Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism

To examine whether genes associated with cellular defense against oxidative stress are associated with insulin sensitivity, patients with type 2 diabetes (n = 7) and age-matched (n = 5) and young (n = 9) control subjects underwent a euglycemic-hyperinsulinemic clamp for 120 min. Muscle samples were obtained before and after the clamp and analyzed for heat shock protein (HSP)72 and heme oxygenase (HO)-1 mRNA, intramuscular triglyceride content, and the maximal activities of β-hyroxyacyl-CoA dehydrogenase (β-HAD) and citrate synthase (CS). Basal expression of both HSP72 and HO-1 mRNA were lower (P < 0.05) by 33 and 55%, respectively, when comparing diabetic patients with age-matched and young control subjects, with no differences between the latter groups. Both basal HSP72 (r = 0.75, P < 0.001) and HO-1 (r = 0.50, P < 0.05) mRNA expression correlated with the glucose infusion rate during the clamp. Significant correlations were also observed between HSP72 mRNA and both β-HAD (r = 0.61, P < 0.01) and CS (r = 0.65, P < 0.01). HSP72 mRNA was induced (P < 0.05) by the clamp in all groups. Although HO-1 mRNA was unaffected by the clamp in both the young and age-matched control subjects, it was increased (P < 0.05) ∼70-fold in the diabetic patients after the clamp. These data demonstrate that genes involved in providing cellular protection against oxidative stress are defective in patients with type 2 diabetes and correlate with insulin-stimulated glucose disposal and markers of muscle oxidative capacity. The data provide new evidence that the pathogenesis of type 2 diabetes involves perturbations to the antioxidant defense mechanism within skeletal muscle.

Modeling the propagation and defense study of internet malicious information

 Dr. Wen's research includes modelling the propagation dynamics of malicious information, exposing the most influential people and source identification of epidemics in social networks. His research is beneficial to both academia and industry in the field of Internet social networks.

The High Court on crime in 2014: Outcomes and jurisprudence

This article examines the Australian High Court decisions in 2014 which relate to criminal matters. This systematic analysis of all High Court judgments commenced in this Journal in 2010 and is now undertaken annually. The article explains the principles that derive from these cases and identifies jurisprudential themes from the decisions. It also sets outthe significance of the cases and the possible wider consequences of the decisions.

Returning a dislocated child's body to the scene of a crime

The 'Event' considered here is my 'abduction' as a child by my parents out of the Netherlands as part of the post war European migration to Australia in the 1950s. The migrant exists in many ways in-between cultures and this also holds for the migrant child. This event created a traumatic split in me as an eight year old boy. It was one that occurred to many children of migrants who left Europe post WWII. The migration in turn engaged with an unspoken racist complicity with Australia's 'White Australia Policy'. The 'white' Dutch were a good fit for this migration and thus the focus here applies to both 1950s Australia and the Netherlands. This article deals with how I expressed the two aspects of dislocation and racism made evident by this event through my art in a collaborative exhibition The Unwanted Land (see Figure 1). As this art is primarily visual, I have included a photo gallery of 28 images at the end of this text to reference and support this discussion.

Defense against packet dropping attacks in opportunistic networks

Opportunistic networks (OppNets) are an interesting topic that are seen to have a promising future. Many protocols have been developed to accommodate the features of OppNets such as frequent partitions, long delays, and no end-to-end path between the source and destination nodes. Embedding security into these protocols is challenging and has taken a lot of attention in research. One of the attacks that OppNets are exposed to is the packet dropping attack, where the malicious node attempts to drop some packets and forwards an incomplete number of packets which results in the distortion of the message. To increase the security levels in OppNets, this paper presents an algorithm developed to detect packet dropping attacks, and finds the malicious node that attempted the attack. The algorithm detects the attack by using an indicative field in the header section of each packet; the indicative field has 3 sub fields - the identification field, the flag field, and the offset field. These 3 fields are used to find if a node receives the complete original number of packets from the previous node. The algorithm will have the advantage of detecting packets dropped by each intermediate node, this helps solve the difficulties of finding malicious nodes by the destination node only.

Detection and defense of application-layer DDoS attacks in backbone web traffic

Web servers are usually located in a well-organized data center where these servers connect with the outside Internet directly through backbones. Meanwhile, the application-layer distributed denials of service (AL-DDoS) attacks are critical threats to the Internet, particularly to those business web servers. Currently, there are some methods designed to handle the AL-DDoS attacks, but most of them cannot be used in heavy backbones. In this paper, we propose a new method to detect AL-DDoS attacks. Our work distinguishes itself from previous methods by considering AL-DDoS attack detection in heavy backbone traffic. Besides, the detection of AL-DDoS attacks is easily misled by flash crowd traffic. In order to overcome this problem, our proposed method constructs a Real-time Frequency Vector (RFV) and real-timely characterizes the traffic as a set of models. By examining the entropy of AL-DDoS attacks and flash crowds, these models can be used to recognize the real AL-DDoS attacks. We integrate the above detection principles into a modularized defense architecture, which consists of a head-end sensor, a detection module and a traffic filter. With a swift AL-DDoS detection speed, the filter is capable of letting the legitimate requests through but the attack traffic is stopped. In the experiment, we adopt certain episodes of real traffic from Sina and Taobao to evaluate our AL-DDoS detection method and architecture. Compared with previous methods, the results show that our approach is very effective in defending AL-DDoS attacks at backbones. © 2013 Elsevier B.V. All rights reserved.

