India's pharmaceutical industry: hype or high tech take-off?

India has built a large pharmaceutical industry through an array of measures in support of domestic firms. The absence of product patents enabled Indian companies to become world leading producers of generic versions of patented drugs. Low costs and a strong engineering tradition continue to sustain competitive strength. The implementation of the World Trade Organization patent regime in 2005 is driving a transformation of the industry. Key elements of the present shake-up include the return of 'big pharma' companies on a large scale and the emergence of several Indian firms that aim to become fullyfledged research-based multinationals. This article provides a description of the development and structure of the Indian pharmaceutical industry and explores questions and challenges arising from its integration into global markets.

Tow testing of Savonius wind turbine above a bluff body complemented by CFD simulation

A simple way to improve its power coefficient (cp) of a Savonius turbine is by its installation above a cuboidal building as the building will redirect the wind and increase its speed significantly. To determinethe gain, a turbine was constructed and installed above a bluff body and tow tested. Detailed measurements of vehicle speed and turbine power were made. Tow test speeds were 8, 10 and 12 m/s, while TSR range was 0.6-1.1. Most importantly, wind speed at the position beside and slightly above the turbine was measured during test runs. The cp calculated using this measured wind speed was used to validate CFD simulation results. Simulation results were also used to obtain the relationships between the wind speed of the free stream and at the anemometer position. Typically, wind speed at the anemometer position is about 9% higher than those of the free stream. These relationships were used to derive the free stream wind speed of each experimental run. The cp calculated using these derived free stream wind speeds showed an increase of 25% at 12 m/s wind speed, compared to the cp reported by previous researchers for a similar turbine operating in unmodified air flow.

The training load of aerial skiing

This study quantified the training load experienced by elite aerial skiers. Nine elite female aerial skiers were monitored during 16 training sessions over a 13 day period. Time-motion, landing impact and heart rate (HR) data were measured from 688 jumps using integrated GPS, accelerometer and HR transmitters while rating of perceived exertion (RPE) was taken using Borg's scale. Each jump was delineated into five components from the GPS time-motion data to determine the work to rest ratios. Participants completed 16 ± 3 jumps per session with a work to rest ratio of 1.9:1 Heart rates averaged 65 ± 3.1% HRmax and peaked at 85 ± 4.4% HRmax while and an RPE score of 12 ± 1 was evoked. Landing impacts were significantly higher (p ≤ 0.001) when participants jumped off ramps with a larger take-off angle or when they completed jumps with a mid-air rotation. The training load experienced by elite aerial skiers may be causative of the high incidence of injuries reported. Significantly differing levels of impact load during the study suggest training load for these athletes can be easily modified and periodised allowing optimised performance and minimised injury.

Effects of approach velocity and foot-target characteristics on the visual regulation of step length

Two questions emerge from the literature concerning the perceptual-motor processes underlying the visual regulation of step length. The first concerns the effects of velocity on the onset of visual control (VCO), when visual regulation of step length begins during goal-directed locomotion. The second concerns the effects of different obstacles such as a target or raised surface on step length regulation. In two separate experiments, participants (Experiment 1 & 2: n=12, 6 female, 6 male) walked, jogged, or sprinted towards an obstacle along a 10 m walkway, consisting of two marker-strips with alternating black and white 0.50 m markings. Each experiment consisted of three targeting or obstacle tasks with the requirement to both negotiate and continue moving (run-through) through the target. Five trials were conducted for each task and approach speed, with trials block randomised between the six participants of each gender. One 50 Hz video camera panned and filmed each trial from an elevated position, adjacent to the walkway. Video footage was digitized to deduce the gait characteristics. Results for the targeting tasks indicate a linear relationship between approach velocity and accuracy of final foot placement (r=0.89). When foot placement was highly constrained by the obstacle step length shortened during the entire approach. VCO was found to occur at an earlier tau-margin for lower approach velocities for both experiments, indicating that the optical variable ‘tau' is affected by approach velocity. A three-phase kinematic profile was found for all tasks, except for the take-off board condition when sprinting. Further research is needed to determine whether this velocity affect on VCO is due to ‘whole-body' approach velocity or whether it is a function of the differences between gait modes.

Environmentally sustainable food production and marketing : opportunity or hype?

Purpose: Identify and analyse the beliefs of value-chain intermediaries regarding the production and marketing of food products conforming to environmentally sustainable standards.

Methodology: In-depth, semi-structured, face-to-face interviews with senior managers of food companies across the value chain.

Findings: In Australia, the demand for foods that are produced under environmentally sustainable standards has been slow to take-off because (a) customers do not perceive these products as offering any special benefits (b) customers distrust the claims made by organisations (c) these products are much more expensive than traditional products, and (d) the implementation of environmental standards is expensive. Customers claim that the use of different terminologies such as organic, green and environmentally friendly in promoting
food products is confusing.

