Life and death : metabolic rate, membrane composition, and life span of animals

Maximum life span differences among animal species exceed life span variation achieved by experimental manipulation by orders of magnitude. The differences in the characteristic maximum life span of species was initially proposed to be due to variation in mass-specific rate of metabolism. This is called the rate-of-living theory of aging and lies at the base of the oxidative-stress theory of aging, currently the most generally accepted explanation of aging. However, the rate-of-living theory of aging while helpful is not completely adequate in explaining the maximum life span. Recently, it has been discovered that the fatty acid composition of cell membranes varies systematically between species, and this underlies the variation in their metabolic rate. When combined with the fact that 1) the products of lipid peroxidation are powerful reactive molecular species, and 2) that fatty acids differ dramatically in their susceptibility to peroxidation, membrane fatty acid composition provides a mechanistic explanation of the variation in maximum life span among animal species. When the connection between metabolic rate and life span was first proposed a century ago, it was not known that membrane composition varies between species. Many of the exceptions to the rate-of-living theory appear explicable when the particular membrane fatty acid composition is considered for each case. Here we review the links between metabolic rate and maximum life span of mammals and birds as well as the linking role of membrane fatty acid composition in determining the maximum life span. The more limited information for ectothermic animals and treatments that extend life span (e.g., caloric restriction) are also reviewed.

Be(ing) prepared : girl guides, colonial life, and national strength

This paper seeks to bridge a gap in feminist critique of gender and empire with regard to the founding of the Girl Guide movement in 1909. In contrast with previous studies of the Boy Scouts, which have briefly considered Guides as a mere derivative organisation, it suggests that the formation of the Guides, and printed material such as the first handbook How Girls Can Help Build Up the Empire (1912), were grounded in notions of the part which women, and girls specifically, could play in the imperial project. This paper proposes that, although tempered by an emphasis on raising children in order to prevent the “degeneration” of the British race, the Guide handbook permits increased non-domestic activity for Edwardian girls, which is justified by aims of preparing for home defence in case of foreign attack and for life in the colonies.

The decision to demutualise : an analysis of the pressures for change. The case of life insurers in Australia and South Africa a comparative perspective

Since the 1980s a wave of demutualisations have occurred across a range of industries from stock exchanges to building societies, savings and loans associations and insurers. In both Australia and South Africa this has had a marked effect on the life insurance markets which had been dominated by mutual life insurers for 150 years. This paper adopts a case study approach to analyse the key drivers of organisational change. It examines the experiences of the Australian Mutual Provident (Australia’s oldest and largest life insurance mutual) and Sanlam (the second largest mutual life office in South Africa) as they proceeded down the path to demutualisation. It suggests a complex array of factors combined to place pressure on the existing mutual structures.

Proposal of a tiered conceptual framework for sustainable design and planning of large-scale development projects in the metropolitan context

The overwhelming threat posed by climate change means that increasingly, emphasis is being placed on the need to integrate sustainability considerations into all areas of policy making, planning and development. Actors in the built environment are progressively considering environmental and social issues alongside functional and economic aspects of development projects. However, to date in Australia and internationally, there have been few practical examples of integrated applications of sustainability principles in the built environment across design, planning, construction, operation and de-construction phases. Notable initiatives have tended to be narrow in scope, focusing on either mitigation or adaptation strategies. Integrated considerations of impacts from component and building scales to city and regional scales and across physical and socio-economic dimensions are urgently needed, particularly for long-life major infrastructure projects. This paper proposes a conceptual framework based on the principal that early intervention is the most cost-effective and efficient means of implementing effective strategies for mitigation and adaptation. A Strategic Environmental Assessment (SEA) approach is forwarded as an umbrella analytical framework, assembled from analytical methods which are strategically ‘tiered’ to inform different stages of the planning and decision-making process. Techniques such as Ecological footprint, Life cycle costing and Risk analysis may be applied to integrate sustainable design, construction and planning considerations which address both mitigation and adaptation dimensions, results of each analysis ultimately being collated into the overall SEA. This integrated conceptual framework for sustainable, resilient and cost-effective infrastructure development will in practice be applied to assess selected case-studies of major development projects in Australia, focusing on the area of stadium development. Practically applied and timed accordingly, the framework would allow assessments to be targeted towards appropriate decision making levels and enable better decision-making and more efficient resource allocation for major infrastructure development projects.

