Bed rest and cognition: effects on executive functioning and reaction time

INTRODUCTION: Executive functions are high-order aspects of cognition heavily dependent upon the prefrontal cortex. Both prefrontal cortex activity and executive function task performance are enhanced by participation in aerobic physical activity, suggesting that a lack of such activity during the bed rest model of prolonged weightlessness might induce executive function deficits. METHODS: Twenty-four healthy males (ages 21-45 yr) undertook 60 d of head-down bed rest (-6 degrees) for the 2nd Berlin Bed Rest Study (BBR2-2). Three executive function tasks (Iowa Gambling Task, working memory, and flanker) and a reaction time task were administered before, during, and after bed rest. RESULTS: Iowa Gambling Task scores were significantly worse during bed rest (1.7 +/- 6.9) than in other sessions (24.3 +/- 7.8). Effects on working memory and flanker task performance were less obvious, requiring practice effects to be considered. Reaction time was significantly slower after bed rest (569 +/- 42 ms) than in earlier tests (529 +/- 45 ms). There was also significantly less intrasubject variability in reaction time after bed rest, consistent with more efficient executive functioning at this stage. DISCUSSION: Our results provide some evidence for a detrimental effect of bed rest on executive functioning. Whether this stems from a lack of aerobic physical activity and/or changes in the prefrontal cortex remains to be determined. Cognitive effects of bed rest could have implications for the planned human exploration of Mars, and for medical and lifestyle conditions with inadequate levels of aerobic physical activity.

Partial state estimation of LTI systems with multiple constant time-delays

Functional observer design for Multi-Input Multi-Output (MIMO) Linear Time-Invariant (LTI) systems with multiple mixed time delays in the states of the system is addressed. Two structures for the design of a minimum-order observer are considered: 1 - delay-dependent, and 2 - internal-delay independent. The parameters of the delay-dependent observer are designed using the Lyapunov Krasovskii approach. The delay-dependent exponential stability of the observer for a specified convergence rate and delay values is guaranteed upon the feasibility of a set of Linear Matrix Inequalities (LMIs) together with a rank condition. Using the descriptor transformation, a modified Jensen's inequality, and improved Park's inequality, the results can be less conservative than the available functional observer design methods that address LTI systems with single state delay. Furthermore, the necessary and sufficient conditions of the asymptotic stability of the internal-delay independent observer are obtained, which are shown to be independent of delay. Two illustrative numerical examples and simulation studies confirm the validity and highlight the performance of the proposed theoretical achievements.

The study to track human arm kinematics applying solutions of Wahba’s Problem upon inertial/magnetic sensors

Long-term, off-site human monitoring systems are emerging with respect to the skyrocketing expenditures engaged with rehabilitation therapies for neurological diseases. Inertial/magnetic sensor modules are well known as a worthy solution for this problem. Much attention and effort are being paid for minimizing drift problem of angular rates, yet the rest of kinematic measurements (earth’s magnetic field and gravitational orientation) are only themselves capable enough to track movements applying the theory for solving historicalWahbas Problem. Further, these solutions give a closed form solution which makes it mostly suitable for real time Mo-Cap systems. This paper examines the feasibility of some typical solutions of Wahba’s Problem named TRIAD method, Davenport’s q method, Singular Value Decomposition method and QUEST algorithm upon current inertial/magnetic sensor measurements for tracking human arm movements. Further, the theoretical assertions are compared through controlled experiments with both simulated and actual accelerometer and magnetometer measurements.

Screen Time Weight-loss Intervention Targeting Children at Home (SWITCH): process evaluation of a randomised controlled trial intervention.

BACKGROUND: The Screen Time Weight-loss Intervention Targeting Children at Home (SWITCH) trial tested a family intervention to reduce screen-based sedentary behaviour in overweight children. The trial found no significant effect of the intervention on children's screen-based sedentary behaviour. To explore these null findings, we conducted a pre-planned process evaluation, focussing on intervention delivery and uptake. METHODS: SWITCH was a randomised controlled trial of a 6-month family intervention to reduce screen time in overweight children aged 9-12 years (n = 251). Community workers met with each child's primary caregiver to deliver the intervention content. Community workers underwent standard training and were monitored once by a member of the research team to assess intervention delivery. The primary caregiver implemented the intervention with their child, and self-reported intervention use at 3 and 6 months. An exploratory analysis determined whether child outcomes at 6 months varied by primary caregiver use of the intervention. RESULTS: Monitoring indicated that community workers delivered all core intervention components to primary caregivers. However, two thirds of primary caregivers reported using any intervention component "sometimes" or less frequently at both time points, suggesting that intervention uptake was poor. Additionally, analyses indicated no effect of primary caregiver intervention use on child outcomes at 6 months, suggesting the intervention itself lacked efficacy. CONCLUSIONS: Poor uptake, and the efficacy of the intervention itself, may have played a role in the null findings of the SWITCH trial on health behaviour and body composition. TRIAL REGISTRATION: The trial was registered in the Australian and New Zealand Clinical Trials Registry (no. ACTRN12611000164998 ); registration date: 10/02/2011.

Gilles Deleuze and early cinema: The modernity of the emancipated time

Although the transition from the movement-image to the time-image is among the most commented-upon Deleuzian problems, Gilles Deleuze neglected the previous transition from ‘images in movement’ to the first regime of the movement-images. As my approach will be transhistorical, focusing especially on early silent movies and recently expanded cinema through early moving images (Lumière Brothers) and 1970s structural films (Malcolm Le Grice), I will reflect on how we can think time and moving images outside of this closed Deleuzian movement-image/time-image conceptual framework. In other words, we can ask: how can we expand this conceptual framework? Drawing on David Martin-Jones’ ‘attraction-image’, my aim is to explore the role of early cinema and the reasons for Gilles Deleuze’s own historical and technical (mis)judgement of early silent cinema. In this sense, the emergent studies on the history of early silent movies, and the growing field of Deleuzian studies on film, together have an important role on the philosophical and historiographical analysis of film’s expression of time and modernity.