Research Limitations: Findings are not generalisable because the study is based on a small sample.

Practical Implications: Value-chain intermediaries are unlikely to voluntarily adopt environmental standards because of low demand for such foods and the high costs of adopting and monitoring environmentally sustainable production and marketing regimes.

Visual regulation during competition long jumps and run-throughs

Previous investigators have reported that the ability of long jumpers to visually regulate their stride pattern as they approach the take-off board is critical for success. The importance of visual regulation (VA) on long jump (LJ) distance was assessed in six national-class competitors during two simulated competitions. Linear regression analyses indicated that increased VR contributes to a high average approach velocity -a key predictor of LJ distance. Early VA enabled the athletes to make small systematic adjustments to stride length in order to strike the board in an optimal take-off position, without sacrificing approach velocity. Athletes practice their LJ approach by repeating the stride pattern of the approach, but without the take-off. The current study established that these 'run-throughs' (AT) don't accurately simulate the VR characteristics of a LJ approach. One strategy to increase the VA required during RT's may be to place additional targets across the runway for the athletes to negotiate whilst approaching the take-off board, without compromising approach velocity.

Visual guidance during competition performance and run-through training in long jumping

To ensure precise foot placement on the take-off board, long jumpers visually regulate their stride pattern during their run-up. A relationship between how much visual guidance they use and the horizontal distance they jump has not, however, been quantified. Run-up precision is often practiced using run-throughs, which exclude the take-off and, therefore, the high physical stress of the complete long jump. The validity with which this common training method simulates the long jump approach remains, however, to be verified. Four state-standard long jumpers and two heptathletes completed two sessions, each comprising six run-throughs and six competition long jumps. A 50 Hz video camera was manually panned from an elevated platform to film each trial, to enable subsequent gait characteristic evaluations. Linear regression analyses identified that a longer visual regulation phase, measured in time, distance or number of strides, was a key predictor of long jump distance. The number of strides that were visually regulated during the long jump approach was, accordingly, positively correlated with long jump distance (r = 0.67, p = 0.001). The amount of visual regulation used during run-throughs was, however, less than half (p = 0.001) of that observed during long jump approaches. Our results should compel long jump coaches to supplement run-through training with additional visual guidance exercises, to encourage their athletes to visually regulate more of their long jump approach.

Information-based regulation of high-velocity foot-targeting tasks

Judging time-to-contact with a target is an important criterion for avoiding harm in everyday walking and running tasks, and maximizing performance in high-velocity sporting tasks. The information-based regulation of step length and duration during target-directed locomotion was examined in relation to gait mode, approach velocity, target task, expertise, and sporting performance during a series of four experiments. The first three experiments examined novice performers (Each n=12, 6 males, 6 females), whilst the last experiment examined expert gymnasts (n=5). Two reference strips with alternating 50cm black and white intervals were placed on either side of the approach strip for all of the experiments. One 50Hz-panning video camera filmed the approach from an elevated position. In Experiment 4, two stationary 250Hz cameras filmed the post-flight performance of the gymnastic vaults and, in addition, two qualified judges provided a performance score for each vaulting trial. The panning video footage in each experiment was digitized to deduce the gait characteristics. In Experiment 4, the high-speed video footage was analyzed three-dimensionally to obtain the performance measures such as post-flight height. The utilization of visual stimulus in target-directed locomotion is affected by the observer's state of motion as characterized by the mode of locomotion and also often the speed of locomotion. In addition, experience plays an important role in the capacity of the observer to utilize visual stimulus to control the muscular action of locomotion when either maintaining or adjusting the step mechanics. The characteristics of the terrain and the target also affect the observer's movement. Visual regulation of step length decreases at higher approach speeds in novice performers, where as expert performers are capable of increasing visual regulation at higher approach speeds. Conservatism in final foot placement by female participants accounts for the observed increase in distance from the critical boundary of the obstacle relative to toe placement. Behavioural effects of gender thus affect the control of final foot placement in obstacle-directed locomotion. The visual control of braking in target-directed locomotion is described by a tau-dot of-0.54. When tau-dot is below -0.54 a hard collision with the obstacle will occur, however, when tau-dot is above -0.54, a soft collision with the target will occur. It is suggested that the tau-dot margin defining the control of braking reveals the braking capacity of the system. In the target-directed locomotion examined a tau-dot greater than -0.70 would possibly exceed the braking capacity of the system, thus, leading to injury if performed. The approach towards the take-off board and vaulting horse in gymnastics is an example of target-directed locomotion in sport. Increased visual regulation of the timing and length of each step is a requirement for a fast running approach, a fundamental building block for the execution of complex vaults in gymnastics. The successful performance of complex vaults in gymnastics leads towards a higher judge's score. Future research suggestions include an investigation of visual regulation of step length in curved target-directed locomotion.