Phylogeny and life histories of the 'Insectivora': controversies and consequences

The evolutionary relationships of the eutherian order Insectivora (Lipotyphla sensu stricto) are the subject of considerable debate. The difficulties in establishing insectivore phylogeny stem from their lack of many shared derived characteristics. The grouping is therefore something of a ‘wastebasket ’ taxon. Most of the older estimates of phylogeny, based on morphological evidence, assumed insectivore monophyly. More recently, molecular phylogenies argue strongly against monophyly, although they differ in the extent of polyphyly inferred for the order. I review the history of insectivore phylogenetics and systematics, focussing on the relationships between the six extant families (Erinaceidae – hedgehogs and moonrats, Talpidae – moles and desmans, Soricidae – shrews, Solenodontidae – solenodons, Tenrecidae – tenrecs and otter-shrews and Chrysochloridae – golden moles). I then examine how these various phylogenetic hypotheses influence the results of comparative analyses and our interpretation of insectivore life-history evolution. I assess which particular controversies have the greatest effect on results, and discuss the implications for comparative analyses where the phylogeny is controversial. I also explore and suggest explanations for certain insectivore life-history trends : increased gestation length and litter size in tenrecs, increased encephalization in moles, and the mixed fast and slow life-history strategies in solenodons. Finally, I consider the implications for comparative analyses of the recent strongly supported phylogenetic hypothesis of an endemic African clade of mammals that includes the insectivore families of tenrecs and golden moles.

Indigenous place-making in the city : dispossessions, occupations and implications for cultural architecture

This paper considers Indigenous place-making practices in light of an idea for a major Victorian Indigenous Cultural Knowledge and Education Centre in central Melbourne as championed by Traditional Owners in Victoria. With only eight Aboriginal architects in the country, collaboration with non-Indigenous architects will be inevitable. Two case studies from the recent past—the Tent Embassy in Canberra and a street corner in Collingwood—reveal that dominant cultures of place-making continue to marginalise Aboriginal people in urban Australia. This paper will contend that delivering spatial justice will require both an opportunity for Indigenous Victorians to build visibility in the centre of the city and a willingness within the dominant culture to be deterritorialised.

The intriguing and forgotten international exchanges in the master plan for the reconstruction of Skopje

At 5:17AM on Friday 26 July 1963, Skopje was struck by an earthquake, which in 17 seconds destroyed approximately 75% of the urban fabric, and changed the course of its history from an unknown town to a city of international focus. Immediate actions and a formidable level of local organization; an unprecedented pouring in of aid from the other Yugoslav republics and from individual nations and organisations; and a monumental role for the United Nations in the co-ordination of international , architectural and urban planning expertise for the city's large-scale and long-term reconstruction, laid the foundation for what has been called 'a precise Marxist revolutionary situation' .1 The detail of the paper concerns Stage 4, Replanning 1963 to 1966 of the planning strategy that was organised into five stages, and has a major interest in the invited United Nations (UN) international competition ~o redesign approximately two square kilometres of the city centre.2 Action is associated with activity as productivity, but in Skopje added to this were symbolic human acts and heroic action such that its inhabitants regained their city and importantly a new position as city in the world.

Palliative and end-of-life care for patients with diabetes

Diabetes complications are common and can contribute to unpleasant symptoms, depression and reduced quality of life. A palliative approach to diabetes care in patients with complications, including modified metabolic targets, can reduce symptoms and hospital admissions and improve quality of life and care transitions. GPs have a key role in co-ordinating palliative and end-of-life care in these patients.

Life satisfaction and morbidity among postmenopausal women

OBJECTIVE: To investigate associations between morbidity and global life satisfaction in postmenopausal women taking into account type and number of diseases.

MATERIALS AND METHODS: A total of 11,084 women (age range 57-66 years) from a population-based cohort of Finnish women (OSTPRE Study) responded to a postal enquiry in 1999. Life satisfaction was measured with a 4-item scale. Self-reported diseases diagnosed by a physician and categorized according to ICD-10 main classes were used as a measure of morbidity. Enquiry data on health and lifestyle were used as covariates in the multivariate logistic models.

RESULTS: Morbidity was strongly associated with life dissatisfaction. Every additional disease increased the risk of life dissatisfaction by 21.1% (p < .001). The risk of dissatisfaction was strongest among women with mental disorders (OR = 5.26; 95%CI 3.84-7.20) and neurological disorders (OR = 3.62; 95%CI 2.60-5.02) compared to the healthy (each p < .001). Smoking, physical inactivity and marital status were also associated with life dissatisfaction (each p < .001) but their introduction to the multivariate model did not attenuate the pattern of associations.

CONCLUSIONS: Morbidity and life dissatisfaction have a disease-specific and dose-dependent relationship. Even if women with mental and neurological disorders have the highest risk for life dissatisfaction, monitoring life satisfaction among aging women regardless of disorders should be undertaken in order to intervene the joint adverse effects of poor health and poor well-being.

