Metabotropic glutamate receptors as targets for novel antipsychotic treatments

In recent years metabotropic glutamate receptors have emerged as key targets for the design of new antipsychotic medications for schizophrenia, in particular mGluR5 and mGluR2/3. These receptors exhibit diverse interactions with other neurotransmitter receptors and critical elements of intracellular signalling cascades known to be important to the pharmacotherapy of schizophrenia. In addition, mGluR5 and mGluR2/3 are intimately involved in behavioural domains related to the symptoms of this disorder. Both animal and clinical studies using novel drugs targeting these receptors have provided encouraging results. The number of patents registered for drugs targeting metabotropic glutamate receptors has grown dramatically, and positive allosteric modulators for both receptors show particular promise.

Fuzzy logic controller and cascade inverter for direct torque control of IM

In this paper, a five-level cascaded H-bridge multilevel inverters topology is applied on induction motor control known as direct torque control (DTC) strategy. More inverter states can be generated by a five-level inverter which improves voltage selection capability. This paper also introduces two different control methods to select the appropriate output voltage vector for reducing the torque and flux error to zero. The first is based on the conventional DTC scheme using a pair of hysteresis comparators and look up table to select the output voltage vector for controlling the torque and flux. The second is based on a new fuzzy logic controller using Sugeno as the inference method to select the output voltage vector by replacing the hysteresis comparators and lookup table in the conventional DTC, to which the results show more reduction in torque ripple and feasibility of smooth stator current. By using Matlab/Simulink, it is verified that using five-level inverter in DTC drive can reduce the torque ripple in comparison with conventional DTC, and further torque ripple reduction is obtained by applying fuzzy logic controller. The simulation results have also verified that using a fuzzy controller instead of a hysteresis controller has resulted in reduction in the flux ripples significantly as well as reduces the total harmonic distortion of the stator current to below 4 %.

Nonlinear backstepping controller design for sharing active and reactive power in three-phase grid-connected photovoltaic systems

In this paper, a nonlinear backstepping controller is designed for three-phase grid-connected solar photovoltaic (PV) systems to share active and reactive power. A cascaded control structure is considered for the purpose of sharing appropriate amount of power. In this cascaded control structure, the dc-link voltage controller is designed for balancing the power flow within the system and the current controller is designed to shape the grid current into a pure sinusoidal waveform. In order to balance the power flow, it is always essential to maintain a constant voltage across the dc-link capacitor for which an incremental conductance (IC) method is used in this paper. This approach also ensures the operation of solar PV arrays at the maximum power point (MPP) under rapidly changing atmospheric conditions. The proposed current controller is designed to guarantee the current injection into the grid in such a way that the system operates at a power factor other than unity which is essential for sharing active and reactive power. The performance of the proposed backstepping approach is verified on a three-phase grid-connected PV system under different atmospheric conditions. Simulation results show the effectiveness of the proposed control scheme in terms of achieving desired control objectives.