DryLab® optimised two-dimensional high performance liquid chromatography for differentiation of ephedrine and pseudoephedrine based methamphetamine samples

In-silico optimised two-dimensional high performance liquid chromatographic (2D-HPLC) separations of a model methamphetamine seizure sample are described, where an excellent match between simulated and real separations was observed. Targeted separation of model compounds was completed with significantly reduced method development time. This separation was completed in the heart-cutting mode of 2D-HPLC where C18 columns were used in both dimensions taking advantage of the selectivity difference of methanol and acetonitrile as the mobile phases. This method development protocol is most significant when optimising the separation of chemically similar chemical compounds as it eliminates potentially hours of trial and error injections to identify the optimised experimental conditions. After only four screening injections the gradient profile for both 2D-HPLC dimensions could be optimised via simulations, ensuring the baseline resolution of diastereomers (ephedrine and pseudoephedrine) in 9.7 min. Depending on which diastereomer is present the potential synthetic pathway can be categorized.

Greater association of peak neuromuscular performance with cortical bone geometry, bone mass and bone strength than bone density : a study in 417 older women

BACKGROUND: We evaluated which aspects of neuromuscular performance are associated with bone mass, density, strength and geometry. METHODS: 417 women aged 60-94years were examined. Countermovement jump, sit-to-stand test, grip strength, forearm and calf muscle cross-sectional area, areal bone mineral content and density (aBMC and aBMD) at the hip and lumbar spine via dual X-ray absorptiometry, and measures of volumetric vBMC and vBMD, bone geometry and section modulus at 4% and 66% of radius length and 4%, 38% and 66% of tibia length via peripheral quantitative computed tomography were performed. The first principal component of the neuromuscular variables was calculated to generate a summary neuromuscular variable. Percentage of total variance in bone parameters explained by the neuromuscular parameters was calculated. Step-wise regression was also performed. RESULTS: At all pQCT bone sites (radius, ulna, tibia, fibula), a greater percentage of total variance in measures of bone mass, cortical geometry and/or bone strength was explained by peak neuromuscular performance than for vBMD. Sit-to-stand performance did not relate strongly to bone parameters. No obvious differential in the explanatory power of neuromuscular performance was seen for DXA aBMC versus aBMD. In step-wise regression, bone mass, cortical morphology, and/or strength remained significant in relation to the first principal component of the neuromuscular variables. In no case was vBMD positively related to neuromuscular performance in the final step-wise regression models. CONCLUSION: Peak neuromuscular performance has a stronger relationship with leg and forearm bone mass and cortical geometry as well as proximal forearm section modulus than with vBMD.

The invisible hand: transversal thinking with new materialism in curriculum design

This proposal invites participation in a design intensive, in which educators bring along an idea for a unit, seminar, lecture, lesson as the basis for a practical and creative workshop merging conceptual art, writing, poetry and curriculum planning, while engaging playfully with New Materialism. In this work we seek to move beyond merely interrogating designs for future subjects, and to embolden our thinking about curriculum, asking questions to explore how the pedagogical imagination works with both the material and immaterial, the corporeal and incorporeal, within ecologies continually transforming in the process of making. Through this, we explore ways to challenge “delivery”, or “conduit” metaphors of education, to see design as “situated” in new ways involving both human and nonhuman elements, resisting stasis, resisting closure. This workshop positions curriculum design in the realm of the artist/activist, rather than that of the bureaucrat/technician and opens up a space for reflection on the processes of making curriculum. The workshop also therefore seeks to question how knowledge around curriculum is produced, and to document the ways in which our work as educators is part of a continuous becoming, as we ourselves, and our designs, co-emerge. We remember that curriculum design is fundamentally a creative project, always taking form and transforming in relation to what surrounds us, rather residing in documents, which tend to conceal the entanglements around their making. Instead, we embody and live curriculum; it is happening now

High-performance multifunctional graphene-PLGA fibers: toward biomimetic and conducting 3D scaffolds

The development of electrically conducting fibers based on known cytocompatible materials is of interest to those engaged in tissue regeneration using electrical stimulation. Herein, it is demonstrated that with the aid of rheological insights, optimized formulations of graphene containing spinnable poly(lactic-co-glycolic acid) (PLGA) dopes can be made possible. This helps extend the general understanding of the mechanics involved in order to deliberately translate the intrinsic superior electrical and mechanical properties of solution-processed graphene into the design process and practical fiber architectural engineering. The as-produced fibers are found to exhibit excellent electrical conductivity and electrochemical performance, good mechanical properties, and cellular affinity. At the highest loading of graphene (24.3 wt%), the conductivity of as-prepared fibers is as high as 150 S m-1 (more than two orders of magnitude higher than the highest conductivity achieved for any type of nanocarbon-PLGA composite fibers) reported previously. Moreover, the Young's modulus and tensile strength of the base fiber are enhanced 647- and 59-folds, respectively, through addition of graphene.