The social life of commercial streets

The social life of cities is a key concept related to social cohesion, which has been the subject of extensive studies in several disciplines including sociology, psychology and the built environment. Social life studies conducted in the built environment discipline have mostly focused on city centres; while the significance of neighbourhoods as integral elements have been sometimes overlooked. As a result, this research will specifically explore commercial streets in residential suburbs. Suburbs are frequently perceived to be lacking in vitality and street life. The method of inquiry in this research investigates how the physical characteristics of commercial streets can either promote, affect or mitigate the social life of neighbourhoods and generate a sociable environment. Therefore, this study captures the social behaviour of three commercial streets in Geelong, Australia. This paper utilizes a qualitative approach to the study of the social life of commercial streets. The primary methodology used in this research is recording, documenting and mapping users’ activities through behavioural observation. The observations have been conducted in four days (on two weekdays and two weekends). The case study has been divided into eight sections that are similar in length. Short movies of 30 seconds have been recorded from each section, every two hours from 8:00 am to 10:00 pm. Afterwards, the movies have been transmitted into street mappings, documenting the type of activities, placement of activities, gender and approximate age by exploiting suitable pictograms. There are several physical characteristics that are believed to be contributing to the social life of commercial streets. This study utilizes a bottom-up approach to evaluate the complexities of the role that built environment plays in terms of vitality through the three selected characteristics, including typomorphology and street layout, diversity of uses, and soft facades. Better understanding of how neighbourhood environments influence the social life of neighbourhoods can provide academics and professionals in architecture and urban design with sound evidence on which to base future research and design.

Young maternal age at first birth and mental health later in life: does the association vary by birth cohort?

BACKGROUND: It is well established that maternal age at childbirth has implications for women's mental health in the short term, however there has been little research regarding longer term implications and whether this association has changed over time. We investigated longer term mental health consequences for young mothers in Australia and contrasted the effects between three birth cohorts. METHODS: Using thirteen waves of data from 4262 women aged 40 years or above participating in the Household, Income and Labour Dynamics in Australia Survey, we compared the mental health of women who had their first child aged 15-19 years, 20-24 years, and 25 years and older. Mental health was measured using the mental health component summary score of the SF-36. We used random-effects linear regression models to generate estimates of the association between age at first birth and mental health, adjusted for early life socioeconomic characteristics (country of birth, parents' employment status and occupation) and later life socioeconomic characteristics (education, employment, income, housing tenure, relationship status and social support). We examined whether the association changed over time, testing for effect modification across three successive birth cohorts. RESULTS: In models adjusted for early life and later life socioeconomic characteristics, there was strong evidence of an association between teenage births and poor mental health, with mental health scores on average 2.76 to 3.96 points lower for mothers aged younger than 20 years than for mothers aged 25 years and older (Late Baby Boom (born 1936-1945): -3.96, 95% CI -5.38, -2.54; Early Baby Boom (born 1946-1955): -3.01, 95% CI -4.32, -1.69; Lucky Few (born 1956-1965): -2.76, 95% CI -4.34, -1.18), and evidence of an association for mothers aged 20-24 years compared to mothers aged 25 years and older in the most recent birth cohort only (-1.09, 95% CI -2.01, -0.17). There was some indication (though weak) that the association increased in more recent cohorts. CONCLUSION: This study highlights that young mothers, and particularly teenage mothers, are a vulnerable group at high risk of poor mental health outcomes compared to mothers aged 25 years and above, and there was some suggestion (though weak) that the health disparities increased over time.

Evolution and significance of the regeneration reserve heritage landscape of Broken Hill: history, values and significance

In 1991, the National Trust of NSW classified the Regeneration Reserves surrounding the City of Broken Hill as an essential cultural heritage asset of the City of Broken Hill, and in 2015 the City of Broken Hill, including the reserves, were elevated to the National Heritage List under the Commonwealth's Environment Protection and Biodiversity Conservation Act 1999. This tract of land, and its proponents, Albert and Margaret Morris, are recognised as pioneers of arid zone revegetation science in Australia; a point noted in the National Heritage List citation. They created at Broken Hill a unique revegetation ‘greenbelt’ of national ecological, landscape architectural and town planning significance. The Morris’ led the advancement of arid zone botanical investigation and taxonomic inquiry, propagation innovation, and revegetation sciencein the 1920s-40s in Australia and applied this spatially. Their research and practical applications, in crafting the regeneration reserves around Broken Hill, demonstrated the need for landscape harmonisation to occur to reduce erosion and dust damage to human and mining activities alike. This pioneering research and practice informs and underpins much arid zone mine reclamation and revegetation work in Australia today. This paper reviews the historical evolution of this cultural landscape, its integral importance to the cultural heritage and mining history of the City of Broken Hill, and its inclusion as part of the Broken Hill National Heritage List citation.