Bone marrow chimeric mice reveal a role for CX3CR1 in maintenance of the monocyte-derived cell population in the olfactory neuroepithelium

Macrophages in the olfactory neuroepithelium are thought to play major roles in tissue homeostasis and repair. However, little information is available at present about possible heterogeneity of these monocyte-derived cells, their turnover rates, and the role of chemokine receptors in this process. To start addressing these issues, this study used Cx3cr1gfp mice, in which the gene sequence for eGFP was knocked into the CX3CR1 gene locus in the mutant allele. Using neuroepithelial whole-mounts from Cx3cr1gfp/+ mice, we show that eGFP+ cells of monocytic origin are distributed in a loose network throughout this tissue and can be subdivided further into two immunophenotypically distinct subsets based on MHC-II glycoprotein expression. BM chimeric mice were created using Cx3cr1gfp/+ donors to investigate turnover of macrophages (and other monocyte-derived cells) in the olfactory neuroepithelium. Our data indicate that the monocyte-derived cell population in the olfactory neuroepithelium is actively replenished by circulating monocytes and under the experimental conditions, completely turned over within 6 months. Transplantation of Cx3cr1gfp/gfp (i.e., CX3CR1-deficient) BM partially impaired the replenishment process and resulted in an overall decline of the total monocyte-derived cell number in the olfactory epithelium. Interestingly, replenishment of the CD68lowMHC-II+ subset appeared minimally affected by CX3CR1 deficiency. Taken together, the established baseline data about heterogeneity of monocyte-derived cells, their replenishment rates, and the role of CX3CR1 provide a solid basis to further examine the importance of different monocyte subsets for neuroregeneration at this unique frontier with the external environment.

A qualitative analysis of the Taiyi Jinhua Zongzhi

The Taiyi Jinhua Zongzhi (太一金華宗旨) is an important Daoist text, in particular to the Longmen branch of the Quanzhen movement. It is attributed to Lü Dongbin and describes a form of meditation called huiguang (回光 – turning around or reversing the light). The text was popularized in the West through a commentary by Carl Jung on Richard Wilhelm’s translation. However, the accuracy of both Jung’s commentary (e.g., Cott & Rock, 2009) and Wilhelm’s translation (e.g., Cleary, 1991) have been questioned. While the Taiyi Jinhua Zongzhi tends to express its message in much clearer language than many Daoist texts, it is still may not be immediately accessible to most readers on first viewing. Thus, the results presented herein are intended to clearly present the main messages of the Taiyi Jinhua Zongzhi for those unfamiliar with the text, while attempting to avoid committing the same errors as, for example, Jung. To do this, the present analysis extracted all the prominent constructs discussed in the text, descriptions of their nature, and the relationships between them. This resulted in five overarching themes, two of which describe the general process of turning the light around, and a further three that describe a stage-like progression resulting from this general process. The constructs and relationships that constitute each theme are discussed in detail with the aid of diagrammatic representations, as are the relationships between the five themes.
It is hoped that this analysis will make the general teachings of the Taiyi Jinhua Zongzhi more accessible to psychologists wishing to pursue studies in the area of Daoism.

Contentious Activism and Inter-Korean Relations

In South Korea, the contentious debate over relations with the North transcends traditional considerations of physical and economic security, and political activists play a critical role in shaping the discussion of these issues as they pursue the separate yet connected agendas of democracy, human rights, and unification.

Providing international observers with a better understanding of policymakers’ management of inter-Korean relations, Danielle L. Chubb traces the development of various policy disputes and perspectives from the 1970s through South Korea’s democratic transition. Focusing on four case studies—the 1980 Kwangju uprising, the June 1987 uprising, the move toward democracy in the 1990s, and the decade of “progressive” government that began with the election of Kim Dae Jung in 1997—she tracks activists’ complex views on reunification along with the rise and fall of more radical voices encouraging the adoption of a North Korean–style form of socialism. While these specific arguments have dissipated over the years, their vestiges can still be found in recent discussions over how to engage with North Korea and bring security and peace to the peninsula.

Extending beyond the South Korean example, this examination shows how the historical trajectory of norms and beliefs can have a significant effect on a state’s threat perception and security policy. It also reveals how political activists, in their role as discursive agents, play an important part in the creation of the norms and beliefs directing public debate over a state’s approach to the ethical and practical demands of its foreign policy.

Privacy preserving for tagging recommender systems

Tagging recommender systems allow Internet users to annotate resources with personalized tags. The connection among users, resources and these annotations, often called afolksonomy, permits users the freedom to explore tags, and to obtain recommendations. Releasing these tagging datasets accelerates both commercial and research work on recommender systems. However, adversaries may re-identify a user and her/his sensitivity information from the tagging dataset using a little background information. Recently, several private techniques have been proposed to address the problem, but most of them lack a strict privacy notion, and can hardly resist the number of possible attacks. This paper proposes an private releasing algorithm to perturb users' profile in a strict privacy notion, differential privacy, with the goal of preserving a user's identity in a tagging dataset. The algorithm includes three privacy preserving operations: Private Tag Clustering is used to shrink the randomized domain and Private Tag Selection is then applied to find the most suitable replacement tags for the original tags. To hide the numbers of tags, the third operation, Weight Perturbation, finally adds Lap lace noise to the weight of tags We present extensive experimental results on two real world datasets, Delicious and Bibsonomy. While the personalization algorithmis successful in both cases.

Psychological Reflections on Post - Modernist Gothic Literature

The thesis consists of a creative component, two short stories, 'The Conservatory' and 'Psychosis', and a novella, 'The Lady of Tangiers', in the genre of Gothic fiction, and accompanying theoretical component with a psychological interpretation of literature, including theories of C.G.Jung, identifying psychological elements including symbolism of the unconscious, transformation and individuation in the short stories 'The Conservatory' and 'Psychosis', and an analysis of the novella 'The Lady of Tangiers', discussing the essay 'The Uncanny' by Sigmund Freud. The critical analysis and interpretation of the writing reflects the psychological development of the individual.

Beckett and Bion: The (Im)patient voice in psychotherapy and literature

This book focuses on Samuel Beckett’s psychoanalytic psychotherapy with W. R. Bion as a central aspect both of Beckett’s and Bion’s radical transformations of literature and psychoanalysis. The recent publication of Beckett’s correspondence during the period of his psychotherapy with Bion provides a starting place for an imaginative reconstruction of this psychotherapy, culminating with Bion’s famous invitation to his patient to dinner and a lecture by C.G. Jung. Following from the course of this psychotherapy, Miller and Souter trace the development of Beckett’s radical use of clinical psychoanalytic method in his writing, suggesting the development within his characters of a literary-analytic working through of transference to an idealized auditor known by various names, apparently based on Bion. Miller and Souter link this pursuit to Beckett’s breakthrough from prose to drama, as the psychology of projective identification is transformed to physical enactment. They also locate Bion’s memory and re-working of his clinical contact with Beckett, who figures as the 'patient zero' of Bion’s pioneering postmodern psychoanalytic clinical theories.