Optimal feature subset selection for neuron spike sorting using the genetic algorithm

It is crucial for a neuron spike sorting algorithm to cluster data from different neurons efficiently. In this study, the search capability of the Genetic Algorithm (GA) is exploited for identifying the optimal feature subset for neuron spike sorting with a clustering algorithm. Two important objectives of the optimization process are considered: to reduce the number of features and increase the clustering performance. Specifically, we employ a binary GA with the silhouette evaluation criterion as the fitness function for neuron spike sorting using the Super-Paramagnetic Clustering (SPC) algorithm. The clustering results of SPC with and without the GA-based feature selector are evaluated using benchmark synthetic neuron spike data sets. The outcome indicates the usefulness of the GA in identifying a smaller feature set with improved clustering performance.

The role of the libero in volleyball as a paradoxical influence on the game: logical debate and the proposal for a rule change

The purpose of this paper is to bring into focus philosophical and logical concerns relating to specific rules that govern the role of the libero in volleyball. The authors contest that the introduction of the position of the libero in volleyball may have actually undermined the continuing logic of the rules of the game. In addressing these questions the authors offer theoretically based rule-change proposals for the sport of volleyball that could be used to inform future training methods or development programmes at both the participatory and elite levels. Discussion may also inform the development of new tools of analysis (e.g. computer software) or the creation of a new breadth of match simulation resources to enhance athlete performance. These tools and devices could then be presented to volleyball coaches in an effort to resolve the issues that have come to light and further inform the philosophical and logical debates about the role of the libero in volleyball.

Neovascularization and pain in abnormal patellar tendons of active jumping athletes

Objective: The aim of this study was to investigate tendon pain in abnormal patellar tendons with and without neovascularization.

Study design: Comparative design.

Setting: Multidisciplinary tendon study group at a competitive volleyball venue.

Participants: One hundred eleven volleyball players volunteered to participate in the study.

Main Outcome Measures: Subjects' patellar tendons were imaged with ultrasound, with and without Doppler. Tendons that were imaging abnormal were categorized according the presence of tendon neovascularization. Subjects completed 3 pain scales that examined function (Victorian Institute of Sport Assessment score, 100-point maximum), pain with tendon load (decline squat, visual analogue scale, 100-mm maximum), and maximum pain for the previous week (visual analogue scale, 100-mm maximum). A 1-tailed Mann-Whitney U test compared pain scores in abnormal tendons without neovascularization to abnormal tendons with neovascularization.

Results: Functional scores were lower (Victorian Institute of Sport score, median, 78; P = 0.045) and pain scores under tendon load were greater (decline squat pain, median, 19; P = 0.048) in subjects with abnormal tendons with neovascularization than subjects with abnormal tendons without neovascularization (Victorian Institute of Sport Assessment score, median, 87; decline squat pain, median, 0).

Conclusions: This study indicates that the presence of neovascularization in abnormal patellar tendons is associated with greater tendon pain compared with abnormal tendons without neovascularization in active jumping athletes.

Vascularity and pain in the patellar tendon of adult jumping athletes : a 5 month longitudinal study

Background: This study investigated changes in tendon vascularity in 102 (67 men and 35 women) volleyball players over a 6 month competitive season.

Methods: Athletes were examined with both grey scale ultrasound and standardised colour Doppler settings. Vessel length and pain were measured each month on five separate occasions. Vascular tendons were divided into (i) those that were vascular on all occasions (persistent vascularity) and (ii) those that were vascular on more than two but less than five occasions (intermittent vascularity).

Results: A total of 41 of the 133 abnormal tendons were vascular on two or more occasions. Of these, 16 had persistent vascularity and 25 had intermittent vascularity. There was no significant difference in the prevalence of vascularity between men and women. None of the tendons had a pattern of vascularity over the season that could be clearly interpreted as the onset or resolution of vascularity. Subjects with changes in both tendons were more likely to have persistent vascularity (p = 0.045). Vessels were longer in tendons with persistent vascularity (p<0.000) and pain was significantly greater (p = 0.043) than in tendons with intermittent vascularity. Tendons with intermittent vascularity had similar pain scores on all days, whether or not they had detectable blood flow.

