The role of nanomedicine in cell based therapeutics in cancer and inflammation.

Cell based therapeutics is one of the most rapidly advancing medical fields, bringing together a range of fields including transplantation, tissue engineering and regeneration, biomaterials and stem cell biology. However, traditional cell-based therapeutics have many limitations, one of which is their harmful effects exhibited on healthy body cells due to their lack of specificity. Nanomedicine is providing an alternative treatment strategy that is more targeted and specific to a range of diseases. Varying from polymers conjugated with drugs or tissue targeting molecules, to proteins encapsulated within a polymer shell, nanomedicine will without a doubt play a major role in designing effective cell-based therapeutics that can overcome certain classical problems. These may include from addressing the problem of non-specificity of contemporary treatments to overcoming mechanical barriers, such as crossing cell membranes. This review summarises the recent work on nano-based cell therapy as a regenerative agent and as a therapeutic for cancer and neurological diseases.

Special issue : Computational intelligence models for image processing and information reasoning

Computational Intelligence (CI) models comprise robust computing methodologies with a high level of machine learning quotient. CI models, in general, are useful for designing computerized intelligent systems/machines that possess useful characteristics mimicking human behaviors and capabilities in solving complex tasks, e.g., learning, adaptation, and evolution. Examples of some popular CI models include fuzzy systems, artificial neural networks, evolutionary algorithms, multi-agent systems, decision trees, rough set theory, knowledge-based systems, and hybrid of these models. This special issue highlights how different computational intelligence models, coupled with other complementary techniques, can be used to handle problems encountered in image processing and information reasoning.

Understanding of mental states in later childhood: an investigation of theory of mind in autism spectrum disorder and typical development with a novel task

The developmental trajectories of Theory of Mind (ToM) in later childhood and into adolescence have not been thoroughly investigated, partly due to a lack of sensitive paradigms that can chart development in typical populations or in individuals with a core deficit in ToM, such as those with autism spectrum disorder (ASD). The present study assessed understanding of emotions, beliefs, and intentions using both an established ToM task (Baron‐Cohen et al., 2001) and the more recently developed Comic Strip Task (CST; Cornish et al., 2010). Participants comprised 12 typically-developing (TD) children (mean age: 12·0 years, range: 9·9‐14·8 years) and 12 high-functioning children with ASD (mean age: 11·0 years, range: 9·1‐13·6 years). Results indicated that the ASD group were not impaired on any of the ToM tasks relative to TD children. It was concluded that although children with high-functioning ASD appear to develop basic ToM skills, they do not generalize these to naturalistic situations. The comic-strip paradigm is suggested as a promising way to approach the measurement of ToM across childhood in typical children and those with ASD.

Estimating the intensity of ward admission and its effect on emergency department access block

Emergency department access block is an urgent problem faced by many public hospitals today. When access block occurs, patients in need of acute care cannot access inpatient wards within an optimal time frame. A widely held belief is that access block is the end product of a long causal chain, which involves poor discharge planning, insufficient bed capacity, and inadequate admission intensity to the wards. This paper studies the last link of the causal chain-the effect of admission intensity on access block, using data from a metropolitan hospital in Australia. We applied several modern statistical methods to analyze the data. First, we modeled the admission events as a nonhomogeneous Poisson process and estimated time-varying admission intensity with penalized regression splines. Next, we established a functional linear model to investigate the effect of the time-varying admission intensity on emergency department access block. Finally, we used functional principal component analysis to explore the variation in the daily time-varying admission intensities. The analyses suggest that improving admission practice during off-peak hours may have most impact on reducing the number of ED access blocks.

Knowledge, attitudes and practices of clinicians in promoting physical activity to prostate cancer survivors

Objectives: 

Introduction: secularization and its discontents

Sigmund Freud’s 1927 work The Future of Illusion expresses the great psychoanalyst’s most whiggish assessment of the situation of Western, post-enlightenment societies. In it, Freud reanimates the ancient tradition of the materialist-Epicurean criticism of religion, with its skepticism concerning all invisible powers. For Freud, famously, the religious belief in higher, supernatural deities—particularly, the monotheistic God—represents a wish-fulfillment and illusion (Freud 1927: 30, 43). This illusion takes its particular shapes from our earliest childhood experiences of helplessness, and the longing for an all-protecting, omnibenevolent father. With the progress of science, and its benefits in technology, Freud opined that the period of the cultural pre-eminence of religion in the West was over. Civilization and its Discontents, written 3 years later, expresses a similarly sceptical assessment of religion. Whether founded in an oceanic, mystical sentiment of oneness, or the refined language of the theologians, religion remains for Freud ‘patently infantile’ (Freud 1930: 86). Between 1927 and 1930, however, Freud’s assessment of the wider prospects of modern Kultur shifted, if it did not entirely reverse. With the fortunes of fascism rising, and the first clouds of renewed European war forming on the horizon, Freud now argues that the psychological price demanded by the modern world’s manifold civilizational advances is perhaps too high. The sexual and aggressive impulses modern society demands subjects renounce must return in the forms of organized violence, collective and individual neuroses—and in the same form of unconscious guilt Freud had argued elsewhere animated the totems and taboos of the great religions (Freud 1913, 1938). Although Freud did not draw the conclusion, the logic of his wider Kulturpessimismus points to the claim that the psychologically deep-set ‘illusions’ of religion could expect a long and viable future.

