Loss and re-adaptation of lumbar intervertebral disc water signal intensity after prolonged bedrest

© 2015, International Society of Musculoskeletal and Neuronal Interactions. All right reserved. The adaptation and re-adaptation process of the intervertebral disc (IVD) to prolonged bedrest is important for understanding IVD physiology and IVD herniations in astronauts. Little information is available on changes in IVD composition. In this study, 24 male subjects underwent 60-day bedrest and In/Out Phase magnetic resonance imaging sequences were performed to evaluate IVD shape and water signal intensity. Scanning was performed before bedrest (baseline), twice during bedrest, and three, six and twenty-four months after bedrest. Area, signal intensity, average height, and anteroposterior diameter of the lumbar L3/4 and L4/5 IVDs were measured. At the end of bedrest, disc height and area were significantly increased with no change in water signal intensity. After bedrest, we observed reduced IVD signal intensity three months (p=0.004 versus baseline), six months (p=0.003 versus baseline), but not twenty-four months (p=0.25 versus baseline) post-bedrest. At these same time points post-bedrest, IVD height and area remained increased. The reduced lumbar IVD water signal intensity in the first months after bedrest implies a reduction of glycosaminoglycans and/or free water in the IVD. Subsequently, at two years after bedrest, IVD hydration status returned towards pre-bedrest levels, suggesting a gradual, but slow, re-adaptation process of the IVD after prolonged bedrest.

Simple and signal-off electrochemical biosensor for mercury(II) based on thymine-mercury-thymine hybridization directly on graphene

Abstract A simple, signal-off and reusable electrochemical biosensor was developed for sensitive and selective detection of mercury(II) based on thymine-mercury(II)-thymine (T-Hg²⁺-T) complex and the remarkable difference in the affinity of graphene with double strand DNA (ds-DNA) and single strand DNA (ss-DNA). Our system was composed of ferrocene-tagged probe DNA and graphene. Due to the noncovalent assembly, the ferrocene-tagged probe ss-DNA was immobilized on the surface of graphene nanosheets directly and employed to amplify the electrochemical signal. In the presence of Hg²⁺, the ferrocene-labeled T-rich DNA probe hybridized with target probe to form ds-DNA via the Hg²⁺-mediated coordination of T-Hg²⁺-T base pairs. As a result, the duplex DNA complex kept away from the graphene surface due to the weak affinity of graphene and ds-DNA, and the redox current decreased substantially. Meanwhile, the graphene decorated GCE surface was released for the reusability. Under the optimal conditions, the proposed sensor showed a linear concentration range from 25 pM to 10 μM with a detection limit of 5 pM for Hg²⁺ detection. The strategy afforded exquisite selectivity for Hg²⁺ against other metal ions in real environmental samples.

An audio signal based model for condition monitoring of sheet metal stamping process

Tool condition monitoring is an important factor in ensuring manufacturing efficiency and product quality. Audio signal based methods are a promising technique for condition monitoring. However, the influence of interfering signals and background noise has hindered the use of this technique in production sites. Blind signal separation (BSS) has the potential to solve this problem by recovering the signal of interest out of the observed mixtures, given that the knowledge about the BSS model is available. In this paper, we discuss the development of the BSS model for sheet metal stamping with a mechanical press system, so that the BSS techniques based on this model can be developed in future. This involves conducting a set of specially designed machine operations and developing a novel signal extraction technique. Also, the link between stamping process conditions and the extracted audio signal associated with stamping was successfully demonstrated by conducting a series of trials with different lubrication conditions and levels of tool wear.

