Modulation of tumor necrosis factor receptors 1 and 2 in chronic hepatitis B and C: The differences and implications in pathogenesis

Tumor necrosis factor (TNF) plays a role in the pathogenesis of chronic hepatitis B (CHB) and chronic hepatitis C (CHC). The difference in the cytokine responses between hepatitis B virus (HBV) and hepatitis C virus (HCV) infections may have implications in the pathogenesis of these diseases. We performed a comparative study to examine the possible differences in the TNF-TNF receptor (TNFR) response between CHB and CHC. We studied the cytokine levels of 38 patients with CHB, 40 patients with CHC and 9 patients with dual hepatitis B and C, and compared them with the baseline levels of 12 healthy controls. The plasma levels of TNF-, interferon-, interleukin (IL)-2, IL-4, IL-10 and soluble TNFR-1 and 2 (sTNFR-1 and 2) were quantified by enzyme-linked immunosorbent assays. The expression of TNFR-1 and 2 in liver tissues was examined in 30 cases of CHB and 15 cases of CHC by semiquantitative reverse transcription polymerase chain reaction. The results showed that sTNFR-1 levels correlated with liver inflammation in all patients, whereas this correlation was not found with sTNFR-2 or other cytokines. Liver inflammation indicators were higher in HCV RNA+ than in HCV RNA– CHC. Most significantly, sTNFR-1 levels correlated with liver inflammation in CHB, but not in CHC. However, the expression of TNFR-1 and 2 in liver was similar between CHB and CHC. These findings suggest that the TNFR signal transduction pathway is modulated differently in HBV and HCV infection.

Artikel 3(1) en (2) van die Mineral and Petroleum Resources Development Act 28 van 2002: 'n herbeskouing

Sections 3(1) and 3(2) of the Mineral and Petroleum Resources Development Act 28 of 2002
This contribution entails a discussion of the impact of section 3 of the Mineral and Petroleum Resources Development Act on various aspects of the new mineral and petroleum law. At the core of the discussion is the question of how this section is interpreted by various commentators, and the implications of the different opinions on the application of the section. The initial discussion highlights problems with the new definition of a "mineral": Soil, including topsoil is at present included in die definition of a "mineral" in the act. The definition should be rectified by the legislature as it has far-reaching consequences in respect of the extent of the state's power in terms of section 3(2) of the act to grant entitlements in respect of minerals, including topsoil. The implications of section 3 for the control and management of minerals are discussed and placed in the context of the question about the constitutionality of the act. It is argued that legislative guidance is urgently needed to clarify continuing uncertainty, caused by sloppy drafting and different opinions about the connection between private law and public law in relation to minerals and the actual position of existing right holders.

Weak intermolecular interactions in sulfonamide salts : structure of 1-ethyl-2-methyl-3-benzyl imidazolium bis[(trifluoromethyl)sulfonyl]amide

The crystal structure of a 1,2,3-trisubstituted imidazolium salt of the bis[(trifluoromethyl)sulfonyl)]amide ion is presented; this salt is a prototype for similar, room temperature liquid, imidazolium salts; the structure shows that the anion and cation interact weakly, with little if any hydrogen bonding present.

Conductive plastic crystal phases of the 1-alkyl-2-methyl pyrrolinium TFSA salts

Characterization of a new family of salts, based on a number of 1-alkyl-2-methyl pyrrolinium cations and the bis(trifluoromethane sulfonyl) amide anion (TFSA), is presented. From the thermal analysis, conductivity and X-ray diffraction (XRD) measurements, at least one of the compounds of the family, 1-ethyl-2-methyl pyrrolinium TFSA, was found to exhibit plastic crystal phases before melting and to exhibit high conductivity in the solid state (1×10⁻⁴ S cm⁻¹ at 25 °C). This plastic crystal behaviour is discussed in comparison with other members of this pyrrolinium salt family.

A new family of ionic liquids based on the 1-alkyl-2-methyl pyrrolinium cation

Five new salts based on 1-alkyl-2-methyl pyrrolinium ion are reported, two involving the iodide ion and three involving the bis(trifluoromethanesulfonyl) amide ion. The iodide salts have melting points around 100 °C, while the amide salts have melting points around room temperature. Two of the amide salts can be easily quenched into the glassy state and exhibit glass transition temperatures around −70 °C. The 2-methyl pyrrolinium cation bears structural similarities to the aromatic imidazolium cations on one hand and the cyclic ammonium cation family based on the pyrrolidinium cation on the other. The properties of the salts reported here are compared within these two related families of salts.

