Aptamer-based therapeutics of the past, present and future: from the perspective of eye-related diseases

 Aptamers have emerged as a novel and powerful class of biomolecules with an immense untapped potential. The ability to synthesise highly specific aptamers against any molecular target make them a vital cog in the design of effective therapeutics for the future. However, only a minutia of the enormous potential of this dynamic class of molecule has been exploited. Several aptamers have been studied for the treatment of eye-related disorders, and one such strategy has been successful in therapy. This review gives an account of several eye diseases and their regulatory biomolecules where other nucleic acid therapeutics have been attempted with limited success and how aptamers, with their exceptional flexibility to chemical modifications, can overcome those inherent shortcomings.

Thinking with the body: Mind and movement in the work of Wayne McGregor | Random Dance

Thinking with the Body was an exhibition at London's Wellcome Collection, offering a glimpse into Wayne McGregor | Random Dance's interdisciplinary research and the impact it has in the rehearsal studio. Staged in the run-up to the first performances of Atomos at Sadler's Wells (Oct 2013), the exhibition featured the results of over a decade of interdisciplinary research into choreographic creativity which has been applied in the studio, in dance education, and to increase public understanding.

Wellcome Collection is a free visitor destination exploring the connections between medicine, life and art in the past, present and future. Wellcome Collection is part of the Wellcome Trust, a global charitable foundation dedicated to achieving improvements in human and animal health.

The exhibition finished on 27 October 2013, but the film exhibits are still available to view online.

The De-Baathification of post-2003 Iraq: purging the past for political power

In addressing the broader de-Baathification question at the intersection between politics and law in post-2003 Iraq this chapter outlines the efforts by Iraqi lawmakers to codify de-Baathification in Iraq’s new constitution of 2005 as well as in subsequent pieces of more detailed legislation. The chapter then goes on to study the actual implementation of these laws in relation to the Iraqi parliamentary elections of 2010 and 2014, as well as the local elections of 2013. Throughout the chapter, special emphasis is given to the considerable discrepancies between the principles enshrined in the formal de-Baathification legislation and the way those principles are applied in practice. Finally, this chapter concludes by suggesting that Iraq needs to openly and honestly deal with its Baathist past if it is ever to move beyond patterns of politicalsectarianism, violence and autocracy.

Indigenous knowledge and climate change: settlement patterns of the past to adaption of the future

For centuries the Aboriginal Peoples of Australia have been confronted with major ecological, geological and climate events, and had to adapt home shelters and settlements to seasonal variations. Many of these changes have been captured in the cultural traditions of the indigenous people reflecting a harsh coastal environment. Weather patterns and climate change were gauged by the occurrence of the tidal changes, landscape changes, recurring weather events and the acknowledgement of six seasons. Community settlements got established and relocated to adapt to the patterns of nature. This paper investigates if this ancient knowledge can provide answers for adaptation of coastal settlements to a changing climate. Drawing upon recent published literature on predicted coastal climate change impacts in the different regions of Australia, and the review of indigenous settlement planning according to a six season cycle, the author explores traditional knowledge as input to a potential Design Based Adaptation Model for coastal settlements along the Australian coast.

The future of the past: digital media in Holocaust museums

This essay critically examines the implications of digital media for the remembrance of the Holocaust in contemporary museum spaces, a development that has seen fundamental shifts in thinking around agency, education and entertainment. Expanding existing discussions of this issue into the Australian context, the essay takes as its central case study the design and integration of interactive StoryPod screen media in Melbourne’s Jewish Holocaust Centre. Addressing both the limitations and potentialities of interactive digital technologies for facilitating visitor-viewers’ engagement with survivor stories, the analysis highlights that digital media can be used to complement and enhance – rather than replace – traditional artefact and photographic displays, and will play an integral role in the Holocaust museums of the future.

