Potential antiarrhythmic and cardioprotective agents based on adenosine

N-Ethylcarboxamidoadenosine (12) was synthesised from adenosine (1) and the 6-chloro-2’,3’-O-isopropylidene-AT-ethylcarboxamidoadenosine (25) was synthesised from inosine (19). Employing molecular modelling techniques and the results from previous structure activity relationships it was possible to design and synthesise a N6-substituted N-ethylcarboxamidoadenosines which possessed an oxygen in the N6-substituent either in the form of an epoxide (which was obtained by cpoxidising an alkene with m-CPBA or dimethyldioxirane) or in the form of a cyclic ether as was the case for N6-((tetrahydro-2H--pyran--2-yl)methyl-N-ethylcarboxamidoadenosine (78). These compounds were tested for their biological activity at the A1 adenosine receptor by their ability to inhibit cAMP accumulation in DDT, MF2 cells. The EC50 values obtained indicated that the N6-(norborn-5-en-2-yl)-N-ethylcarboxamidoadenosines were the most potent. Of theseN6-(S-endo-norbrn-5-en-2-yI)-N-ethylcarboxaniidoadenosine (56) was the most potent (0.2 nM). N6-(exo-norborn-5-en-2-yl)-2-iodo-N-ethylcarboxamidoadenosine (79) was synthesised from guanosine (22) and was also evaluated for its potency at the A, receptor (24.8 ± 1.5 nM). At present 79 is being evaluated for its selectivity for the A1 receptor compared to the other three receptor subtypes (A2a, A2b, A3). A series of N6-(benzyl)-N-ethylcarboxamidoadenosines were synthesised with substitutions at the 4-position of the phenyl ring. Another series of compounds were synthesised which replaced the methylene spacer between the N6H and the N6-aromatic or lipophilic substituent The replacement groups -were carbonyl and trans-2- cyclopropyl moieties. The N6-acyl compounds were obtained by reacting 2’,3’-O- di(tert-butyldimethylsilyl)-AT-ethylcarboxamidoadenosinc (59) with the appropriate acid chloride and then deprotecting with lelrabutylammonium fluoride in tetrahydrofuran. The compound N6-(4-(1,2-dihydroxy)ethyl)benzyl-N- ethylcarboxamidoadenosine (125) was synthesised by the reaction of 4-(1,2-0- isopropylidene-ethyl)benzyl aminc (123) with 6-chloro-2,3-0-isopropylidene-N- ethylcarboxamidoadenosine (25). Compound 123 was synthesised from an epoxidation of vinylbenzyl phthalimide (118) followed by an acidic ring opening to yield the diol which was isopropylidenated to yield 4-(l,2-O-isopropylidene- elhyl)benzyl phlhalimide (122), It was hoped that the presence of the diol functionality in 125 would increase water solubility whilst maintaining potency at the A3 receptor.

The study into fault tolerance based on rollback-recovery for clusters

The provision of fault tolerance is an important aspect to the success of distributed and cluster computing. Through this research , a transparent, autonomic and efficient fault tolerant facility was designed and implemented; thereby relieving the burden of a user having to handle and react to the failure of an application.

Experiments with stochastic processes : facade subdivision based on wind motion

Constraint based tools for architectural design exploration need to satisfy aesthetic and functional criteria as well as combine discrete and continuous modes of exploration. In this paper, we examine the possibilities for stochastic processes in design space exploration.

Specifically, we address the application of a stochastic wind motion model to the subdivision of an external building envelope into smaller discrete components. Instead of deterministic subdivision constraints, we introduce explicit uncertainty into the system of subdivision. To address these aims, we develop a model of stochastic wind motion; create a subdivision scheme that is governed by the wind model and explore a design space of a facade subdivision problem. A discrete version of the facade, composed of light strips and panels, based on the bamboo elements deformed by continuous wind motion, is developed. The results of the experiments are presented in the paper.

Three dimensional stability charts for slopes based on limit analysis methods

This paper uses finite element upper and lower bound limit analysis to produce chart solutions for three-dimensional (3D) natural slopes for both short- and long-term stability. The presented chart solutions are convenient tools that can be used for preliminary design purposes. The rigorous limit analysis results in this paper were found to bracket the true factor of safety within ±10% or better, which can be used as a benchmark for the solutions from other methods. The depth of the slip surfaces is observed to be generally shallow for most analyzed cases, particularly for the long-term slope stability problem. In addition, it was found that using a two-dimensional (2D) analysis may lead to significant differences in estimating safety factors, which can differ by 2%–60% depending on the slope geometry and soil properties. Therefore, great care and judgement are required when applying 2D analyses to 3D slope problems.