Microeconomic reform and productivity in Australia-boom or blip

The impact of microeconomic reform in Australia as indicated by aggregate productivity growth estimates is examined. Aggregate evaluations are few. The Productivity Commission / Australian Bureau of Statistics estimates of ‘market sector MFP’ since the mid 1960s showing recent increasing productivity growth for the Australian economy are examined. ‘Market sector’ series for 62 per cent of the economy are reconstructed for whole economy. The whole economy estimates add support to a spike shown in ‘multifactor’ productivity growth in the 1990s rather than sustained increase with a microeconomic reform as a factor. Simple regression estimates support the point findings and indicate the presence of unknown factors and cyclicality in the estimates.

Utility of real-time decision-making in commercial data stream mining domains

The objective is to measure utility of real-time commercial decision making. It is important due to a higher possibility of mistakes in real-time decisions, problems with recording actual occurrences, and significant costs associated with predictions produced by algorithms. The first contribution is to use overall utility and represent individual utility with a monetary value instead of a prediction. The second is to calculate the benefit from predictions using the utility-based decision threshold. The third is to incorporate cost of predictions. For experiments, overall utility is used to evaluate communal and spike detection, and their adaptive versions. The overall utility results show that with fewer alerts, communal detection is better than spike detection. With more alerts, adaptive communal and spike detection are better than their static versions. To maximise overall utility with all algorithms, only 1% to 4% in the highest predictions should be alerts.

A comparative study of secondary Ion emission from water ice under Ion bombardment by Au+, Au3+, and C60+

Secondary ion emission from water ice has been studied using Au⁺, Au₃⁺, and C₆₀⁺ primary ions. In contrast to the gas phase in which the spectra are dominated by the (H₂O)_nH⁺ series of ions, the spectra from ice using all three primary ions are principally composed of two series of cluster ions (H₂O)_nH⁺ and (H₂O)_n⁺. Dependent on the conditions, the unprotonated series can dominate the spectra. Since in the gas phase (H₂O)_n⁺ is unstable with respect to the formation of the protonated ion series, the presence of the solid must provide a means to stabilize their formation. The cluster ion yields under Au⁺ bombardment are very low and can be understood in terms of sputtering on the borderline between linear cascade and thermal spike behavior. There is a 10⁴ increase in yield across the whole spectrum compared to Au⁺ when Au₃⁺ and C₆₀⁺ species are used as primary ions. The character of the spectra differed between these two primary ions, but insights into the mechanism of secondary ion emission for both is discussed within an energy deposition framework provided by the fluid flow-based mesoscale energy deposition footprint (MEDF) model that predicts a cone-shaped zone of activation and emission. C₆₀⁺ differs from Au^₃+ in that it delivers its energy closer to the surface, and it is argued this has consequences for the cluster ion distribution and yield. Increasing the ion dose by sputtering suppresses the yield of (H₂O)_n⁺ and increases the yield of the protonated ions in the small cluster region, whereas the yield in the large cluster regime is suppressed significantly. The three primary ions show rather different behavior, and this is discussed in the light of the sputtering models. Finally, negative ion spectra including cluster ions have been observed for the first time. C₆₀⁺ delivers the highest yields, but these are less than 10 times the positive ion yields, probably because the O and OH fragment ions on which the clusters are based are easily neutralized by protons.

Three-month bilateral hopping intervention is ineffective in initiating bone biomarker response in healthy elderly men.

In animal studies, bone adaptation has been initiated successfully without the transient force spike associated with high impact exercises. Consequently, a 12-week bilateral hopping on the balls of the feet intervention was conducted. 25 elderly men (age 72(SD4) years, height 171(6) cm, weight 75(9) kg) were randomly assigned into exercise and control groups. Ten subjects in each group completed the study. Carboxyterminal propeptide of type I collagen (CICP), bone-specific alkaline phosphatase (bALP) and carboxyterminal telopeptide of type I collagen (CTx) were measured from venous blood samples at baseline, at 2 weeks and at the end of the intervention. Maximal ground reaction force (GRF), osteogenic index (OI) and jump height (JH) were determined from bilateral hopping test and balance was assessed with velocity of center of pressure (COPvelocity) while standing on the preferred leg with eyes open. The intervention consisted of 5–7 sets of 10 s timed bilateral hopping exercise at 75–90% intensity three times/week. There was no significant group 9 time interaction for GRF, OI and JH (P = 0.065). GRF (11% change from baseline vs. 4%), OI (15 vs. 6%) and COPvelocity (-10 vs. -1%) were not influenced by the intervention (P[0.170), while the control group improved JH (P = 0.031) (2 vs. 18%). For the biomarkers, no effect was observed in MANOVA (P = 0.536) or in univariate analyses (P = 0.082 to P = 0.820) (CICP -2 vs. -3%, CTx 8 vs. -12%, bALP 0 vs. -3.7%). Allowing transient impact force spikes may be necessary to initiate a bone response in elderly men as the intervention was ineffective.

