Recession-oscopy : can universities be the light at the end?

This paper paints the philosophical and ethical backdrop to some of the issues raised in Australian Universities’ Review vol. 53, no. 2. It links academic performance pay; the measurement of research output; and the astonishing pay levels of vice chancellors to the present global financial crisis. These are explained as part of a general malaise of institutions, which has its roots in the early Enlightenment. Drawing from semioticians Charles Sanders Peirce and John Deely it uses the terms ideoscopy and cenoscopy to characterise the hijacking of unwarranted scientific status for much of the way our world is managed. But crisis can lead to opportunity. Consequently, the paper points to the glaring opportunity for thinkers who can articulate the present situation in a way which could avert disaster.

End-of-life care for aged care residents presenting to emergency departments

Background: The number of patients from Aged Care presenting to acute care is increasing, many of whom have a life limiting illness.

Aims: To identify differences in relation to Aged Care Residents presenting to Emergency departments who died during a hospital admission compared to those who were referred to the hospital based palliative care.

Methods: Review of a stratified random sample of 90 Aged Care residents transferred to acute care who died during admission in 2009; half the sample received palliative care. Comparisons were made with regard to age; gender; co-morbidities; symptoms, investigations and active treatment; prior admissions and costs.

Results: The median age of patients was 87.5 years, 61% were female and 38% had three or more admissions in the year prior to death. Patients with a length of stay of four or more days were 2.98 times (CI, 95%:1.11-8.03) and patients with agitation were 3.08 (CI 95%:1.10- 8.64) times more likely to be referred to palliative care. Patients who received palliative care had significantly fewer investigations or active treatment in the 24 hours prior to their death (p< 0.01) and palliated patients had significantly lower average costs per day of admission ($1022, SD=$441) compared to those who were not palliated ($ 831; SD= $ 1041) (p< 0.001).

Discussion: Our study indicates there is a difference between dying patients who received palliative care compared to those who did not in an acute care setting. Further research into the outcomes of patients discharged back to Aged Care facilities for palliative care warrants investigation.

Home hemodialysis : a successful option for obese and bariatric people with end-stage kidney disease

The increasing prevalence of obesity in developed countries is reflected in the chronic kidney disease, dialysis, and transplant populations. The added risk factor of obesity increases the risk of vascular events, inflammation, insulin resistance, blood pressure, dyslipidemia, and mortality risk. Nephrology center policies may exclude obese people from transplantation programs resulting in many years of dialysis. The case of a 215-kg Australian male who has successfully dialyzed at home for more than 8 years will be used to illustrate the important considerations and clinical support that these people require for successful home dialysis treatment. The aim of this paper is to report on a program that has successfully trained 23 obese (body mass index >30) people who commenced on home hemodialysis between 2001 and 2009. Body weight ranged between 94.0 and 215 kg (mean 126, SD 26.19) and body mass index ranged between 34.9 and 71 (mean 43.38, SD 9.99) at the start of home training. During the 8.5 years of follow-up, average time on home dialysis was 43.7 months. Home hemodialysis is a feasible treatment for obese people to facilitate longer and more frequent dialysis, resulting in improved hemodynamic stability and improved quality of life. For obese people with end-stage kidney disease, home hemodialysis has shown to be cost-effective and can result in greater treatment efficacy than in-center hospital dialysis.

What drives the end user to build a feral information system?

A Feral Information Systems (FIS) is any technological artefact (e.g. spreadsheets) that end users employ instead of the mandated Enterprise System (ES). ES proponents suggest that the installation of an ES will boost productivity. However, Production Possibility Frontier theory provides insights as to why the introduction of an ES may instead suppress an end user's productivity. Structuration Theory offers insights that explain how certain end users may have access to powerful resources. Rather than submitting to the ES, the end user can employ FIS to block or circumvent aspects of the ES. Further, the concept of life chances helps explain why individuals may or may not develop the core skills required to construct an alternate to the ES, the FIS. In relation to the ES usage, an end user may adopt one of four Modes of Operation, namely: Submit, Dismiss, Hidden, or Defiant.

Framework for a Residential Energy Information System (REMIS) to promote energy efficient behaviour in residential energy end users

Previous studies on residential energy end use behavior reported significant reduction in energy end use of 7% to 24% when feedback is used to modify behavior in an energy efficient manner. However, most feedback systems investigated in previous studies have not benefited from advanced information systems (IS). IS can shape energy efficiency behavior by providing real-time feedback on energy consumption, cost and environmental impact. Such systems represent a new and less-researched subfield of energy informatics. This paper provides a conceptual framework for showing the potential use of IS to modify residential energy use behavior towards better energy efficiency. The framework builds on research in residential energy end use, in particular energy end use behavioral model. It provides conceptual inputs for a blue-print to develop a residential energy management information system (REMIS) and also highlights the use of new information and communications technologies (ICT) that had not been widely used, setting the grounds for further research in this area.

