A question of self-preservation : immunopathology in influenza virus infection

Influenza A viruses that circulate normally in the human population cause a debilitating, though generally transient, illness that is sometimes fatal, particularly in the elderly. Severe complications arising from pandemic influenza or the highly pathogenic avian H5N1 viruses are often associated with rapid, massive inflammatory cell infiltration, acute respiratory distress, reactive hemophagocytosis and multiple organ involvement. Histological and pathological indicators strongly suggest a key role for an excessive host response in mediating at least some of this pathology. Here, we review the current literature on how various effector arms of the immune system can act deleteriously to initiate or exacerbate pathological damage in this viral pneumonia. Generally, the same immunological factors mediating tissue damage during the anti-influenza immune response are also critical for efficient elimination of virus, thereby posing a significant challenge in the design of harmless yet effective therapeutic strategies for tackling influenza virus.

Sound absorption characteristics of a precast panel system made from environmentally sustainable concrete

This paper investigates the sound absorption characteristics of a precast panel system made from an environmentally sustainable concrete which can be used as an acoustical material. A current research project undertaken at the School of Architecture and Building, Deakin University, aims at utilising alternative materials and innovative approach to concrete precasting in the production of architecturally pleasing concrete panels. The normal incidence sound absorption coefficients of the assemblies were measured using an impedance tube. In general, the peak frequencies reduced with increasing thickness of concrete. The preliminary results indicate that the sound absorption of a three-layer variation of the panel meet design specifications related to acoustic performance. The major benefits of this investigated approach to concrete and concrete precasting are the ease of tunability to specific peak frequency, improved aesthetics and utilisation of industrial waste.

Environmentally friendly sound absorbing noise barrier made from concrete waste - further developments

This paper reports on the second phase of a research project aimed at the development of an environmentally friendly noise barrier for urban freeways, also known as KMAK [1]. The concrete barrier, which has some unique capabilities to mitigate transportation noise, is made from recycled concrete (RC) aggregate and industrial by-products such as fly ash and reclaimed water. The current developmental work expands on a research project that resulted in a two-layer (2L) concrete barrier. Two prototypes of the 2L barrier were produced, followed by extensive acoustic testing and a number of simulations where standard timber and/or concrete barriers were substituted with KMAK barrier [2]. Current research investigates a variety of architectural finishes applied to the original KMAK barrier with the aim of improving its visual appearance and also fine-tuning its acoustic performance. The new three-layer (3L) barrier optimizes sound absorption in a frequency range characteristic similar to that of transportation noise, especially road traffic noise. Three major aspects related to the development of architectural finishes were considered; environmentally responsible materials, surface features, and production methods. The findings of the current investigation demonstrate that there is a positive correlation between surface features, percentage of perforation as well as depth of the architectural layer, and increased potential of the 3L barrier to mitigate transportation noise. On average, the addition of perforated architectural finish contributes to a 20% increase in sound absorption. The preliminary results also show that the sound absorbency of the 3L barrier can be better controlled and tuned to specific noise frequency than the 2L type. The visual appearance has been significantly improved with the addition of the architectural finish, which makes the barrier an attractive, feasible, and viable alternative to road barriers made from standard concrete or timber.

Managing industrial world heritage sites : preservation, presentation and sustainability

This thesis uses case study methodology to explore how the concept of sustainable development is being applied at industrial World Heritage sites. The thesis proposes a model of sustainable heritage management that is relevant to industrial heritage sites, as well as to other complex heritage sites, including historic urban landscapes.

