Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen

We have previously demonstrated that well-trained subjects who completed a 3 week training programme in which selected high-intensity interval training (HIT) sessions were commenced with low muscle glycogen content increased the maximal activities of several oxidative enzymes that promote endurance adaptations to a greater extent than subjects who began all training sessions with normal glycogen levels. The aim of the present study was to investigate acute skeletal muscle signalling responses to a single bout of HIT commenced with low or normal muscle glycogen stores in an attempt to elucidate potential mechanism(s) that might underlie our previous observations. Six endurance-trained cyclists/triathletes performed a 100 min ride at ∼70% peak O₂ uptake (AT) on day 1 and HIT (8 × 5 min work bouts at maximal self-selected effort with 1 min rest) 24 h later (HIGH). Another six subjects, matched for fitness and training history, performed AT on day 1 then 1–2 h later, HIT (LOW). Muscle biopsies were taken before and after HIT. Muscle glycogen concentration was higher in HIGH versus LOW before the HIT (390 ± 28 versus 256 ± 67 μmol (g dry wt)⁻¹). After HIT, glycogen levels were reduced in both groups (P < 0.05) but HIGH was elevated compared with LOW (229 ± 29 versus 124 ± 41 μmol (g dry wt)−1; P < 0.05). Phosphorylation of 5'AMP-activated protein kinase (AMPK) increased after HIT, but the magnitude of increase was greater in LOW (P < 0.05). Despite the augmented AMPK response in LOW after HIT, selected downstream AMPK substrates were similar between groups. Phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) was unchanged for both groups before and after the HIT training sessions. We conclude that despite a greater activation AMPK phosphorylation when HIT was commenced with low compared with normal muscle glycogen availability, the localization and phosphorylation state of selected downstream targets of AMPK were similar in response to the two interventions.

Responses to Australian society and culture by Greek-Australian writers

Focuses on the themes and preoccupations in Greek-Australian literature that reflect the influence of Australia on the traditional sense of identity of Greek migrants. Predominant concerns connected with identity are those of nostalgic references to the homeland, feelings of alienation and discrimination. These themes are related to what is recognised in life and in literature as "xenitia". Second generation writers reveal an acceptance of belonging to two cultures and having dual identities.

Student responses to activities designed to develop generic professional skills

This paper reports on student responses to a range of assessment activities in a final-year engineering unit. Existing assessment activities were supplemented with new activities, the overall aim being to link the assessment activities more effectively to the material being studied, and to develop a range of generic skills important in professional engineering practice. A class survey was undertaken at the beginning of the semester to establish the initial attitudes to the new assessment activities. This was followed up with an end-of-semester survey to determine the change in perceived value of the assessment activities, and to collect student feedback regarding the activities. The perceived value of the assessment activities was determined using a Likert rating scale, while student feedback was collected using open-ended questions. The assessment activities evaluated were group work, case study investigation, report writing, oral presentation, group self-assessment, industrial interviews, and written reflective journals. The responses indicate that engineering students value a range of assessment activities. They value highly visits to real engineering organizations, and—contrary to popular belief —value and enjoy oral presentation exercises.

Professional experience in new times: issues and responses to a changing education landscape

This paper discusses policy and practice relevant to teacher education and professional experience programs in Australia, aiming to assist not only reading our past and present, but also offering strategic direction with respect to the challenges and opportunities that are emerging within the Australian context. A meta-analysis of current major trends in Australian educational reform and the implications of an 'education revolution' for professional experience are discussed. The paper maps and examines broadly key education agendas of 'productivity, participation and quality'. In relation to these agendas, significant policy trends are identified under the headings of partnerships, preparation and professional learning, and the implications of each for the field of teacher education and professional experience are explored. Some comparisons with similar reforms that have occurred in Scotland and England are offered to provide insights and alternative directions for those working in the field. Finally, a range of possibilities and suggestions, along with cautionary tales of locally based professional experience practices, are provided.

Enlistment and non-enlistment in wartime Australia : responses to the 1916 call to arms appeal

This article examines men’s responses to the 1916 ‘Call to Arms’ appeal, in which Australia’s federal government questioned military-aged male citizens on their willingness to enlist voluntarily in the armed forces for service at the front. It argues that the appeal illuminated men’s difficult negotiation of choice, in which they weighed their personal sense of obligation to the state at war, to their families, and to themselves. It shows how men not only confronted their decision, but measured their responsibilities against others’, producing a subjective order of sacrifice that paralysed recruiting. In the absence of conscription, that private decision-making was critical to the nature of Australia’s commitment to the war, as men assessed and re-assessed the limits of obligation for themselves.

An empirical investigation of women's affective responses to filmed violence

This thesis examined the subjective emotional responses of women to depictions of violent and sexually violent film. Findings highlighted the significance of contextual factors, such as the gender of the perpetrator and victim upon viewers, and found that exposure to sexual violence in the media has important implications for women. The portfolio's four case studies demonstrate the complexities involved in making risk judgements and treatment planning given the diversity of offences and needs, as well as the implications these decisions can have when determining the amenability of offenders to specific sex offender treatment.

Individual differences in affective responses to violence and sexual violence

The thesis aimed to identify and compare individual differences in anger related affective responses upon exposure to neutral, violent and sexually violent film. The findings revealed that both graphic and non-graphic sexually violent film content may have a stronger impact on viewers' anger levels than exposure to standard violent film. The portfolio examined in four case studies the utility of the Violence Risk Scale when seeking to identify factors associated with risk of violent recidivism and subsequent treatment targets for intellectually disabled offenders . Treatment indications must consider the impaired cognitive and adaptive abilities and the difficulties inherent in modifying the behavioural characteristics of intellectually disabled offenders.