Good works and god's work

Eighty per cent of the world’s population profess religious faith, making religious belief a common human characteristic found in all cultures and societies. Within development studies’ literature and practice, religion and faith have been largely ignored or misunderstood. While religious organisations are primarily concerned with providing spiritual leadership,an interest in the physical welfare of their communities is also a core aspect of their existence. Within Vanuatu, an important community space is the church building with a range of community development activities taking place within it. This case study considers how community development activities are incorporated into the daily ministries of Christian Churches in Vanuatu, including the use of church buildings as the location for these activities.

Food Product Information: Trusted Sources and Delivery Media

Consumers receive food-related information from various sources and strive to make informed food choices regarding their health, lifestyle and belief. To be effective and reliable, the information consumers receive needs to be from a credible source and delivered to them in a way they trust. The aim of this study was to investigate the sources and media channels of that information consumer trust. An online and hardcopy survey of 298 consumers currently living in Australia was carried out. Many consumers believe that the source of food product information is important (87%). As a source of general and nutritional information, Health Professionals, Scientists and Government sources are the most trusted sources, with at least 80% of participants confident of the information coming from these sources. Retailer advertising and social media are the least trusted sources with just 29% and 11%, respectively, confident of these sources. As a delivery medium, printed food labels (67%) and printed brochures or fact sheets (56%) remain the most trusted delivery media compared with electronic media, such as mobile phone or the Internet.

A novel serogenetic approach determines the community prevalence of celiac disease and informs improved diagnostic pathways

Background
Changing perspectives on the natural history of celiac disease (CD), new serology and genetic tests, and amended histological criteria for diagnosis cast doubt on past prevalence estimates for CD. We set out to establish a more accurate prevalence estimate for CD using a novel serogenetic approach.

Methods
The human leukocyte antigen (HLA)-DQ genotype was determined in 356 patients with ‘biopsy-confirmed’ CD, and in two age-stratified, randomly selected community cohorts of 1,390 women and 1,158 men. Sera were screened for CD-specific serology.

Results
Only five ‘biopsy-confirmed’ patients with CD did not possess the susceptibility alleles HLA-DQ2.5, DQ8, or DQ2.2, and four of these were misdiagnoses. HLA-DQ2.5, DQ8, or DQ2.2 was present in 56% of all women and men in the community cohorts. Transglutaminase (TG)-2 IgA and composite TG2/deamidated gliadin peptide (DGP) IgA/IgG were abnormal in 4.6% and 5.6%, respectively, of the community women and 6.9% and 6.9%, respectively, of the community men, but in the screen-positive group, only 71% and 75%, respectively, of women and 65% and 63%, respectively, of men possessed HLA-DQ2.5, DQ8, or DQ2.2. Medical review was possible for 41% of seropositive women and 50% of seropositive men, and led to biopsy-confirmed CD in 10 women (0.7%) and 6 men (0.5%), but based on relative risk for HLA-DQ2.5, DQ8, or DQ2.2 in all TG2 IgA or TG2/DGP IgA/IgG screen-positive subjects, CD affected 1.3% or 1.9%, respectively, of females and 1.3% or 1.2%, respectively, of men. Serogenetic data from these community cohorts indicated that testing screen positives for HLA-DQ, or carrying out HLA-DQ and further serology, could have reduced unnecessary gastroscopies due to false-positive serology by at least 40% and by over 70%, respectively.

Conclusions
Screening with TG2 IgA serology and requiring biopsy confirmation caused the community prevalence of CD to be substantially underestimated. Testing for HLA-DQ genes and confirmatory serology could reduce the numbers of unnecessary gastroscopies.

The self-efficacy of gifted students : an investigation into the written English self-efficacy of verbal and non-verbally gifted adolescents

Self-efficacy is a belief. It can encourage or hamper students from learning to their full potential. Students who are efficacious are more motivated, more persistent to meet their goals and are more likely to take learning risks. The research into the self-efficacy of students classified as verbally or non-verbally gifted is in its infancy. This book details a Doctoral dissertation that investigated the written English self-efficacy of adolescent students. Results identified verbally gifted students had higher written English self-efficacy, were more intrinsically motivated, had higher levels of creativity and wrote superior essays compared to non-verbally gifted and non-gifted students. Findings highlighted differences between gender as female student?s recorded higher self-efficacy and written English performance scores and interestingly, students from lower socio-economic backgrounds reported higher self-efficacy compared to students from higher socio-economic backgrounds. Pedagogical implications are considered with teachers encouraged to realise the impact of self-efficacy upon student learning, motivation and persistence regardless of their academic ability.

