Transfer learning using the online Fuzzy Min-Max neural network

In this paper, we present an empirical analysis on transfer learning using the Fuzzy Min–Max (FMM) neural network with an online learning strategy. Three transfer learning benchmark data sets, i.e., 20 Newsgroups, WiFi Time, and Botswana, are used for evaluation. In addition, the data samples are corrupted with white Gaussian noise up to 50 %, in order to assess the robustness of the online FMM network in handling noisy transfer learning tasks. The results are analyzed and compared with those from other methods. The outcomes indicate that the online FMM network is effective for undertaking transfer learning tasks in noisy environments.

Working hours in supply chain Chinese and Thai factories: evidence from the fair labor association's 'soccer project'

This article examines the determinants of working excessive hours, defined as working in excess of 60 hours per week or for more than six consecutive days, in Chinese and Thai supply chain factories. We use a matched employer-employee dataset collected from 15 Chinese and Thai footwear and sporting apparel supply chain factories, which supply international brands. Matched employer-employee data allow us to examine the effect of worker and firm characteristics on hours worked. We find that in addition to the demographic and human capital characteristics of workers, firm-level characteristics and worker awareness of how to refuse overtime are important in explaining variation in hours worked. © John Wiley & Sons Ltd/London School of Economics 2011.

Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids.

Previous efforts in the prospective evaluation of individuals who experience attenuated psychotic symptoms have attempted to isolate mechanisms underlying the onset of full-threshold psychotic illness. In contrast, there has been little research investigating specific predictors of positive outcomes. In this study, we sought to determine biological and clinical factors associated with treatment response, here indexed by functional improvement in a pre-post examination of a 12-week randomized controlled intervention in individuals at ultra-high risk (UHR) for psychosis. Participants received either long-chain omega-3 (ω-3) polyunsaturated fatty acids (PUFAs) or placebo. To allow the determination of factors specifically relevant to each intervention, and to be able to contrast them, both treatment groups were investigated in parallel. Univariate linear regression analysis indicated that higher levels of erythrocyte membrane α-linolenic acid (ALA; the parent fatty acid of the ω-3 family) and more severe negative symptoms at baseline predicted subsequent functional improvement in the treatment group, whereas less severe positive symptoms and lower functioning at baseline were predictive in the placebo group. A multivariate machine learning analysis, known as Gaussian Process Classification (GPC), confirmed that baseline fatty acids predicted response to treatment in the ω-3 PUFA group with high levels of sensitivity, specificity and accuracy. In addition, GPC revealed that baseline fatty acids were predictive in the placebo group. In conclusion, our investigation indicates that UHR patients with higher levels of ALA may specifically benefit from ω-3 PUFA supplementation. In addition, multivariate machine learning analysis suggests that fatty acids could potentially be used to inform prognostic evaluations and treatment decisions at the level of the individual. Notably, multiple statistical analyses were conducted in a relatively small sample, limiting the conclusions that can be drawn from what we believe to be a first-of-its-kind study. Additional studies with larger samples are therefore needed to evaluate the generalizability of these findings.

Photoinduced reversible shape conversion of silver nanoparticles assisted by TiO₂.

Silver nanoprisms were transformed into nanodecahedra through photoinduction of ultraviolet (UV) light in the presence of titanium dioxide (TiO2) quantum dots (QDs). Subsequently, the silver nanodecahedra were reconverted to silver nanoprisms under sodium lamp if there was sufficient citrate in the reaction system. The localized surface plasmon resonance (LSPR) optical properties of silver nanoparticles were tuned during photoinduced shape conversion. The photocatalytic activity of TiO2 QDs assisted the conversion of prisms to decahedra upon UV light irradiation. Nevertheless, the presence of TiO2 did not inhibit the photoinduced reconversion from decahedra to prisms by sodium light. It was demonstrated that citrate was indispensable in the photoinduction process. In addition, oxygen in solution played a vital role in the reversible shape conversion of silver nanoparticles. Moreover, simulated sunlight can convert silver nanoprisms to nanodecahedra instead of UV light with assistance of TiO2 QDs, which would promote the photoinduced reaction of silver nanoparticles based on a natural light source.

DNA transfer by examination tools--a risk for forensic casework?

The introduction of profiling systems with increased sensitivity has led to a concurrent increase in the risk of detecting contaminating DNA in forensic casework. To evaluate the contamination risk of tools used during exhibit examination we have assessed the occurrence and level of DNA transferred between mock casework exhibits, comprised of cotton or glass substrates, and high-risk vectors (scissors, forceps, and gloves). The subsequent impact of such transfer in the profiling of a target sample was also investigated. Dried blood or touch DNA, deposited on the primary substrate, was transferred via the vector to the secondary substrate, which was either DNA-free or contained a target sample (dried blood or touch DNA). Pairwise combinations of both heavy and light contact were applied by each vector in order to simulate various levels of contamination. The transfer of dried blood to DNA-free cotton was observed for all vectors and transfer scenarios, with transfer substantially lower when glass was the substrate. Overall touch DNA transferred less efficiently, with significantly lower transfer rates than blood when transferred to DNA-free cotton; the greatest transfer of touch DNA occurred between cotton and glass substrates. In the presence of a target sample, the detectability of transferred DNA decreased due to the presence of background DNA. Transfer had no impact on the detectability of the target profile, however, in casework scenarios where the suspect profiles are not known, profile interpretation becomes complicated by the addition of contaminating alleles and the probative value of the evidence may be affected. The results of this study reiterate the need for examiners to adhere to stringent laboratory cleaning protocols, particularly in the interest of contamination minimisation, and to reduce the handling of items to prevent intra-item transfer.

