Internal representation of movement in children with developmental coordination disorder : a mental rotation task

Recent studies show that children with developmental coordination disorder (DCD) have difficulties in generating an accurate visuospatial representation of an intended action, which are shown by deficits in motor imagery. This study sought to test this hypothesis further using a mental rotation paradigm. It was predicted that children with DCD would not conform to the typical pattern of responding when required to imagine movement of their limbs. Participants included 16 children with DCD and 18 control children; mean age for the DCD group was 10 years 4 months, and for controls 10 years. The task required children to judge the handedness of single-hand images that were presented at angles between 0° and 180° at 45° intervals in either direction. Results were broadly consistent with the hypothesis above. Responses of the control children conformed to the typical pattern of mental rotation: a moderate trade-off between response time and angle of rotation. The response pattern for the DCD group was less typical, with a small trade-off function. Response accuracy did not differ between groups. It was suggested that children with DCD, unlike controls, do not automatically enlist motor imagery when performing mental rotation, but rely on an alternative object-based strategy that preserves speed and accuracy. This occurs because these children manifest a reduced ability to make imagined transformations from an egocentric or first-person perspective.

Procedural learning in children with developmental coordination disorder

Despite the fact that developmental coordination disorder (DCD) is characterised by a deficit in the ability to learn or automate motor skills, few studies have examined motor learning over repeated trials. In this study we examined procedural learning in a group of 10 children with DCD (aged 8–12 years) and age-matched controls without DCD. The learning task was modelled on that of Nissen and Bullemer [Cognitive Psychology 19 (1987) 1]. Children performed a serial reaction time (SRT) task in which they were required to learn a spatial sequence that repeated itself every 10 trials. Children were not aware of the repetition. Spatial targets were four (horizontal) locations presented on a computer monitor. Children responded using four response keys with the same horizontal mapping as the stimulus. They were tested over five blocks of 100 trials each. The first four blocks presented the same repeating sequence, while the fifth block was randomised. Procedural learning was indexed by the slope of the regression of RT on blocks 1–4. Results showed that most children displayed strong procedural learning of the sequence, despite having no explicit knowledge about it. Overall, there was no group difference in the magnitude of learning over blocks of trials – most children performed within the normal range. Procedural learning for simple sequential movements appears to be intact in children with DCD. This suggests that cortico-striatal circuits that are strongly implicated in the sequencing of simple movements appear to be function normally in DCD.

The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3

The somatic JAK2 valine-to-phenylalanine (V617F) mutation has been detected in up to 90% of patients with polycythemia and in a sizeable proportion of patients with other myeloproliferative disorders such as essential thrombocythemia and idiopathic myelofibrosis. Suppressor of cytokine signaling 3 (SOCS3) is known to be a strong negative regulator of erythropoietin (EPO) signaling through interaction with both the EPO receptor (EPOR) and JAK2. We report here that JAK2 V617F cannot be regulated and that its activation is actually potentiated in the presence of SOCS3. Instead of acting as a suppressor, SOCS3 enhanced the proliferation of cells expressing both JAK2 V617F and EPOR. Additionally, although SOCS1 and SOCS2 are degraded in the presence of JAK2 V617F, turnover of SOCS3 is inhibited by the JAK2 mutant kinase and this correlated with marked tyrosine phosphorylation of SOCS3 protein. We also observed constitutive tyrosine phosphorylation of SOCS3 in peripheral blood mononuclear cells (PBMCs) derived from patients homozygous for the JAK2 V617F mutant. These findings suggest that the JAK2 V617F has overcome normal SOCS regulation by hyperphosphorylating SOCS3, rendering it unable to inhibit the mutant kinase. Thus, JAK2 V617F may even exploit SOCS3 to potentiate its myeloproliferative capacity.

Personality, behavioural and affective characteristics of hazardous drinkers

The aim of this study was to investigate the influence of appetitive and aversive motivation on hazardous drinking behaviour by drawing on Reinforcement Sensitivity Theory (RST). A between-groups design examined differences between hazardous drinkers and matched controls on self-report and behavioural appetitive and aversive motivation. The relationship between motivational processes and changes in affective states following behavioural task performance was also examined. Data from 27 hazardous drinkers (M = 21.88 years, SD = 3.29) and 27 gender and age matched controls (M = 21.85 years, SD = 4.08) were utilised. The Card Arranging Reward Responsivity Objective Test (CARROT) assessed behavioural appetitive motivation and the computerised Q-TASK provided an index of behavioural aversive motivation. Self-report appetitive and aversive motivation was measured using the Sensitivity to Punishment and Reward Questionnaire (SPSRQ). Brief scales tapping state positive and negative affect were also administered. Hazardous drinkers were significantly higher than controls on self-report but not behavioural measures of appetitive motivation. Results also indicated that hazardous drinkers reported significantly higher levels of negative affect. These data suggest that hazardous drinkers are characterised by high trait appetitive motivation and state negative affect. It was suggested that RST may provide a useful framework for understanding both the appetitive and aversive motivational processes involved in drinking behaviour.

Predicting prosocial personality from attachment facets: are some facets more critical than others?

Research across various countries and relationship contexts suggests that attachment anxiety and avoidance are associated with people’s prosocial feelings, tendencies, and behaviors (e.g., Gillath et al., 2005; Karantzas, Evans, & Foddy, 2007). In the present paper we extend the two dimensional model of attachment to include a series of nested facets. Doing so allowed us to examine whether the multifaceted nested factor model provides a better explanation of the associations between attachment and the components of prosocial personality as compared to the bi-factor model (attachment anxiety and avoidance). Three hundred and eighty participants, aged 18 to 33 years completed self-report measures of adult attachment and prosocial personality. Data were fitted to various models – as expected the nested model provided a better fit to the data and explained a significantly larger proportion of the variance in prosocial tendencies than the bi-factor model. The attachment facets were found to make distinct contributions to prosocial personality beyond the broad attachment dimensions (e.g., the preoccupied facet was uniquely associated with personal distress). Implications for the revised attachment structure across various prosocial contexts are discussed, as are the limitations of using the Experience in Close Relationships Scale (ECR; Brennan et al., 1998) to test a multifaceted attachment model.

The experiences of living with a person with an eating disorder: the impact on the carers

Using a combination of focus groups and individual in-depth interviews, the experience of living with a person with an eating disorder was explored in 24 carers. Attention was given to the progression of the disorder to understand its impact upon the family throughout the stages of the illness. Caring for a person with an eating disorder impacted upon the primary carer and the family throughout the course of the illness. Despite this, the impact on the carers was seldom acknowledged and the needs of these carers and their families were unrecognized and neglected by health professionals.