Finding aesthetic form inside the tome: the doctorate and arts based educational research

 In this paper we outline how the elements and forms of arts informed research can be used in doctoral education. Drawing on Cole and Knowles (2008) interrogation of the elements and forms of arts informed research, we rework their questions and apply them to the Australian model of the Doctor of Philosophy and consider the possibilities for arts based educational research within this model; its impacts on the doctorate itself and our role as supervisors. In the paper we ask: How can the arts (broadly conceived) inform the doctoral research process? How can the arts inform the representational form of doctoral research? What might this mean for us as supervisors? In our discussion we draw upon our work as researchers and supervisors, and consider Halse's (2011) concept of the ‘supervision as becoming’ (p. 569). Through an analysis of our supervision practices we reframe supervision as becoming in part, beyond a practice of hierarchical relationships and/or becoming as the mirror of the supervisor. Rather, we offer an explanation of research training and credentialing as taking forward a vision of new practices which although they are informed by the arts and arts based practices are however not risk averse. While we agree with Cole and Knowles (2008) to connect the work of the academy with the life and lives of communities through research that is accessible, evocative, embodied, empathic, and provocative is productive, something else is required in these times. SuperVision, is required both on the part of the candidate and the supervisors and/or supervisory panel to ensure that the PhD is executed in a way that can meet the university requirements and further is enabling of a sustainable career pathway beyond the initial doctoral education.

Professional knowledge and standards-based reforms: Learning from the experiences of early career teachers

This article explores the paradoxical situation of early career teachers in this era of standards-based reforms, beginning with the experiences of an English teacher working in a state school in Queensland, Australia and expanding to consider the viewpoints of her colleagues. Our goal is to trace the ways she and the other early career teachers at this particular school negotiate the tensions between the current emphases on standardisation of curricula, testing regimes and teaching standards and their burgeoning sense of their identities as teachers. We shall raise questions about the status of the professional knowledge that these early career teachers bring to their work, showing examples of how this knowledge puts them at odds with standards-based reforms, including the professional standards recently introduced by the Australian Institute for Teaching and School Leadership (AITSL) and the National Assessment Program – Literacy and Numeracy (NAPLAN).

Project and Module Based Teaching and Learning

This paper proposes a new teaching and learning approach-project and module based teaching and learning (PMBTL). The PMBTL approach incorporates the merits of project/problem based and module based learning methods, and overcomes the limitations of these methods. The correlation between teaching, learning, practice and assessment is emphasized in this approach, and new methods have been proposed accordingly. The distinct features of these new methods differentiate the PMBTL approach from conventional teaching approaches. Evaluation of this approach on practical teaching and learning activities demonstrates the effectiveness and stability of the approach in improving the performance and quality of teaching and learning. The approach proposed in this paper is also intuitive to the design of other teaching units.

Physical environments, policies and practices for physical activity and screen-based sedentary behaviour among preschoolers within child care centres in Melbourne, Australia and Kingston, Canada

Characteristics of preschool and child care centres have previously been shown to be associated with children's health behaviours such as physical activity and screen-based sedentary behaviour. This paper investigates differences in physical environments, policies and practices between child care centres in Melbourne, Australia and Kingston, Canada which may be associated with such behaviours.

Enhancing critical analysis and problem-solving skills in undergraduate psychology: An evaluation of a collaborative learning and problem-based learning approach

Critical analysis and problem-solving skills are two graduate attributes that are important in ensuring that graduates are well equipped in working across research and practice settings within the discipline of psychology. Despite the importance of these skills, few psychology undergraduate programmes have undertaken any systematic development, implementation, and evaluation of curriculum activities to foster these graduate skills. The current study reports on the development and implementation of a tutorial programme designed to enhance the critical analysis and problem-solving skills of undergraduate psychology students. Underpinned by collaborative learning and problem-based learning, the tutorial programme was administered to 273 third year undergraduate students in psychology. Latent Growth Curve Modelling revealed that students demonstrated a significant linear increase in self-reported critical analysis and problem-solving skills across the tutorial programme. The findings suggest that the development of inquiry-based curriculum offers important opportunities for psychology undergraduates to develop critical analysis and problem-solving skills. © 2013 The Australian Psychological Society.