A serverless ultra-lightweight secure search protocol for EPC Class-1 Gen-2 UHF RFID tags

Radio Frequency Identification (RFID) is a technology that enables the non-contact, automatic and unique identification of objects using radio waves. Its use for commercial applications has recently become attractive with RFID technology seen as the replacement for the optical barcode system that is currently in widespread use. RFID has many advantages over the traditional barcode and these advantages have the potential to significantly increase the efficiency of decentralised business environments such as logistics and supply chain management. One of the important features of an RFID system is its ability to search for a particular tag among a group of tags. In order to ensure the privacy and security of the tags, the search has to be conducted in a secure fashion. To our knowledge not much work has been done in this secure search area of RFID. The limited work that has been done does not comply with the EPC Class-1 Gen-2 standards since most of them use expensive hash operations or sophisticated encryption schemes that cannot be implemented on low-cost passive tags that are highly resource constrained. Our work aims to fill this gap by proposing a serverless ultra-lightweight secure search protocol that does not use the expensive hash functions or any complex encryption schemes but achieves compliance with EPC Class-1 Gen-2 standards while meeting the required security requirements. Our protocol is based on XOR encryption and random numbers - operations that are easily implemented on low-cost RFID tags. Our protocol also provides additional protection using a blind-factor to prevent tracking attacks. Since our protocol is EPC Class-1 Gen-2 compliant it makes it possible to implement it on low-cost passive RFID tags.

A secure search protocol based on Quadratic Residues for EPC Class-1 Gen-2 UHF RFID tags

Radio Frequency Identification (RFID) is a technological revolution that is expected to soon replace barcode systems. One of the important features of an RFID system is its ability to search for a particular tag among a group of tags. This task is quite common where RFID systems play a vital role. To our knowledge not much work has been done in this secure search area of RFID. Also, most of the existing work do not comply with the C1G2 standards. Our work aims to fill that gap by proposing a protocol based on Quadratic Residues property that does not use the expensive hash functions or any complex encryption schemes but achieves total compliance with industry standards while meeting the security requirements.

Book Review: Diabetes and wellbeing: Managing psychological and emotional challenges of diabetes types 1 and 2

Book Review in peer revewed Journal of Diabetes Nursing about the psychological and emotional challenges associated with living with Diabetes. The book is recommended to both health professionals and people with Diabetes.

Security protocols for EPC class-1 Gen-2 RFID multi-tag systems

The objective of the research is to develop security protocols for EPC C1G2 RFID Passive Tags in the areas of ownership transfer and grouping proof.

Acylmethyl(aryl)tellurium(IV,II) derivatives : intramolecular secondary bonding and steric rigidity

Electrophilic substitution of acylmethanes (methyl ketones), RCOCH3 (R = i-Pr, 1; Et, 2; Me, 3) with aryltellurium trichlorides, ArTeCl3 (Ar = 1-C10H7, Np, A; 2,4,6-Me3C6H2, Mes, B; 4-MeOC6H4, Anisyl, C) under mild conditions affords the corresponding acylmethyl(aryl)tellurium dichlorides (RCOCH2)ArTeCl2. Reduction of the dichlorides, gives tellurides, (i-PrCOCH2)ArTe, 1A–1C, which give the corresponding dihalides, (i-PrCOCH2)ArTeX2 (X = Cl, 1Aa–1Ca; Br, 1Ab–1Cb; I, 1Ac–1Cc) when reacted in situ with SO2Cl2, Br2 or I2. The unsymmetric tellurides are labile towards disproportionation and attempts to obtain them lead to the isolation of Ar2Te2 except in the case of (i-PrCOCH2)MesTe ( 1B), which represents an interesting example of a kinetically stable aryl(alkyl)telluride. All the dihalomesityltellurium(IV) derivatives show separate 1H and 13C NMR signals for the ortho methyls irrespective of the sizes of R and X ligands. The telluride, 1B with free rotation about Te–C(mesityl) bond shows, like the unsymmetric diorganotellurium(IV) dihalides, only one 125Te NMR signal. The 1,4-chelating behavior of the acyl ligand among diorganotellurium(IV) compounds is inferred from the X-ray diffraction data for 1Aa, 1Ac, 1Ba, 1Bb, 1Ca and 1Cc which are indicative of the presence of intramolecular TeO secondary bonding interactions (SBIs) at least in the solid state. As a consequence, steric repulsion in case of the mesityltellurium(IV) derivatives, 1Ba and 1Bb, reaches the threshold so as to cause loss of two-fold rotational symmetry of the mesityl group about the Te–C(mesityl) bond axis. Intermolecular C–HO H-bonding interactions appears to stabilize such an orientation of the aryl ligand at least in the solid state.