Rethinking the spatiality of literacy practices in multicultural conditions

Moving beyond the limitations of the ‘space-as-container’ ontology (Gotham, 2003), this paper offers Bakhtinian (dialogical) perspective on the use of cultural-semiotic spaces, in particular with regard to the production of new transcultural meanings and hybrid literacy practices as a result of interaction between differences. From this perspective cultural-semiotic space is not a neutral backdrop against which literacy practices unfold, but rather it is in the constant process of change due to the struggle between centrifugal and centripetal forces that operate on the level of spatial and textual politics – that is, between the processes of cultural and textual uniformization and local fragmentation. Given the dialogical nature of space and its relations to cultural identities of migrant and minority students and their literacy practices, the paper argues for rethinking literacy studies in multicultural conditions. This task becomes more urgent in the current educational era of standards, accountability and classroom pedagogies that are not attuned to the particularities of students’ intertextual practices and emergent transcultural places in which they live.

Cycles of genocide, stories of denial : Atom Egoyan's Ararat

This article focuses on Atom Egoyan's Ararat and explores how, through a convoluted narrative structure, Egoyan grapples with denial of the Armenian Genocide and the consequences of those denials for present generations—both Turkish and Armenian—illuminated in the film as an extension of the genocide. Egoyan uses a film-within-a-film to move beyond a popular definition of genocide as mass killing alone and links the understanding of stories, truths, and perspectives in everyday life to the dehumanizing acts of genocide. Employing the philosopher Emmanuel Levinas’ ethical theory of the Other (the ethical) and philosophical understandings of ontology (dehumanization) to illuminate the genocide and its ongoing denial, this article contends that Egoyan's focus on the generations of genocide survivors points to the ethical responsibility to one another that underlies everyday lives and sits at the heart of what is absent in the acts of genocide.

Crisis of meanings : divergent experiences and perceptions of the marine environment in Victoria, Australia

The oceans of the world are regularly depicted as under threat from human exploitation with the problem portrayed as being of 'global' concern. In a world market characterised by the division of labour, many of those who eat fish do so without directly experiencing the ocean as a domain of productive utility. Rather, their encounters are with representations that depict the 'natural' world as an aesthetic object of contemplation, and environmentalist discourses that identify human activities as' threatening marine ecosystems. So prevalent is this experience that tangible institutions, such as state fisheries management bodies, have emerged, acting to reinforce the ontology of this 'contemplated' ocean, giving weight to the illusion that humans can, and should, appreciate it only from afar. In this representation, commercial fishers are regularly depicted as transgressing a 'natural' boundary between humans and the environment. It is when the world is simultaneously encountered as an object of consumptive utility and aesthetic utility that the human role in the environment becomes ambiguous and a sense of crisis arises. This paper investigates disjunctions in experiences and understandings that contribute to environmental anxiety, and debates over the appropriate use of the ocean.

The profit imperative

This wide-ranging work convincingly argues that a minority can only radically transform a pattern of production and consumption through the commercial sphere of a liberal democracy. In constructing the argument, creative use is made of important works in ontology, social philosophy, political philosophy, sociology, micro-economics and ethics.

The nature of change

This thesis presents a conceptual framework that describes the diversity of real things found in nature: individual, categorical and universal things. The multi-faceted approach to causality represents a paradigm shift; enabling, for the first time, the integration of random, ordered and stochastic events in a single schematic.

Study of 'post-critical' thought and religious epistemology : with special reference to Michael Polanyi, Paul Tillich and Thomas F. Torrance

Explores the foundational problem in epistemology posed by Immanuel Kant and illustrates, from the 'post-critical' position, with special reference to Michael Polanyi, Paul Tillich and Thomas F. Torrance, how they serve as alternative philosophical and religious responses to the Kantian critical philosophy.

Subjects and expressive worlds in the work of Merleau-Ponty

Examines Merleau-Ponty's claim that the relationship between subjects, world and others is one of interdependence. Questions traditional accounts of subjectivity based on dichotomous schemas and expands into the expressive domains of art, language and sexuality. Gives some forward-looking reflections as regards ethics arising out of Merleau-Ponty's new ontology.