Adaptation and self-undermining postmodern views of the world

This paper examines the artistic construction of fictional and non-fictional characters and worlds and shows how adaptation changes non-fiction into fiction. This is illustrated with two films, Adaptation (Spike Jonze, 2002) and American Splendor (Shari Springer Berman and Robert Pulcini, 2003). These films are examples of self-reflexive intertextuality, in which the film chronicles the process of its own making and contains multiple portrayals of the characters and story world that inform reading/viewing. Postmodern irony is implicated in this process, which is shown to be self-undermining. The self-loathing of the characters Laroche, Orlean, Kaufman and Pekar is related to the self-loathing arising from Schopenhauer's view of the world, in which the will to life must be renounced to achieve equanimity. The dialogue that results from reading/viewing informed by differences and switching undermines the interpretation of critics that the non-fiction works and film adaptations reflect the postmodern world view, in which a person's self is created by the rush of phenomena, where persons do not change and nothing is resolved.

Energy deficiency, menstrual disturbances, and low bone mass : what do exercising Australian women know about the female athlete triad?

Purpose: Prevention of the female athlete triad is essential to protect female athletes’ health. The aim of this study was to investigate the knowledge, attitudes, and behaviors of regularly exercising adult women in Australia toward eating patterns, menstrual cycles, and bone health.
Methods: A total of 191 female exercisers, age 18–40 yr, engaging in ≥2 hr/wk of strenuous activity, completed a survey. After 11 surveys were excluded (due to incomplete answers), the 180 participants were categorized into lean-build sports (n = 82; running/ athletics, triathlon, swimming, cycling, dancing, rowing), non-lean-build sports (n = 94; basketball, netball, soccer, hockey, volleyball, tennis, trampoline, squash, Australian football), or gym/fitness activities (n = 4).
Results: Mean (± SD) training volume was 9.0 ± 5.5 hr/wk, with participants competing from local up to international level. Only 10% of respondents could name the 3 components of the female athlete triad. Regardless of reported history of stress fracture, 45% of the respondents did not think that amenorrhea (absence of menses for ≥3 months) could affect bone health, and 22% of those involved in lean-build sports would do nothing if experiencing amenorrhea (vs. 3.2% in non-lean-build sports, p = .005). Lean-build sports, history of amenorrhea, and history of stress fracture were all significantly associated with not taking action in the presence of amenorrhea (all p < .005). Conclusions: Few active Australian women are aware of the detrimental effects of menstrual dysfunction on bone health. Education programs are needed to prevent the female athlete triad and ensure that appropriate actions are taken by athletes when experiencing amenorrhea.

Measuring the destruction of heritage and spikes of violence in Iraq

Since the invasion of 2003, Iraq has suffered an extraordinary era of both heritage destruction and devastating spikes in violence. While cases such as the 2003 attacks on the Iraq National Museum and the Iraq National Library and Archive, as well as the systematic looting of Iraq’s sensitive archaeological sites, understandably caused outrage among scholars of heritage studies across the world, little attention has been paid to the destruction of Iraq’s many significant Islamic sites – particularly during the ethno-religious sectarian violence that raged across the nation in 2006-7. This paper presents the first results of a three year project funded by the Australian Research Council which aims to empirically test the assumption that a significant relationship exists between this spike in violence and the targeting of sites of Islamic heritage (mosques, shrines, etc.). To do this, the paper will compare and contrast the information in the world’s first database of heritage destruction (created by the author) and existing measures of violence in Iraq (such as the Iraq Body Count database). This will set the precedent for studies of both heritage and violence and enable policy formation towards the minimization of heritage destruction and spikes in violence during times of conflict.

