31 resultados para ruminal epithelium
Filtro por publicador
- Aberystwyth University Repository - Reino Unido (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (3)
- Aquatic Commons (4)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (3)
- Aston University Research Archive (4)
- B-Digital - Universidade Fernando Pessoa - Portugal (3)
- Biblioteca de Teses e Dissertações da USP (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (7)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (30)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (25)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (29)
- Boston University Digital Common (1)
- CaltechTHESIS (2)
- CentAUR: Central Archive University of Reading - UK (53)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (16)
- Cochin University of Science & Technology (CUSAT), India (2)
- CORA - Cork Open Research Archive - University College Cork - Ireland (2)
- Deakin Research Online - Australia (31)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (1)
- Digital Commons - Michigan Tech (1)
- Digital Repository at Iowa State University (1)
- DigitalCommons@The Texas Medical Center (1)
- DigitalCommons@University of Nebraska - Lincoln (1)
- Duke University (14)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (13)
- FAUBA DIGITAL: Repositorio institucional científico y académico de la Facultad de Agronomia de la Universidad de Buenos Aires (1)
- Helda - Digital Repository of University of Helsinki (33)
- Indian Institute of Science - Bangalore - Índia (6)
- Infoteca EMBRAPA (2)
- INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES (IPEN) - Repositório Digital da Produção Técnico Científica - BibliotecaTerezine Arantes Ferra (1)
- Instituto Politécnico do Porto, Portugal (3)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (6)
- National Center for Biotechnology Information - NCBI (21)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (2)
- QSpace: Queen's University - Canada (2)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (142)
- Queensland University of Technology - ePrints Archive (82)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (2)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (1)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (1)
- Repositorio Institucional de la Universidad Nacional Agraria (12)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (294)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (3)
- SAPIENTIA - Universidade do Algarve - Portugal (5)
- School of Medicine, Washington University, United States (1)
- Universidad Autónoma de Nuevo León, Mexico (4)
- Universidad del Rosario, Colombia (8)
- Universidad Politécnica de Madrid (9)
- Universidade de Lisboa - Repositório Aberto (4)
- Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP) (1)
- Universidade Federal do Pará (1)
- Universidade Federal do Rio Grande do Norte (UFRN) (17)
- Universitat de Girona, Spain (6)
- Université de Lausanne, Switzerland (17)
- Université de Montréal, Canada (25)
- Université Laval Mémoires et thèses électroniques (1)
- University of Connecticut - USA (5)
- University of Queensland eSpace - Australia (4)
- University of Washington (1)
- WestminsterResearch - UK (1)
Resumo:
Small variations in signalling pathways have been linked to phenotypic diversity and speciation. In vertebrates, teeth represent a reservoir of adaptive morphological structures that are prone to evolutionary change. Cyprinid fish display an impressive diversity in tooth number, but the signals that generate such diversity are unknown. Here, we show that retinoic acid (RA) availability influences tooth number size in Cyprinids. Heterozygous adult zebrafish heterozygous for the cyp26b1 mutant that encodes an enzyme able to degrade RA possess an extra tooth in the ventral row. Expression analysis of pharyngeal mesenchyme markers such as dlx2a and lhx6 shows lateral, anterior and dorsal expansion of these markers in RA-treated embryos, whereas the expression of the dental epithelium markers dlx2b and dlx3b is unchanged. Our analysis suggests that changes in RA signalling play an important role in the diversification of teeth in Cyprinids. Our work illustrates that through subtle changes in the expression of rate-limiting enzymes, the RA pathway is an active player of tooth evolution in fish.