Climate-related spatial and temporal variation in bill morphology over the past century in Australian parrots

Aim: Allen's rule posits that the appendages of endothermic organisms will be larger in warmer climates to allow for dumping of heat loads. Given a link between appendage size and climate, we tested the prediction that climate change has driven the evolution of larger bills in birds, resulting in measurable changes over the recent past. Location: Australia. Methods: We explored geographical and temporal variation in bill surface area of five Australian parrot species to determine whether individuals from warmer climates have larger bills, and whether there have been increases in bill surface area over time, consistent with climatic warming. Measurements were obtained from museum specimens dating from 1871 to 2008. These data were then related to geographical location, collection date and locality-specific climate data, in order to construct and compare models of spatio-temporal and climate-related variation in bill morphology. Results: There have been increases in bill surface area in mulga parrots (Psephotus varius), gang-gang cockatoos (Callocephalon fimbriatum), red-rumped parrots (Psephotus haematonotus) and male crimson rosellas (Platycercus elegans), equating to a c. 4-10% increase in bill surface area since 1871. Average maximum summer temperature in the 5 years prior to specimen collection also positively predicted bill surface area in mulga parrots, red-rumped parrots and crimson rosellas, consistent with Allen's rule. With the exception of red-rumped parrots, however, models with geographical location and year of collection were still better predictors of bill surface area than local climate at the date of collection. Main conclusions: Our analysis provides evidence that four species of parrot have exhibited adaptive change in bills over the past century potentially mitigating the thermal stress caused by climatic warming. Although consistent with the predicted effects of climate change, the temporal patterns we observe may have additional causes, however, such as changes in primary productivity, habitat or food availability.

Echoes of the past: the influence of spiritualism on contemporary belief

At once controversial and intriguing, Spiritualism has spread from the United States to become a global movement. Bringing together perspectives from within the movement and without, this unique collection treats readers to insights about Spiritualism's history, belief, and practice.Based on the belief that the dead can communicate with the living through mediums, Spiritualism touches concepts as timelessly fascinating as human mortality and the continuing existence of the soul beyond bodily death. This comprehensive work will help readers parse the mysteries of this uniquely American religion through three thematically organized volumes: Spiritualism in the U.S. and Globally, Evidence and Beliefs, and Cultural and Social Issues. Drawing on fields as diverse as psychology, sociology, religious studies, anthropology, history, ethnic and gender studies, literature, and art, this broad-based collection frames Spiritualism through the views of a team of international scholars.Among the many things that separate Spiritualism from mainstream religions is the involvement of women in central leadership roles. Such cultural and political elements of the movement are one aspect of this study. Of equal interest to believers and skeptics alike will be the work of scholars who have devoted themselves to examining the claim that communication through mediums proves the existence of life after death.

Tradition : connecting the past and present : a case study of Xintiandi in Shanghai

Tradition and modernisation are often seen as a binary opposition. In an urban environment, traditional built form seems incompatible to modern way of life, and the adaptation of traditional neighbourhoods to modern use often causes controversy. Nowadays, ideas about ‘what is tradition’ become shifting, and traditional townscape does not necessarily mean an obstacle to modernisation. This paper reveals how the role of traditional elements is played in China’s urban development. The case study of Xintiandi, Shanghai, where traditional townscape is restored, highlights the connection of the city’s past and present. Xintiandi is a successful yet controversial city renewal project, where Shanghai’s traditional housing form Shikumen is restored and put into adaptive uses. In the course of urban modernisation, the role of tradition as a representation of the connection between the city’s past and present deserves more study. This paper aims to add a perspective to the literature on the study of tradition. It argues for the diversity and fluidity of the ideas about tradition., In this view, tradition is not necessarily in dichotomy with, or opposite to modernisation; rather, tradition justifies the needs of modernisation and supplements its outcomes. The paper is developed in light of works on tradition by Shils, Hobsbawm, Giddens and others; The case study of Xintiandi shows what Old Shanghai tradition means to this city today, and how traditional elements are adapted and used in the course of urban modernisation.

The past and future of fish consumption: can supplies meet healthy eating recommendations?

In many developed countries fish and shellfish are increasingly promoted as healthy alternatives to other animal protein. We analysed how much fish was available to UK and global populations after accounting for processing losses, and compared this to recommended levels of fish consumption. In 2012, UK domestic fish landings per capita fell 81% below the recommended intake, although declines were masked by increased imports and aquaculture from the 1970s onwards. Global wild fish supply per capita declined by 32% from its peak in 1970. However, overall fish supplies per capita increased by 10% over the same period due to rapidly expanding aquaculture production. Whilst aquaculture has so far prevented a downturn in global fish supplies, many developed nations continue to aspire to consume more fish than they produce. Until demand is balanced with sustainable methods of production governments should consider carefully the social and environmental implications of greater fish consumption.