16 resultados para molecular Coulombic over barrier model
Filtro por publicador
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (2)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (7)
- Aquatic Commons (2)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (7)
- Aston University Research Archive (14)
- Biblioteca Digital - Universidad Icesi - Colombia (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (13)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (7)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (36)
- Bucknell University Digital Commons - Pensilvania - USA (3)
- CaltechTHESIS (6)
- Cambridge University Engineering Department Publications Database (9)
- CentAUR: Central Archive University of Reading - UK (46)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (56)
- Cochin University of Science & Technology (CUSAT), India (2)
- Collection Of Biostatistics Research Archive (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (4)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (16)
- Department of Computer Science E-Repository - King's College London, Strand, London (2)
- Digital Archives@Colby (1)
- Digital Commons @ DU | University of Denver Research (1)
- Digital Commons at Florida International University (4)
- DigitalCommons - The University of Maine Research (1)
- DigitalCommons@The Texas Medical Center (7)
- DigitalCommons@University of Nebraska - Lincoln (2)
- Diposit Digital de la UB - Universidade de Barcelona (1)
- Duke University (7)
- Düsseldorfer Dokumenten- und Publikationsservice (1)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (26)
- Glasgow Theses Service (1)
- Greenwich Academic Literature Archive - UK (3)
- Helda - Digital Repository of University of Helsinki (59)
- Indian Institute of Science - Bangalore - Índia (148)
- Instituto Politécnico de Leiria (1)
- Massachusetts Institute of Technology (2)
- Ministerio de Cultura, Spain (1)
- National Center for Biotechnology Information - NCBI (12)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (2)
- Publishing Network for Geoscientific & Environmental Data (7)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (48)
- Queensland University of Technology - ePrints Archive (290)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (1)
- Repositorio de la Universidad del Pacífico - PERU (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (45)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (2)
- SAPIENTIA - Universidade do Algarve - Portugal (1)
- Savoirs UdeS : plateforme de diffusion de la production intellectuelle de l’Université de Sherbrooke - Canada (1)
- Universidad de Alicante (1)
- Universidad del Rosario, Colombia (2)
- Universidad Politécnica de Madrid (4)
- Universidade Complutense de Madrid (2)
- Universidade de Lisboa - Repositório Aberto (1)
- Universidade Federal do Pará (2)
- Universitat de Girona, Spain (1)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (4)
- Université de Montréal, Canada (5)
- University of Michigan (8)
- University of Queensland eSpace - Australia (23)
- University of Washington (1)
Resumo:
OBJECTIVES: The detailed structure of brain-derived Aβ amyloid fibrils is unknown. To approach this issue, we investigate the molecular architecture of Aβ(1-40) fibrils grown in either human cerebrospinal fluid solution, in chemically simple phosphate buffer in vitro or extracted from a cell culture model of Aβ amyloid plaque formation. METHODS: We have used hydrogen-deuterium exchange (HX) combined with nuclear magnetic resonance, transmission electron microscopy, seeding experiments both in vitro and in cell culture as well as several other spectroscopic measurements to compare the morphology and residue-specific conformation of these different Aβ fibrils. RESULTS AND CONCLUSIONS: Our data reveal that, despite considerable variations in morphology, the spectroscopic properties and the pattern of slowly exchanging backbone amides are closely similar in the fibrils investigated. This finding implies that a fundamentally conserved molecular architecture of Aβ peptide fold is common to Aβ fibrils.