On the security of compressed sensing-based signal cryptosystem

With the development of the cyber-physical systems (CPS), the security analysis of the data therein becomes more and more important. Recently, due to the advantage of joint encryption and compression for data transmission in CPS, the emerging compressed sensing (CS)-based cryptosystem has attracted much attention, where security is of extreme importance. The existing methods only analyze the security of the plaintext under the assumption that the key is absolutely safe. However, for sparse plaintext, the prior sparsity knowledge of the plaintext could be exploited to partly retrieve the key, and then the plaintext, from the ciphertext. So, the existing methods do not provide a satisfactory security analysis. In this paper, it is conducted in the information theory frame, where the plaintext sparsity feature and the mutual information of the ciphertext, key, and plaintext are involved. In addition, the perfect secrecy criteria (Shannon-sense and Wyner-sense) are extended to measure the security. While the security level is given, the illegal access risk is also discussed. It is shown that the CS-based cryptosystem achieves the extended Wyner-sense perfect secrecy, but when the key is used repeatedly, both the plaintext and the key could be conditionally accessed.

Design of an optimal ANFIS traffic signal controller by using cuckoo search for an isolated intersection

An optimal design of Adaptive Neuro-Fuzzy Inference System (ANFIS) traffic signal controller is presented in this paper. The proposed controller aims to adjust a set of green times for traffic lights in a single intersection with the purpose of minimizing travel delay time and traffic congestion. The ANFIS controller is trained, to learned how to set green times for each traffic phase. This intelligent controller uses the Cuckoo Search (CS) algorithm to tune its parameters during the learning pried. Evaluating the performance of the proposed controller in comparison with the performance of a FLS controller (FLC) with predefined rules and membership functions, and also three fixed-Time controllers, illustrates the better performance of the optimal ANFIS controller against the other benchmark controllers.

EEG signal analysis for BCI application using fuzzy system

An approach to EEG signal classification for brain-computer interface (BCI) application using fuzzy standard additive model is introduced in this paper. The Wilcoxon test is employed to rank wavelet coefficients. Top ranking wavelets are used to form a feature set that serves as inputs to the fuzzy classifiers. Experiments are carried out using two benchmark datasets, Ia and Ib, downloaded from the BCI competition II. Prevalent classifiers including feedforward neural network, support vector machine, k-nearest neighbours, ensemble learning Adaboost and adaptive neuro-fuzzy inference system are also implemented for comparisons. Experimental results show the dominance of the proposed method against competing approaches.

Computational intelligence-based traffic signal timing optimization

 Traffic congestion has explicit effects on productivity and efficiency, as well as side effects on environmental sustainability and health. Controlling traffic flows at intersections is recognized as a beneficial technique, to decrease daily travel times. This thesis applies computational intelligence to optimize traffic signals' timing and reduce urban traffic.

Design of distributed adaptive neural traffic signal timing controller by cuckoo search optimization

This paper focuses on designing an adaptive controller for controlling traffic signal timing. Urban traffic is an inevitable part in modern cities and traffic signal controllers are effective tools to control it. In this regard, this paper proposes a distributed neural network (NN) controller for traffic signal timing. This controller applies cuckoo search (CS) optimization methods to find the optimal parameters in design of an adaptive traffic signal timing control system. The evaluation of the performance of the designed controller is done in a multi-intersection traffic network. The developed controller shows a promising improvement in reducing travel delay time compared to traditional fixed-time control systems.

Phase asymmetry of heart rate variability signal

Heart rate asymmetry (HRA) is considered as a physiological phenomenon in healthy subjects. In this article, we propose a novel HRA index, Slope Index (SI), to quantify phase asymmetry of heart rate variability (HRV) system. We assessed the performance of proposed index in comparison with conventional (Guzik's Index (GI) and Porta's Index (PI)) HRA indices. As illustrative examples, we used two case studies: (i) differentiate physiologic RR series from synthetic RR series; and (ii) discriminate arrhythmia subjects from Healthy using beat-to-beat heart rate time series. The results showed that SI is a superior parameter than GI and PI for both case studies with maximum ROC area of 0.84 and 0.82 respectively. In contrast, GI and PI had ROC areas {0.78, 0.61} and {0.50, 0.56} in two case studies respectively. We also performed surrogate analysis to show that phase asymmetry is caused by a physiologic phenomena rather than a random nature of the signal. In conclusion, quantification of phase asymmetry of HRV provides additional information on HRA, which might have a potential clinical use to discriminate pathological HRV in future.