Jail up; crime down does not justify Australia becoming an incarceration nation

The imprisonment rate in Australia is at unprecedented high levels, both interms of actual prisoner numbers and the rate at which it is increasing. Forthe first time in recorded history the incarceration rate in Australia has morethan doubled in less than 25 years. Prison is the harshest form ofpunishment in our system of justice and imposes considerable hardship onoffenders. It also comes at a considerable financial cost to the community.Accordingly, the surge in prisoner numbers is a significant macro social,economic and legal development. The increase did not occur pursuant to anoverarching strategic plan and is an area that is under-researched. Theprison population increase has arisen as a result of a ‘tough on crime’approach that continues without any sign of abatement. The use ofimprisonment should only be increased if there is a demonstrable benefit tothe community. This article examines whether there is a sound rationalebehind the rising trend in prison numbers. The increasing incarceration ratehas coincided with a significant reduction in the crime rate. A causalconnection between the two events (increased prisoner numbers andreduced crime) could constitute a powerful argument in favour of the surgein prison numbers. However, an examination of the empirical data inAustralia fails to demonstrate even a tenable link between these events. Wealso conclude that at the theoretical level there is no rationale for theincreased use of imprisonment. If the imprisonment rate continues to rise,there is a risk of a prison and financial crisis similar to that currently beingexperienced in the United States, which has resulted in an extremecounter-reaction in the form of a retrospective reduction of some prison terms.

Alcohol-related crime in city entertainment precincts: Public perception and experience of alcohol-related crime and support for strategies to reduce such crime

INTRODUCTION AND AIMS: Bars, pubs and taverns in cities are often concentrated in entertainment precincts that are associated with higher rates of alcohol-related crime. This study assessed public perception and experiences of such crime in two city entertainment precincts, and support for alcohol-related crime reduction strategies. DESIGN AND METHODS: A cross-sectional household telephone survey in two Australian regions assessed: perception and experiences of crime; support for crime reduction strategies; and differences in such perceptions and support. RESULTS: Six hundred ninety-four people completed the survey (32%). Most agreed that alcohol was a problem in their entertainment precinct (90%) with violence the most common alcohol-related problem reported (97%). Almost all crime reduction strategies were supported by more than 50% of participants, including visitors to the entertainment precincts, with the latter being slightly less likely to support earlier closing and restrictions on premises density. Participants in one region were more likely to support earlier closing and lock-out times. Those at-risk of acute alcohol harm were less likely to support more restrictive policies. DISCUSSION AND CONCLUSIONS: High levels of community concern and support for alcohol harm-reduction strategies, including restrictive strategies, provide policy makers with a basis for implementing evidence-based strategies to reduce such harms in city entertainment precincts. [Tindall J, Groombridge D, Wiggers J, Gillham K, Palmer D, Clinton-McHarg T, Lecathelinais C, Miller P. Alcohol-related crime in city entertainment precincts: Public perception and experience of alcohol-related crime and support for strategies to reduce such crime. Drug Alcohol Rev 2015].

Effects of omega-3 PUFA on the vitamin E and glutathione antioxidant defense system in individuals at ultra-high risk of psychosis

BACKGROUND: Oxidative stress and impaired antioxidant defenses are reported in schizophrenia and are associated with disturbed neurodevelopment, brain structural alterations, glutamatergic imbalance, increased negative symptoms, and cognitive impairment. There is evidence that oxidative stress predates the onset of acute psychotic illness. Here, we investigate the effects of omega-3 PUFA on the vitamin E and glutathione antioxidant defense system (AODS). METHOD: In 64 help-seeking UHR-individuals (13-25 years of age), vitamin E levels and glutathione were investigated before and after 12 weeks of treatment with either 1.2g/d omega-3 (PUFA-E) or saturated fatty acids (SFA-E), with each condition also containing 30.4mg/d alpha-tocopherol to ensure absorption without additional oxidative risk. RESULTS: In multivariate tests, the effects on the AODS (alpha-tocopherol, total glutathione) were not significantly different (p=0.13, p=0.11, respectively) between treatment conditions. According to univariate findings, only PUFA-E caused a significant alpha-tocopherol increase, while PUFA-E and SFA-E caused a significant gamma- and delta-tocopherol decrease. Total glutathione (GSHt) was decreased by PUFA-E supplementation. CONCLUSION: Effects of the PUFA-E condition on the vitamin E and glutathione AODS could be mechanisms underlying its clinical effectiveness. In terms of the vitamin E protection system, PUFA-E seems to directly support the antioxidative defense at membrane level. The effect of PUFA-E on GSHt is not yet fully understood, but could reflect antioxidative effects, resulting in decreased demand for glutathione. It is still necessary to further clarify which type of PUFA/antioxidant combination, and in which dose, is effective at each stage of psychotic illness.

Performing desistance: how might theories of desistance from crime help us understand the possibilities of prison theatre?

Despite the ubiquity of theatre projects in prisons there has been little (published) discussion of the application of theatre to the theories of criminology or rehabilitation of offenders, and scant examination of the potential for criminological theories to inform theatre practice in criminal justice settings. This article seeks to address this deficit and argues that positioning prison theatre within the discipline of positive criminology, specifically contemporary theories of desistance from crime, provides a theoretical framework for understanding the contribution that prison theatre might be making in the correctional setting. Through a review of related literature, the article explores how prison theatre may be motivating offenders toward the construction of a more adaptive narrative identity and toward the acquisition of capabilities that might usefully assist them in the process of desisting from crime.