Australian police responses to transnational crime and terrorism

This chapter outlines the Australian federal policing and allied agency responses to international drug trafficking activity and terrorism. The chapter is situated alongside a broader analysis of the structure of each key agency and the various interagency enforcement mechanisms established domestically and internationally to improve enforcement performance.

A-Reit price responses to cash rate changes

With the rapid increasing number and assets of A-REITs, there has been an urgent need to study the relationship between the changes of cash rates and the A-REITs returns. This study investigates whether there were relationships between Australian-Real Estate Investment Trusts stock returns and policy interest rate changes in the past decade by using event study with a multivariate regression model. The findings indicate that cash rate changes have no significantly positive or negative influence on the equity A-REIT stock prices. A series of successive cash rate changes do not take a continuous and dramatic effect on the equity A-REIT stock prices in each economic cycle. Moreover, the A-REITs with relatively smaller assets show more significant fluctuation to the changes of cash rates, and the A-REITs owning more than $ 10 billion in capital assets have relatively steady stock prices. Overall, the findings from this research lead to a call for comprehensive research into various areas in order to ascertain the determinants of A-REIT price changes.

Indigenous family violence : an attempt to understand the problems and inform appropriate and effective responses to criminal justice system intervention

Whilst high levels of concern about the prevalence of family violence within Indigenous communities have long been expressed, progress in the development of evidence-based intervention programs for known perpetrators has been slow. This review of the literature aims to provide a resource for practitioners who work in this area, and a framework from within which culturally specific violence prevention programs can be developed and delivered. It is suggested that effective responses to Indigenous family violence need to be informed by culturally informed models of violence, and that significant work is needed to develop interventions that successfully manage the risk of perpetrators of family violence committing further offences.

Mechanisms involved in the renal responses to intravenous and renal artery infusions of noradrenaline in conscious dogs

1. The renal haemodynamic and glomerular filtration rate (G.F.R.) responses to intravenous and intrarenal infusions of noradrenaline were studied in conscious dogs, either with or without prior blockade of angiotensin II formation with teprotide.

2. Infusion noradrenaline by either route resulted in dose-related rises in plasma renin activity.

3. Pretreatment with teprotide reduced the rise in mean arterial pressure and abolished the rise in G.F.R. seen during intravenous infusions of noradrenaline (0.1, 0.2 and 0.4 microgram/kg . min). Noradrenaline also reduced filtration fraction more after teprotide pretreatment.

4. Renal blood flow rose and renal vascular resistance fell in response to I.V. noradrenaline infusions. This renal vasodilatation was unaffected by pretreatment of the dogs with teprotide, indomethacin or DL-propranolol. However after pentolinium pretreatment, I.V. noradrenaline infusion caused a dose-related renal vasoconstriction.

5. Infusion of noradrenaline into the renal artery (0.02, 0.05 and 0.1 microgram/kg . min) resulted in rises in mean arterial pressure and G.F.R. which were abolished by teprotide pretreatment. Filtration fraction rose when noradrenaline was administered alone but fell when it was infused after teprotide treatment.

6. Thus angiotensin II formed as the result of increased renin release acted to maintain G.F.R. and filtration fraction during noradrenaline infusion. In addition, I.V. noradrenaline infusions in conscious dogs caused reflex vasodilatation of the renal vasculature.

Comparison of aspirin and indomethacin pre-treatments on the responses to reduced renal artery pressure in conscious dogs

To examine the role of prostaglandins in physiologically induced renin release, we reduced renal artery pressure within the autoregulatory range in chronically instrumented conscious dogs with aspirin, indomethacin or no pre-treatment. In untreated dogs, reduction of renal artery pressure to 60 mmHg for 90 min produced rises in plasma renin activity (+ 5.4 +/- 1.0 ng ml.-1 hr-1) and mean arterial pressure (+ 17 +/- 2 mmHg) without significant effect on renal blood flow (n = 13). Aspirin pre-treatment (2 X 25-40 mg kg-1 orally) had no effect on the renin, arterial pressure or renal blood flow responses to renal artery pressure reduction (n = 7). In contrast, indomethacin pre-treatment (2 X 2-3 mg kg-1 orally) significantly lessened the increase in plasma renin activity during reduced renal artery pressure (+ 2.0 +/- 0.3 ng ml.-1 hr-1, n = 11). The relative effectiveness of aspirin and indomethacin in inhibiting prostaglandin production in the kidney was then tested in separate experiments by measuring the renal blood flow responses to renal artery injections of arachidonate (5-200 micrograms kg-1). In the doses used above, aspirin markedly attenuated the blood flow response to arachidonate but indomethacin had almost no effect. Both aspirin and indomethacin abolished the hypotensive effect of intravenous arachidonate (0.5 mg kg-1). These results tentatively suggest that indomethacin may not effectively inhibit renal prostaglandin production in conscious dogs at the doses used in these experiments. Thus the reduced renin release in response to lowered renal artery pressure in indomethacin pre-treated dogs may have been due to another, non-prostaglandin action of indomethacin. The results from the aspirin pre-treated dogs suggest that prostaglandins are not involved in the release of renin in response to reduced renal artery pressure in conscious dogs.