Genome - wide association study identifies novel breast cancer susceptibility loci

Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate risks. To identify further susceptibility alleles, we conducted a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls, followed by a third stage in which 30 single nucleotide polymorphisms (SNPs) were tested for confirmation in 21,860 cases and 22,578 controls from 22 studies. We used 227,876 SNPs that were estimated to correlate with 77% of known common SNPs in Europeans at r² > 0.5. SNPs in five novel independent loci exhibited strong and consistent evidence of association with breast cancer (P < 10^-7). Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 and LSP1). At the second stage, 1,792 SNPs were significant at the P < 0.05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach.

Robert Boyle's theory of nature, with reference to his understanding of natural laws

Argues that the theory of nature-cum-theology and the view of of natural laws of the 17th century natural philosopher, Robert Boyle, were more complex and eclectic than is usually believed. Support is given for construing Boyle as a more complex thinker than previous scholars have suggested.

The Menzies Government and the grand alliance during 1939

This article is a study of the Australian government's exchanges with the Chamberlain government over the ultimately unsuccessful attempt to negotiate a Grand Alliance between the United Kingdom, France and the Soviet Union during 1939. Robert Menzies and Stanley Bruce carefully weighed the arguments for and against before deciding to support the proposal for an Alliance. Yet there was considerable ambivalence about their support as evidenced by Bruce's panicky response to the Molotov-Ribbentrop Pact. In its own very small and distant way the Menzies government contributed to the inertia that marked the British Empire's failure to secure a Grand Alliance in 1939.