69 resultados para spatial and stochastic modelling, bio-chemical kinetics, multi-scale simulation, systems biology


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In this paper, the zero-order Sugeno Fuzzy Inference System (FIS) that preserves the monotonicity property is studied. The sufficient conditions for the zero-order Sugeno FIS model to satisfy the monotonicity property are exploited as a set of useful governing equations to facilitate the FIS modelling process. The sufficient conditions suggest a fuzzy partition (at the rule antecedent part) and a monotonically-ordered rule base (at the rule consequent part) that can preserve the monotonicity property. The investigation focuses on the use of two Similarity Reasoning (SR)-based methods, i.e., Analogical Reasoning (AR) and Fuzzy Rule Interpolation (FRI), to deduce each conclusion separately. It is shown that AR and FRI may not be a direct solution to modelling of a multi-input FIS model that fulfils the monotonicity property, owing to the difficulty in getting a set of monotonically-ordered conclusions. As such, a Non-Linear Programming (NLP)-based SR scheme for constructing a monotonicity-preserving multi-input FIS model is proposed. In the proposed scheme, AR or FRI is first used to predict the rule conclusion of each observation. Then, a search algorithm is adopted to look for a set of consequents with minimized root means square errors as compared with the predicted conclusions. A constraint imposed by the sufficient conditions is also included in the search process. Applicability of the proposed scheme to undertaking fuzzy Failure Mode and Effect Analysis (FMEA) tasks is demonstrated. The results indicate that the proposed NLP-based SR scheme is useful for preserving the monotonicity property for building a multi-input FIS model with an incomplete rule base.

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The confirmed vector of Ross River virus, Ochlerotatus camptorhynchus (Thomson), is the dominant mosquito species inhabiting saline marshes in coastal Victoria. This paper re-examines previously published data on Oc. camptorhynchus, plus additional data collected since that time, and provides greater spatial and temporal definition of Oc. camptorhynchus numbers at seven sites across the Gippsland Lakes system of eastern Victoria. A total of 357 672 Oc. camptorhynchus was captured from 1188 trap-nights across the seven trap sites during trapping seasons from 1990 to 2001. The  dominance of Oc. camptorhynchus across the seven sites averaged 75%, with significant differences in mean abundance of Oc. camptorhynchus found between all trap sites. Significant differences in monthly abundance of Oc. camptorhynchus were observed for Wellington Shire. Increase in populations of Oc. camptorhynchus was associated with increases in rainfall at all trap sites, higher minimum temperatures at two of the seven trap sites, and wind speed at one trap site. Prioritisation of mosquito control may be applied based on spatial and temporal factors according to the findings of this study.

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In this paper, we incorporate the insurance concept in buying and selling model for agents to trade in the open multi-agent marketplace. During buying, agents purchase insurance as a method to search for potential sellers and select their partners based on the information provided by insurance agents. During selling, agents purchase insurance as a method to protect themselves against potential risk. The insurance concept greatly simplifies the trading procedure in the open marketplace. The novelty of this proposal is that it ensures a dynamic trading environment while agents continue to seek maximum utility and being fully protected by insurance. Our experimental results confirm the feasibility of our approach.

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The infaunal bivalve Soletellina alba is susceptible to mass mortalities during annual winter flooding in the Hopkins River Estuary, southern Australia. Periods of low salinity (≤1) are the likely cause of these mass mortality events, which can occur in seasonally-closed estuaries when high winter flows are sufficient to flush all salt water from the estuary. Core samples of S. alba were collected from two water depths across four times and at three sites near the mouth of the estuary. Minimal to zero abundances of large S. alba (>1 mm) were expected to be sampled, particularly at the shallower water depth, during a typical winter flood event. However, the present study occurred during a period of drought, which led to the absence of winter flooding. This absence of winter flooding prevented the occurrence of lethal salinities (i.e. ≤1) in the estuary during this period and a greater number of living S. alba adults were sampled. Abundances of juvenile and adult S. alba were still variable, even in the absence of winter flooding, and reflected an interaction between date, site and water depth. However, no mass mortalities of adults were observed during the drought conditions in contrast to what occurs during typical winter flood events and provides support for the hypothesis that winter flooding is responsible for past mass mortalities.

