent to cooperate with others so as to ensure that a given task is achieved timely and cost effectively. Currently multi-agent systems maximize this through mechanisms such as coalition formation, trust and risk assessments, etc. In this paper, we incorporate the concept of insurance with trust and risk mechanisms in multi-agent systems. The novelty of this proposal is that it ensures continuous sharing of resources while encouraging expected utility to be maximized in a dynamic environment. Our experimental results confirm the feasibility of our approach.

Stimulus determinants and receptor mechanisms involved in the tactual perception of woollen fabrics

The dimensions of touch sensations were investigated in a series of human psychophysical experiments using woollen fabrics as stimuli and words from the textile industry literature as verbal descriptors of touch sensations. Roughness was shown to be an important dimension and was found to be encoded by two out of the four receptors in the skin that respond to specific frequencies of mechanical vibration.

N-acetylcysteine in psychiatry - current therapeutic evidence and potential mechanisms of action

There is an expanding field of research investigating the benefits of alternatives to current pharmacological therapies in psychiatry. N-acetylcysteine (NAC) is emerging as a useful agent in the treatment of psychiatric disorders. Like many therapies, the clinical origins of NAC are far removed from its current use in psychiatry. Whereas the mechanisms of NAC are only beginning to be understood, it is likely that NAC is exerting benefits beyond being a precursor to the antioxidant, glutathione, modulating glutamatergic, neurotropic and inflammatory pathways. This review outlines the current literature regarding the use of NAC in disorders including addiction, compulsive and grooming disorders, schizophrenia and bipolar disorder. N-acetylcysteine has shown promising results in populations with these disorders, including those in whom treatment efficacy has previously been limited. The therapeutic potential of this acetylated amino acid is beginning to emerge in the field of psychiatric research.

Interplay of ethical trust and social moral norms : environment modelling and computational mechanisms in agent-based social simulation

In many agent-based models theoretical and computational mechanisms are needed for model abstraction and design. However, it can be challenging to arrive at the appropriate mechanisms and models. This research on the interplay of ethical trust and social moral norms addresses that challenge via an analytical framework on the spread of moral norms, the modelling of social environment and the selection of spread mechanisms as applied to agent-based social simulation. We describe the mechanism alignment mapping, two forms of interaction modelling between the social environment and agents, and the results obtained from the simulation of our computational model. These results provide an insight into how the agent-based paradigm can be applied as a technique of investigation for normative moral processes in computational social sciences.

Antimanic-like activity of candesartan in mice: possible involvement of antioxidant, anti-inflammatory and neurotrophic mechanisms

Activation of the brain angiotensin II type 1 receptor (AT1R) triggers pro-oxidant and pro-inflammatory mechanisms which are involved in the neurobiology of bipolar disorder (BD). Candesartan (CDS) is an AT1 receptor antagonist with potential neuroprotective properties. Herein we investigated CDS effects against oxidative, neurotrophic inflammatory and cognitive effects of amphetamine (AMPH)-induced mania. In the reversal protocol adult mice were given AMPH 2mg/kg i.p. or saline and between days 8 and 14 received CDS 0.1, 0.3 or 1mg/kg orally, lithium (Li) 47.5mg/kg i.p., or saline. In the prevention treatment, mice were pretreated with CDS, Li or saline prior to AMPH. Locomotor activity and working memory performance were assessed. Glutathione (GSH), thiobarbituric acid-reactive substance (TBARS) and TNF-α levels were evaluated in the hippocampus (HC) and cerebellar vermis (CV). Brain-derived neurotrophic factor (BDNF) and glycogen synthase kinase 3-beta (GSK-3beta) levels were measured in the HC. CDS and Li prevented and reversed the AMPH-induced increases in locomotor activity. Only CDS prevented and reversed AMPH-induced working memory deficits. CDS prevented AMPH-induced alterations in GSH (HC and CV), TBARS (HC and CV), TNF-α (HC and CV) and BDNF (HC) levels. Li prevented alterations in BDNF and phospho-Ser9-GSK3beta. CDS reversed AMPH-induced alterations in GSH (HC and CV), TBARS (HC), TNF-α (CV) and BDNF levels. Li reversed AMPH-induced alterations in TNF-α (HC and CV) and BDNF (HC) levels. CDS is effective in reversing and preventing AMPH-induced behavioral and biochemical alterations, providing a rationale for the design of clinical trials investigating CDS׳s possible therapeutic effects.

Bovine lactoferrin targets apoptotic and EGFR mechanisms in breast cancer

 This research investigated the anti-cancer effects of milk protein, lactoferrin. It was found that lactoferrin specifically induced cell death in breast cancer cells and was non-toxic to normal mammary gland cells. Key molecular mechanisms targeted by lactoferrin were elucidated in this study which provides important insight into the activity of this protein as an anti-cancer agent.

Defense and traceback mechanisms in opportunistic wireless networks

 In this thesis, we have identified a novel attack in OppNets, a special type of packet dropping attack where the malicious node(s) drops one or more packets (not all the packets) and then injects new fake packets instead. We name this novel attack as the Catabolism attack and propose a novel attack detection and traceback approach against this attack referred to as the Anabolism defence. As part of the Anabolism defence approach we have proposed three techniques: time-based, Merkle tree based and Hash chain based techniques for attack detection and malicious node(s) traceback. We provide mathematical models that show our novel detection and traceback mechanisms to be very effective and detailed simulation results show our defence mechanisms to achieve a very high accuracy and detection rate.

Influence of backpressure during ECAP on the monotonic and cyclic deformation behavior of AA5754 and Cu99.5

Ultrafine-grained (UFG) metals produced by equal channel angular pressing (ECAP) exhibit outstanding mechanical properties. They show high strength under monotonic loading as well as strongly enhanced fatigue lives in the Wöhler S-N-plot compared to their coarse grained (CG) counterparts. It could be shown that the fatigue lives can be significantly enhanced further by applying backpressure during ECAP. Besides the positive effect of backpressure on the processability of hard to deform materials via ECAP, the hydrostatic stress induced by backpressure also influences the mechanical properties under monotonic and cyclic loading. Therefore the influence of backpressure on ECAPed Cu99.5 and on the ECAPed aluminum alloy AA5754 was investigated. It is shown that backpressure has no effect on the hardness and grain size in Cu99.5 but changes the grain boundary misorientation to higher fractions of low angle grain boundaries. Also the temperature dependency of the yield strength as well as the hardening behavior under monotonic compression is affected. The cyclic deformation behavior of Cu99.5 is not strongly influenced by backpressure, but the mean stress level changes drastically. The fatigue life increases with the application of backpressure at low plastic amplitudes due to a change in the crack initiation and propagation. Aim of this work is the investigation of the influence of backpressure during equal channel angular pressing (ECAP) on the mechanical properties under monotonic and cyclic loading. Therefore we performed hardness measurements, compression, and fatigue tests on ECAPed Cu99.5 and AA5754. The results are discussed in terms of microstructure and relevant deformation and damage mechanisms.