A class of optimal fault tolerant Jacobian for minimal redundant manipulators based on symmetric geometries

Design of locally optimal fault tolerant manipulators has been recently addressed via using the constraints of the desired null space for the Jacobian matrix of the manipulators. In the present paper the Jacobian matrices for optimal fault tolerance are presented based on geometric properties of column vectors instead of the null space. They are equally fault tolerant to a single joint failure from the worst-case relative manipulability and worst-case dexterity points of view. The optimality is achieved through a symmetric distribution of points on spheres.

Driver recognition based on dynamic handgrip pattern on steeling wheel

This paper proposes a novel biometric authentication method based on the recognition of drivers' dynamic handgrip on steering wheel. A pressure sensitive mat mounted on a steering wheel is employed to collect handgrip data exerted by the hands of drivers who intend to start the vehicle. Then, the likelihood-ratio-based classifier is designed to distinguish rightful driver of a car after analyzing their inherent dynamic features of grasping. The experimental results obtained in this study show that mean acceptance rates of 85.4% for the trained subjects and mean rejection rates of 82.65% for the un-trained ones are achieved by the classifier in the two batches of testing. It can be concluded that the driver verification approach based on dynamic handgrip recognition on steering wheel is a promising biometric technology and will be further explored in the near future in smart car design.

Review of low actuation voltage RF MEMS electrostatic switches based on metallic and carbon alloys

Radio frequency micro electro mechanical systems (RF MEMS) have enabled a new generation of devices that bring many advantages due to their very high performances. There are many incentives for the integration of the RF MEMS switches and electronic devices on the same chip. However, the high actuation voltage of RF MEMS switches compared to electronic devices poses a major problem. By reducing the actuation voltage of the RF MEMS switch, it is possible to integrate it into current electronic devices. Lowering the actuation voltage will have an impact on RF parameters of the RF MEMS switches. This investigation focuses on recent progress in reducing the actuation voltage with an emphasis on a modular approach that gives acceptable design parameters. A number of rules that should be considered in design and fabrication of low actuation RF MEMS switches are suggested.

Project-oriented design-based learning: aligning students’ views with industry needs

This paper focuses on the alignment of students' views on project-oriented design-based learning (PODBL) with today's industrial needs. A Collaborative relationship between academic institutions and industrial expectations is a significant process towards analytical thinking (linking the theory and practice). Improving students' knowledge as well as the students' transition into industry, requires efficient joint ventures by both learning institutions and industry partners. Project-based learning (PBL) is well developed and implemented in most engineering schools and departments around the world. What requires closer attention is the focus on design within this project-based learning framework. Today design projects have been used to motivate and teach science in elementary, middle, and high school classrooms. They are also used to assist students with possible science and engineering careers. For these reasons, design-based learning (DBL) is intended to be an effective approach to learning that is centered on a design problem-solving structure adopted for a problem-oriented project-based education. Based on an industry design forum, which the authors conducted in Melbourne, Australia in 2012, a research study was performed to investigate the industry and academic requirements for students focusing on achieving design skills. To transform the present situation in the academic teaching and learning environment and to fulfill industry needs, this research study also investigated the students' views on design skills.

Project oriented design based learning – staff perspectives

The focus of this paper is to get staff perception on design based learning in their respective disciplines and how they could be aligned to the newly proposed model, in project oriented design based learning (PODBL). In academia, students and staff are supposed to work together in order to achieve a balanced learning and teaching process. By using different teaching and learning approaches, teachers are aware of escalating the student knowledge to fulfill current technology needs. This paper is part of a continuing process of a research project, which analyses better teaching and learning approaches in engineering. As part of this research, face-to-face interviews with staff members of the school of engineering in Deakin University who are teaching engineering design were conducted. The interview questions are based on
qualitative analysis. The questions covered here are designed to determine the staff level of experience from teaching engineering using design based learning approach as an educational model. From the analysed results, this research encourages the school to practice a unique pedagogy that will accomplish the students learning outcomes.

Technology integration in project oriented design based learning for distance education

Technology plays critical role in delivering modern education to the next generation. Proper and effective use of technology is extremely important especially for distance education. Students who enroll in distance mode have a number of limitations as most of them work full time along with the commitments to the family. This paper discusses technology integration for the distance students based on the Project Oriented Design Based Learning.