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Multi-tenure reserve networks aim to connect areas managed for biodiversity conservation across public and private land and address the impacts of fragmentation on both biotic and social systems. The operation and function of Australian multi-tenure reserve networks as perceived by their land managers was investigated. Overall, the conservation of natural assets was the most frequently reported primary reason for involvement in a network. The perceived aims of the respective networks largely reflected the response identified for involvement and management. Over 88% of managers considered their involvement in multi-tenure reserve networks to be a positive or very positive experience. A lack of resources and time for management were considered major limitations of these networks. The majority (80%) of private land managers within networks were willing to be included in a national reserve system of conservation lands. As the Australian National Reserve System currently incorporates mostly public land, these findings have important and potentially positive implications for a greater role for protected private land.

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This paper addresses the problem of interconnection networks performance modeling of large-scale distributed systems with emphases on multi-cluster computing systems. The study of interconnection networks is important because the overall performance of a distributed system is often critically hinged on the effectiveness of its interconnection network. We present an analytical model that considers stochastic quantities as well as processor heterogeneity of the target system. The model is validated through comprehensive simulation, which demonstrates that the proposed model exhibits a good degree of accuracy for various system sizes and under different operating conditions.

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This paper addresses the problem of performance modeling of heterogeneous multi-cluster computing systems. We present an analytical model that can be employed to explore the effectiveness of different design approaches so that one can have an intelligent choice during design and evaluation of a cost effective large-scale heterogeneous distributed computing system. The proposed model considers stochastic quantities as well as processor heterogeneity of the target system. The analysis is based on a parametric fat-tree network, the m-port n-tree, and a deterministic routing algorithm. The correctness of the proposed model is validated through comprehensive simulation of different types of clusters.

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Chapter six is a case study of modeling nutrient dynamics in cultivated soils.

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Should computer programming be taught within schools of architecture?

Incorporating even low-level computer programming within architectural education curricula is a matter of debate but we have found it useful to do so for two reasons: as an introduction or at least a consolidation of the realm of descriptive geometry and in providing an environment for experimenting in morphological time-based change.

Mathematics and descriptive geometry formed a significant proportion of architectural education until the end of the 19th century. This proportion has declined in contemporary curricula, possibly at some cost for despite major advances in automated manufacture, Cartesian measurement is still the principal ‘language’ with which to describe building for construction purposes. When computer programming is used as a platform for instruction in logic and spatial representation, the waning interest in mathematics as a basis for spatial description can be readdressed using a left-field approach. Students gain insights into topology, Cartesian space and morphology through programmatic form finding, as opposed to through direct manipulation.

In this context, it matters to the architect-programmer how the program operates more than what it does. This paper describes an assignment where students are given a figurative conceptual space comprising the three Cartesian axes with a cube at its centre. Six Phileban solids mark the Cartesian axial limits to the space. Any point in this space represents a hybrid of one, two or three transformations from the central cube towards the various Phileban solids. Students are asked to predict the topological and morphological outcomes of the operations. Through programming, they become aware of morphogenesis and hybridisation. Here we articulate the hypothesis above and report on the outcome from a student group, whose work reveals wider learning opportunities for architecture students in computer programming than conventionally assumed.

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Spatial and temporal variation in the breeding of Masked Lapwings (Vanellus miles) in Australia were examined using data from Birds Australia’s Nest Record Scheme (NRS; 1957–2002), the Atlas of Australian Birds (1998–2006), and climatic data (1952–2006). Breeding in north-western Australia was concentrated in summer, while in other regions the peak of breeding occurred during spring. Breeding success varied between regions and years but was generally highest in Tasmania. Clutch-size (mean 3.57 eggs ± 0.033 s.e., n = 549 clutches) did not vary regionally or temporally. In the north-east, breeding became earlier over time (~1.9 days per year, NRS), while in the south-east, breeding became later (~0.9 days per year); in other regions temporal trends were not evident. Only Tasmania showed a significant temporal change in breeding success (decrease of ~1.5% per year). All regions experienced warming climates, and annual rainfall increased in north-western regions and decreased in eastern regions. There were weak or no relationships between the amount or success of breeding, clutch-size and the climatic variables considered (with the possible exception of Tasmania), suggesting either that data limitations precluded us from detecting subtle effects or that Masked Lapwings have been little influenced or are resilient to changes in climate over most of their range.