On 4 June 2008 Siberian Red Knots at Elbe Mouth kissed the canonical evening migration departure rule goodbye

Observations of departing Siberian-breeding Red Knots Calidris canutus canutus from their central staging site during northward migration, the Schleswig-Holstein Wadden Sea, Germany, in early June 2008, challenge the established notion that departing long-distance migrating waders only leave around sunset. During four days we scanned several thousand Red Knots for colour-ringed individuals and found a total of 20 different individuals that were previously ringed at either their main wintering site, the Banc d'Arguin in Mauritania, or at stopover sites on the Atlantic coast of France. Body masses of captured Red Knots in Schleswig-Holstein were higher than 200 g and hematocrite values showed an average of 58%, clearly indicating that they were ready for take-off. On all except one evening, we noted impressive departure movements during the incoming tide. On that exceptional evening a cold front thunderstorm passed over the area. Late the next morning, thousands of Red Knots departed during the incoming tide. We assume that the birds avoided taking off in adverse weather conditions and elaborate why Red Knots presumably traded off advantages from departing during twilight. We suggest that during spring migration, schedules are so tight that further delays decrease fitness, either because it would cause another full day of exposure to high predation risk by falcons, or because of conditions upon arrival on the tundra.

Take your shoes off to reduce patellofemoral joint stress during running

Elevated patellofemoral joint stress is thought to contribute to the development and progression of patellofemoral pain syndrome. The purpose of this study was to determine if running barefoot decreases patellofemoral joint stress in comparison to shod running. Running barefoot decreased peak patellofemoral joint stress by 12% (p=0.000) in comparison to shod running. The reduction in patellofemoral joint stress was a result of reduced patellofemoral joint reaction forces (12%, p=0.000) while running barefoot.

Commonwealth legislative power and "non punitive" detention: a constitutional roadmap

In 2004 The High Court handed down a number of decisions concerning detention imposed for purposes allegedly unrelated to punishment. This paper outlines the way the Federal Constitution restricts (and also facilitates) the imposition of "non punitive detention" by our governments. Such laws (as passed by the Federal Legislature) are constitutionally valid provided they can be characterised as falling within a legislative head of power under  section 51 off he Constitution. The power to detain for non punitive purposes can be reposed by the Legislature in the either the Executive or Judicial arms of government. Detention by the Executive is non punitive (and therefore does not offend the separation of powers) even though it involves a deprivation of liberty, provided it is imposed for “legitimate non punitive purposes”.  Legitimacy is in turn determined by reference to the section 51 heads of power. Detention for non punitive purposes by the judicial arm of government is constitutionally valid provided that (i) a “judicial process ” is adopted and (ii) (arguably) there is some link (albeit tenuous) with a previous finding of criminal guilt. The continuing existence of the “constitutional immunity ”from being detained by other than judicial order identified by the High Court in its 1992 decision in Lim v Minister for Immigration is called into question.

Solar aided power generation from coal fired power stations: THERMSOLV software

Although the thermodynamic advantages of using solar energy to replace the bleed off steam in the regeneration system of Rankine cycle coal fired power stations has been proven theoretically, the practical techno/economic feasibility of the concept has yet to be confirmed relative to real power station applications. To investigate this concept further, a computer modelling software “THERMSOLV” was developed by Deakin University researchers, together with the support of the Victorian power industry and Australian Research Council (ARC). This newly developed software simulates the steam cycle to assess the techno/economic merit of the solar aided concept for various power station structures, locations and local electricity market conditions. Two case studies, one in Victoria Australia and one in Yunnan Province, China, have been carried out to show the application of the software. This paper reports the structure and functions of the software, and the results of the two case studies.

Solar adsorption refrigeration : an alternative/auxiliary way for thermal storage for air conditioning

This paper presents an idea of using solar powered adsorption ice making system as an alternative or an auxiliary way for the traditional ice storage air conditioning systems. A simple solar adsorption refrigeration system runs in intermittent cycle. It makes cooling effect at night, and the cooling effect can be stored for the day use. It fits in well with the cycle of the existing off-peak ice storage air conditioning system. On the top of green effect of the solar powered ice making system, the idea is specifically beneficial for places where the price of the off-peak electricity is not significantly lower than peak price. Based on our many years experience on the solar ice making systems, the paper discusses the technical feature of the solar ice making technology and the solutions we are working on to attack the problems which may have potential damage to application of the solar ice making system for air conditioning purposes.