95 resultados para HISTOLOGICAL CRITERIA


Relevância:

20.00% 20.00%

Publicador:

Resumo:

Reports a study in which the MBTI, FIRO-B and PP measures were correlated with employee performance indicators of high potential candidates for management development. The participants were 37 middle level managers in a large trans-national company. Results indicate a disturbing disconnect between measures used in training and development and actual business outcomes that can be presumed to express organisational priorities and goals.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Contractor prequalification is concerned with assessing the likelihood of contractors meeting client and project requirements. The criteria used in this assessment have been developed in a largely idiosyncratic manner to date and with little or no consultation with the contractors affected. As a result, contractors are faced with a variety of calls for information by prequalifiers, the collection of which can be quite costly. This is leading to expensive duplication of effort by contractors in providing what is often similar information but in different formats. Furthermore, previous research has shown that the benefits of the information to prequalifiers are uncertain - many prequalifiers analyse the information in only a cursory manner. What is needed is some form of cost-benefit analysis to be carried out which will establish a common set of criteria for all to use.

As a precursor to this, the research described in this paper compares the different attitudes of both prequalifiers and contractors to prequalification criteria commonly in use in the Australian building industry. This was carried out via a postal questionnaire involving 49 contractors and 15 prequalifiers across Australia. The respondents were divided into three groups; (1) contractors doing work for mainly private sector clients and (2) contractors doing work for mainly private sector clients, and (3) construction prequalifiers (clients).

The results show that both clients and contractors have divergent opinions on the importance and value of the criteria in use. The possible reasons for these differences are discussed and the likely implications for future research in the topic.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

The ordered weighted averaging (OWA) determination method with stress function was proposed by Yager, and it makes the OWA operator elements scatter in the shape of the stress function. In this paper, we extend the OWA determination with the stress function method using an optimization model. The proposed method transforms the OWA optimal solution elements into the interpolation points of the stress function. The proposed method extends the basic form of the stress function method with both scale and vertical shift transformations.We also explore a number of properties of this optimization-based stress function method. The OWA operator optimal solution elements can distribute as the shape of the given stress function in a parameterized way, in which case, the solution always possesses the arithmetic average operator as a special case.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Australia is one of the world’s most urbanised nations, with 74.92% of the population living in 17 major cities of 100,000 people or more. To improve the productivity, liveability and sustainability of Australia’s cities, there is an increasing emphasis in urban management policies on democratic stakeholder participation. In order to obtain a full picture of stakeholders’ concerns efficiently, and manage antagonism, prejudice and conflicts between stakeholders effectively, it is important for participatory decision-making in urban development to be able to select and integrate stakeholder analysis and engagement methods. This paper investigates the characteristics of stakeholder participation approaches in urban development, and proposes criteria for approach selection and integration. The outcome is a multi-criteria mechanism for selecting and integrating approaches to stakeholder participation. This could enable effective, efficient and democratic participation in decision-making process of urban development. Meanwhile, the capacity of Australian state, territory and local governments can be largely enhanced to understand and unpack the complex challenges of urban-ecological conditions, and generate a compromise solution that best represents the preferences of stakeholders.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

The climate change scenarios of the Intergovernmental Panel on Climate Change (IPCC) predict a significant increase in temperatures over the next decades. Architecture and building occupants have to respond to this change, but little information is currently available in how far the predicted changes are likely to affect comfort and energy performance in buildings. This study therefore investigates the climate change sensitivity of the following parameters: adaptive thermal comfort according to Ashrae Standard 55 and EN 15251, energy consumption, heating and cooling loads, and length of heating and cooling periods. The study is based on parametric simulations of typical office room configurations in the context of Athens, Greece. They refer to different building design priorities and account for different occupant behaviour by using an ideal and worst case scenario. To evaluate the impact of the climate change, simulations are compared based on a common standard weather data set for Athens, and a generated climate change data set for the IPCC A2 scenario. The results show a significant impact of the climate change on all investigated parameters. They also indicate that in this context the optimisation of comfort and energy performance is likely to be related to finding the best possible balance between building (design) and occupant behaviour and other contextual influences, rather than a straightforward optimisation of separated single parameters.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

