Evaluation of a community pharmacy-based intervention for improving patient adherence to antihypertensives: a randomised controlled trial

Background
The majority of patients using antihypertensive medications fail to achieve their recommended target blood pressure. Poor daily adherence with medication regimens and a lack of persistence with medication use are two of the major reasons for failure to reach target blood pressure. There is no single intervention to improve adherence with antihypertensives that is consistently effective. Community pharmacists are in an ideal position to promote adherence to chronic medications. This study aims to test a specific intervention package that could be integrated into the community pharmacy workflow to enable pharmacists to improve patient adherence and/or persistence with antihypertensive medications - Hypertension Adherence Program in Pharmacy (HAPPY).

Methods/Design
The HAPPY trial is a multi-centre prospective randomised controlled trial. Fifty-six pharmacies have been recruited from three Australian states. To identify potential patients, a software application (MedeMine CVD) extracted data from a community pharmacy dispensing software system (FRED Dispense®). The pharmacies have been randomised to either 'Pharmacist Care Group' (PCG) or 'Usual Care Group' (UCG). To check for 'Hawthorne effect' in the UCG, a third group of patients 'Hidden Control Group' (HCG) will be identified in the UCG pharmacies, which will be made known to the pharmacists at the end of six months. Each study group requires 182 patients. Data will be collected at baseline, three and six months in the PCG and at baseline and six months in the UCG. Changes in patient adherence and persistence at the end of six months will be measured using the self-reported Morisky score, the Tool for Adherence Behaviour Screening and medication refill data.

Discussion
To our knowledge, this is the first research testing a comprehensive package of evidence-based interventions that could be integrated into the community pharmacy workflow to enable pharmacists to improve patient adherence and/or persistence with antihypertensive medications. The unique features of the HAPPY trial include the use of MedeMine CVD to identify patients who could potentially benefit from the service, control for the 'Hawthorne effect' in the UCG and the offer of the intervention package at the end of six months to patients in the UCG, a strategy that is expected to improve retention.

Trial Registration
Australian New Zealand Clinical Trial Registry ACTRN12609000705280

Effects of snow cover on the timing and success of reproduction in high-Arctic pink-footed geese Anser brachyrhynchus

During four breeding seasons, 2003–2006, we studied the relationship between snow cover and nesting performance in pink-footed geese (Anser brachyrhynchus) in a key breeding site on Svalbard. Snow cover in late May, i.e., at the time of egg laying of geese, was derived from MODIS satellite images. Snow cover had a profound cascading effect on reproductive output via the number of nesting pairs and timing of nesting, which affected nest success, while there was only a tendency for a negative effect on clutch size. Hence, we estimated a five-fold difference in the number of young produced (to post-hatching) between years with little snow and years with high snow cover. The results from the study area correlated with whole-population productivity estimates recorded in autumn. Thus, snow cover derived from MODIS satellite images appears to provide a useful indicator of the breeding conditions in the Arctic.

A novel palladium-catalysed approach to functionalised N-heterocycles

The efficient preparation of molecules used as pharmaceutical treatments is highly sought after. This thesis details the development of a new, rapid and efficient method for the synthesis of molecular scaffolds which results in a reduction in the time, money, effort and the generation of waste during the synthetic process.

Geeks and nerds : computers, gender and the mathematics classroom

This paper presents some of the findings of a pilot study concerning gender differences in behaviour in a Year 10 co- educational secondary mathematics classroom that used computers. Analysis of interactions between students and the teacher and engagement with the task, the computer and the mathematics suggest some evidence of gender difference. A number of factors were hypothesised as relating to behaviour and this paper discusses the preliminary findings in relation to students' experience with computers and their style of interaction with computers.

Automatic labeling of sports video using umpire gesture recognition

We present results on an extension to our approach for automatic sports video annotation. Sports video is augmented with accelerometer data from wrist bands worn by umpires in the game. We solve the problem of automatic segmentation and robust gesture classification using a hierarchical hidden Markov model in conjunction with a filler model. The hierarchical model allows us to consider gestures at different levels of abstraction and the filler model allows us to handle extraneous umpire movements. Results are presented for labeling video for a game of Cricket.

Content structure discovery in educational videos using shared structures in the hierarchical hidden Markov models

In this paper, we present an application of the hierarchical HMM for structure discovery in educational videos. The HHMM has recently been extended to accommodate the concept of shared structure, ie: a state might multiply inherit from more than one parents. Utilising the expressiveness of this model, we concentrate on a specific class of video -educational videos - in which the hierarchy of semantic units is simpler and clearly defined in terms of topics and its subunits. We model the hierarchy of topical structures by an HHMM and demonstrate the usefulness of the model in detecting topic transitions.

