Communication of scientific uncertainty : international case studies on the development of folate and vitamin D Dietary Reference Values.

Transparent evidence-based decision making has been promoted worldwide to engender trust in science and policy making. Yet, little attention has been given to transparency implementation. The degree of transparency (focused on how uncertain evidence was handled) during the development of folate and vitamin D Dietary Reference Values was explored in three a priori defined areas: (i) value request; (ii) evidence evaluation; and (iii) final values.

Adopting global virtual engineering teams in AEC Projects: a qualitative meta-analysis of innovation diffusion studies

Purpose - This study aims to present an integrated conceptual model in order to highlight the major aspects of diffusion of innovations in the architecture, engineering and construction (AEC) context. To this end, a critical review of literature is conducted, accompaniedbysynthesising the findings of previous studies. The driving force behind this study is stemmed from the fragmentation of literature on innovation diffusion, and paucity of research on diffusion of Global Virtual Engineering Teams (GVETs) as the platform formany technological innovations in relevant literature. Thus, the present study is intended to facilitate filling the gap in GVETs literature. That is, the proposed model will offer a foundation for academia for grounding studies on any innovation including GVETs in the literature on innovation diffusion in the AEC context. Design/methodology/approach - This paper draws upon the qualitative meta-analysis approach encompassing a critical review of the relevant literature. To this end, the review builds upon studies found within 15 prestigious journals in AEC. The domain of this review was confined to areas described as "innovation", "innovation diffusion" and "innovation adoption", along with keywords used within a broad review of recently published GVETs literature. The rigour of review is augmented by incorporating 35 authoritative works from other disciplines published in 21 well-known journals in the manufacturing, business and management fields. Moreover, the study deploys the peer-debriefing approach through conducting unstructured interviews with five Australian scholars to verify a model presenting an aggregated summary of previous studies. Findings - The key findings of the study include the following items: Synthesising the fragmented studies on innovation diffusion in the AEC context. In doing so, a model capturing the major aspects affecting diffusion of an innovation in AEC projects is presented; providing a foundation to address the drawbacks of previous studies within the sphere of GVETs, based on the developed model. Research limitations/implications - The developed model was only enhanced using a small sample size of academics, as such not empirically validated. Originality/value - As possibly, the first literature review of innovation in the AEC context, this paper contributes to the sphere by sensitising the AEC body of knowledge on innovation diffusion as a concise conceptual model, albeit verified through the peer-debriefing approach. This study will also further establish the research field in AEC on GVETs along with other methods reliant on virtual working such as building information modelling (BIM) through providing an expanded foundation for future inquiries and creation of knowledge.

The political economy of markets and development: a case study of health care consumption in the State of Kerala, India

Marketing theory has largely ignored the issue of power in influencing exchanges. Most of the studies either disregard the role of power, or resource power is the only dimension taken into account. In this study, we expand the existing understanding by centrally situating the role of socio-political power in the consumption process. We examine the health care system in the Indian state of Kerala and highlight that socio-political power is a crucial determinant of consumption levels. In the process, we argue that in a resource—constrained Third World society socio-political empowerment is critical to the development process.

Rethinking creativity: three case studies of the social processes of creativity

Creativity and innovation are often seen as being important in terms of organisations, not only dealing with large amounts of change, but also being able to flourish in uncertain times. Yet, despite large amounts of creativity research, it continues to be a contested subject and fragmented field which leaves researchers without clear direction. Thus the approach to studying creativity needs to be rethought in order to develop new insights into the phenomenon. This research contributes to the debate on creativity by developing concepts around how creativity unfolds within a specific social context. It does this by approaching the study of creativity from a critical perspective and conducting a series of case studies into creativity in organisations. This research finds that, while the production of an artefact is a prerequisite, creativity is not an enduring feature of a given artefact. Rather, creativity exists when an artefact is labelled creative within a particular social system. In addition, as part of the interpretive research process, aspects of identity work emerged. Exploration of creativity as part of the process of identity work provides novel insight into creativity and a conceptual map which may be utilized as part of ongoing research into creativity. This research makes a significant contribution to the understanding of creativity by unpacking the processes of creativity, in three diverse organisational settings, and showing how creativity may be conceptualised as a contextually bound, socially constructed label which is underpinned by identity related motives.