Reflective positioning : the impact of conversations in the social and cultural environment of midwifery practice settings on professional learning for students

Literature reviews on the topic of reflection and reflective practice encompassed midwifery, nursing, medicine, allied health, education and professional education. This investigation also included socio-psychological theories by leading authors such as Benner (nursing), Schön (professional education) and positioning theory by Harré and others. Positioning is a psycho-sociological ontology in which individuals metaphorically position themselves within three entities: people, institutions, and societies, where conversations are constructed and make an impact upon the social world. The social and cultural structures and interactions developed in Archer’s morphogenesis were examined in terms of the impact of possible encounters and the transformational effects of learning experiences in practice settings. These bodies of work provided the theoretical framework for the author’s research of students’ experiences in midwifery education for postgraduate students from which selected excerpts with three participating students and their supervising midwives are presented. These excerpts are related to reflective practices and the professional conversations conducted between students and midwives. It was found that reflective positioning applied in midwifery education by students can serve as an analytical tool in explaining social and cultural elements of clinical placements to influence and transform their learning. The potency of conversations that occur in everyday moment-to-moment interactions do contribute to students’ induction in professional midwifery practice and their identity formation as a midwife.

Identifying co-regulating microrna groups

Background: Current miRNA target prediction tools have the common problem that their false positive rate is high. This renders identification of co-regulating groups of miRNAs and target genes unreliable. In this study, we describe a procedure to identify highly probable co-regulating miRNAs and the corresponding co-regulated gene groups. Our procedure involves a sequence of statistical tests: (1) identify genes that are highly probable miRNA targets; (2) determine for each such gene, the minimum number of miRNAs that co-regulate it with high probability; (3) find, for each such gene, the combination of the determined minimum size of miRNAs that co-regulate it with the lowest p-value; and (4) discover for each such combination of miRNAs, the group of genes that are co-regulated by these miRNAs with the lowest p-value computed based on GO term annotations of the genes.
Results: Our method identifies 4, 3 and 2-term miRNA groups that co-regulate gene groups of size at least 3 in human. Our result suggests some interesting hypothesis on the functional role of several miRNAs through a "guilt by association" reasoning. For example, miR-130, miR-19 and miR-101 are known neurodegenerative diseases associated miRNAs. Our 3-term miRNA table shows that miR-130/19/101 form a co-regulating group of rank 22 (p-value =1.16 × 10^-2). Since miR-144 is co-regulating with miR-130, miR-19 and miR-101 of rank 4 (p-value = 1.16 × 10^-2) in our 4-term miRNA table, this suggests hsa-miR-144 may be neurodegenerative diseases related miRNA. Conclusions: This work identifies highly probable co-regulating miRNAs, which are refined from the prediction by computational tools using (1) signal-to-noise ratio to get high accurate regulating miRNAs for every gene, and (2) Gene Ontology to obtain functional related co-regulating miRNA groups. Our result has partly been supported by biological experiments. Based on prediction by TargetScanS, we found highly probable target gene groups in the Supplementary Information. This result might help biologists to find small set of miRNAs for genes of interest rather than huge amount of miRNA set.

Inaccurate autobiography – the ‘true-invention’ of a life

This paper takes the Aristotelian binary of praxis and poiesis and approaches the process of autobiography via its double lens. Drawing on a reading of Hannah Arendt done by Julia Kristeva, it considers the question of whether the activity (that is: praxis) of making-narrative might constitute an activity that is particularly ‘human’. It is framed by the playful and serious challenge offered by Derridean deconstruction to think two things at once, and to practice an inhabiting of binary ultimatums. Given this, it goes on to suggest that making in an autobiographical fashion, rather than involvinganythingprimarily representative or documentary, is more paradoxically akin to the invention of what is most true about that which we are in the habit of calling ‘our life’. Indeed, it can be argued that this praxisinvents that very ‘life’ – the latter being an entity or categorythat logically does not precede thesame writing that purports to describe it, but rather arises with its activity. This self-reflexivity (a manoeuvre that at once describes and invokes the very thing described) coincides with Derrida’s explication of invention’s mechanism.