DryLab® optimised two-dimensional high performance liquid chromatography for differentiation of ephedrine and pseudoephedrine based methamphetamine samples

In-silico optimised two-dimensional high performance liquid chromatographic (2D-HPLC) separations of a model methamphetamine seizure sample are described, where an excellent match between simulated and real separations was observed. Targeted separation of model compounds was completed with significantly reduced method development time. This separation was completed in the heart-cutting mode of 2D-HPLC where C18 columns were used in both dimensions taking advantage of the selectivity difference of methanol and acetonitrile as the mobile phases. This method development protocol is most significant when optimising the separation of chemically similar chemical compounds as it eliminates potentially hours of trial and error injections to identify the optimised experimental conditions. After only four screening injections the gradient profile for both 2D-HPLC dimensions could be optimised via simulations, ensuring the baseline resolution of diastereomers (ephedrine and pseudoephedrine) in 9.7 min. Depending on which diastereomer is present the potential synthetic pathway can be categorized.

Numerical investigation of a grating and graphene-based multilayer surface plasmon resonance biosensor

A multilayer surface plasmon resonance biosensor (SPRB) incorporating a grating-graphene configuration is investigated for enhanced sensitivity. The numerical analysis of the impact of integrating a periodic array of subwavelength grating on top of a layer of graphene sheet for improving sensitivity is presented. The result of monitoring the biomolecular interactions of DNA hybridization is compared against the outcome of the conventional SPRB, a graphene-based multilayer SPRB, and a multilayer layer grating SPRB, and is mathematically validated. It is demonstrated that the inclusion of a grating and graphene layer on top of the gold thin film is an excellent candidate for a highly sensitive SPRB. To achieve further enhancement of sensitivity, the subwavelength grating is numerically optimized against its geometry including grating configurations (rectangular, sinusoidal, and triangular), grating depth, volume factor, and grating period. © 2014 Taylor & Francis.

Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes

Phenotypic screening is making a comeback in drug discovery as the maturation of chemical proteomics methods has facilitated target identification for bioactive small molecules. A limitation of these approaches is that time-consuming genetic methods or other means are often required to determine the biologically relevant target (or targets) from among multiple protein-compound interactions that are typically detected. Here, we have combined phenotypic screening of a directed small-molecule library with competitive activity-based protein profiling to map and functionally characterize the targets of screening hits. Using this approach, we identify carboxylesterase 3 (Ces3, also known as Ces1d) as a primary molecular target of bioactive compounds that promote lipid storage in adipocytes. We further show that Ces3 activity is markedly elevated during adipocyte differentiation. Treatment of two mouse models of obesity-diabetes with a Ces3 inhibitor ameliorates multiple features of metabolic syndrome, illustrating the power of the described strategy to accelerate the identification and pharmacologic validation of new therapeutic targets.

Molecular insights and oligonucleotide based targeted gene therapy against cancer

The thesis helps to unravel the function of T lymphoma invasion and metastasis protein (TIAM1) and nucleolin, a nucleolar protein in retinoblastoma tumorigenesis. Aptamer based targeted imaging; drug and gene delivery to retinoblastoma and epithelial cancer cells was attained. The work work finally opened up avenues for cancer stem cell targeting using aptamers, imaging of cancer cells using novel bio-orthogonal agent and use of aptamer for blocking the miRNA-17-92 cluster maturation.

Popularity of reinforcement-based and belief-based learning models: an evolutionary approach

In an evolutionary model, players from a given population meet randomly in pairs each instant to play a coordination game. At each instant, the learning model used is determined via some replicator dynamics that respects payoff fitness. We allow for two such models: a belief-based best-response model that uses a costly predictor, and a costless reinforcement-based one. This generates dynamics over the choice of learning models and the consequent choices of endogenous variables. We report conditions under which the long run outcomes are efficient (or inefficient) and they support the exclusive use of either of the models (or their co-existence).