Youth depression alleviation: the Fish Oil Youth Depression Study (YoDA-F): A randomized, double-blind, placebo-controlled treatment trial.

US authorities have recommended 'black-box' warnings for antidepressants because of the increased risk of suicidality for individuals up to age 25. There is thus a clinical and ethical imperative to provide effective treatment for youth depression with an acceptable risk-benefit balance. Long-chain omega-3 polyunsaturated fatty acids (PUFAs) play an important role in a range of physiological processes in living organisms. Supplementation with omega-3 PUFAs has been shown to have a range of beneficial effects on both physical and mental health, and results of previous trials suggest that omega-3 PUFAs may be a safe and effective treatment for depression. However, conclusions from these trials have been limited by their relatively small sample sizes.

Robustness enhancement of quantization based audio watermarking method using adaptive safe-band

This paper presents a novel adaptive safe-band for quantization based audio watermarking methods, aiming to improve robustness. Considerable number of audio watermarking methods have been developed using quantization based techniques. These techniques are generally vulnerable to signal processing attacks. For these conventional quantization based techniques, robustness can be marginally improved by choosing larger step sizes at the cost of significant perceptual quality degradation. We first introduce fixed size safe-band between two quantization steps to improve robustness. This safe-band will act as a buffer to withstand certain types of attacks. Then we further improve the robustness by adaptively changing the size of the safe-band based on the audio signal feature used for watermarking. Compared with conventional quantization based method and the fixed size safe-band based method, the proposed adaptive safe-band based quantization method is more robust to attacks. The effectiveness of the proposed technique is demonstrated by simulation results. © 2014 IEEE.

Creating spaces in intensive care for safe communication : a video-reflexive ethnographic study

The built environment in acute care settings is a new focus in patient safety research, with few studies focusing primarily on the design of ward environments and the location and choice of material objects such as light fittings and hand-washing basins.

The pricing of deposit insurance in the presence of systematic risk

Based on the Merton (1977) put option framework, we develop a deposit insurance pricing model that incorporates asset correlations, a measurement for the systematic risk of a bank, to account for the risk of joint bank failures. Estimates from our model suggest that actuarially fair risk-based deposit insurance that considers only individual bank failure risk is underpriced, leaving insurance providers exposed to net losses. Our estimates also capture the size premium where big banks are priced with higher deposit insurance than small banks. This result is particularly relevant to the current regulatory concerns on big banks that are too-big-to-fail. Above all, our approach provides a unifying framework for integrating risk-based deposit insurance with risk-based Basel capital requirements.

Perioperative Mortality Rate (POMR): a global indicator of access to safe surgery and anaesthesia

The unmet global burden of surgical disease is substantial. Currently, two billion people do not have access to emergency and essential surgical care. This results in unnecessary deaths from injury, infection, complications of pregnancy, and abdominal emergencies. Inadequately treated surgical disease results in disability, and many children suffer deformity without corrective surgery.