The end of the Keating-Howard-Rudd-Gillard era?

Australian political discourse is dominated by ahistorical hyperbole, every election defeat is a landslide, every consecutive electoral loss indicates complete political marginalisation, every poll slump is a crisis, and every struggling leader is the worst ever. Australian Labor is not faring well but we need to distinguish between the ebbs and flows of the political cycle and the fundamentals. Australian politics may be approaching a fundamental break. The political era that began in the early 1990s may be coming to an end and with it Labor's hegemonic position in Australian politics that has endured since Gough Whitlam.

Curtain call - end of the world party

BLINDSIDE’s project presented as part of our 'Curtain Call' curated event series, brings together artists who tease out notions of catastrophe, celebration and transformation against the backdrop of the last party on earth.
The 5,125 year Mayan Calendar comes to an end on the 21st of December and BLINDSIDE has invited artists to consider this cataclysmic event for its annual program Curtain Call.

Fresh from the LA Art Fair, Adelaide-based artist Patrick Rees along with Melbourne-based artists Kirsty Audrey Hulm, Boe-Lin Bastian, Drew Pettifer and Joel Zika & Simon Pericich consider the possibilities.

Internet cognitive behavioural therapy for panic disorder : does the inclusion of stress management information improve end-state functioning?

Previous research has established Internet-based cognitive behavioural therapy (CBT) for panic disorder (PD) as effective in reducing panic severity and frequency. There is evidence, however, that such programs are less effective at improving overall end-state functioning, defined by a PD clinician severity rating of ≤2 and panic free. In order to test the effect on end-state functioning of the incorporation of stress management material within a CBT program for PD, 32 people with PD were randomised to either Internet-based CBT (PO1), Internet-based CBT plus stress management (PO2) or an Internet-based information-only control condition (IC). Both CBT treatments were more effective at posttreatment assessment than the control condition in reducing PD severity, panic and agoraphobia-related cognition, negative affect and self-ratings of health. PO2 was more effective than PO1 at posttreatment assessment on PD severity and general anxiety, although at 3-month follow-up these differences were no longer apparent. This study provides further support for the efficacy of Internet-based CBT for PD and suggests that although the incorporation of stress management material confers short-term advantages over a standard program, it is not associated with any longer term improvements on panic severity and related cognitions, negative affect, general wellbeing and end-state functioning.

The P-Loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in Pre-mRNA 3′ end formation

 Cleavage factor IA (CF IA), cleavage and polyadenylation factor (CPF), constitute major protein complexes required for pre-mRNA 3' end formation in yeast. The Clp1 protein associates with Pcf11, Rna15 and Rna14 in CF IA but its functional role remained unclear. Clp1 carries an evolutionarily conserved P-loop motif that was previously shown to bind ATP. Interestingly, human and archaean Clp1 homologues, but not the yeast protein, carry 5' RNA kinase activity. We show that depletion of Clp1 in yeast promoted defective 3' end formation and RNA polymerase II termination; however, cells expressing Clp1 with mutant P-loops displayed only minor defects in gene expression. Similarly, purified and reconstituted mutant CF IA factors that interfered with ATP binding complemented CF IA depleted extracts in coupled in vitro transcription/3' end processing reactions. We found that Clp1 was required to assemble recombinant CF IA and that certain P-loop mutants failed to interact with the CF IA subunit Pcf11. In contrast, mutations in Clp1 enhanced binding to the 3' endonuclease Ysh1 that is a component of CPF. Our results support a structural role for the Clp1 P-loop motif. ATP binding by Clp1 likely contributes to CF IA formation and cross-factor interactions during the dynamic process of 3' end formation.

Coupled RNA polymerase II transcription and 3′ end formation with yeast whole-cell extracts

 RNA polymerase II (RNAP II) transcription and pre-mRNA 3' end formation are linked through physical and functional interactions. We describe here a highly efficient yeast in vitro system that reproduces both transcription and 3' end formation in a single reaction. The system is based on simple whole-cell extracts that were supplemented with a hybrid Gal4-VP16 transcriptional activator and supercoiled plasmid DNA templates encoding G-less cassette reporters. We found that the coupling of transcription and processing in vitro enhanced pre-mRNA 3' end formation and reproduced requirements for poly(A) signals and polyadenylation factors. Unexpectedly, however, we show that in vitro transcripts lacked m⁷G-caps. Reconstitution experiments with CF IA factor assembled entirely from heterologous components suggested that the CTD interaction domain of the Pcf11 subunit was required for proper RNAP II termination but not 3' end formation. Moreover, we observed reduced termination activity associated with extracts prepared from cells carrying a mutation in the 5'-3' exonuclease Rat1 or following chemical inhibition of exonuclease activity. Thus, in vitro transcription coupled to pre-mRNA processing recapitulates hallmarks of poly(A)-dependent RNAP II termination. The in vitro transcription/processing system presented here should provide a useful tool to further define the role of factors involved in coupling.