Integration of cloud based learning in project oriented design based learning

The School of Engineering at Deakin University has been practicing design based learning as one of its engineering learning principles for further development in the learning and teaching process. It has been exploring the student and industry perspectives in this regards and has embarked in the development of a new framework for a project oriented design based learning approach for the development of the engineering curriculum. Along with this change in the engineering curriculum Deakin University also has been going through a major change in the delivery of education. The policy shift has been initiated through Live the Future: Agenda 2020 which focusses on Cloud and Located Learning. This change in policy has had an impact on delivery framework for the project oriented design based learning model which has been incorporated through the use of lecture videos, a learning management system called Cloud Deakin and online tutorials through the eLive system.

Segmenting Australian online panellists based on volunteering motivations

Purpose– The purpose of this paper is to seek to assess whether online commercial panel volunteering can be segmented based on their motivations, using the volunteer functions inventor. The authors also investigate whether segments exist which differ in demographic characteristics.Design/methodology/approach– The authors survey 484 Australian online panel volunteers using a adapted version of the 30 item of the volunteer function inventory (VFI) scale developed by Clary et al. (1998). Data were analysed using confirmatory factor analysis (CFA) and cluster analysis, as well as ANOVA and χ2 test comparisons of demographics between clusters.Findings– CFA verifies that the VFI scale is suitable instrument to gauge online participants’ motivations. Cluster analysis produced a five-cluster solution, where respondents with low motivations overall comprised the largest grouping. Segments are interpreted by assessing the difference between the total sample average and the segment profile. The examination also identifies that the only demographic factor that varies across the five clusters is “respondents” employment status”.Research limitations/implications– Future research could explore if differences in segments result in differences in online participation. The high number or respondents with low motivations may explain the relatively high levels of churn that take place within online panels and as a result panel operators would need to continually attract new members. Further research could also investigate whether the levels of motivation change over time and if so what effect such variation would produce on respondents’ retention.Originality/value– Research on online panel respondents’ motivation is still limited and investigating online panellists’ motivation as volunteers is very important as it unveils, as in the study herein reported, that alternative types of respondents may be driven by different factors when joining an online panel (or completing a given survey). Recruitment strategies could, therefore, be shaped to suit the motivation of the different segments. By refining the matching between volunteers’ profiles and their motivation, managers could improve how volunteers are recruited, managed and retained.

A universal optimization strategy for ant colony optimization algorithms based on the Physarum-inspired mathematical model

Ant colony optimization (ACO) algorithms often fall into the local optimal solution and have lower search efficiency for solving the travelling salesman problem (TSP). According to these shortcomings, this paper proposes a universal optimization strategy for updating the pheromone matrix in the ACO algorithms. The new optimization strategy takes advantages of the unique feature of critical paths reserved in the process of evolving adaptive networks of the Physarum-inspired mathematical model (PMM). The optimized algorithms, denoted as PMACO algorithms, can enhance the amount of pheromone in the critical paths and promote the exploitation of the optimal solution. Experimental results in synthetic and real networks show that the PMACO algorithms are more efficient and robust than the traditional ACO algorithms, which are adaptable to solve the TSP with single or multiple objectives. Meanwhile, we further analyse the influence of parameters on the performance of the PMACO algorithms. Based on these analyses, the best values of these parameters are worked out for the TSP.

Slope stability charts for two-layered purely cohesive soils based on finite-element limit analysis methods

Stability charts for soil slopes, first produced in the first half of the twentieth century, continue to be used extensively as design tools, and draw the attention of many investigators. This paper uses finite-element upper and lower bound limit analysis to assess the short-term stability of slopes in which the slopematerial and subgrade foundation material have two distinctly different undrained strengths. The stability charts are proposed, and the exact theoretical solutions are bracketed to within 4.2% or better. In addition, results from the limit-equilibrium method (LEM) have been used for comparison. Differences of up to 20% were found between the numerical limit analysis and LEM solutions. It also shown that the LEM sometimes leads to errors, although it is widely used in practice for slope stability assessments.

A shadow-like task migration model based on context semantics for mobile and pervasive environments

Pervasive computing is a user-centric mobile computing paradigm, in which tasks should be migrated over different platforms in a shadow-like way when users move around. In this paper, we propose a context-sensitive task migration model that recovers program states and rebinds resources for task migrations based on context semantics through inserting resource description and state description sections in source programs. Based on our model, we design and develop a task migration framework xMozart which extends the Mozart platform in terms of context awareness. Our approach can recover task states and rebind resources in the context-aware way, as well as support multi- modality I/O interactions. The extensive experiments demonstrate that our approach can migrate tasks by resuming them from the last broken points like shadows moving along with the users.