Heritage destruction and violence in Iraq : bombing mosques and ethno-religious sectarian violence, 2006-7

Since the invasion of 2003, Iraq has suffered an extraordinary era of both heritage destruction and devastating spikes in violence. While cases such as the 2003 attacks on the Iraq National Museum and the Iraq National Library and Archive, as well as the systematic looting of Iraq’s sensitive archaeological sites, understandably caused outrage among scholars of heritage studies across the world, little attention has been paid to the destruction of Iraq’s many significant Islamic sites – particularly during the ethno-religious sectarian violence that raged across the nation in 2006-7. This paper presents the first results of a three year project funded by the Australian Research Council which aims to empirically test the assumption that a significant relationship exists between this spike in violence and the targeting of sites of Islamic heritage (mosques, shrines, etc.). To do this, the paper will compare and contrast the information in the world’s first database of heritage destruction (created by the author) and existing measures of violence in Iraq (such as the Iraq Body Count database). This will set the precedent for studies of both heritage and violence and enable policy formation towards the minimization of heritage destruction and spikes in violence during times of conflict.

Culture and violence in Iraq : bombing mosques and ethno-sectarian violence, 2006

Since the invasion of 2003, Iraq has suffered an extraordinary era of both heritage destruction and devastating spikes in violence. While cases such as the 2003 attacks on the Iraq National Museum and the Iraq National Library and Archive, as well as the systematic looting of Iraq’s sensitive archaeological sites, understandably caused outrage among scholars of heritage studies across the world, little attention has been paid to the destruction of Iraq’s many significant Islamic sites – particularly during the ethno-religious sectarian violence that raged across the nation in 2006-7. This paper presents the first results of a three year project funded by the Australian Research Council which aims to empirically test the assumption that a significant relationship exists between this spike in violence and the targeting of sites of Islamic heritage (mosques, shrines, etc.). To do this, the paper will compare and contrast the information in the world’s first database of heritage destruction (created by the author) and existing measures of violence in Iraq (such as the Iraq Body Count database). This will set the precedent for studies of both heritage and violence and enable policy formation towards the minimization of heritage destruction and spikes in violence during times of conflict.

Effect of vascular endothelial growth factor upregulation on retinal gene expression in the Kimba mouse

Background:  The Kimba mouse carries a human vascular endothelial growth factor transgene causing retinal neovascularisation similar to that seen in diabetic retinopathy. Here, we examine the relationship between differential gene expression induced by vascular endothelial growth factor overexpression and the architectural changes that occur in the retinae of these mice.

Methods:  Retinal gene expression changes in juvenile and adult Kimba mice were assayed by microarray and compared with age-matched wild-type littermates. Transcription of selected genes was validated by quantitative real-time polymerase chain reaction. Protein translation was determined using immunohistochemistry and enzyme-linked immunosorbent assay.

Results:  Semaphorin 3C was upregulated, and nuclear receptor subfamily 2, group 3, member 3 (Nr2e3) was downregulated in juvenile Kimba mice. Betacellulin and endothelin 2 were upregulated in adults. Semaphorin 3C colocalized with glial fibrillary acidic protein in Müller cells of Kimba retinae at greater signal intensities than in wild type. Endothelin 2 colocalised to Müller cell end feet and extended into the outer limiting membrane. Endothelin receptor type B staining was most pronounced in the inner nuclear layer, the region containing Müller cell somata.

Conclusions:  An early spike in vascular endothelial growth factor induced significant long-term retinal neovascularisation associated with changes to the retinal ganglion, photoreceptor and Müller cells. Overexpression of vascular endothelial growth factor led to dysregulation of photoreceptor metabolism through differential expression of Nr2e3, endothelin 2, betacellulin and semaphorin 3C. Alterations in the expression of these genes may therefore play key roles in the pathological mechanisms that result from retinal neovascularisation.

Race, genetic determinism and the media: an exploratory study of media coverage of genetics and Indigenous Australians

Social scientists and Indigenous people have voiced concerns that media messages about genetics and race may increase the public's belief in genetic determinism and even increase levels of racism. The degree of genetic determinism in media messages has been examined as a determining factor. This study is the first to consider the implications of this area of scholarship for the indigenous minority in Australia. A search of the last two decades of major Australian newspapers was undertaken for articles that discussed Indigenous Australians and genetics. The review found 212 articles, of which 58 concerned traits or conditions that were presented in a genetically deterministic or antideterministic fashion. These 58 articles were analysed by topic, slant, and time period. Overall, 23 articles were anti-deterministic, 18 were deterministic, 14 presented both sides and three were ambiguous. There was a spike in anti-deterministic articles in the years after the Human Genome Diversity Project, and a parallel increase in deterministic articles since the completion of the Human Genome Project in 2000. Potential implications of the nature of media coverage of genetics for Indigenous Australians is discussed. Further research is required to test directly the impact of these messages on Australians.