Examination of the role of intestinal Fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay

Transcellular diffusion across the absorptive epithelial cells (enterocytes) of the small intestine is the main route of absorption for most orally administered drugs. The process by which lipophilic compounds transverse the aqueous environment of the cytoplasm, however, remains poorly defined. In the present study, we have identified a structurally diverse group of lipophilic drugs that display low micromolar binding affinities for a cytosolic lipid-binding protein—intestinal fatty acid-binding protein (I-FABP). Binding to I-FABP significantly enhanced the transport of lipophilic drug molecules across a model membrane, and the degree of transport enhancement was related to both drug lipophilicity and I-FABP binding affinity. These data suggest that intracellular lipid-binding proteins such as I-FABP may enhance the membrane transport of lipophilic xenobiotics and facilitate drug access to the enterocyte cytoplasm and cytoplasmic organelles.

Management of SPMD based parallel processing on clusters of workstations

Current attempts to manage parallel applications on Clusters of Workstations (COWs) have either generally followed the parallel execution environment approach or been extensions to existing network operating systems, both of which do not provide complete or satisfactory solutions. The efficient and transparent management of parallelism within the COW environment requires enhanced methods of process instantiation, mapping of parallel process to workstations, maintenance of process relationships, process communication facilities, and process coordination mechanisms. The aim of this research is to synthesise, design, develop and experimentally study a system capable of efficiently and transparently managing SPMD parallelism on a COW. This system should both improve the performance of SPMD based parallel programs and relieve the programmer from the involvement into parallelism management in order to allow them to concentrate on application programming. It is also the aim of this research to show that such a system, to achieve these objectives, is best achieved by adding new special services and exploiting the existing services of a client/server and microkernel based distributed operating system. To achieve these goals the research methods of the experimental computer science should be employed. In order to specify the scope of this project, this work investigated the issues related to parallel processing on COWs and surveyed a number of relevant systems including PVM, NOW and MOSIX. It was shown that although the MOSIX system provide a number of good services related to parallelism management, none of the system forms a complete solution. The problems identified with these systems include: instantiation services that are not suited to parallel processing; duplication of services between the parallelism management environment and the operating system; and poor levels of transparency. A high performance and transparent system capable of managing the execution of SPMD parallel applications was synthesised and the specific services of process instantiation, process mapping and process interaction detailed. The process instantiation service designed here provides the capability to instantiate parallel processes using either creation or duplication methods and also supports multiple and group based instantiation which is specifically design for SPMD parallel processing. The process mapping service provides the combination of process allocation and dynamic load balancing to ensure the load of a COW remains balanced not only at the time a parallel program is initialised but also during the execution of the program. The process interaction service guarantees to maintain transparently process relationships, communications and coordination services between parallel processes regardless of their location within the COW. The combination of these services provides an original architecture and organisation of a system that is capable of fully managing the execution of SPMD parallel applications on a COW. A logical design of a parallelism management system was developed derived from the synthesised system and was shown that it should ideally be based on a distributed operating system employing the client server model. The client/server based distributed operating system provides the level of transparency, modularity and flexibility necessary for a complete parallelism management system. The services identified in the synthesised system have been mapped to a set of server processes including: Process Instantiation Server providing advanced multiple and group based process creation and duplication; Process Mapping Server combining load collection, process allocation and dynamic load balancing services; and Process Interaction Server providing transparent interprocess communication and coordination. A Process Migration Server was also identified as vital to support both the instantiation and mapping servers. The RHODOS client/server and microkernel based distributed operating system was selected to carry out research into the detailed design and to be used for the implementation this parallelism management system. RHODOS was enhanced to provide the required servers and resulted in the development of the REX Manager, Global Scheduler and Process Migration Manager to provide the services of process instantiation, mapping and migration, respectively. The process interaction services were already provided within RHODOS and only required some extensions to the existing Process Manager and IPC Managers. Through a variety of experiments it was shown that when this system was used to support the execution of SPMD parallel applications the overall execution times were improved, especially when multiple and group based instantiation services are employed. The RHODOS PMS was also shown to greatly reduce the programming burden experienced by users when writing SPMD parallel applications by providing a small set of powerful primitives specially designed to support parallel processing. The system was also shown to be applicable and has been used in a variety of other research areas such as Distributed Shared Memory, Parallelising Compilers and assisting the port of PVM to the RHODOS system. The RHODOS Parallelism Management System (PMS) provides a unique and creative solution to the problem of transparently and efficiently controlling the execution of SPMD parallel applications on COWs. Combining advanced services such as multiple and group based process creation and duplication; combined process allocation and dynamic load balancing; and complete COW wide transparency produces a totally new system that addresses many of the problems not addressed in other systems.

Performance execution of multiple NAS parallel programs on a cluster

Currently, coordinated scheduling of multiple parallel applications across computers has been considered as the critical factor to achieve high execution performance. We claim in this report that the performance and costs of the execution of parallel applications could be improved if not only dedicated clusters but also non-dedicated clusters were used and several parallel applications were executed concurreontly. To support this claim we carried out experimental study into the performance of multiple NAS parallel programs executing concurrently on a non-dedicated cluster.