Understanding and development of supply chain agility and flexibility: a structured literature review

This paper provides a review of the literature while contributing to academic understanding of the concepts of agility and flexibility within the supply chain. The research identified 83 peer-reviewed articles through a structured review technique, which is based on a three-stage refinement process. Data reduction procedures using codification, sentence strings and a review of keywords, title, abstract and conclusion were used in the search. The papers identified focused on organizational and supply chain agility and flexibility. The acknowledged gaps in understanding and development of agility and flexibility in supply chains were identified and categorized in terms of conceptual, contextual and methodological gaps. Subsequent to the gap analysis, this paper argues that effective relationship integration with key partners is a fundamental mechanism for mitigating the problem of control dissipation, which has hindered academic understanding with respect to development and application of agile and flexible capabilities in supply chains. The findings in this paper will help academics to gain a better understanding and to develop the concepts of supply chain agility and flexibility. In addition, the findings indicate that supply chain stakeholders need to address the issue of relationship integration when undertaking, or participating in agility and flexibility development programmes, so as to maximize supply chain performance. The paper concludes by highlighting implications for managers and researchers, and proposes a number of areas for future investigation.

Identification and characterization of a novel IL-4 receptor α chain (IL-4Rα) antagonist to inhibit IL-4 signalling

BACKGROUND/AIMS: In recent times, allergy has become a financial, physical and psychological burden to the society as a whole. In allergic cascades, cytokine IL-4 binds to IL-4 receptor (IL-4R), consequently producing allergen-specific IgE antibodies by B cells. In addition, among other functions, IL-4 is also responsible for B and T cell proliferation and differentiation. Hence, characterization of novel antagonists that inhibit IL-4 signalling forms the overall aim of this study. METHODS: Phage display was used to screen a random 12-mer synthetic peptide library with a human IL-4Rα to identify peptide candidates. Once identified, the peptides were commercially synthesized and used for in vitro immunoassays. RESULTS: We have successfully used phage display to identify M13 phage clones that demonstrated specific binding to IL-4Rα. The peptide N1 was synthesized for use in ELISA, demonstrating significant binding to IL-4Rα and inhibiting interaction with cytokine IL-4. Furthermore, the peptide was tested in a transfected HEK-Blue IL-4 reporter cell line model, which produces alkaline phosphatase (AP). QUANTI-Blue, a substrate, breaks down in the presence of AP producing a blue coloration. Using this colorimetric analysis, >50% inhibition of IL-4 signalling was achieved. CONCLUSION: We have successfully identified and characterised a synthetic peptide antagonist against IL-4Rα, which effectively inhibits IL-4 interaction with the IL-4Rα in vitro. Since IL-4 interaction with IL-4Rα is a common pathway for many allergies, a prophylactic treatment can be devised by inhibiting this interaction for future treatment of allergies.

Controllable graphene oxide mediated efficient electron transfer pathways across self-assembly monolayers: a new class of graphene based electrodes

In this paper, the influence of chemically reduced graphene oxide sheets (CRGOs) on the electrochemical performance through methyl or carboxylic acid terminated self-assembled monolayers (SAMs) is reported. The gold electrode was initially modified with methyl or carboxylic acid terminated alkanethiols with various carbon chain lengths (n = 4, 6, 8 and 11) and subsequently immobilization of the CRGOs on a SAM surface was achieved via a hydrophobic and electrostatic interaction. By using the potassium ferricyanide as a redox probe, it was observed that CRGOs could effectively enhance the heterogeneous electron transfer (ET) of the SAM due to a tunneling effect. The assemblies based on thiol end groups with methyl head groups were observed to afford more hydrophobic interaction binding with CRGOs with a higher reduction time than the assemblies developed with thiol end groups and a -COOH group which were shown to bind more electrostatically with CRGOs, a lowering reduction time. The Nyquist plots developed show a gradual decrease of the charge transfer resistance (Rct) of [Fe(CN)6]3-/4- redox couple at the CRGOs-SAMs electrode with the controllable adsorption of different CRGO's onto the SAM. Depending on the chain length and terminal functional group the electron transfer rate kinetics were observed to differ considerably.

The inventory centralization impacts on sustainability of the blood supply chain

This paper studies the significance of inventory centralization at the second echelon of a two-echelon supply chain with perishable items when the agents of the second echelon use an ( S − 1, S) inventory policy. The replenishment at the first echelon is considered to be stochastic. The context in which the studied problem exists is in the blood supply network where the first echelon includes a single blood bank that receives stochastic supply from donors. The second echelon contains hospitals receiving external demands (transfusions). In our proposed structure, some of the hospitals in close proximity of each other maintain centralized inventories to serve their demands in addition to the demands by other neighbour hospitals. The results demonstrate that centralization of hospitals’ inventory is a key factor in the blood supply chain and can increase the sustainability and resilient of the blood supply chain. Using numerical study, it was observed that reducing the number of hospitals that hold inventory from 7 to 3 decreases out date and shortage in the supply chain by 21% and 40% respectively. 2016 Elsevier Ltd. All rights reserved.