Synergistic effects within a C2-symmetric organocatalyst : the potential formation of a chiral catalytic pocket

This study describes the synthesis of five novel C2-symmetric organocatalysts that facilitate the on-water asymmetric aldol reaction at low catalyst loading (1 mol%) without the use of additives. Each catalyst is composed of two diprolinamide units joined by a symmetric alkyl bridging group allowing for systematic modulation of catalytic site proximity. Typically, catalysts in this manuscript which bear the catalytic units in close proximity gave the best reaction outcomes in terms of conversion (up to >99%), diastereomeric ratio (4/96, syn/anti) and enantiomeric excess (up to 97%). This effect has been attributed to the assembly of a chiral pocket, facilitated by hydrogen bonding at the oil-in-water interface.

Formation of cortical plasticity in older adults following tDCS and motor training

Neurodegeneration accompanies the process of natural aging, reducing the ability to perform functional daily activities. Transcranial direct current stimulation (tDCS) alters neuronal excitability and motor performance; however its beneficial effect on the induction of primary motor cortex (M1) plasticity in older adults is unclear. Moreover, little is known as to whether the tDCS electrode arrangement differentially affects M1 plasticity and motor performance in this population. In a double-blinded, cross-over trial, we compared unilateral, bilateral and sham tDCS combined with visuomotor tracking, on M1 plasticity and motor performance of the non-dominant upper limb, immediately post and 30 min following stimulation. We found (a) unilateral and bilateral tDCS decreased tracking error by 12–22% at both time points; with sham decreasing tracking error by 10% at 30 min only, (b) at both time points, motor evoked potentials (MEPs) were facilitated (38–54%) and short-interval intracortical inhibition was released (21–36%) for unilateral and bilateral conditions relative to sham, (c) there were no differences between unilateral and bilateral conditions for any measure. These findings suggest that tDCS modulated elements of M1 plasticity, which improved motor performance irrespective of the electrode arrangement. The results provide preliminary evidence indicating that tDCS is a safe non-invasive tool to preserve or improve neurological function and motor control in older adults.

Dancing habitus: the formation of a group (dance)

This article discusses how six individual dancers came to belong, stylistically, to a group, in a project that did not aim explicitly to create or bring about that belonging. The studio-based research project tested the creation of a group improvised dance through practising over a significant period of time with ‘scores’ or verbal propositions, usually relating to physical, bodily or movement notions such as tangling and untangling or being subject to gravity. This article looks at one question within the research: namely, whether the dancing individuals came, over time, to belong to a group, and if so, what enabled that belonging and what made the dance a group dance? The project did not centre on an objective to direct the creation of a ‘groupness’ or stylistic consistency but, rather, it supported the investigation of how this ‘groupness’ might come about.

Molecular gels for controlled formation of micro-/nano-structures

The preparation of nano structured materials such as nanoparticles, nanofiber and nanowires have been a focus of research in the last two decades. Due to their large surface-to-volume ration and superior properties compared to the conventional macroscopic materials, these materials promise to revolutionize many fields such as electronics, catalysis, and biomedicine. Hence, controlling the growth of these nanostructures has been a global interest. Although controlling the formation of macroscopically sized inorganic materials can be easily achieved, it is a challenge if the size of a material is reduced to a micrometer or nanometer scale. Synthesis of structures using organic templates has been demonstrated to be a simple and convenient approach, since the organic matter can be easily removed by calcination or suitable solvents. These organic templates include colloidal particles and fibers of polymers, aggregates of surfactants, carbon materials such as carbon nanotubes, organic crystals and fibers in small-molecule gels (SMGs) and polymer gels.

Converting Mrs Crouch: women, wonders and the formation of English methodism, 1738-1741

This article examines the development of English Methodism during the formative period between 1738 and 1741, focusing upon the experiences of women, who made up the majority of Methodists both at this time and through much of the movement’s history. In particular, the role that women and questions of gender played in the conflict between the Wesley brothers and the Moravian leadership in London is considered. Using accounts written by the male leaders of both groups and the women who supported them, it is argued that women’s choices determined the outcome of this early battle, shaping the nascent movement in crucial ways.