Scheduling of a parallel computation-bound application and sequential applications executing concurrently on a cluster - a case study.

Studies have shown that most of the computers in a non-dedicated cluster are often idle or lightly loaded. The underutilized computers in a non-dedicated cluster can be employed to execute parallel applications. The aim of this study is to learn how concurrent execution of a computation-bound and sequential applications influence their execution performance and cluster utilization. The result of the study has demonstrated that a computation-bound parallel application benefits from load balancing, and at the same time sequential applications suffer only an insignificant slowdown of execution. Overall, the utilization of a non-dedicated cluster is improved.

Automated parallel application creation and execution tool for clusters

This research investigated an automated approach to re-writing traditional sequential computer programs into parallel programs for networked computers. A tool was designed and developed for generating parallel programs automatically and also executing these parallel programs on a network of computers. Performance is maximized by utilising all idle resources.

Linear-motor based five-axis parallel machine for effective material processing

The aim of the work was to reduce the cost and improve the performance of five-axis machines. The main performance criteria were motion cycle-time and positioning accuracy/precision. A novel machine that utilizes the concept of parallel-kinematics and linear motor technology is proposed, designed, built and controlled for this sake.

Parallel readings

The story of the nineteenth-century Western encounter with Buddhism demonstrates more about these first Western interpreters and their socio-historical context then about Buddhism. In parallel, this thesis also demonstrates, from the perspective of Buddhism, how the mind works to bring an object, like Buddhism, into consciousness.

Investigations into the parallel synthesis of novel pyrrole-oxazole analogues of the insecticide pirate

Investigations into the parallel synthesis of selected analogues of a structurally unique pyrrole-oxazole analogue of the pyrrole insecticide pirate, are reported. Acylaminoketone salts were obtained from ketobromides in moderate to high yields and excellent purity. A number of N-tosyl pyrroles were obtained; however, formation of the target acyl tosyl pyrroles was thwarted by the stereoelectronic effects of the pyrrole substituents. During the pyrrole subunit chemistry, an interesting pyrrole derivative, vinyl pyrrole, was isolated. By restricting diversity to the aryl subunit, the parallel synthesis of selected pyrrole-oxazoles in moderate purity, was achieved when electron-donating or no groups were present on the aryl ring.

An parallel information retrieval method for e-commerce

An online transaction always retrieves a large amount of information before making decisions. Currently, the parallel methods for retrieving such information can only provide a similar performance to serial methods. In this paper we first perform an analysis to determine the factors that affect the performance of exiting methods, i.e., HQR and EHQR, and show that the several of these factors are not considered by these methods. Motivated by this, we propose a new dispatch scheme called AEHQR, which takes into account the features of parallel dispatching. In addition, we provide cost models that determine the optimal performance achievable by any parallel dispatching method. Using experimental comparison, we illustrate that the AEHQR is significantly outperforms the HQR and EHQR under all conditions.

Parallel computing on clusters and enterprise grids : practice and experience

We assert that companies can make more money and research institutions can improve their performance if inexpensive clusters and enterprise grids are exploited. In this paper, we have demonstrated that our claim is valid by showing the study of how programming environments, tools and middleware could be used for the execution of parallel and sequential applications, multiple parallel applications executing simultaneously on a non-dedicated cluster, and parallel applications on an enterprise grid and that the execution performance was improved. For this purpose an execution environment, and parallel and sequential benchmark applications selected for, and used in, the experiments were characterised.

Spamcooling : a parallel heterogeneous ensemble spam filtering system based on active learning techniques

Anti-spam technology is developing rapidly in recent years. With the emerging applications of machine learning in diverse fields, researchers as well as manufacturers around the world have attempted a large number of related algorithms to prevent spam. In this paper, we designed an effective anti-spam protection system, SpamCooling, based on the mechanism of active learning and parallel heterogeneous ensemble learning techniques. The system adopts a batch method to filter spam and can be easily incorporated with existing mail clients (MUA). It can actively obtain user feedbacks for providing users with personalized spam filtering experiences. The parallel heterogeneous ensemble method can help system achieve high spam detection rate as well as low ham misclassification rate.

Parallel TAFE and higher education studies in construction management : from collaboration to dual qualifications.

Collaboration between TAFE (vocational colleges) and universities in Australia in construction management has been problematic, with exchanges between the two sectors limited to linear articulation and prescribed credit transfer. Articulation pathways have traditionally been viewed as the poor relation of university entry. In 2005, the first pilot project in dual sector construction education was conducted at RMIT University in Melbourne. Higher education students completed electives in practical units within the TAFE sector. Due to the overwhelming success of the project, practical electives were firmly embedded in the construction management programme in 2007 and this paper reports on the third, final phase of the project in 2009 which has seen construction management students graduate with a dual qualification – both a TAFE qualification and a Higher Education degree. The case studies of this final phase reveal that students and industry want the benefits of a practical qualification. The data raises critical questions about education pathways and suggests long-term implications for construction and dual sector education in Australia.