POEM, A 3-dimensional exon taxonomy and patterns in untranslated exons

Background: The existence of exons and introns has been known for thirty years. Despite this knowledge, there is a lack of formal research into the categorization of exons. Exon taxonomies used by researchers tend to be selected ad hoc or based on an information poor de-facto standard. Exons have been shown to have specific properties and functions based on among other things their location and order. These factors should play a role in the naming to increase specificity about which exon type(s) are in question.

Results: POEM (Protein Oriented Exon Monikers) is a new taxonomy focused on protein proximal exons. It integrates three dimensions of information (Global Position, Regional Position and Region), thus its exon categories are based on known statistical exon features. POEM is applied to two congruent untranslated exon datasets resulting in the following statistical properties. Using the POEM taxonomy previous wide ranging estimates of initial 5' untranslated region exons are resolved. According to our datasets, 29–36% of genes have wholly untranslated first exons. Untranslated exon containing sequences are shown to have consistently up to 6 times more 5' untranslated exons than 3' untranslated exons. Finally, three exon patterns are determined which account for 70% of untranslated exon genes.

Conclusion: We describe a thorough three-dimensional exon taxonomy called POEM, which is biologically and statistically relevant. No previous taxonomy provides such fine grained information and yet still includes all valid information dimensions. The use of POEM will improve the accuracy of genefinder comparisons and analysis by means of a common taxonomy. It will also facilitate unambiguous communication due to its fine granularity

What do general practitioners think depression is? A taxonomy of distress and depression for general practice

Objective:
To create a taxonomy of distress and depression for use in primary care, that mirrors the thinking and practice of experienced general practitioners.

Design:
Qualitative study, using an ethnomethodological approach, with observation of videotaped routine GP–patient consultations and in-depth interviews with GPs.

Setting and participants:
The study was conducted in metropolitan Melbourne in 2005. Fourteen GPs conducted 36 patient consultations where depression was a focus; nine GPs participated in in-depth interviews to elicit details of how they recognised and diagnosed depression in their patients.

Results:
GPs consider distress and depression in three steps. In the first step, a change in a group of symptoms and signs is observed (eg, facial expression, loss of drive). The second step categorises the syndrome according to whether or not there is an identifiable environmental cause (reactive or “endogenous”), with the final step categorising the reactive syndromes according to their most prominent symptoms: either anxiety and worry, or helplessness and hopelessness. The resulting taxonomy includes: endogenous depression (a chronic and perhaps characterological depression characterised by a lack of interest and motivation); anxious depressive reaction (stress or worry); and hopeless depressive reaction (demoralisation).

Conclusion:
This simple and parsimonious taxonomy has validity based on its derivation from within the primary care setting.

A strategy taxonomy for foreign direct investment in China

Taxonomies explaining internationalisation strategy are effective in relating connected variables to the decisionmaking process and entry mode strategies of organisations. Almost no taxonomies for entry modes into China exist, where the local conditions affecting entry are significantly different to those in other countries have been developed. The taxonomy developed in this paper from research into 40 Australian companies which had successfully and unsuccessfully internationalised into China identified resource transferability and international experience as connected variables that can categorise the factors of entry choice. High levels of resource transferability lead to contracting partnerships or wholly owned foreign enterprises. Low levels led to importing or joint ventures. High levels of international experience led to wholly-owned foreign enterprises or joint ventures. Low levels led to contracting partnerships or importing. The factors that drive these decisions were developed using a framework of resource-based view constructs, supporting the application of the resource-based view to internationalisation strategy.

An international strategy taxonomy for entry into China

Taxonomies explaining internationalisation strategy are effective in relating connected variables to the decision-making process and entry mode strategies of organisations. The taxonomy developed in this paper from research into 40 Australian companies which had successfully and unsuccessfully internationalised into China identified resource transferability and international experience as connected variables that can categorise the factors of entry choice. High levels of resource transferability lead to joint ventures or wholly-owned foreign enterprises. Low levels led to exporting/importing or project/client based/licensing. High levels of international experience led to wholly-owned foreign enterprises or joint ventures. Low levels led to project/client based/licensing or exporting/importing.

A preliminary taxonomy of crowdsourcing

Many firms are now asking how they can benefit from the new form of outsourcing labelled “crowdsourcing”. Like many other forms of outsourcing, crowdsourcing is now being “talked up” by a somewhat credulous trade press. However, the term crowdsourcing has been used to describe several related, but different phenomena, and what might be successful with one form of crowdsourcing may not be with another. In this paper the notion of crowdsourcing is decomposed to create a taxonomy that expands our understanding of what is meant by the term. This taxonomy focuses on the different capability levels of crowdsourcing suppliers; different motivations; and different allocation of benefits. The management implications of these distinctions are then considered in light of what we know about other forms of outsourcing.

Siro and solo spinning

This chapter describes two modifications made to the conventional ring spinning technology, termed Sirospun™ and Solospun™, which were primarily aimed at significantly reducing the production cost of fabrics. Both were invented at CSIRO in Australia, hence the name ‘Siro’ spinning. The properties of Sirospun and Solospun yarns are different from those of conventional ring-spun yarns and this has opened new market opportunities.

Social commerce activities – a taxonomy

In recent years businesses large and small have jumped on the Social Commerce bandwagon, all in the hope of utilising social media services to facilitate various Social Commerce activities. Given the growing influence of social media on social, economic and political events globally, the rise in business interest in Social Commerce is not unexpected. This paper examines the Social Commerce activities of several Fortune 500 businesses. It analyses and categorises how businesses utilise social media to interact with customers, trading partners, employees and other important stakeholders. Two important themes have emerged, firstly, businesses utilise social media services mostly to facilitate Pre- and Post-transactional type Social Commerce activities such as marketing and customer support. Opportunities exist for businesses to leverage social media for transactional type Social Commerce activities such as purchase, payment, and order-fulfilment. Secondly, the business use of social media seems haphazard. Stakeholders wishing to succeed in Social Commerce will have to reformulate their strategies to take advantage of how users behave on social media services and opportunities to draw synergy from utilising an assortment of social media services. The paper contributes to theory by developing a taxonomy of Social Commerce activities. It contributes to practice by highlighting opportunities to engage in Social Commerce activities, in particular, to leverage opportunities from implementing Transactional Social Commerce.

Representação espacial na cognição ambiental urbana : aspectos de uso do solo e presença social

In the present paper different representations of urban character that influence environmental cognition are tested. Two main features involved in urban identity are the functional and social aspects of urban environment. Land use of lots is aggregated into different intensity measures that explore functional characterization of urban spaces. Social presence related to residential use and movement in urban space are also evaluated by intensity and social-economic characteristics. All selected attributes come from normal governmental data bases. Thus, one of the challenges is to transpose/interchange data from different scale units into a unique spatial representation unit, creating a common spatial base in a GIS environment.

Alight (piano solo) BEAUTIFUL and LONGING

A composition written on the piano; a light, elegant and beautiful journey.

Online learning environment : taxonomy of asynchronous online discussion forums

Due to its perceived benefits, asynchronous discussion forums have become progressively popular in higher education. The ultimate goal of developing an asynchronous discussion forum is to create an online learning environment that will achieve high levels of learning. This paper reviews the exiting literature and develops taxonomy of the asynchronous discussion forums with the aims of increasing the understanding and awareness of various types of asynchronous discussion forums. The taxonomy will help increase the online course designers' ability to design more effective learning experiences for student success and satisfaction. It will also help researchers to understand the features of the various asynchronous discussion forums.