Are voluntary wheel running and open-field behavior correlated in mice? Different answers from comparative and artificial selection approaches

Voluntary wheel running and open-field behavior are probably the two most widely used measures of locomotion in laboratory rodents. We tested whether these two behaviors are correlated in mice using two approaches: the phylogenetic comparative method using inbred strains of mice and an ongoing artificial selection experiment on voluntary wheel running. After taking into account the measurement error and phylogenetic relationships among inbred strains, we obtained a significant positive correlation between distance run on wheels and distance moved in the open-field for both sexes. Thigmotaxis was negatively correlated with distance run on wheels in females but not in males. By contrast, mice from four replicate lines bred for high wheel running did not differ in either distance covered or thigmotaxis in the open field as compared with mice from four non-selected control lines. Overall, results obtained in the selection experiment were generally opposite to those observed among inbred strains. Possible reasons for this discrepancy are discussed.

Kinematics analysis of 6-DOF parallel micro-manipulators with offset U-Joints : a case study

This paper analyses the kinematics of a special 6-DOF parallel micro-manipulator with offset RR-joint configuration. Kinematics equations are derived and numerical methodologies to solve the inverse and forward kinematics are presented. The inverse and forward kinematics of such robots compared with those of 6-UCU parallel robots are more complicated due to the existence of offsets between joints of RR-pairs. The characteristics of RR-pairs used in this manipulator are investigated and kinematics constraints of these offset U-joints are mathematically explained in order to find the best initial guesses for the numerical solution. Both inverse and forward kinematics of the case study 6-DOF parallel micro-manipulator are modelled and computational analyses are performed to numerically verify accuracy and effectiveness of the proposed methodologies.

Kinematics analysis of 6-DOF parallel micro-manipulators with offset u-joints : a case study

This paper analyses the kinematics of a special 6-DOF parallel micro-manipulator with offset RR-joint configuration. Kinematics equations are derived and numerical methodologies to solve the inverse and forward kinematics are presented. The inverse and forward kinematics of such robots compared with those of 6-UCU parallel robots are more complicated due to the existence of offsets between joints of RR-pairs. The characteristics of RR-pairs used in this manipulator are investigated and kinematics constraints of these offset U-joints are mathematically explained in order to find the best initial guesses for the numerical solution. Both inverse and forward kinematics of the case study 6-DOF parallel micro-manipulator are modelled and computational analyses are performed to numerically verify accuracy and effectiveness of the proposed methodologies.

Forward kinematics analysis of offset 6-RRCRR parallel manipulators

A methodology for the numerical solution of the forward kinematics problem of 6-RRCRR parallel manipulators with orthogonal non-intersecting RR-joint configuration is presented in this article. The inverse and forward kinematics solutions of such robots compared with that of parallel robots with orthogonal intersecting RR-joint or universal joint configurations are much more complicated due to the existence of dependent joint variables. The constraints of RR-joints are analysed and the numerical algorithm for the forward kinematics solution is assessed. Numerical results for the solution of the forward kinematics of 6-RRCRR parallel robot under study are provided to confirm the accuracy and efficiency of the procedure.

Inverse kinematics analysis of 6-RRCRR parallel manipulators

This paper presents a solution to the inverse kinematics of 6-RRCRR parallel manipulators with orthogonal non-intersecting RR-joint configuration. The inverse kinematics solution of such parallel robots compared with that of parallel robots with orthogonal intersecting RR-joint or universal joint configuration is more complex due to the existence of RR-joint variables. A novel methodology is established to define 6 independent variables of the actuators and 12 dependent RR-joint variables using the pose of the mobile platform with respect to the base frame. The constraint of RR-joints are analysed and the numerical algorithm to obtain joint variables is assessed. The forward kinematics of a 6- RRCRR parallel manipulator is modelled and computational analysis is performed in order to numerically verify the accuracy and effectiveness of the proposed methodology for the inverse kinematics analysis. Numerical results of a trajectory tracking simulation are provided. The results verify high accuracy for the proposed inverse kinematics solution of this special family of parallel micromanipulators.

The effect of an ultra-endurance running race on mucosal and humoral immune function

There are reports of the effect of endurance exercise on mucosal immune function and of the effect of short duration exercise on humoral immune function. However, little is known of the effect of endurance exercise on humoral immune function and the related risk of infection. This study examined the effects of an ultra-endurance running race on salivary immunoglobulin-A (s-IgA), serum IgA, leukocyte subset concentrations and the incidence of upper respiratory tract infections (URTI). 

Leg muscle pH following sprint running

In an effort to compare the disturbances in leg muscle pH during sprint running, muscle biopsies were obtained from the gastrocnemius and vastus lateralis muscles of six healthy men (three endurance-trained and three nonendurance-trained) before and after a treadmill sprint run (TSR) to fatigue (54-105 s) at roughly 125% of their aerobic capacities. Following the TSR, repeated blood samples were taken from a hand vein and later analyzed for pH, PCO2, and lactic acid (HLa). The muscle specimens were analyzed in duplicate for pH and HLa. Resting-muscle pH was 7.03 +/- 0.02 (means +/- SE) and 7.04 +/- 0.01 for the gastrocnemius and vastus lateralis muscles, respectively. At the termination of the TSR, the pH in these muscles was 6.88 +/- 0.05 and 6.86 +/- 0.03, respectively. After a 400-m timed run on the track, the pH in the gastrocnemius of four of the subjects averaged 6.63 +/- 0.03, while blood pH and HLa were 7.10 +/- 0.03 and 12.3 mM, respectively. Although no differences in pH and HLa were observed between the vastus lateralis and gastrocnemius muscles at the end of the treadmill trial, it is speculated that the lesser disturbance in acid-base balance seen in endurance performers may have been due to a lesser production of metabolites in their running musculature when compared to nonendurance performers.

