The influence of temporary hydrogenation on ECAP formability and low cycle fatigue life of CP titanium

It is generally believed that thermo-hydrogen processing has a beneficial effect on tensile ductility and fatigue properties of titanium. This study was concerned with investigating whether this also applies to titanium of commercial purity (CP) with an ultrafine-grained structure obtained by equal-channel angular pressing (ECAP). It was shown that despite the possibility to manipulate the microstructure of titanium the thermo-hydrogen processing offers, temporary hydrogenation was not able to improve ductility and low cycle fatigue life of CP titanium over the levels achievable by straight ECAP.

Bimodal grain size distributions in UFG materials produced by SPD - their evolution and effect on the fatigue and monotonic strength properties

In ultrafine-grained (UFG) materials produced by severe plastic deformation (SPD) techniques such as ECAP (equal channel angular pressing), bimodal grain size distributions have been observed under different circumstances, for example shortly after ECAP, after rest or anneal and/or after mild cyclic deformation at rather low homologous temperature. It has been shown that the mechanical monotonic and fatigue properties of some UFG materials can be modified (sometimes enhanced) by introducing a bimodal grain size distribution by a mild annealing treatment which leads, in some cases, to a good combination of strength and ductility. Here, the conditions under which bimodal grain size distributions evolve by (adiabatic) heating during ECAP and during subsequent annealing or cyclic deformation will be explored, and the effects on the mechanical properties, as studied by the authors and as reported so far in the literature, will be reviewed and discussed. In particular, the role of temperature rise during ECAP will be considered in some detail.

Fatigue crack growth in ultrafine grained aluminium alloy

The microstructure, fatigue crack growth behaviour and hardness of ultra fine grained 6061 aluminium alloy obtained by equal angle channel processing was studied. ECAP resulted in significant grain refinement down to the sub micron level and corresponding increase in hardness. Results point to a similar fatigue threshold stress intensity range and fatigue crack growth rates for 1, 2, 4 and 6 passes of ECAP.

Nitrosative stress, hypernitrosylation, and autoimmune responses to nitrosylated proteins: new pathways in neuroprogressive disorders Including depression and chronic fatigue syndrome.

Nitric oxide plays an indispensable role in modulating cellular signaling and redox pathways. This role is mainly effected by the readily reversible nitrosylation of selective protein cysteine thiols. The reversibility and sophistication of this signaling system is enabled and regulated by a number of enzymes which form part of the thioredoxin, glutathione, and pyridoxine antioxidant systems. Increases in nitric oxide levels initially lead to a defensive increase in the number of nitrosylated proteins in an effort to preserve their function. However, in an environment of chronic oxidative and nitrosative stress (O&NS), nitrosylation of crucial cysteine groups within key enzymes of the thioredoxin, glutathione, and pyridoxine systems leads to their inactivation thereby disabling denitrosylation and transnitrosylation and subsequently a state described as "hypernitrosylation." This state leads to the development of pathology in multiple domains such as the inhibition of enzymes of the electron transport chain, decreased mitochondrial function, and altered conformation of proteins and amino acids leading to loss of immune tolerance and development of autoimmunity. Hypernitrosylation also leads to altered function or inactivation of proteins involved in the regulation of apoptosis, autophagy, proteomic degradation, transcription factor activity, immune-inflammatory pathways, energy production, and neural function and survival. Hypernitrosylation, as a consequence of chronically elevated O&NS and activated immune-inflammatory pathways, can explain many characteristic abnormalities observed in neuroprogressive disease including major depression and chronic fatigue syndrome/myalgic encephalomyelitis. In those disorders, increased bacterial translocation may drive hypernitrosylation and autoimmune responses against nitrosylated proteins.

Bending fatigue testing of commercial purity titanium for dental implants

High fatigue strength is one of the major requirements for dental implant materials. It was previously shown that the fatigue strength under conventional stress-control tension–compression testing can be doubled for commercially pure (CP) titanium processed by equal channel angular pressing. However, the fatigue endurance of an implant exposed to cyclic loading in corrosive media (bodily fluids) may potentially be compromised. In this work, non-conventional bending fatigue testing in air and in simulated body fluid (SBF) has been carried out for coarse-grained and ultrafine-grained CP titanium.

Clinical case report: yoga for fatigue in five young adult survivors of childhood cancer

PURPOSE: Cancer-related fatigue (CRF) is a distressing consequence of cancer and its treatment. CRF impacts many young adult (YA) survivors of childhood cancer, compromising work, social relationships, and daily activities. No satisfactory treatment exists. This pilot study aimed to assess the feasibility, safety, and preliminary efficacy of an 8-week twice/week Iyengar yoga (IY) intervention for treating persistent fatigue in YA survivors of childhood cancer. 

Prediction of non-proportional cyclic hardening and multiaxial fatigue life for FCC and BCC metals under constant amplitude of strain cycling

The fatigue lives are reduced accompanying an additional cyclic hardening under strain controlled non-proportional cyclic loading in which principal directions of stress and strain are altered within a cycle. This study predicts non-proportional cyclic hardening and multiaxial fatigue life for several BCC and FCC metals under constant amplitude strain cycling. A novel procedure to determine non-proportional cyclic hardening form uniaxial tensile properties has discussed in this study. Standard plastic strain energy density based fatigue criteria with considering the non-proportional cyclic hardening effect successfully predicts multiaxial fatigue lives. The predictions of non-proportional cyclic hardening and multiaxial fatigue life through models are validated by experimental results of various BCC and FCC metals which are collected from literatures.

Compassion fatigue and resilience: a qualitative analysis of social work practice

Compassion fatigue is a term used to describe behaviour and emotions experienced by those who help people who have experienced trauma. It is viewed as a potential consequence of stress related to such exposure and is understood to be influenced by the practitioner’s empathic response. The aims of this study were to obtain greater understanding of social workers experience of working with distressed clients; examine what develops personal, professional and organisational resilience; and explore ways in which workers can be better protected from compassion fatigue. The research design was qualitative using semi-structured interviews involving six social workers presently working with distressed clients or clients known to have experienced distress. Four major themes were identified using thematic analysis: (i) the complexities of social work, (ii) supportive and unsupportive contexts, (iii) promoting personal well-being/selfprotection and (iv) resilience as a changing systemic and complex process. The findings provide important insights into the participants’ experiences of working with distressed clients and, more specifically, their experience of compassion fatigue and stories of resilience. The research provides clear direction for future research at organisational, educational and interpersonal levels.

Self-reported fatigue in children with advanced cancer: results of the PediQUEST study (TH309-A)

Background. Pediatric cancer-related fatigue, particularly self-reported, is poorly understood. Research Objectives. To describe fatigue and identify factors associated with it in the largest cohort of children with advanced cancer self-reporting symptoms to date.

Premature thermal fatigue failure of aluminium injection dies with duplex surface treatment

The premature failure of an aluminium injection die with a duplex surface treatment (plasma nitriding and physical vapor deposition coating) was investigated, in an effort to identify the causes of such premature failure of the component. The manufacturing and the operating conditions were documented. Analytical tools were used, including scanning electron microscopy with energy dispersive X-ray capability, X-ray diffraction, and instrumented microhardness testing. Preliminary observations showed a microstructure of coarse tempered martensite, and a considerably rough surface with porosity and cracks. A detailed analysis of crack initiation sites identified sulfur inclusions in the subsurface, underneath the coating. A further revision of the processing conditions revealed that a sulfur-impregnated grinding stone had been used to polish the die. The chemical composition of such grinding stone matched that of the inclusions found in the subsurface of the failed component. Thus, searched causes of premature failure could be discussed on the lights of the present findings.