Systemic apomorphine alters HPA axis responses to interleukin-1β adminstration but not sound stress

Apomorphine is a dopamine receptor agonist that was recently licensed for the treatment of erectile dysfunction. However, although sexual activity can be stressful, there has been little investigation into whether treatments for erectile dysfunction affect stress responses. We have examined whether a single dose of apomorphine, sufficient to produce penile erections (50 μg/kg, i.a.), can alter basal or stress-induced plasma ACTH levels, or activity of central pathways thought to control the hypothalamic-pituitary-adrenal axis in rats. An immune challenge (interleukin-1β, 1 μg/kg, i.a.) was used as a physical stressor while sound stress (100 dB white noise, 30 min) was used as a psychological stressor. Intravascular administration of apomorphine had no effect on basal ACTH levels but did substantially increase the number of Fos-positive amygdala and nucleus tractus solitarius catecholamine cells. Administration of apomorphine prior to immune challenge augmented the normal ACTH response to this stressor at 90 min and there was a corresponding increase in the number of Fos-positive paraventricular nucleus corticotropin-releasing factor cells, paraventricular nucleus oxytocin cells and nucleus tractus solitarius catecholamine cells. However, apomorphine treatment did not alter ACTH or Fos responses to sound stress. These data suggest that erection-inducing levels of apomorphine interfere with hypothalamic-pituitary-adrenal axis inhibitory feedback mechanisms in response to a physical stressor, but have no effect on the response to a psychological stressor. Consequently, it is likely that apomorphine acts on a hypothalamic-pituitary-adrenal axis control pathway that is unique to physical stressors. A candidate for this site of action is the nucleus tractus solitarius catecholamine cell population and, in particular, A2 noradrenergic neurons.

Affect computing in film through sound energy dynamics

We develop an algorithm for the detection and classification of affective sound events underscored by specific patterns of sound energy dynamics. We relate the portrayal of these events to proposed high level affect or emotional coloring of the events. In this paper, four possible characteristic sound energy events are identified that convey well established meanings through their dynamics to portray and deliver certain affect, sentiment related to the horror film genre. Our algorithm is developed with the ultimate aim of automatically structuring sections of films that contain distinct shades of emotion related to horror themes for nonlinear media access and navigation. An average of 82% of the energy events, obtained from the analysis of the audio tracks of sections of four sample films corresponded correctly to the proposed affect. While the discrimination between certain sound energy event types was low, the algorithm correctly detected 71% of the occurrences of the sound energy events within audio tracks of the films analyzed, and thus forms a useful basis for determining affective scenes characteristic of horror in movies.

Social identity and sound change : the case of Wo in Shanghainese

Research has shown that language change is driven on one hand by forces internal to language itself such as grammar-internal systematic pressure, and on the other hand by social motives such as social identity. Language contact presents new features, but why is it that some of them are incorporated as variation and evolving into language change, while others are not? This paper reports a study on a sound change in Shanghainese, a dialect of the Chinese language. Data were collected in natural contexts of conversation followed by a brief interview with informants to gain identity related information about them. It has found that previously negative perception of status attached to a new sound induced by language/dialect contact changed into a positive perception, and people started to identify positively with this new sound. Further, there were differences in various different age and gender groups in taking up the new sound. As a result, this sound has evolved from a nonnative alternative to a systematic variation and it is being established as a sound change. This study has thus further confirmed that social identity plays a pivotal role in driving language features into language variation and language change.

Preservation of confucian values in early childhood education : a study of experts’ and educators’ views

Confucian values form the core of the Chinese culture, penetrating all levels of social life, and also set the standards for family, community and political behavior. The teaching of values is deemed to be an important aspect of young children’s education and usually the responsibility for this is seen to rest with the family. Much interest has been generated recently on the teaching of core values in early childhood curriculum in order to encourage tolerance, acceptance, trust, openness, and honesty in children. Research on Confucianism is popularly conducted in different cultural contexts all over the world. Furthermore research has shown that Confucianism continues to exert a major influence on the everyday lives of Asian communities. Given the interest in Confucian values, this research study was designed to examine the expressed views of three cohorts of professionals in Hong Kong about the preservation of such values and their application to early childhood teaching. This study confirmed the view that there is a need to preserve cultural values to enable the child to be accepted in the society, especially with the value of ‘Ren’ helping one to learn how to interact with others and with the value of ‘Li’ further defining the appropriate behaviour in this interaction.