During the summer season 2009/10, a comprehensive environmental impact assessment of the sewage discharge was conducted at Davis Station in the Vestfold Hills region of East Antarctica. As part of this project, a survey of the histology of liver, gill, gonad and muscle tissues in the Antarctic rock cod Trematomus bernacchii from nearshore sites in the receiving environment close to Davis Station in was completed. Fish from 4 sites were examined; 1 site adjacent to the Davis Station sewage outfall (within 500 m of the point of discharge), 2 sites approximately 2 km from the outfall (Anchorage Island and Antennae farm), and 1 site approximately 10 km away from the outfall and adjacent to an Adelie penguin population (Kazak Island). All fish sampled from the sewage outfall site exhibited significant histological alterations in all major tissues. Fish from the other 3 sites showed some alterations in either gill and/or liver tissues. Pathological abnormalities present in all fish collected near the sewage outfall included: extensive multifocal cysts of unknown etiology with necrotic liquification; multifocal granuloma with associated inflammation; coagulative necrosis in the liver; and lamellar hyperplasia with associated proliferation and lamella fusion of the gills. Results of this work form part of a weight of evidence approach alongside ecological monitoring, chemical analysis, ecotoxicological testing and dispersal modelling of the discharge plume which is being used to inform and direct upgrades to the Australian Antarctic Divisions operations and current sewage discharge practises at Davis Station.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Port Phillip Bay, Victoria, is a pollutant-impacted environment that is extensively fished both professionally and recreationally. Consumption of contaminated fish represents a potential threat to human health, and fish exposed to environmental contaminants may themselves be affected in a similar fashion. This study describes a fish health index based on histological alterations identified in multiple organs of the sand flathead Platycephalus bassensis. Alterations were evident in tissues from all individuals assessed, with common pathologies observed in the gills, skin, kidney, liver and spleen. Alterations commonly present included necrosis, melanomacrophage centres, inflammation and multiple alterations of the gill epithelium (e.g. hyperplasia and hypertrophy). Fish health, calculated using severity of histological alterations, differed significantly across Port Phillip Bay, with heavily industrialized regions of Altona and St. Helens showing greatest alteration prevalence across multiple organs. This study indicates that the health of P.bassensis from Altona, St. Helens, and Mornington to a lesser extent, are currently compromised, potentially due to complex pollutant exposures which require further investigation

Relevância:

20.00% 20.00%

Publicador:

Resumo:

The central problem of automatic retrieval from unformatted text is that computational devices are not adequately trained to look for associated information. However for complete understanding and information retrieval, a complete artificial intelligence would have to be built. This paper describes a method for achieving significant information retrieval by using a semantic search engine. The underlying semantic information is stored in a network of clarified words, linked by logical connections. We employ simple scoring techniques on collections of paths in this network to establish a degree of relevance between a document and a clarified search criterion. This technique has been applied with success to test examples and can be easily scaled up to search large documents.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Epoetin-δ (Dynepo™ Shire Pharmaceuticals, Basing stoke, UK) is a synthetic form of erythropoietin (EPO) whose resemblance with endogenous EPO makes it hard to identify using the classical identification criteria. Urine samples collected from six healthy volunteers treated with epoetin-δ injections and from a control population were immuno-purified and analyzed with the usual IEF method. On the basis of the EPO profiles integration, a linear multivariate model was computed for discriminant analysis. For each sample, a pattern classification algorithm returned a bands distribution and intensity score (bands intensity score) saying how representative this sample is of one of the two classes, positive or negative. Effort profiles were also integrated in the model. The method yielded a good sensitivity versus specificity relation and was used to determine the detection window of the molecule following multiple injections. The bands intensity score, which can be generalized to epoetin-α and epoetin-β, is proposed as an alternative criterion and a supplementary evidence for the identification of EPO abuse.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

In general, rock masses are inhomogeneous, discontinuous media composed of rock material and naturally occurring discontinuities such as joints, fractures and bedding planes. Because of these features, the strength of rock masses is notoriously difficult to assess. Nonetheless, many criteria have been proposed for estimating rock mass strength. Based on the finite element upper and lower bound limit analysis methods, this study examined two empirical yield criteria for rock masses, the Hoek-Brown failure criterion (2002) and the Douglas criterion (2002). The comparisons showed that very different results may be obtained using the same input parameters. Therefore, it is interesting to discuss the source of these differences.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Background: Both male and female pigeons have the ability to produce a nutrient solution in their crop for the nourishment of their young. The production of the nutrient solution has been likened to lactation in mammals, and hence the product has been called pigeon ‘milk’. It has been shown that pigeon ‘milk’ is essential for growth and development of the pigeon squab, and without it they fail to thrive. Studies have investigated the nutritional value of pigeon ‘milk’ but very little else is known about what it is or how it is produced. This study aimed to gain insight into the process by studying gene expression in the ‘lactating’ crop.
Results: Macroscopic comparison of ‘lactating’ and non-’lactating’ crop reveals that the ‘lactating’ crop is enlarged and thickened with two very obvious lateral lobes that contain discrete rice-shaped pellets of pigeon ‘milk’. This was characterised histologically by an increase in the number and depth of rete pegs extending from the basal layer of the epithelium to the lamina propria, and extensive proliferation and folding of the germinal layer into the superficial epithelium. A global gene expression profile comparison between ‘lactating’ crop and non-’lactating’ crop showed that 542 genes are up-regulated in the ‘lactating’ crop, and 639 genes are down-regulated. Pathway analysis revealed that genes up-regulated in ‘lactating’ crop were involved in the proliferation of melanocytes, extracellular matrix-receptor interaction, the adherens junction and the wingless (wnt) signalling pathway. Gene ontology analysis showed that antioxidant response and microtubule transport were enriched in ‘lactating’ crop.
Conclusions: There is a hyperplastic response in the pigeon crop epithelium during ‘lactation’ that leads to localised cellular stress and expression of antioxidant protein-encoding genes. The differentiated, cornified cells that form the pigeon ‘milk’ are of keratinocyte lineage and contain triglycerides that are likely endocytosed as very low density lipoprotein (VLDL) and repackaged as triglyceride in vesicles that are transported intracellularly by microtubules. This mechanism is an interesting example of the evolution of a system with analogies to mammalian lactation, as pigeon ‘milk’ fulfils a similar function to mammalian milk, but is produced by a different mechanism.