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In situ neutron diffraction and Elasto-Plastic Self-Consistent (EPSC) polycrystal modelling have been employed to investigate which deformation mechanisms are involved in the plasticity of extruded AZ31 Mg alloy during the tensile loading along the extrusion direction. On the basis of this study we were able to determine the relative activity of the slip and twinning deformation modes. By tuning the parameters of the EPSC model (i.e. the critical resolved shear strengths and hardening parameters), excellent agreement with the experimental data has been achieved. It is shown that the strain in the crystallographic ⟨c ⟩direction is accommodated mainly by ⟨c + a ⟩ dislocation slip on second-order pyramidal planes. The results further indicate that either slip of ⟨a ⟩dislocations occurs on {10.1} pyramidal planes or cross-slip from basal and prismatic planes takes place.

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Volunteer non-major chemistry students, taking an introductory university chemistry course (n= 17) were interviewed about their understanding of a variety of chemical diagrams. All the students’ interviewed appreciated that diagrams of laboratory equipment were useful to show how to set up laboratory equipment. However students’ ability to explain specific diagrams at either the macroscopic or sub-microscopic level varied greatly. The results highlighted the poor level of understanding that some students had even after completing both exercises and experiments using the diagrams. The connection between the diagrams of the macroscopic level (equipment), the sub-microscopic level (molecular) and the symbolic level (equations) was not always apparent to students. The results indicate a need for chemical diagrams to be used carefully and more explicitly to ensure the learner understanding.

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Homeostasis in the intact organism is achieved implicitly by repeated incremental feedback (inhibitory) and feedforward (stimulatory) adjustments enforced via intermittent signal exchange. In separated systems, neurohormone signals act deterministically on target cells via quantifiable effector-response functions. On the other hand, in vivo interglandular signaling dynamics have not been estimable to date. Indeed, experimentally isolating components of an interactive network definitionally disrupts time-sensitive linkages. We implement and validate analytical reconstruction of endogenous effector-response properties via a composite model comprising (i) a deterministic basic feedback and feedforward ensemble structure; (ii) judicious statistical allowance for possible stochastic variability in individual biologically interpretable dose–response properties; and (iii) the sole data requirement of serially observed concentrations of a paired signal (input) and response (output). Application of this analytical strategy to a prototypical neuroendocrine axis in the conscious uninjected horse, sheep, and human (i) illustrates probabilistic estimation of endogenous effector dose–response properties; and (ii) unmasks statistically vivid (2- to 5-fold) random fluctuations in inferred target-gland responsivity within any given pulse train. In conclusion, balanced mathematical formalism allows one to (i) reconstruct deterministic properties of interglandular signaling in the intact mammal and (ii) quantify apparent signal-response variability over short time scales in vivo. The present proof-of-principle experiments introduce a previously undescribed means to estimate time-evolving signal-response relationships without isotope infusion or pathway disruption.

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Research over the last decade has shown that auditorily cuing the location of visual targets reduces the time taken to locate and identify targets for both free-field and virtually presented sounds. The first study conducted for this thesis confirmed these findings over an extensive region of free-field space. However, the number of sound locations that are measured and stored in the data library of most 3-D audio spatial systems is limited, so that there is often a discrepancy in position between the cued and physical location of the target. Sampling limitations in the systems also produce temporal delays in which the stored data can be conveyed to operators. To investigate the effects of spatial and temporal disparities in audio cuing of visual search, and to provide evidence to alleviate concerns that psychological research lags behind the capabilities to design and implement synthetic interfaces, experiments were conducted to examine (a) the magnitude of spatial separation, and (b) the duration of temporal delay that intervened between auditory spatial cues and visual targets to alter response times to locate targets and discriminate their shape, relative to when the stimuli were spatially aligned, and temporally synchronised, respectively. Participants listened to free-field sound localisation cues that were presented with a single, highly visible target that could appear anywhere across 360° of azimuthal space on the vertical mid-line (spatial separation), or extended to 45° above and below the vertical mid-line (temporal delay). A vertical or horizontal spatial separation of 40° between the stimuli significantly increased response times, while separations of 30° or less did not reach significance. Response times were slowed at most target locations when auditory cues occurred 770 msecs prior to the appearance of targets, but not with similar durations of temporal delay (i.e., 440 msecs or less). When sounds followed the appearance of targets, the stimulus onset asynchrony that affected response times was dependent on target location, and ranged from 440 msecs at higher elevations and rearward of participants, to 1,100 msecs on the vertical mid-line. If targets appeared in the frontal field of view, no delay of acoustical stimulation affected performance. Finally, when conditions of spatial separation and temporal delay were combined, visual search times were degraded with a shorter stimulus onset asynchrony than when only the temporal relationship between the stimuli was varied, but responses to spatial separation were unaffected. The implications of the results for the development of synthetic audio spatial systems to aid visual search tasks was discussed.