Genome - wide association study identifies novel breast cancer susceptibility loci

Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate risks. To identify further susceptibility alleles, we conducted a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls, followed by a third stage in which 30 single nucleotide polymorphisms (SNPs) were tested for confirmation in 21,860 cases and 22,578 controls from 22 studies. We used 227,876 SNPs that were estimated to correlate with 77% of known common SNPs in Europeans at r² > 0.5. SNPs in five novel independent loci exhibited strong and consistent evidence of association with breast cancer (P < 10^-7). Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 and LSP1). At the second stage, 1,792 SNPs were significant at the P < 0.05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach.

Hope of a nation - experiences of social exclusion giving rise to spaces of inclusion for people living with HIV and AIDs in South Africa : a reflection

South Africa has one of the highest rates of HIV/AIDS in the world. No one particular group is affected by the virus – rather, it is indiscriminate. Responses to HIV are diverse, and can be starkly contradictory. This author lived among the Xhosa people in rural Eastern Cape, working in community development. The program was a population-based youth empowerment program around HIV prevention. The work involved engaging youth in a range of civic participation activities, and networking with other community based groups and organisations, health and social services, and government departments. This reflection out a narrative of the lived experiences of social exclusion and social connectedness for people living with HIV/AIDS in rural Eastern Cape. It draws out the paradox of how the high prevalence of stigma and discrimination towards those with the illness, and their subsequent experience of social exclusion, actually creates opportunities for social connectedness through support group participation. This in turn is fashioning an emerging social movement breaking down barriers of stigma, and contributing to broader social change to support HIV action.

The reflection begins by outlining the current context and underlying determinants of the proliferation of HIV in the Eastern Cape, including a discussion of exclusion as a determinant. An exploration of how exclusion is also experienced as an outcome of positive HIV status follows. Finally, an explanation of how the experience of exclusion can be transformed into spaces of connectedness, and implications for health promotion practice in this context is also presented.

Supporting bereaved individuals

This research found that grief-related beliefs contained elements of a traditional stereotypic view. Further, a bereaved individual's general way of coping influenced how others expected them to grieve. Finally, aspects of both a bereaved individual and support provider were found to impact the willingness of individuals to offer bereavement-related support.

Age, growth and reproduction of deepwater dogfishes from southeastern Australia

The productivity of six deepwater dogfishes was investigated by examining their age, growth and reproductive biology. A new method of ageing was developed, and compared with existing techniques. Some species live greater than 50 years, and populations may not sustain commercial fisheries.

The other side of social exclusion : interrogating the role of the privileged in reproducing inequality

As the chapters in this book demonstrate, social exclusion is a key concept used to understand various forms of inequality in contemporary capitalist societies. I argue in this chapter that while the concept of social exclusion has been important in illustrating the structural dimensions of unequal social relations and examining the costs of those relations for excluded groups, it has done little to address those of us who benefit most from existing social divisions and inequalities. Nor do most of the writings on social exclusion examine how these inequalities are reproduced by and through the daily practices and life-style pursuits of privileged groups.

In this chapter I will interrogate the concept of privilege as the other side of social exclusion and will argue that the lack of critical interrogation of the position of the privileged side of social divisions allows the privileged to reinforce their dominance. I aim to make privilege more visible and consider the extent to which those who are privileged can overcome their own self interest in the maintenance of dominance to enable them to challenge it.

Mid-Holocene vertebrate bone Concentration-Lagerstätte on oceanic island Mauritius provides a window into the ecosystem of the dodo (Raphus cucullatus)

Although the recent history of human colonisation and impact on Mauritius is well documented, virtually no records of the pre-human native ecosystem exist, making it difficult to assess the magnitude of the changes brought about by human settlement. Here, we describe a 4000-year-old fossil bed at Mare aux Songes (MAS) in south-eastern Mauritius that contains both macrofossils (vertebrate fauna, gastropods, insects and flora) and microfossils (diatoms, pollen, spores and phytoliths). With >250 bone fragments/m2 and comprising 50% of all known extinct and extant vertebrate species (ns = 44) of Mauritius, MAS may constitute the first Holocene vertebrate bone Concentration-Lagerstätte identified on an oceanic volcanic island. Fossil remains are dominated by extinct giant tortoises Cylindraspis spp. (63%), passerines (10%), small bats (7.8%) and dodo Raphus cucullatus (7.1%). Twelve radiocarbon ages [four of them duplicates] from bones and other material suggest that accumulation of fossils took place within several centuries. An exceptional combination of abiotic conditions led to preservation of bones, bone collagen, plant tissue and microfossils. Although bone collagen is well preserved, DNA from dodo and other Mauritian vertebrates has proved difficult. Our analysis suggests that from ca 4000 years ago (4 ka), rising sea levels created a freshwater lake at MAS, generating an oasis in an otherwise dry environment which attracted a diverse vertebrate fauna. Subsequent aridification in the south-west Indian Ocean region may have increased carcass accumulation during droughts, contributing to the exceptionally high fossil concentration. The abundance of floral and faunal remains in this Lagerstätte offers a unique opportunity to reconstruct a pre-human ecosystem on an oceanic island, providing a key foundation for assessing the vulnerability of island ecosystems to human impact.

Silence and silenced : implications for the spirituality of survivors of sexual abuse

Survivors of sexual abuse are frequently met with cultures of silence which make it difficult for their experiences to be acknowledged. Furthermore, many have been subjected to threats and intimidation in efforts to ensure that they remain silent about what has happened to them. One response to such experiences is to keep oneself busy and avoid ever being quiet enough to experience a sense of silence within. However, many spiritual traditions promote the embracing of silence as essential for those seeking spiritual development. This paper explores these diverse experiences of silence for survivors of sexual abuse and considers why spiritualities which promote silence can be problematic.

Belonging, connectedness and social exclusion

Promoting connectedness and/or a sense of belonging are strategies used in addressing social exclusion. While belonging and connectedness are often used interchangeably, this paper demonstrates that while they may be co-existent, it is equally possible to have one without the other. Hence, this paper contends that these two concepts need to be carefully distinguished by those planning and delivering social work services. Furthermore, consideration of both connectedness and belonging enables a more nuanced understanding of social exclusion which challenges the assumption that inclusion and exclusion are binary opposites, and that it is possible to be both included and excluded at the same time.

A depth of data : research messages on the state of social work education in England

In the light of extensive media coverage of social work education, this article uses information from the Department of Health funded three-years multi-method evaluation of the social work degree qualification in England to discuss areas in which qualifying education might be improved. It argues that too great a concern with the 'A' level performance of social work applicants risks not paying enough attention to the non-academic qualities that they will need to work in the changing world of children's and adult services. Better partnership working between employers and universities will help students make the transition into the workplace. This includes greater opportunities for employers and practitioners to be involved in candidate selection and teaching on qualifying programmes.