Communication of scientific uncertainty: International case studies on the development of folate and vitamin D Dietary Reference Values

Objective Transparent evidence-based decision making has been promoted worldwide to engender trust in science and policy making. Yet, little attention has been given to transparency implementation. The degree of transparency (focused on how uncertain evidence was handled) during the development of folate and vitamin D Dietary Reference Values was explored in three a priori defined areas: (i) value request; (ii) evidence evaluation; and (iii) final values. Design Qualitative case studies (semi-structured interviews and desk research). A common protocol was used for data collection, interview thematic analysis and reporting. Results were coordinated via cross-case synthesis. Setting Australia and New Zealand, Netherlands, Nordic countries, Poland, Spain and UK. Subjects Twenty-one interviews were conducted in six case studies. Results Transparency of process was not universally observed across countries or areas of the recommendation setting process. Transparency practices were most commonly seen surrounding the request to develop reference values (e.g. access to risk manager/assessor problem formulation discussions) and evidence evaluation (e.g. disclosure of risk assessor data sourcing/evaluation protocols). Fewer transparency practices were observed to assist with handling uncertainty in the evidence base during the development of quantitative reference values. Conclusions Implementation of transparency policies may be limited by a lack of dedicated resources and best practice procedures, particularly to assist with the latter stages of reference value development. Challenges remain regarding the best practice for transparently communicating the influence of uncertain evidence on the final reference values. Resolving this issue may assist the evolution of nutrition risk assessment and better inform the recommendation setting process.

The application of Lob in the UAE: a case study of a housing project

Line of Balance (LOB) scheduling technique is a significant technique that plays a vital role in repetitive construction projects. It became more demanding in the construction industry due to the construction of mega repetitive projects e.g. housing schemes, high rise buildings, railways and highways, etc. This paper aims to evaluate the real application of LOB in repetitive housing projects in the UAE which could fill the gap as there is lack of similar empirical studies in the Middle East. The paper firstly presents a concise literature review on the application and limitation of LOB comparing to CPM in repetitive projects. Then, a case study of 275 villas housing project in the UAE is demonstrated and analysed, where LOB technique was used and monitored throughout the lifecycle of the project. The findings point out significant controlling benefits of using LOB comparing with CPM in the project and address some limitations hindering the efficient use of LOB in the UAE.

Early recognition of ipilimumab-related autoimmune hypophysitis in patients with metastatic melanoma: case studies and recommendations for management

Ipilimumab is a human anti-CTLA-4 monoclonal antibody recently approved for the treatment of advanced melanoma. Stimulation of T-cell activity unmasks antitumor activity, but can cause immune-related adverse events. Autoimmune hypophysitis is of particular importance because its presentation can be subtle but life threatening. We present two cases where early recognition of ipilimumab-related autoimmune hypophysitis led to timely intervention and low subsequent morbidity, without compromise of antitumor effects. We provide recommendations for detection and management of this potentially life-threatening complication of ipilimumab.

Investigating the issue of pollution in the micro-scale design of mega-cities : a case study of Enghelab Street, Tehran

Today there is a growing concern about urbanization and its impact on environmental pollution, which threatens human health and quality of life especially in mega cities. The mega city of Tehran, the capital of Iran, deals with various types of pollution. Although a large body of research has highlighted the significance of study on urban pollution in mega cities, only a few studies have addressed the issue at the micro scale. However, most of the research is restricted to air and noise pollution, whereas visual pollution as an important type of pollution that can be interpreted more deeply on a micro-scale, has been neglected. This study aims to evaluate some of the major issues of environmental pollution in Tehran by focusing on the micro-scale of the street. Therefore, as the central part of Tehran is one of the most affected divisions in the city, Enghelab Street has been selected as the case study for this research. This paper argues that identification and implementation of pollution mitigating strategies in Tehran’s master plan is not responsive enough to the whole city. This study of Enghelab Street reveals that policy making strategies for decreasing pollution should be initiated from micro-scale with further emphasis on psychological health. In the future, the lessons learned from the case study of Enghelab will help other major cities in developing countries to combat pollution through initiating from most affected districts in small scale.

Implementation of innovative technologies in small-scale construction firms: five Australian case studies

Purpose - The users of construction technologies such as builders and trades people have been acknowledged as sources of potentially important innovations. These innovations may be in the form of safer, less labour intensive, or cheaper methods and processes. The purpose of this paper is to assess whether the Australian construction industry is providing an environment where user-based innovation is being supported and implemented. Design/methodology/approach - An explorative study was undertaken to provide an insight into actual experiences of the implementation of user-based innovation. The data were collected through faceto- face semi-structured interviews providing case studies on multiple aspects of the implementation of innovative construction technologies. The cases involved a cross section of advances, including product, tool, and system technologies. Findings - The main motivation behind developing the technologies was problem solving. The associated industries of manufacturing and retail, as well as consultants within the construction industry present the greatest barriers to implementation. Originality/value - This research provides a better understanding of the factors that are preventing the successful implementation of user-based innovative construction technologies in small firms.