Law and theology in Gilbert of Foliot's (c. 1105/10-1187/88) correspondence

Lord Peter Stein, eminent historian of Roman law, described the interaction of law and theology in the writings of one twelfth-century writer as a kind of 'universal jurisprudence' , The twelfth-century figure to whom he referred was Master Vacarius (c. 1115/2O-c. 1200), well-known English Roman lawyer and Anglo-Norman canonist. While Stein drew this conclusion largely on the basis of an analysis of Vacatius' strictly 'legal' work, the Liber pauperum, I have shown elsewhere, following a systematic study ofVacarius' other works, dealing with maniage, christology and heresy, that, when seen together, they demonstrate a use of law as a universal heuristic device to resolve conflict in law and theology.

Multicentre phase I/II study of PI-88, a heparanase inhibitor in combination with docetaxel in patients with metastatic castrate-resistant prostate cancer

Background: Docetaxel (Taxotere) improve survival and prostate-specific antigen (PSA) response rates in patients with metastatic castrate-resistant prostate cancer (CRPC). We studied the combination of PI-88, an inhibitor of angiogenesis and heparanase activity, and docetaxel in chemotherapy-naive CRPC.

Patients and methods: We conducted a multicentre open-label phase I/II trial of PI-88 in combination with docetaxel. The primary end point was PSA response. Secondary end points included toxicity, radiologic response and overall survival. Doses of PI-88 were escalated to the maximum tolerated dose; whereas docetaxel was given at a fixed 75 mg/m2 dose every three weeks

Results: Twenty-one patients were enrolled in the dose-escalation component. A further 35 patients were randomly allocated to the study to evaluate the two schedules in phase II trial. The trial was stopped early by the Safety Data Review Board due to a higher-than-expected febrile neutropenia of 27%. In the pooled population, the PSA response (50% reduction) was 70%, median survival was 61 weeks (6–99 weeks) and 1-year survival was 71%.

Conclusions: The regimen of docetaxel and PI-88 is active in CRPC but associated with significant haematologic toxicity. Further evaluation of different scheduling and dosing of PI-88 and docetaxel may be warranted to optimise efficacy with a more manageable safety profile.