Validity of an upper-body-mounted accelerometer to measure peak vertical and resultant force during running and change-of-direction tasks

This study assessed the validity of a tri-axial accelerometer worn on the upper body to estimate peak forces during running and change-of-direction tasks. Seventeen participants completed four different running and change-of-direction tasks (0°, 45°, 90°, and 180°; five trials per condition). Peak crania-caudal and resultant acceleration was converted to force and compared against peak force plate ground reaction force (GRF) in two formats (raw and smoothed). The resultant smoothed (10 Hz) and crania-caudal raw (except 180°) accelerometer values were not significantly different to resultant and vertical GRF for all running and change-of-direction tasks, respectively. Resultant accelerometer measures showed no to strong significant correlations (r = 0.00–0.76) and moderate to large measurement errors (coefficient of variation [CV] = 11.7–23.9%). Crania-caudal accelerometer measures showed small to moderate correlations (r = − 0.26 to 0.39) and moderate to large measurement errors (CV = 15.0–20.6%). Accelerometers, within integrated micro-technology tracking devices and worn on the upper body, can provide a relative measure of peak impact force experienced during running and two change-of-direction tasks (45° and 90°) provided that resultant smoothed values are used.

Effect of weighted vest suit worn during daily activities on running speed, jumping power, and agility in young men

Effect of weighted vest suit worn during daily activities on running speed, jumping power, and agility in young men. J Strength Cond Res 26(11): 3030-3035, 2012-Previous weighted vest interventions using exercise in addition to hypergravity have been successful in improving postural balance and power production capacity. The purpose of this study was to investigate if hypergravity alone in daily activities excluding sporting activities is effective in improving neuromuscular performance in young adults. Eight male subjects (age = 32 [SD: 6] years, height = 178 [5] cm, and body mass = 81 [8] kg) wore weighted vests 3 d.wk-1 for 3 weeks during waking hours, excluding sporting activities. Control group comprised 9 male subjects (age = 32 [6] years, height = 179 [5] cm, and body mass = 83 [9] kg). Performance was assessed with countermovement jump (body mass normalized peak power), figure-of-8 running test (running time), and running velocity test at baseline and at the end of the intervention. At baseline, the groups did not differ from each other (multivariate analysis of variance [MANOVA] p = 0.828). A significant group × time interaction (MANOVA F = 5.1, p = 0.015) was observed for performance variables. Analysis of covariance indicated that the intervention improved the figureof- 8 running time (p = 0.016) (22.2 vs. 0.5%), whereas normalized peak power (0.0 vs. 1.6%) and running velocity (1.3 vs. 0.1%) were unaffected (p ≥ 0.095). Wearing weighted vests was effective in slightly improving agility-related performance in young men. Because the effect was small, applying hypergravity only during exercise probably suffices. It appears that a proper volume and intensity of hypergravity could be in the order of 5-10% body weight vest worn during up to 50% of the training sessions for a period of 3-4 weeks.

Take your shoes off to reduce patellofemoral joint stress during running

Elevated patellofemoral joint stress is thought to contribute to the development and progression of patellofemoral pain syndrome. The purpose of this study was to determine if running barefoot decreases patellofemoral joint stress in comparison to shod running. Running barefoot decreased peak patellofemoral joint stress by 12% (p=0.000) in comparison to shod running. The reduction in patellofemoral joint stress was a result of reduced patellofemoral joint reaction forces (12%, p=0.000) while running barefoot.

Effect of caffeine supplementation on repeated sprint running performance

This study examined the effects of 6 mg-kg-1 caffeine ingestion in team-sport players (N.=10) on repeated-sprint running performance (5 sets of 6 x 20 m) and reaction times, 60 min after caffeine or placebo ingestion. Methods. Best single sprint and total set sprint times, blood lactate and simple and choice reaction times (RT) were measured. Total sprint times across sets 1, 3 and 5 (departure every 25 s) were significantly faster after caffeine (85.49±5.55 s) than placebo (86.98±5.78 s) (P<0.05). Similarly, total sprint times across sets 2 and 4 (departure every 60 s), were significantly faster after caffeine (55.99±3.64 s) than placebo (56.77±3.74 s) (P<0.05). Significantly higher blood lactates were recorded in caffeine compared to placebo after set 3 (13.1±1.2 vs 10.3±1.4 mmolL ') (P<0.05) and set 5 (13.1±1.3 vs 103±1.6 mmol-L"1) (P<0.01). There were no significant effects on simple or choice RT, although effect sizes suggested improved post-exercise times after caffeine. Caffeine ingestion 60 min prior to exercise can enhance repeated sprint running performance and is not detrimental to reaction times. [PUBLICATION ABSTRACT]