Self-aware virtualised autonomic self-management of non-dedicated clusters

This research aims at improving the accessibility of cluster computer systems by introducing autonomic self-management facilities incorporating; 1) resource discovery and self awareness, 2) virtualised resource pools, and 3) automated cluster membership and self configuration. These facilities simplify the user's programming workload and improve system usability.

Offering clusters from clouds using WSDL and stateful web services

This paper presents cloud’s higher layer abstraction and support for users in the form of Cluster as a Service.

Parallel computing on clusters and enterprise grids : practice and experience

We assert that companies can make more money and research institutions can improve their performance if inexpensive clusters and enterprise grids are exploited. In this paper, we have demonstrated that our claim is valid by showing the study of how programming environments, tools and middleware could be used for the execution of parallel and sequential applications, multiple parallel applications executing simultaneously on a non-dedicated cluster, and parallel applications on an enterprise grid and that the execution performance was improved. For this purpose an execution environment, and parallel and sequential benchmark applications selected for, and used in, the experiments were characterised.

Toward ease of discovery, selection and use of clusters within a cloud

While the emergence of clouds had lead to a significant paradigm shift in business and research, cloud computing is still in its infancy. Specifically, there is no effective publication and discovery service nor are cloud services easy to use. This paper presents a new technology for offering ease of discovery, selection and use of clusters hosted within clouds. By improving these services, cloud clusters become easily accessible to all clients, software services to noncomputing human user.

Clusters driven implementation of a brain inspired model for multi-view pattern identifications

The human brain processes information in both unimodal and multimodal fashion where information is progressively captured, accumulated, abstracted and seamlessly fused. Subsequently, the fusion of multimodal inputs allows a holistic understanding of a problem. The proliferation of technology has produced various sources of electronic data and continues to do so exponentially. Finding patterns from such multi-source and multimodal data could be compared to the multimodal and multidimensional information processing in the human brain. Therefore, such brain functionality could be taken as an inspiration to develop a methodology for exploring multimodal and multi-source electronic data and further identifying multi-view patterns. In this paper, we first propose a brain inspired conceptual model that allows exploration and identification of patterns at different levels of granularity, different types of hierarchies and different types of modalities. Secondly, we present a cluster driven approach for the implementation of the proposed brain inspired model. Particularly, the Growing Self Organising Maps (GSOM) based cross-clustering approach is discussed. Furthermore, the acquisition of multi-view patterns with clusters driven implementation is demonstrated with experimental results.

IaaS clouds vs. clusters for HPC: a performance study

The increasing amount of data collected in the fields of physics and bio-informatics allows researchers to build realistic, and therefore accurate, models/simulations and gain a deeper understanding of complex systems. This analysis is often at the cost of greatly increased processing requirements. Cloud computing, which provides on demand resources, can offset increased analysis requirements. While beneficial to researchers, adaption of clouds has been slow due to network and performance uncertainties. We compare the performance of cloud computers to clusters to make clear the advantages and limitations of clouds. Focus has been put on understanding how virtualization and the underlying network effects performance of High Performance Computing (HPC) applications. Collected results indicate that performance comparable to high performance clusters is achievable on cloud computers depending on the type of application run.

Content validity of visual analog scales to assess symptom severity of acute angioedema attacks in adults with hereditary angioedema : an interview study

Background: Hereditary angioedema (HAE) is a rare, debilitating, potentially life-threatening condition characterized by recurrent acute attacks of edema of the skin, face/upper airway, and gastrointestinal and urogenital tracts. During a laryngeal attack, people with HAE may be at risk of suffocation, while other attacks are often associated with intense pain, disfigurement, disability, and/or vomiting. The intensity of some symptoms is known only to the person experiencing them. Thus, interview studies are needed to explore such experience and patient-reported outcome measures (PROMs) are required for systematic assessment of symptoms in the clinical setting and in clinical trials of treatments for acute HAE attacks.

Objective: The aim of this interview study was to assess the content validity and suitability of four visual analog scale (VAS) instruments for use in clinical studies. The VAS instruments were designed to assess symptoms at abdominal, oro-facial-pharyngeal-laryngeal, peripheral, and urogenital attack locations. This is the first known study to report qualitative data about the patient's experience of the rare disorder, HAE.

Methods: Semi-structured exploratory and cognitive debriefing interviews were conducted with 27 adults with a confirmed clinical/laboratory diagnosis of HAE (baseline plasma level of functional plasma protein C1 esterase inhibitor [C1INH] <50% of normal without evidence for acquired angioedema). There were 17 participants from the US and 10 from Italy, with mean age 42.5 (SD 14.5) years, range 18–72 years, mean HAE duration 21.3 (SD 14.1) years, range 1–45 years, 67% female, and 44% VAS-naïve. Experience of acute angioedema attacks was first explored, noting spontaneous mentions by participants of HAE symptomatology. Cognitive debriefing of the VAS instruments was undertaken to assess the suitability, comprehensibility, and relevance of the VAS items. Asymptomatic participants completed the VAS instruments relevant to their angioedema experience, reporting as if they were experiencing an acute angioedema attack at the time. Interviews were conducted in the clinic setting in the US and Italy over an 8-month period.

Results: Participants mentioned spontaneously almost all aspects of acute angioedema attacks covered by the four VAS instruments, thus providing strong support for inclusion of nearly all VAS items, with no important symptoms missing. Predominant symptoms found to be associated with acute angioedema attacks were edema and pain, and there was evidence of varying degrees of disruption to everyday activities supporting the inclusion of an overall severity item reflecting the disabling effects of HAE symptoms. VAS item wording was understood by participants.

Conclusion: This interview study explored and reported the patient experience of HAE attacks. It demonstrated the content validity of the four anatomical location HAE VAS instruments and their suitability for use in clinical trials of recombinant human C1INH (rhC1INH) treatment for ascertaining trial participants' assessments of the severity of acute angioedema symptoms.

Patient participation in symptom management in an acute oncology setting

Cancer and cancer treatments are associated with high symptom burden. Effective, safe and quality symptom management requires patient participation in symptom identification and treatment. This mixed methods, in depth investigation of symptom management practices uncovered patient, clinician and symptom factors that play a role in patients’ ability and willingness to participate.