Evolution of a contagious cancer: epigenetic variation in devil facial tumour disease

The emergence of Devil Facial Tumour Disease (DFTD), a highly contagious cancer, is driving Tasmanian devils (Sarcophilus harrisii) to extinction. The cancer is a genetically and chromosomally stable clonal cell line which is transmitted by biting during social interactions. In the present study, we explore the Devil Facial Tumour (DFT) epigenome and the genes involved in DNA methylation homeostasis. We show that tumour cells have similar levels of methylation to peripheral nerves, the tissue from which DFTD originated. We did not observe any strain or region-specific epimutations. However, we revealed a significant increase in hypomethylation in DFT samples over time (p < 0.0001). We propose that loss of methylation is not because of a maintenance deficiency, as an upregulation of DNA methyltransferase 1 gene was observed in tumours compared with nerves (p < 0.005). Instead, we believe that loss of methylation is owing to active demethylation, supported by the temporal increase in MBD2 and MBD4 (p < 0.001). The implications of these changes on disease phenotypes need to be explored. Our work shows that DFTD should not be treated as a static entity, but rather as an evolving parasite with epigenetic plasticity. Understanding the role of epimutations in the evolution of this parasitic cancer will provide unique insights into the role of epigenetic plasticity in cancer evolution and progression in traditional cancers that arise and die with their hosts.

Forward secure attribute-based signatures

Attribute-Based Signatures (ABS) is a versatile primitive which allows an entity to sign a message with fine-grained control over identifying information. A valid ABS only attests to the fact that “A single user, whose attributes satisfy the predicate, has endorsed the message”. While ABS has been well investigated since its introduction, it is unfortunate that key exposure–an inherent weakness of digital signatures–has never been formally studied in the scenario of ABS. We fill this gap by proposing a new notion called forward secure ABS, its formal security models and a generic (also the first) design based on well established crypto primitives.

Further observations on certificateless public key encryption

Certificateless public key encryption can be classified into two types, namely, CLE and CLE † , both of which were introduced by Al-Riyami and Paterson in Asiacrypt 2003. Most works about certificateless public key encryption belong to CLE, where the partial secret key is uniquely determined by an entity’s identity. In CLE † , an entity’s partial secret key is not only determined by the identity information but also by his/her (partial) public key. Such techniques can enhance the resilience of certificateless public key encryption against a cheating KGC. In this paper, we first formalize the security definitions of CLE † . After that, we demonstrate the gap between the security model of CLE † and CLE, by showing the insecurity of a CLE † scheme proposed by Lai and Kou in PKC 2007. We give an attack that can successfully break the indistinguishability of their CLE † scheme, although their scheme can be proved secure in the security model of CLE. Therefore, it does not suffice to consider the security of CLE † in the security model of CLE. Finally, we show how to secure Lai-Kou’s scheme by providing a new scheme with the security proof in the model of CLE †

Attribute-based signatures with efficient revocation

Based signatures (ABS for short) allow an entity to sign messages with a fine-grained control over identity information. The signature attests not to the identity of the individual who endorsed a message, but instead to a claim regarding the attributes he/she holds. ABS has been well investigated since its introduction but little has been done on the revocation in ABS. In this paper, we divide ABS revocation as fine-grained attribute-revocation and coarse-grained user-revocation. The latter is the focus of this paper, and we present a concrete design-to address the issue of coarse-grained user-revocation in ABS without the need of any other third parties.

Fungal Mastoiditis in immunocompromised children

The immunocompromised host is subject to a variety of opportunistic infections. Mycotic infections, including invasive fungal sinusitis, are a dreaded complication in immune deficient children. Fungal mastoiditis has rarely been described in this population. Our experience with 2 cases of fungal mastoiditis in immunocompromised children is reviewed. Case histories describing aggressive medical management with and without surgical intervention and a review of the literature are presented.Fungal mastoiditis is a rare entity described in isolated case reports in the adult literature. It is seen almost entirely in immunocompromised patients, particularly those lacking cell-mediated immunity. The first case of Aspergillus mastoiditis was described in 1985.1 Reports of fungal mastoiditis have been primarily of patients with leukemia, and, more recently, of patients with acquired immunodeficiency syndrome.2,3 Using a computerized search of the MEDLINE database, we identified 1 report (in a non–English language journal) of fungal mastoiditis in a pediatric patient.4 We report 2 cases of fungal mastoiditis in immunosuppressed children.

