Microfluidic platforms for the investigation of intercellular signalling mechanisms

Intercellular signalling has been identified as a highly complex process, responsible for orchestrating many physiological functions. While conventional methods of investigation have been useful, their limitations are impeding further development. Microfluidics offers an opportunity to overcome some of these limitations. Most notably, microfluidic systems can emulate the in-vivo environments. Further, they enable exceptionally precise control of the microenvironment, allowing complex mechanisms to be selectively isolated and studied in detail. There has thus been a growing adoption of microfluidic platforms for investigation of cell signalling mechanisms. This review provides an overview of the different signalling mechanisms and discusses the methods used to study them, with a focus on the microfluidic devices developed for this purpose.

Comparative mobile platforms security solutions

 Mobile platform security solution has become especially important for mobile computing paradigms, due to the fact that increasing amounts of private and sensitive information are being stored on the smartphones' on-device memory or MicroSD/SD cards. This paper aims to consider a comparative approach to the security aspects of the current smartphone systems, including: iOS, Android, BlackBerry (QNX), and Windows Phone.

Social media conflict: platforms for racial vilification, or acts of provocation and citizenship?

Although racism remains an issue for social media sites such as YouTube, this focus often overshadows the site’s productive capacity to generate ‘agonistic publics’ from which expressions of cultural citizenship and solidarity might emerge. This paper examines these issues through two case studies: the recent proliferation of mobile phone video recordings of racist rants on public transport, and racist interactions surrounding the performance of a Maori ‘flash mob’ haka in New Zealand that was recorded and uploaded to YouTube. We contrast these incidents as they are played out primarily through social media, with the case of Australian Football League player Adam Goodes and the broadcast media reaction to a racial slur aimed against him by a crowd member during the AFL’s Indigenous Round. We discuss the prevalence of vitriolic exchange and racial bigotry, but also, and more importantly, the productive and equally aggressive defence of more inclusive and tolerant forms of cultural identification that play out across these different media forms. Drawing on theories of cultural citizenship along with the political theory of Chantal Mouffe, we point to the capacities of YouTube as ‘platform’, and to social media practices, in facilitating ground-up antiracism and generating dynamic, contested and confronting micropublics.

Service level agreement management framework for utility-oriented computing platforms

With the increasing popularity of utility-oriented computing where the resources are traded as services, efficient management of quality of service (QoS) has become increasingly significant to both service consumers and service providers. In the context of distributed multimedia content adaptation deployment on service-oriented computing, how to ensure the stringent QoS requirements of the content adaptation is a significant and immediate challenge. However, QoS guarantees in the distributed multimedia content adaptation deployment on service-oriented platform context have not been accorded the attention it deserves. In this paper, we address this problem. We formulate the SLA management for distributed multimedia content adaptation deployment on service-oriented computing as an integer programming problem. We propose an SLA management framework that enables the service provider to determine deliverable QoS before settling SLA with potential service consumers to optimize QoS guarantees. We analyzed the performance of the proposed strategy under various conditions in terms of the SLA success rate, rejection rate and impact of the resource data errors on potential violation of the agreed upon SLA. We also compared the proposed SLA management framework with a baseline approach in which the distributed multimedia content adaptation is deployed on a service-oriented platform without SLA consideration. The results of the experiments show that the proposed SLA management framework substantially outperforms the baseline approach confirming that SLA management is a core requirement for the deployment of distributed multimedia content adaptation on service-oriented systems.

Wave hazards on microtidal shore platforms : testing the relationship between morphology and exposure

Open-ocean rocky coasts are dangerous environments when there is a coincidence of recreational activities occurring in areas of high wave energy. Management of drowning fatalities and near-drowning incidents on these landforms is difficult as traditional approaches to beach safety cannot be easily transferred to rocky shores. In this study, we take a morphological approach to quantifying the relative danger of shore platforms in microtidal regions. Platform elevation and nearshore water depth are key variables in determining the likelihood of wave overtopping of the platform edge. The relationship between these variables is tested along a 70-km-long section of the Otway Ranges coast in Victoria, Australia. It is found that exposure is highly variable along short (100 m scale) sections of shore platforms. This variability is driven by the complexity of the nearshore morphology which can have metre-scale relief. As exposed platforms may occur in areas of low wave energy, the morphological exposure index is combined with nearshore wave energy to produce a risk rating. Risk, like exposure, was found to be highly spatially variable. The relationship between elevation and water depth has the potential to provide managers with a tool for assessing safety on rocky shores.