Proactive versus reactive business ethics performance: a conceptual framework of profile analysis and case illustrations

The topic of this paper focuses on proactive versus reactive business ethics performance in the marketplace. The internal perception of a corporation and the external perception of the same corporation are used as generic determinants of business ethics performance. In turn, they are underpinned by evolutionary and contextual issues in the marketplace. The authors provide a generic conceptual framework of proactive and reactive business ethics performance. Case illustrations underpin the positives and negatives of proactive and reactive business ethics in the marketplace. A profile analysis process of proactive and reactive business ethics performance is also outlined. The gap between the internal and external perceptions of a corporation’s actions becomes crucial to achieve successful business ethics performance in the marketplace. Therefore, a corporation’s current business ethics performance should always be regarded as an on-the-spot-account that is either proactive or reactive. An important insight of this research is that business ethics performance requires the ongoing re-connection with reality by corporations.

Wheel of fortune : the re-gifting of art-life

My essay for the Waterwheel project entitled “Wheel of fortune: re-gifting art-life” will examine the Waterwheel project from the point of view of gift economies and discuss the benefits and sustainability of this model for collaboration and cooperation. This essay builds upon the history of gift economies, focusing on the gift as a mode of collaboration and platform for exchange. The alchemical notion of the gift that Gordon Matta- Clark café “FOOD” offers will be discussed as a precursor to the transformation of relations evident in the workshop series organized by Erin Manning and Brian Massumi. In particular, this essay will emphasize the way transformation has been used to rethink the gift as modeling of collaboration and re-imagining of the ties between research creation and social activism. From these discussions the context and ethos by which to understand the aims of the Waterwheel project will be addressed.

Staging a cultural collaboration: Louise Lightfoot and Ananda Shivaram's first Indian Dance Tour of Australia, 1947-1949

One of the most highly stylized of the Indian forms of dance-drama, Kathakali has also received the greatest amount of attention on the global stage. We argue that its international exposure began with the performances of Ananda Shivaram, as managed by the Australian impresario Louise Lightfoot, in a landmark intercultural collaboration. From 1947 to 1949, Shivaram, along with an ensemble of Australian dancers, successfully toured Australia, adapting a range of Kathakali dance-dramas to performance in an international context. Lightfoot organized and publicized the tour, translated texts, and explained the art of Kathakali - virtually unknown - to excited Australian audiences. Using newspaper reports, advertisements, program brochures, and promoter's notes, we chart the performer's and the impresario's journeys, how they fostered intercultural understanding, and how Shivaram became a cultural ambassador for India.

Mother and toddler activity in the zone of proximal development for pretend play as a predictor of higher child IQ

This study investigated the pretend play of mother—toddler dyads in relation to later child IQ. Twenty-one toddlers were videotaped in monthly play sessions with their mothers, from age 8 to 17 months, and later assessed at 5 years of age on the Stanford-Binet IV. Children's and mothers' pretend play levels and frequencies were measured using Brown's (1997) Pretend Play Observation Scale. Dyadic play activity was analyzed using the conceptual frameworks of scaffolding and Vygotsky's Zone of Proximal Development (ZPD). Toddlers later assessed as having higher IQ demonstrated more rapid learning in the ZPD for pretend play and experienced earlier maternal transfer of responsibility for play. These findings support other evidence on the differential early development of high ability or gifted children and the role of caregiver interactions in that development.

Putting the Research to Use: This study provides evidence that gifted children show differential development, in this case more rapid learning, from the first year of life. It also demonstrates how responsive parental interactions can support this advanced development. For family and professional caregivers, the findings imply that optimum caregiving for the young gifted child involves interactions that are both responsive to individual potential and appropriately challenging. In regard to the methodological challenges of researching early giftedness, the study demonstrated that the constructs of the ZPD and scaffolding were useful frameworks for investigating early gifted development and caregiver influences on that development. Pretend play activity was also shown to be an effective measure and a useful context for the study of gifted development in infants and toddlers. It would be valuable for future researchers in this area to utilize similar approaches that are grounded in the unique developmental characteristics of young children, and that aim to account for the interactive contexts that are so important in children's lives. The field of gifted education, in general, would also benefit from an increased awareness and exploration of the role of play in the development of intellect, imagination and creativity.