Internationalization to China: a model for Australian architectural, engineering and construction firms

The experiences of an architectural, an engineering, and a construction organization, when internationalizing to China, are compared to extant theories of internationalization to develop an enhanced explanation if these organizations’ internationalization. The research examines the explanatory power of both the Uppsala internationalization model and network theory for internationalization. The research determined that, whilst these organizations utilized an incremental internationalization process, the stages differed from those identified in the Uppsala model. Part of this difference reflects the fact that the participants are service organizations and the Uppsala model is more relevant to manufacturing organizations. Network theory was also found to predict some of the participant behaviors; however, it did not correctly predict the reasons for forming partnerships, which was to gain knowledge rather than develop networks. The stages of the internationalization into China identified were: (1) experiencing a motivation to internationalize; (2) adopting one of a variety of entry modes; (3) experiencing a motivation to increase internationalization to the level of a wholly-owned foreign entity; (4) establishment of a wholly-owned foreign entity (WOFE), either by acquisition or development; and (5) further horizontal expansion (such as movement to new locations). A range of different motivations for both stages one and three were identified.

A comparison of schizophrenia, schizoaffective disorder, and bipolar disorder: results from the second Australian national psychosis survey

Introduction It remains uncertain whether schizoaffective disorder (SAD) is a discrete diagnostic entity, is a variant of either a psychotic mood disorder such as bipolar disorder (BDP) or schizophrenia (SCZ), or exists on a spectral continuum between these disorders. The present study examined whether SCZ, SAD, and BDP differed qualitatively on demographic and clinical variables based on a large Australian dataset.

Medulloblastoma Down Under 2013 : a report from the third annual meeting of the International Medulloblastoma Working Group.

Medulloblastoma is curable in approximately 70% of patients. Over the past decade, progress in improving survival using conventional therapies has stalled, resulting in reduced quality of life due to treatment-related side effects, which are a major concern in survivors. The vast amount of genomic and molecular data generated over the last 5-10 years encourages optimism that improved risk stratification and new molecular targets will improve outcomes. It is now clear that medulloblastoma is not a single-disease entity, but instead consists of at least four distinct molecular subgroups: WNT/Wingless, Sonic Hedgehog, Group 3, and Group 4. The Medulloblastoma Down Under 2013 meeting, which convened at Bunker Bay, Australia, brought together 50 leading clinicians and scientists. The 2-day agenda included focused sessions on pathology and molecular stratification, genomics and mouse models, high-throughput drug screening, and clinical trial design. The meeting established a global action plan to translate novel biologic insights and drug targeting into treatment regimens to improve outcomes. A consensus was reached in several key areas, with the most important being that a novel classification scheme for medulloblastoma based on the four molecular subgroups, as well as histopathologic features, should be presented for consideration in the upcoming fifth edition of the World Health Organization's classification of tumours of the central nervous system. Three other notable areas of agreement were as follows: (1) to establish a central repository of annotated mouse models that are readily accessible and freely available to the international research community; (2) to institute common eligibility criteria between the Children's Oncology Group and the International Society of Paediatric Oncology Europe and initiate joint or parallel clinical trials; (3) to share preliminary high-throughput screening data across discovery labs to hasten the development of novel therapeutics. Medulloblastoma Down Under 2013 was an effective forum for meaningful discussion, which resulted in enhancing international collaborative clinical and translational research of this rare disease. This template could be applied to other fields to devise global action plans addressing all aspects of a disease, from improved disease classification, treatment stratification, and drug targeting to superior treatment regimens to be assessed in cooperative international clinical trials.