An alternative LQR-based excitation controller design for power systems to enhance small-signal stability

This paper presents a new approach to design excitation controller for power systems to enhance small-signal stability. Partial feedback linearization scheme is used to design the controller for a linearized power system model which transforms a part of this model into a new system through linear coordinate transformation. In this paper, the excitation control law as a function of state variables is determined from the dynamics of the partly transformed new system provided that the controller stabilizes the remaining dynamics of the system which are not transformed through feedback linearization. The stability of the remaining dynamics is also discussed in this paper. Since the proposed control scheme uses state variables as feedback, it is analogous to a linear quadratic regulator (LQR) based excitation controller. Therefore, the performance of the proposed scheme is evaluated on a single machine infinite bus (SMIB) system and compared to that of an LQR controller.

Blind channel estimation and signal retrieving for MIMO relay systems

In this paper, we propose a blind channel estimation and signal retrieving algorithm for two-hop multiple-input multiple-output (MIMO) relay systems. This new algorithm integrates two blind source separation (BSS) methods to estimate the individual channel state information (CSI) of the source-relay and relay-destination links. In particular, a first-order Z-domain precoding technique is developed for the blind estimation of the relay-destination channel matrix, where the signals received at the relay node are pre-processed by a set of precoders before being transmitted to the destination node. With the estimated signals at the relay node, we propose an algorithm based on the constant modulus and signal mutual information properties to estimate the source-relay channel matrix. Compared with training-based MIMO relay channel estimation approaches, the proposed algorithm has a better bandwidth efficiency as no bandwidth is wasted for sending the training sequences. Numerical examples are shown to demonstrate the performance of the proposed algorithm.

Signal processing for automated EEG quality assessment

An automated signal quality assessment method was proposed for the EEG signals, which will help in testing new BCI algorithms so that the testing can be made on high quality signals only. This research includes the development of novel feature extraction technique and a new clustering algorithm for EEG signals.

Characterising an ECG signal using statistical modelling: a feasibility study

For clinical use, in electrocardiogram (ECG) signal analysis it is important to detect not only the centre of the P wave, the QRS complex and the T wave, but also the time intervals, such as the ST segment. Much research focused entirely on qrs complex detection, via methods such as wavelet transforms, spline fitting and neural networks. However, drawbacks include the false classification of a severe noise spike as a QRS complex, possibly requiring manual editing, or the omission of information contained in other regions of the ECG signal. While some attempts were made to develop algorithms to detect additional signal characteristics, such as P and T waves, the reported success rates are subject to change from person-to-person and beat-to-beat. To address this variability we propose the use of Markov-chain Monte Carlo statistical modelling to extract the key features of an ECG signal and we report on a feasibility study to investigate the utility of the approach. The modelling approach is examined with reference to a realistic computer generated ECG signal, where details such as wave morphology and noise levels are variable.

A digital signal processor controlled smart battery charger for photovoltaic power systems

An off-grid photovoltaic power system requires an energy storage system, especially batteries, for mitigation of variability and intermittency problems, and for assured service reliability and availability. The longevity and reliability of such batteries depend on the effectiveness of the charging system. This paper presents the modelling, simulation and hardware implementation of a four-stage switch-mode charger based on the single-ended primary inductance converter. The digital signal processor based controller implements algorithms for the system's power balance control, maximum power point tracking to improve charging speed and efficiency, four-stage optimal charging, and system's protection. The protection algorithm provides over-charge, overdischarge, over-temperature and short circuit protection capabilities. The proposed system has the following advantages: ability to continuously charge the batteries even at reduced solar irradiation, higher efficiency, and use of adaptive thermally compensated set points for optimum performance. A prototype is built and experimental results are presented to validate the simulation results.