Investigating the written English self-efficacy of gifted and non- gifted adolescents

Self-efficacy is a belief. It can encourage or hamper students from learning to their full potential. Students who are efficacious are more motivated, more persistent to meet their goals and are more likely to take learning risks. The research into the self-efficacy of students classified as verbally or non-verbally gifted is in its infancy. This book details a Doctoral dissertation that investigated the written English self-efficacy of adolescent students. Results identified verbally gifted students had higher written English self-efficacy, were more intrinsically motivated, had higher levels of creativity and wrote superior essays compared to non-verbally gifted and non-gifted students. Findings highlighted differences between gender as female student?s recorded higher self-efficacy and written English performance scores and interestingly, students from lower socio-economic backgrounds reported higher self-efficacy compared to students from higher socio-economic backgrounds. Pedagogical implications are considered with teachers encouraged to realise the impact of self-efficacy upon student learning, motivation and persistence regardless of their academic ability.

The Black Side of the Sun: Camus, Theology, and the Problem of Evil

Albert Camus is typically categorized as an atheistic thinker, in the same breath as Sartre. Yet there is a sizable, often sympathetic, theological response to his works, which deal at great length with Christian themes, wrestle with the problem of evil, and are animated by his own avowed desire — in strong contrast with Sartre and other existentialists — to preserve a sense of the sacred without belief in human immortality. This essay reconstructs three components of Camus’s rapport and disagreement with Christian theology, which he approached pre-eminently through the figure of Augustine, central to his early Diplome thesis. First, we recount the young Camus’s neopagan ‘‘religiosity’’ — a sense of the inhuman majesty and beauty of the natural world at the heart of what he termed (and later regretted terming) the ‘‘absurd,’’ and rooted in Camus’s own unitive experiences growing up amidst the sea, sand, and blazing sun of North Africa. Second, we look at Camus’s engagement with the problem of evil, which for Camus — as for many early modern thinkers such as Bayle or Voltaire — represented the decisive immanent tension in later medieval theology, vindicating — in ethical terms — the modern rebellions against altar, pulpit, and throne. The essay closes by rebutting the charge, strongly argued recently by Ronald Srigley, that Camus was (both) anti-modern because anti-Christian. Camus’s aim, we propose, was instead to bring together a neopagan sense of the wonder of the natural world and our participation in it, with the egalitarian components of Christian ethics, severed from secularized eschatological content.

Reintegration: The contribution of offence, offender and respondent factors

Community attitudes toward offender reintegration, in particular sex offenders, were investigated. Findings revealed the public are more supportive of reintegrative policies than they are willing to be involved in the reintegration process. Predictors of reintegrative attitudes were also investigated with a belief in redeemability found to be the strongest predictor.

Shared beliefs, expectations and surprises: adaptation decisions of village tank farmers in Sri Lanka

This study examined adaptation decisions of village tank farmers in Sri Lanka, focusing on how commonly held beliefs on local rainfall influence their adaptation choices. Findings suggest that farmers’ have shared beliefs consistent with local pattern of rainfall variability that help to explain short-, medium- and long-term decisions of adaptation.

A comparison of maternal calcium and magnesium levels in pre-eclamptic and normotensive pregnancies: an observational case–control study

Objective : Supplementing pregnant women at high risk of developing pre-eclampsia with calcium may reduce the incidence of the disease. This study examines differences in serum and hair concentrations of calcium and magnesium between women with pre-eclamptic and normotensive pregnancies.Design : Observational case–control study.Setting : Two teaching hospitals in Cape Town, South Africa.PopulationWomen with pre-eclamptic (N = 96) or normotensive (N = 96) pregnancies, who delivered a single, live infant.MethodsDemographic and current pregnancy details were retrieved from clinical notes. Each participant completed a dietary questionnaire. Venous blood samples were taken from each participant to assess serum calcium and magnesium concentrations. Hair samples were obtained from all participants and calcium and magnesium levels were measured by inductively coupled plasma optical emission spectrometry (ICPOES).Main outcome measureHair and serum calcium and magnesium concentrations were compared between women with pre-eclamptic and normotensive pregnancies.ResultsDiet and socio-economic status in the two groups were similar. There was no significant difference in the hair calcium level between women with pre-eclamptic [1241 parts per million (ppm); range, 331–4654 ppm] and normotensive (1146 ppm; range, 480–4136 ppm) pregnancies (P = 0.5). Hair calcium levels in both groups were not affected by HIV infection.ConclusionWoman with pre-eclampsia showed no difference in chronic calcium status relative to normotensive women. This finding does not support the current belief that the mechanism by which calcium supplementation reduces the risk of developing pre-eclampsia is by correcting a nutritional deficiency.