Artspeak : articulating artistic process across cultural boundaries through digital theatre

In early 2009, researchers in the English Department of the University of Amsterdam collaborated with researchers in the Drama Department, Deakin University, Australia on a project which brought English as a Second Language students from The Netherlands into the rehearsal studio of Australian students engaged in play-building on Australian themes. The project aims were multiple and interconnected. We extended a language acquisition framework established by the Dutch investigators in previous collaborations with the Universities of Venice and Southampton, and combined this with an investigation of ways to harness technology in order to teach Australian students to communicate with and about their art. The Dutch language students were prompted to develop art-related language literacy (description, interpretation, criticism), through live, video-streamed interaction with drama students in Australia at critical points in the development of a group-devised performance (conception, rehearsal, performance). The Australian student improved their capacity to articulate the aims and processes which drove their art-making by illuminating the art-making process for the Dutch students, and providing them with a real-life context for the use of extended vocabulary whilst making them partners in the process of shaping the work. All participants engaged in the common task of assessing the capacity of the art work produced to communicate meaning to a non-Australian audience.

Retrieval

Retrieval was a site-specific performance installation which transformed five floors of the National Library of Australia in Nov-Dec 2010. Devised in collaboration with a team of 30 young performers, the production lead the audience on a quest deep into the library to retrieve priceless cultural memories before all was lost. Louise Morris working in collaboration with co-designer Matthew Aberline and the artistic team created the installed environments for the production. The production won numerous awards including Best New Project- Express Media and Best Original Work- CAT awards.

Bringing innovation to centre stage : the rhetoric of commercialisation and cross-sector collaboration

As a key element in Australia's national innovation system, public sector organizations, such as universities and public-funded research agencies, have increasingly become involved in R&D collaborations with firms. Government policy has encouraged this cross-sector collaboration, and in the most recent policy "act" has focused on the commercialisation of research findings (through which R&D outputs are translated into marketable commodities) and has encouraged public sector organizations to become more directly involved in this activity. But while the policy rhetoric has contributed to a discourse of marketization, through which cultural change in the research performing organizations is both promoted and legitimised, there are other voices in the unfolding policy drama which point to the complex and multifaceted nature of commercialisation in national economies. These countervailing voices emphasise the multiple roles that public sector organizations play in national innovation systems, and this introduces organizational role ambiguity into the discourse leading to confusion among the research performing actors. It is concluded that, given the complex and subtle nature of innovation processes, the traditional dichotomy between applied (or commercially-focused) research and "public good" research is no longer tenable nor helpful in the policy debates.

Technical features of BIM servers for collaboration on building and construction projects

This paper reviews the technical features and requirements of Building Information Modelling (BIM)-servers as collaboration platforms for multi-disciplinary building and construction projects. Multi-disciplinary collaboration is the norm in the Architecture, Engineering, and Construction (AEC) industries, especially in complex projects. The widespread adoption of object-oriented Computer-aided Design (CAD) tools that support BIM capabilities has generated greater interest in model based exchange of information across disciplines and consultants who have traditionally collaborated through the frequent exchange of 2D drawings and documents. BIM-servers are collaboration platforms that are expected to provide the technical capability to support this inter-disciplinary exchange of 3D models in addition to intelligent management of the related drawings, documents and other forms of data. Since BIM-servers are a recent technical development a review of their technical features can help further development. This paper serves this objective by providing a review of the technical features and requirements for using BIM-servers as multi-disciplinary collaboration platforms on building and construction projects. The methodologies include focus group interviews (FIGs) with representatives from the diverse AEC disciplines, a case study on a state-of-the-art BIM-server, and a critical review and analysis of current collaboration platforms that are available to the AEC industries. This paper concludes that greater emphasis should be placed on supporting technical requirements to facilitate technology management and implementation across disciplines. Their implications for user-centric technology development in design and construction industry are also discussed.

WORK: hybridity and endurance within solo dance practice and performance

Editorial : Surveillance and sport

Sports represent an ideal field to explore the importance of everyday surveillance practices. The routines of preparation associated with conducting or participating in a sports mega event at international level highlight unique facets of surveillance as everyday and normalised elements of elite international or professional sports performance. While these routines do have potential individual or social costs, or are open to various forms of subversion by athletes willing to challenge the broader objectives of fair play, other forces, such as the media or formal governance reactions to a detected rule violation, provide fuel for more rigorous forms of surveillance. This spiral of surveillance permeates downwards to impact on prospective elite athletes, and outwards to impact on other forms of behaviour considered to compromise integrity or fair play. How these values mirror and intersect with norms of surveillance in everyday life is a fruitful site for on-going research and theorisation.