Learning people movement model from multiple cameras for behaviour recognition

In surveillance systems for monitoring people behaviours, it is important to build systems that can adapt to the signatures of people's tasks and movements in the environment. At the same time, it is important to cope with noisy observations produced by a set of cameras with possibly different characteristics. In previous work, we have implemented a distributed surveillance system designed for complex indoor environments [1]. The system uses the Abstract Hidden Markov mEmory Model (AHMEM) for modelling and specifying complex human behaviours that can take place in the environment. Given a sequence of observations from a set of cameras, the system employs approximate probabilistic inference to compute the likelihood of different possible behaviours in real-time. This paper describes the techniques that can be used to learn the different camera noise models and the human movement models to be used in this system. The system is able to monitor and classify people behaviours as data is being gathered, and we provide classification results showing the system is able to identify behaviours of people from their movement signatures.

Elaborative relational structures in the research prose of sociology : an intercultural study

This paper investigates elaborative relational structures utilised by native English speaking and native Polish speaking scholars in sociology research articles written in English. The examined texts have been produced in American, Australian and Polish academic discourse communities. The study utilised the framework of the analysis of the rhetorical structure of tests (FARS) as an analytical tool (Golebiowski 2009, 2011). The following types of elaboration relations are discussed : amplification, extension, reformulation, explanation, instantiation and addition. Elaboration is analysed with respect to its textual function, frequency of employment, hierarchical location, recursiveness, discoursal prominence and explicitness. The elaborative systems in the examined texts are shown to be complex, with pervasive presence of multi-stage recursive structures. It is suggested that elaborativeness may be a general characteristic of the style of writing sociology, which, as a relatively new discipline, requires establishing of wide grounds for the proposed claims, where writers persuade their readers not only of the specific claims of their text, but also of frameworks of thought in which the claims are placed. It is hypothesized that the similarities in the elaborativeness across texts result from the shared stylistic conventions and traditions of the disciplinary research community of sociology, while differences in the mode of employment of elaboration relations are attributed to cultural norms and conventions as well as educational systems prevailing within the discourse communities constituting the social contexts of the studied texts.
Golebiowski, Z. (2011). Scholarly criticism across discourse communities. In Salager-Meyer, Françoise and Lewin, Beverly A. (eds), Crossed words : Criticism in scholarly writing, pp. 203-224, Peter Lang International Academic Publishers, Berlin, Germany.
Golebiowski Z. (2009). The use of contrastive strategies in a sociology research paper: A cross-cultural study. In Suomela-Salmi, Eija and Dervin, Fred (eds), Cross-linguistic and cross-cultural perspectives on academic discourse, pp. 165-186, John Benjamins Publishing Company, Philadelphia.

Synthesis of flavonoids and flavonoid-based designed multiple ligands for hypertension

The flavonoids, a family of compounds found in nature, possess a wealth of established health benefits. In this research, a library of novel flavonoid compounds was synthesised for therapeutic evaluation. A particular focus was the attachment of 3ʹ,4ʹ-dihydroxyflavonol, an antioxidant and antihypertensive flavonoid, to other known antihypertensives, to provide dual action compounds for the treatment of hypertension.

Furphy as (metafictive) Aboriginal ethnographer

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How ready are you? A preliminary investigation into the workplace readiness of final-year education students at a regional university

One criticism of teacher-training programs is that they do not sufficiently prepare graduating teachers for the transition between higher education and the demands and practicalities of classroom teaching. This lack of workplace readiness or 'teacher ready' status of graduates has been attributed to insufficient pre-service practical experience and the failure of training programs to adequately coach pre-service teachers in the delivery of quality pedagogy (Nelson, 2005). On the other hand, the Australian Council of Deans of Education (2005, p. 3) argues that teacher-training programs should provide foundational knowledge and skills with the onus on the profession to build on these foundations and elevate the teacher 'to the point of full and complete practitioner-readiness'. Central Queensland University has tried to respond to these concerns through the introduction of the Bachelor of Learning Management. This paper reports on a preliminary investigation into the perceived strengths and weaknesses of the program in preparing graduates and enabling workplace readiness. Towards the end of 2005 a cohort of final year students was asked to identify their levels of confidence in the transition from university to work; and how the cohort could have been better prepared. It is intended that the issues identified will be translated into recommendations for future program improvements.

Global forms and local forces : PhD enrollments and graduations in Australia, Canada, the Czech Republic, the United Kingdom, and the United States

 This chapter presents and discusses data from five different nations—Australia, Canada, the Czech Republic, the United Kingdom, and the United States—on doctoral candidates and graduates. These data are from governmental and institutional sources for the years 1998–2004, a sample that enables changes across a five-year span to be identified. They span important basic characteristics, such as gender, age, discipline, and study load (that is, full-time or part-time study). Therefore, readers can see national as well as international trends and differences in such characteristics and can match these to equivalent and/or contemporary data in their own nations. The five countries considered here are among those whose data were discussed at the 2007 CIRGE research synthesis meeting in Australia. Although these countries are not universally representative of doctoral education, their practices do offer a vivid sense of how vastly the enterprise of doctoral education differs in its scope and dimensions around the world

A novel approach to priority-setting for HIV prevention among adults in Uganda

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