Optimum design and analysis study of stand-alone residential solar PV microgrid

Today’s power system network has become more complex and it has more responsibilities and challenges to provide secure, reliable and quality energysupply to the communities. A small entity of electrical network known as Microgrid (MG) is more popular nowadays to enhance reliablity and secure level of energy supply, in case of any energy crisis in the utility network. The MG can also provide clean energy supply by integrating renewable energy sources effectively. TheMG with small scale solar photovoltaic (PV) power system is more suitable to provide reliable and clean energy supply for remote or urban communities in residential level. This paper presents the basic analysis study of stand-alone solar photovoltaic (PV) MG power system which has been developed with the aid of Matlab - Simulink software, on the basis of residential load profile and solar exposure level in a particular area of Geelong, Victoria State. The simulation result depicts the control behavior of MG power system with optimum sizing of PV (4.385 kW)and battery storage (480Ah/48V) facility, fulfills daily energy needs in residential load level. This study provides a good platform to develop an effective and reliable stand-alone MG power system for the remote communities in the near future.

Writer-as-narrator: engaging the debate around the (un)reliable narrator in memoir and the personal essay

Subjective and personal forms of nonfiction writing are enjoying exponential popularity in English language publishing currently, as an interested public engages with ‘true’ stories of society and culture. Yet a paradox exists at the centre of this form of writing. As readers, we want to know who the writer is and what she has to tell us. Yet as writers we use a persona, a constructed character, a narrator who is only partially the writer, to deliver the narrative. How is a writer able to convey ‘true’ stories that are inherently reliant on memory, within a constructed narrative persona?We find a ‘gap’ between the writer and the narrator/protagonist on the page, an empowered creative space in which composition occurs, facilitating a balance between the facts and lived experiences from which ‘true’ stories are crafted, and the acknowledged fallibility of human memory. While the gap between writer and writer-as-narrator provides an enabling space for creative composition, it also creates space for the perception of unreliability. The width of this gap, we argue, is crucial. Only if the gap is small, if writer and writer-as-narrator share a set of passionately held values, can the writer-as-narrator become a believable entity, satisfying the reader with the ‘truth’ of their story.

Optimizing health literacy: improving health and reducing health inequities: a selection of information sheets from the health literacy toolkit for low- and middle-income countries

This series of information sheets introduces health literacy, its relevance to public policy, and the ways it can be used to inform the promotion of good health, the prevention and management of communicable and noncommunicable diseases, and the reduction of health inequities. It provides information and links to further resources to assist organizations and governments to incorporate health literaacy responses into practice, service delivery systems, and policy.

A dynamic time warped clustering technique for discrete event simulation-based system analysis

Abstract This paper introduces a novel approach for discrete event simulation output analysis. The approach combines dynamic time warping and clustering to enable the identification of system behaviours contributing to overall system performance, by linking the clustering cases to specific causal events within the system. Simulation model event logs have been analysed to group entity flows based on the path taken and travel time through the system. The proposed approach is investigated for a discrete event simulation of an international airport baggage handling system. Results show that the method is able to automatically identify key factors that influence the overall dwell time of system entities, such as bags that fail primary screening. The novel analysis methodology provides insight into system performance, beyond that achievable through traditional analysis techniques. This technique also has potential application to agent-based modelling paradigms and also business event logs traditionally studied using process mining techniques.

Aggregating cultural heritage data for research use: The humanities networked infrastructure (HuNI)

This paper looks at the Humanities Networked Infrastructure (HuNI), a service which aggregates data from thirty Australian data sources and makes them available for use by researchers across the humanities and creative arts. We discuss the methods used by HuNI to aggregate data, as well as the conceptual framework which has shaped the design of HuNI’s Data Model around six core entity types. Two of the key functions available to users of HuNI – building collections and creating links – are discussed, together with their design rationale.

Nonsuicidal self-injury in Indian adolescents: nonexistent or unacknowledged?

Nonsuicidal self-injury (NSSI) has been a neglected entity in low- and middle-income countries (LMICs). In this correspondence (letter to the editor), authors are advocating for greater research in this area in LMICs as it will help to compare and contrast prevalence rates of NSSI in these countries with high-income countries (HICs), identify context-specific risk and protective factors to better understand the pathophysiology of NSSI and devise context-specific interventions resulting in improvement in adolescent mental health worldwide.