Semantic trajectory based event detection and event pattern mining

Video event detection is an effective way to automatically understand the semantic content of the video. However, due to the mismatch between low-level visual features and high-level semantics, the research of video event detection encounters a number of challenges, such as how to extract the suitable information from video, how to represent the event, how to build up reasoning mechanism to infer the event according to video information. In this paper, we propose a novel event detection method. The method detects the video event based on the semantic trajectory, which is a high-level semantic description of the moving object’s trajectory in the video. The proposed method consists of three phases to transform low-level visual features to middle-level raw trajectory information and then to high-level semantic trajectory information. Event reasoning is then carried out with the assistance of semantic trajectory information and background knowledge. Additionally, to release the users’ burden in manual event definition, a method is further proposed to automatically discover the event-related semantic trajectory pattern from the sample semantic trajectories. Furthermore, in order to effectively use the discovered semantic trajectory patterns, the associative classification-based event detection framework is adopted to discover the possibly occurred event. Empirical studies show our methods can effectively and efficiently detect video events.

Histological and global gene expression analysis of the ‘lactating’ pigeon crop

Background: Both male and female pigeons have the ability to produce a nutrient solution in their crop for the nourishment of their young. The production of the nutrient solution has been likened to lactation in mammals, and hence the product has been called pigeon ‘milk’. It has been shown that pigeon ‘milk’ is essential for growth and development of the pigeon squab, and without it they fail to thrive. Studies have investigated the nutritional value of pigeon ‘milk’ but very little else is known about what it is or how it is produced. This study aimed to gain insight into the process by studying gene expression in the ‘lactating’ crop.
Results: Macroscopic comparison of ‘lactating’ and non-’lactating’ crop reveals that the ‘lactating’ crop is enlarged and thickened with two very obvious lateral lobes that contain discrete rice-shaped pellets of pigeon ‘milk’. This was characterised histologically by an increase in the number and depth of rete pegs extending from the basal layer of the epithelium to the lamina propria, and extensive proliferation and folding of the germinal layer into the superficial epithelium. A global gene expression profile comparison between ‘lactating’ crop and non-’lactating’ crop showed that 542 genes are up-regulated in the ‘lactating’ crop, and 639 genes are down-regulated. Pathway analysis revealed that genes up-regulated in ‘lactating’ crop were involved in the proliferation of melanocytes, extracellular matrix-receptor interaction, the adherens junction and the wingless (wnt) signalling pathway. Gene ontology analysis showed that antioxidant response and microtubule transport were enriched in ‘lactating’ crop.
Conclusions: There is a hyperplastic response in the pigeon crop epithelium during ‘lactation’ that leads to localised cellular stress and expression of antioxidant protein-encoding genes. The differentiated, cornified cells that form the pigeon ‘milk’ are of keratinocyte lineage and contain triglycerides that are likely endocytosed as very low density lipoprotein (VLDL) and repackaged as triglyceride in vesicles that are transported intracellularly by microtubules. This mechanism is an interesting example of the evolution of a system with analogies to mammalian lactation, as pigeon ‘milk’ fulfils a similar function to mammalian milk, but is produced by a different mechanism.

Transcriptional insights on the regenerative mechanics of axotomized neurons in vitro

Axotomized neurons have the innate ability to undergo regenerative sprouting but this is often impeded by the inhibitory central nervous system environment. To gain mechanistic insights into the key molecular determinates that specifically underlie neuronal regeneration at a transcriptomic level, we have undertaken a DNA microarray study on mature cortical neuronal clusters maintained in vitro at 8, 15, 24 and 48 hrs following complete axonal severance. A total of 305 genes, each with a minimum fold change of ±1.5 for at least one out of the four time points and which achieved statistical significance (one-way ANOVA, P < 0.05), were identified by DAVID and classified into 14 different functional clusters according to Gene Ontology. From our data, we conclude that post-injury regenerative sprouting is an intricate process that requires two distinct pathways. Firstly, it involves restructuring of the neurite cytoskeleton, determined by compound actin and microtubule dynamics, protein trafficking and concomitant modulation of both guidance cues and neurotrophic factors. Secondly, it elicits a cell survival response whereby genes are regulated to protect against oxidative stress, inflammation and cellular ion imbalance. Our data reveal that neurons have the capability to fight insults by elevating biological antioxidants, regulating secondary messengers, suppressing apoptotic genes, controlling ion-associated processes and by expressing cell cycle proteins that, in the context of neuronal injury, could potentially have functions outside their normal role in cell division. Overall, vigilant control of cell survival responses against pernicious secondary processes is vital to avoid cell death and ensure successful neurite regeneration.